In vitro and in vivo studies of the biological activity of novel arylimidamides against Trypanosoma cruzi
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2014 |
| Outros Autores: | , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/15725 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. |
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Araújo, J. S. deSilva, C. F. daBatista, D. G. J.Silva, P. B. daMeuser, M. B.Aiub, C. A. F.Silva, M. F. V. daLima, C. F. AraújoBanerjee, M.Farahat, A. A.Stephens, C. E.Kumar, ABoykin, D. W.Soeiro, M. N. C.2016-09-08T16:44:05Z2016-09-08T16:44:05Z2014ARAÚJO, J. S; et al. In Vitro and In Vivo Studies of the Biological Activity of Novel Arylimidamides against Trypanosoma cruzi. Antimicrobial Agents and Chemotherapy, v.58, n.7, p.4191-4195, July 2014.0066-4804https://www.arca.fiocruz.br/handle/icict/1572510.1128/AAC.01403-131098-6596engAmerican Society for MicrobiologyTrypanosoma cruziDoença de ChagasTécnicas In VitroTrypanosoma cruziChagas DiseaseIn vitro techiniquesNovel ArylimidamidesIn vitro and in vivo studies of the biological activity of novel arylimidamides against Trypanosoma cruziinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Genética e Biologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Genética e Biologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Departamento de Biofísica e Biometria.Rio de Janeiro, RJ, Brasil.Georgia State University. Department of Chemistry. Atlanta, Georgia, USA.Georgia State University. Department of Chemistry. Atlanta, Georgia, USA / Mansoura University. Faculty of Pharmacy. Deparment of Chemistry. Mansoura, Egypt.Georgia Regents University. Department of Chemistry and Physics. Augusta, GA, USA..Georgia State University. Department of Chemistry. Atlanta, Georgia, USA.Georgia State University. Department of Chemistry. Atlanta, Georgia, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fifteen novel arylimidamides (AIAs) (6 bis-amidino and 9 mono-amidino analogues) were assayed against Trypanosoma cruzi in vitro and in vivo. All the bis-AIAs were more effective than the mono-AIAs, and two analogues, DB1967 and DB1989, were further evaluated in vivo. Although both of them reduced parasitemia, protection against mortality was not achieved. Our results show that the number of amidino-terminal units affects the efficacy of arylimidamides against T. cruzi.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALve_js_araujo_etal_IOC_2014.pdfve_js_araujo_etal_IOC_2014.pdfVersão do Editorapplication/pdf523136https://www.arca.fiocruz.br/bitstream/icict/15725/5/ve_js_araujo_etal_IOC_2014.pdf132f06de8c88f543e8c8f4de9174919cMD55js_araujo_etal_IOC_2014.pdfjs_araujo_etal_IOC_2014.pdfVersão Ahead of Printapplication/pdf611583https://www.arca.fiocruz.br/bitstream/icict/15725/2/js_araujo_etal_IOC_2014.pdfccc4d5bdbb7c5639a365b61f09d5882eMD52zac005142835so1.pdfzac005142835so1.pdfMaterial Suplementarapplication/pdf431461https://www.arca.fiocruz.br/bitstream/icict/15725/6/zac005142835so1.pdfda57926996fb7ea76509d3dc0a14bb0fMD56LICENSElicense.txtlicense.txttext/plain; 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| dc.title.pt_BR.fl_str_mv |
In vitro and in vivo studies of the biological activity of novel arylimidamides against Trypanosoma cruzi |
| title |
In vitro and in vivo studies of the biological activity of novel arylimidamides against Trypanosoma cruzi |
| spellingShingle |
In vitro and in vivo studies of the biological activity of novel arylimidamides against Trypanosoma cruzi Araújo, J. S. de Trypanosoma cruzi Doença de Chagas Técnicas In Vitro Trypanosoma cruzi Chagas Disease In vitro techiniques Novel Arylimidamides |
| title_short |
In vitro and in vivo studies of the biological activity of novel arylimidamides against Trypanosoma cruzi |
| title_full |
In vitro and in vivo studies of the biological activity of novel arylimidamides against Trypanosoma cruzi |
| title_fullStr |
In vitro and in vivo studies of the biological activity of novel arylimidamides against Trypanosoma cruzi |
| title_full_unstemmed |
In vitro and in vivo studies of the biological activity of novel arylimidamides against Trypanosoma cruzi |
| title_sort |
In vitro and in vivo studies of the biological activity of novel arylimidamides against Trypanosoma cruzi |
| author |
Araújo, J. S. de |
| author_facet |
Araújo, J. S. de Silva, C. F. da Batista, D. G. J. Silva, P. B. da Meuser, M. B. Aiub, C. A. F. Silva, M. F. V. da Lima, C. F. Araújo Banerjee, M. Farahat, A. A. Stephens, C. E. Kumar, A Boykin, D. W. Soeiro, M. N. C. |
| author_role |
author |
| author2 |
Silva, C. F. da Batista, D. G. J. Silva, P. B. da Meuser, M. B. Aiub, C. A. F. Silva, M. F. V. da Lima, C. F. Araújo Banerjee, M. Farahat, A. A. Stephens, C. E. Kumar, A Boykin, D. W. Soeiro, M. N. C. |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Araújo, J. S. de Silva, C. F. da Batista, D. G. J. Silva, P. B. da Meuser, M. B. Aiub, C. A. F. Silva, M. F. V. da Lima, C. F. Araújo Banerjee, M. Farahat, A. A. Stephens, C. E. Kumar, A Boykin, D. W. Soeiro, M. N. C. |
| dc.subject.other.pt_BR.fl_str_mv |
Trypanosoma cruzi Doença de Chagas Técnicas In Vitro |
| topic |
Trypanosoma cruzi Doença de Chagas Técnicas In Vitro Trypanosoma cruzi Chagas Disease In vitro techiniques Novel Arylimidamides |
| dc.subject.en.pt_BR.fl_str_mv |
Trypanosoma cruzi Chagas Disease In vitro techiniques Novel Arylimidamides |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. |
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2014 |
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2014 |
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2016-09-08T16:44:05Z |
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2016-09-08T16:44:05Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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ARAÚJO, J. S; et al. In Vitro and In Vivo Studies of the Biological Activity of Novel Arylimidamides against Trypanosoma cruzi. Antimicrobial Agents and Chemotherapy, v.58, n.7, p.4191-4195, July 2014. |
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https://www.arca.fiocruz.br/handle/icict/15725 |
| dc.identifier.issn.pt_BR.fl_str_mv |
0066-4804 |
| dc.identifier.doi.none.fl_str_mv |
10.1128/AAC.01403-13 |
| dc.identifier.eissn.none.fl_str_mv |
1098-6596 |
| identifier_str_mv |
ARAÚJO, J. S; et al. In Vitro and In Vivo Studies of the Biological Activity of Novel Arylimidamides against Trypanosoma cruzi. Antimicrobial Agents and Chemotherapy, v.58, n.7, p.4191-4195, July 2014. 0066-4804 10.1128/AAC.01403-13 1098-6596 |
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eng |
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openAccess |
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American Society for Microbiology |
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American Society for Microbiology |
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