Liver ultrasound elastography for the evaluation of periportal fibrosis in schistosomiasis mansoni: a cross-sectional study
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/32301 |
Resumo: | Universidade Federal de Pernambuco. Centro de Ciências da Saúde. Recife, PE, Brasil. |
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Santos, Joelma CarvalhoBatista, Andrea DóriaVasconcelos, Carla Maria MolaLemos, Roberto SouzaSouza Junior, Valter Romão deDessein, AlainDessein, HéliaMontenegro, Silvia Maria LucenaLopes, Edmundo Pessoa AlmeidaDomingues, Ana Lúcia Coutinho2019-03-29T15:41:58Z2019-03-29T15:41:58Z2018SANTOS, Joelma Carvalho et al. Liver ultrasound elastography for the evaluation of periportal fibrosis in schistosomiasis mansoni: a cross-sectional study. PLoS Neglected Tropical Diseases, v. 12, n. 11, p. 1-9, Nov. 2018.1935-2735https://www.arca.fiocruz.br/handle/icict/3230110.1371/journal.pntd.000686810.1371/journal.pntd.0006868engLiver ultrasound elastography for the evaluation of periportal fibrosis in schistosomiasis mansoni: a cross-sectional studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Pernambuco. Centro de Ciências da Saúde. Recife, PE, Brasil.Universidade Federal de Pernambuco. Hospital das Clínicas. Recife, PE, Brasil.Universidade Federal de Pernambuco. Recife, PE, Brasil.Universidade Federal de Pernambuco. Centro de Ciências da Saúde. Recife, PE, Brasil.Universidade Federal de Pernambuco. Recife, PE, Brasil.Faculté de Médecine. Aix-Marseille Université. Marseille, France.Faculté de Médecine. Aix-Marseille Université. Marseille, France.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil.Universidade Federal de Pernambuco. Centro de Ciências da Saúde. Recife, PE, Brasil / Universidade Federal de Pernambuco. Hospital das Clínicas. Recife, PE, Brasil.Universidade Federal de Pernambuco. Centro de Ciências da Saúde. Recife, PE, Brasil / Universidade Federal de Pernambuco. Hospital das Clínicas. Recife, PE, Brasil.ARFI elastrography has been used as a noninvasive method to assess the severity of liver fibrosis in viral hepatitis, although with few studies in schistosomiasis mansoni. We aimed to evaluate the performance of point shear wave elastography (pSWE) for predicting significant periportal fibrosis (PPF) in schistosomotic patients and to determine its best cutoff point. Methodology/principal findings This cross-sectional study included 358 adult schistosomotic patients subjected to US and pSWE on the right lobe. Two hundred two patients (62.0%) were women, with a median age of 54 (ranging 18–92) years. The pSWE measurements were compared to the US patterns of PPF, as gold standard, according to the Niamey classification. The performance of pSWE was calculated as the area under the ROC curve (AUC). Patients were further classified into two groups: 86 patients with mild PPF and 272 patients with significant PPF. The median pSWE of the significant fibrosis group was higher (1.40 m/s) than that of mild fibrosis group (1.14 m/s, p<0.001). AUC was 0.719 with ≤1.11 m/s as the best cutoff value for excluding significant PPF. Sensitivity and negative predictive values were 80.5% and 40.5%, respectively. Whereas, for confirming significant PPF, the best cutoff value was >1.39 m/s, with specificity of 86.1% and positive predictive value of 92.0%. Conclusions/significance pSWE was able to differentiate significant from mild PPF, with better performance to predict significant PPF.Ultrasound elastographyPeriportal fibrosisSchistosomiasis mansoniAdolescenteAdultoEnvelhecidoIdoso, 80 anos ou maisTécnicas de Imagem de Elasticidade / métodosFêmeaHumanosFígado / diagnóstico por imagemCirrose Hepática / diagnósticoCirrose Hepática / diagnóstico por imagemMasculinoMeia idadeEsquistossomose mansônica / diagnósticoEsquistossomose mansoni / diagnóstico por imagemSensibilidade e EspecificidadeUltrassonografia / métodosAdulto joveminfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83094https://www.arca.fiocruz.br/bitstream/icict/32301/1/license.txtee3692f7b0b97d5638099ab94397d05fMD51ORIGINALLiver ultrasound elastography for the evaluation of periportal fibrosis in schistosomiasis mansoniA cross-sectional study.pdfLiver ultrasound elastography for the evaluation of periportal fibrosis in schistosomiasis mansoniA cross-sectional study.pdfapplication/pdf741224https://www.arca.fiocruz.br/bitstream/icict/32301/2/Liver%20ultrasound%20elastography%20for%20the%20evaluation%20of%20periportal%20fibrosis%20in%20schistosomiasis%20mansoniA%20cross-sectional%20study.pdfe3e9bfd993826946c73496dede74234dMD52TEXTLiver ultrasound elastography for the evaluation of periportal fibrosis in schistosomiasis mansoniA cross-sectional study.pdf.txtLiver ultrasound elastography for the evaluation of periportal fibrosis in schistosomiasis mansoniA cross-sectional study.pdf.txtExtracted texttext/plain33337https://www.arca.fiocruz.br/bitstream/icict/32301/3/Liver%20ultrasound%20elastography%20for%20the%20evaluation%20of%20periportal%20fibrosis%20in%20schistosomiasis%20mansoniA%20cross-sectional%20study.pdf.txtbe76a1791b6fd603c16269f91e2ff8f4MD53icict/323012019-04-04 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| dc.title.pt_BR.fl_str_mv |
