Antimalarial Activity of Cocos nucifera Husk Fibre: Further Studies

Detalhes bibliográficos
Autor(a) principal: Adebayo, Joseph Oluwatope
Data de Publicação: 2013
Outros Autores: Balogun, E. A., Malomo, S. O., Soladoye, A. O., Olatunji, L. A., Kolawole, O. M., Oguntoye, O. S., Babatunde, A. S., Akinola, O. B., Aguiar, Anna Caroline Campos, Andrade, Isabel Mayer de, Souza, Nicolli Bellotti de, Krettli, Antoniana Ursine
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/59433
Resumo: Department of Biochemistry. University of Ilorin. Ilorin, Nigeria.
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spelling Adebayo, Joseph OluwatopeBalogun, E. A.Malomo, S. O.Soladoye, A. O.Olatunji, L. A.Kolawole, O. M.Oguntoye, O. S.Babatunde, A. S.Akinola, O. B.Aguiar, Anna Caroline CamposAndrade, Isabel Mayer deSouza, Nicolli Bellotti deKrettli, Antoniana Ursine2023-07-06T13:05:07Z2023-07-06T13:05:07Z2013ADEBAYO, Joseph Oluwatope et al. Antimalarial Activity of Cocos nucifera Husk Fibre: Further Studies. Evidence-Based Complementary and Alternative Medicine, v. 2013, p. 1-9, Article ID 742476, 2013.1741-427Xhttps://www.arca.fiocruz.br/handle/icict/5943310.1155/2013/742476engHindawiAntimalarial Activity of Cocos nucifera Husk Fibre: Further Studiesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleDepartment of Biochemistry. University of Ilorin. Ilorin, Nigeria.Department of Biochemistry. University of Ilorin. Ilorin, Nigeria.Department of Biochemistry. University of Ilorin. Ilorin, Nigeria.Department of Physiology. University of Ilorin. Ilorin, Nigeria.Department of Physiology. University of Ilorin. Ilorin, Nigeria.Department of Microbiology. University of Ilorin. Ilorin, Nigeria.Department of Chemistry. University of Ilorin. Ilorin, Nigeria.Department of Hematology, University of Ilorin, Ilorin, Nigeria.Department of Anatomy. University of Ilorin. Ilorin, Nigeria.Universidade Federal de Minas Gerais. Faculdade de Medicina. Programa de Pós Graduação em Medicina Molecular. Belo Horizonte, MG, Brazil / Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Malária. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Malária. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Malária. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Faculdade de Medicina. Programa de Pós Graduação em Medicina Molecular. Belo Horizonte, MG, Brazil / Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Malária. Belo Horizonte, MG, Brazil.In this study, the antimalarial and toxicity potentials of husk fibre extracts of five Nigerian varieties of Cocos nucifera were evaluated in vitro. The only active extract fraction, West African Tall (WAT) ethyl acetate extract fraction, was then evaluated for its phytochemical constituents, antimalarial and toxicity potentials at varying doses (31.25-500 mg/kg body weight) using various organ function indices. The results revealed that WAT ethyl acetate extract fraction (WATEAEF) contained alkaloids, tannins, and flavonoids and was active against Plasmodium falciparum W2 strain maintained in continuous culture, with a selectivity index of 30.3. The same extract fraction was active in vivo against Plasmodium berghei NK65, causing more than 50% reduction in parasitaemia on days 4 and 6 after inoculation at various doses administered. WATEAEF did not significantly alter (P > 0.05) function indices of the liver and cardiovascular system at all doses administered but significantly increased (P < 0.05) plasma creatinine concentration at 250 and 500 mg/Kg body weight compared to controls. The results of this study suggest that WATEAEF possesses antimalarial activity and may not adversely affect normal liver function nor predispose subjects to cardiovascular diseases but may impair normal kidney function at higher doses. Further studies are underway to isolate the active principles.Cocos nuciferaAntimalarial ActivityPlasmodium falciparum W2Plasmodium berghei NK65info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALECAM2013-742476.pdfECAM2013-742476.pdfapplication/pdf151520https://www.arca.fiocruz.br/bitstream/icict/59433/2/ECAM2013-742476.pdfcd2a94f758c6173771c27adc4639f9b4MD52LICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/59433/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51icict/594332023-07-06 22:05:55.599oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-07-07T01:05:55Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv Antimalarial Activity of Cocos nucifera Husk Fibre: Further Studies
title Antimalarial Activity of Cocos nucifera Husk Fibre: Further Studies
spellingShingle Antimalarial Activity of Cocos nucifera Husk Fibre: Further Studies
Adebayo, Joseph Oluwatope
Cocos nucifera
Antimalarial Activity
Plasmodium falciparum W2
Plasmodium berghei NK65
title_short Antimalarial Activity of Cocos nucifera Husk Fibre: Further Studies
title_full Antimalarial Activity of Cocos nucifera Husk Fibre: Further Studies
title_fullStr Antimalarial Activity of Cocos nucifera Husk Fibre: Further Studies
title_full_unstemmed Antimalarial Activity of Cocos nucifera Husk Fibre: Further Studies
title_sort Antimalarial Activity of Cocos nucifera Husk Fibre: Further Studies
author Adebayo, Joseph Oluwatope
author_facet Adebayo, Joseph Oluwatope
Balogun, E. A.
Malomo, S. O.
Soladoye, A. O.
Olatunji, L. A.
Kolawole, O. M.
Oguntoye, O. S.
Babatunde, A. S.
Akinola, O. B.
Aguiar, Anna Caroline Campos
Andrade, Isabel Mayer de
Souza, Nicolli Bellotti de
Krettli, Antoniana Ursine
author_role author
author2 Balogun, E. A.
Malomo, S. O.
Soladoye, A. O.
Olatunji, L. A.
Kolawole, O. M.
Oguntoye, O. S.
Babatunde, A. S.
Akinola, O. B.
Aguiar, Anna Caroline Campos
Andrade, Isabel Mayer de
Souza, Nicolli Bellotti de
Krettli, Antoniana Ursine
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Adebayo, Joseph Oluwatope
Balogun, E. A.
Malomo, S. O.
Soladoye, A. O.
Olatunji, L. A.
Kolawole, O. M.
Oguntoye, O. S.
Babatunde, A. S.
Akinola, O. B.
Aguiar, Anna Caroline Campos
Andrade, Isabel Mayer de
Souza, Nicolli Bellotti de
Krettli, Antoniana Ursine
dc.subject.en.none.fl_str_mv Cocos nucifera
Antimalarial Activity
Plasmodium falciparum W2
Plasmodium berghei NK65
topic Cocos nucifera
Antimalarial Activity
Plasmodium falciparum W2
Plasmodium berghei NK65
description Department of Biochemistry. University of Ilorin. Ilorin, Nigeria.
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2023-07-06T13:05:07Z
dc.date.available.fl_str_mv 2023-07-06T13:05:07Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ADEBAYO, Joseph Oluwatope et al. Antimalarial Activity of Cocos nucifera Husk Fibre: Further Studies. Evidence-Based Complementary and Alternative Medicine, v. 2013, p. 1-9, Article ID 742476, 2013.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/59433
dc.identifier.issn.en_US.fl_str_mv 1741-427X
dc.identifier.doi.none.fl_str_mv 10.1155/2013/742476
identifier_str_mv ADEBAYO, Joseph Oluwatope et al. Antimalarial Activity of Cocos nucifera Husk Fibre: Further Studies. Evidence-Based Complementary and Alternative Medicine, v. 2013, p. 1-9, Article ID 742476, 2013.
1741-427X
10.1155/2013/742476
url https://www.arca.fiocruz.br/handle/icict/59433
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dc.publisher.none.fl_str_mv Hindawi
publisher.none.fl_str_mv Hindawi
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