Liver ultrasound elastography for the evaluation of periportal fibrosis in schistosomiasis mansoni: a cross-sectional study |
| title |
Liver ultrasound elastography for the evaluation of periportal fibrosis in schistosomiasis mansoni: a cross-sectional study |
| spellingShingle |
Liver ultrasound elastography for the evaluation of periportal fibrosis in schistosomiasis mansoni: a cross-sectional study Santos, Joelma Carvalho Ultrasound elastography Periportal fibrosis Schistosomiasis mansoni Adolescente Adulto Envelhecido Idoso, 80 anos ou mais Técnicas de Imagem de Elasticidade / métodos Fêmea Humanos Fígado / diagnóstico por imagem Cirrose Hepática / diagnóstico Cirrose Hepática / diagnóstico por imagem Masculino Meia idade Esquistossomose mansônica / diagnóstico Esquistossomose mansoni / diagnóstico por imagem Sensibilidade e Especificidade Ultrassonografia / métodos Adulto jovem |
| title_short |
Liver ultrasound elastography for the evaluation of periportal fibrosis in schistosomiasis mansoni: a cross-sectional study |
| title_full |
Liver ultrasound elastography for the evaluation of periportal fibrosis in schistosomiasis mansoni: a cross-sectional study |
| title_fullStr |
Liver ultrasound elastography for the evaluation of periportal fibrosis in schistosomiasis mansoni: a cross-sectional study |
| title_full_unstemmed |
Liver ultrasound elastography for the evaluation of periportal fibrosis in schistosomiasis mansoni: a cross-sectional study |
| title_sort |
Liver ultrasound elastography for the evaluation of periportal fibrosis in schistosomiasis mansoni: a cross-sectional study |
| author |
Santos, Joelma Carvalho |
| author_facet |
Santos, Joelma Carvalho Batista, Andrea Dória Vasconcelos, Carla Maria Mola Lemos, Roberto Souza Souza Junior, Valter Romão de Dessein, Alain Dessein, Hélia Montenegro, Silvia Maria Lucena Lopes, Edmundo Pessoa Almeida Domingues, Ana Lúcia Coutinho |
| author_role |
author |
| author2 |
Batista, Andrea Dória Vasconcelos, Carla Maria Mola Lemos, Roberto Souza Souza Junior, Valter Romão de Dessein, Alain Dessein, Hélia Montenegro, Silvia Maria Lucena Lopes, Edmundo Pessoa Almeida Domingues, Ana Lúcia Coutinho |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Santos, Joelma Carvalho Batista, Andrea Dória Vasconcelos, Carla Maria Mola Lemos, Roberto Souza Souza Junior, Valter Romão de Dessein, Alain Dessein, Hélia Montenegro, Silvia Maria Lucena Lopes, Edmundo Pessoa Almeida Domingues, Ana Lúcia Coutinho |
| dc.subject.en.pt_BR.fl_str_mv |
Ultrasound elastography Periportal fibrosis Schistosomiasis mansoni |
| topic |
Ultrasound elastography Periportal fibrosis Schistosomiasis mansoni Adolescente Adulto Envelhecido Idoso, 80 anos ou mais Técnicas de Imagem de Elasticidade / métodos Fêmea Humanos Fígado / diagnóstico por imagem Cirrose Hepática / diagnóstico Cirrose Hepática / diagnóstico por imagem Masculino Meia idade Esquistossomose mansônica / diagnóstico Esquistossomose mansoni / diagnóstico por imagem Sensibilidade e Especificidade Ultrassonografia / métodos Adulto jovem |
| dc.subject.decs.pt_BR.fl_str_mv |
Adolescente Adulto Envelhecido Idoso, 80 anos ou mais Técnicas de Imagem de Elasticidade / métodos Fêmea Humanos Fígado / diagnóstico por imagem Cirrose Hepática / diagnóstico Cirrose Hepática / diagnóstico por imagem Masculino Meia idade Esquistossomose mansônica / diagnóstico Esquistossomose mansoni / diagnóstico por imagem Sensibilidade e Especificidade Ultrassonografia / métodos Adulto jovem |
| description |
Universidade Federal de Pernambuco. Centro de Ciências da Saúde. Recife, PE, Brasil. |
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2018 |
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2018 |
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2019-03-29T15:41:58Z |
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2019-03-29T15:41:58Z |
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SANTOS, Joelma Carvalho et al. Liver ultrasound elastography for the evaluation of periportal fibrosis in schistosomiasis mansoni: a cross-sectional study. PLoS Neglected Tropical Diseases, v. 12, n. 11, p. 1-9, Nov. 2018. |
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https://www.arca.fiocruz.br/handle/icict/32301 |
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1935-2735 |
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10.1371/journal.pntd.0006868 |
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10.1371/journal.pntd.0006868 |
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SANTOS, Joelma Carvalho et al. Liver ultrasound elastography for the evaluation of periportal fibrosis in schistosomiasis mansoni: a cross-sectional study. PLoS Neglected Tropical Diseases, v. 12, n. 11, p. 1-9, Nov. 2018. 1935-2735 10.1371/journal.pntd.0006868 |
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