Magnetic bead-based immunoassay allows rapid, inexpensive, and quantitative detection of human SARS-CoV‑2 antibodies
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/46087 |
Resumo: | Universidade Federal do Paraná. Setor Litoral. Matinhos. PR, Brasil. |
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Huergo, Luciano F.Selim, Khaled A.Conzentino, Marcelo S.Gerhardt, Edileusa C. M.Santos, Adrian R. S.Wagner, BerenikeAlford, Janette T.Deobald, NelliPedrosa, Fabio O.Souza, Emanuel Maltempi deNogueira, Meri B.Raboni, Sônia M.Souto, DênioRego, Fabiane G. M.Zanette, Dalila LucíolaAoki, Mateus NóbregaNardin, Jeanine M.Fornazari, BrunaMorales, Hugo M. P.Borges, Vânia A.Nelde, AnnikaWalz, Juliane S.Becker, MatthiasSchneiderhan-Marra, NicoleRothbauer, UlrichReis, Rodrigo A.Forchhammer, Karl2021-02-16T18:51:28Z2021-02-16T18:51:28Z2021HUERGO, Luciano F. et al. Magnetic bead-based immunoassay allows rapid, inexpensive, and quantitative detection of human SARS-CoV‑2 antibodies. ACS Sensors, p. 1-6, 2021.2379-3694https://www.arca.fiocruz.br/handle/icict/4608710.1021/acssensors.0c02544porAmerican Chemical SocietyCOVID-19ELISASARS-CoV-2Coronavirus InfectionsEnzyme-Linked Immunosorbent AssayImmunological ModelsAntibodiesMethodsInfecciones por CoronavirusEnsayo de Inmunoadsorción EnzimáticaModelos InmunológicosAnticuerposMétodosInfections à coronavirusTest ELISAModèles immunologiquesAnticorpsMéthodesInfecções por CoronavirusEnsaio de Imunoadsorção EnzimáticaModelos ImunológicosAnticorposMétodosMagnetic bead-based immunoassay allows rapid, inexpensive, and quantitative detection of human SARS-CoV‑2 antibodiesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Paraná. Setor Litoral. Matinhos. PR, Brasil.Interfaculty Institute for Microbiology and Infection Medicine. Eberhard Karls University of Tübingen. Tübingen, Germany.Universidade Federal do Paraná. Setor Litoral. Matinhos. PR, Brasil.Universidade Federal do Paraná. Departamento de Bioquímica e Biologia Molecular. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Bioquímica e Biologia Molecular. Curitiba, PR, Brasil.Interfaculty Institute for Microbiology and Infection Medicine. Eberhard Karls University of Tübingen. Tübingen, Germany .Interfaculty Institute for Microbiology and Infection Medicine. Eberhard Karls University of Tübingen. Tübingen, Germany.Interfaculty Institute for Microbiology and Infection Medicine. Eberhard Karls University of Tübingen. Tübingen, Germany.Universidade Federal do Paraná. Departamento de Bioquímica e Biologia Molecular. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Bioquímica e Biologia Molecular. Curitiba, PR, Brasil.Universidade Federal do Paraná. Complexo Hospital de Clínicas. Curitiba, PR, Brasil.Universidade Federal do Paraná. Complexo Hospital de Clínicas. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Química. Curitiba, PR, Brasil.Universidade Federal do Paraná. Programa de Pós-Graduação em Ciências Farmacêuticas. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Hospital Erasto Gaertner. Curitiba, PR, Brasil.Hospital Erasto Gaertner. Curitiba, PR, Brasil.Hospital Erasto Gaertner. Curitiba, PR, Brasil.Secretaria Municipal de Saúde de Guaratuba. Guaratuba, PR. Brasil.Clinical Collaboration Unit Translational Immunology. German Cancer Consortium (DKTK). / Department of Internal Medicine. University Hospital Tübingen.Tübingen, Germany. / Department of Immunology. Institute for Cell Biology and Cluster of Excellence. Tübingen University. Tübingen, Germany.Clinical Collaboration Unit Translational Immunology. German Cancer Consortium (DKTK). / Department of Internal Medicine and Departament of Hematooogy, Oncology, Clinical Immunology and Rheumatology. University Hospital Tübingen.Tübingen, Germany. / Department of Immunology. Institute for Cell Biology and Cluster of Excellence. Tübingen University. Tübingen, Germany.Tübingen University. Institute of Natural and Medical Sciences. Tübingen, Germany.Tübingen University. Institute of Natural and Medical Sciences. Tübingen, Germany.Tübingen University. Institute of Natural and Medical Sciences. Tübingen, Germany. / Tübingen University. Pharmaceutical Biotechnology. Tübingen, Germany.Universidade Federal do Paraná. Setor Litoral. Matinhos. PR, Brasil.Interfaculty Institute for Microbiology and Infection Medicine. Eberhard Karls University of Tübingen. Tübingen, Germany.Immunological methods to detect SARS-CoV-2 seroconversion in humans are important to track COVID-19 cases and the humoral response to SARS-CoV-2 infections and immunization to future vaccines. The aim of this work was to develop a simple chromogenic magnetic bead-based immunoassay which allows rapid, inexpensive, and quantitative detection of human antibodies against SARS-CoV-2 in serum, plasma, or blood. Recombinant 6xHis-tagged SARS-CoV-2 Nucleocapsid protein was mobilized on the surface of Ni2+ magnetic beads and challenged with serum or blood samples obtained from controls or COVID-19 cases. The beads were washed, incubated with anti-human IgG-HPR conjugate, and immersed into a solution containing a chromogenic HPR substrate. Bead transfer and homogenization between solutions was aided by a simple low-cost device. The method was validated by two independent laboratories, and the performance to detect SARS-CoV-2 seroconversion in humans was in the same range as obtained using the gold standard immunoassays ELISA and Luminex, though requiring only a fraction of consumables, instrumentation, time to deliver results, and volume of sample. Furthermore, the results obtained with the method described can be visually interpreted without compromising accuracy as demonstrated by validation at a point-of-care unit. The magnetic bead immunoassay throughput can be customized on demand and is readily adapted to be used with any other 6xHis tagged protein or peptide as antigen to track other diseases.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83084https://www.arca.fiocruz.br/bitstream/icict/46087/1/license.txt783568c2893d2e25a99990b126be1772MD51ORIGINALacssensors.0c02544OK.pdfacssensors.0c02544OK.pdfapplication/pdf1916501https://www.arca.fiocruz.br/bitstream/icict/46087/2/acssensors.0c02544OK.pdfd92d1569a8cddc731183d8fd1cbd1327MD52TEXTacssensors.0c02544OK.pdf.txtacssensors.0c02544OK.pdf.txtExtracted texttext/plain29395https://www.arca.fiocruz.br/bitstream/icict/46087/3/acssensors.0c02544OK.pdf.txt755ad866e7a690a5d299dd390e6f6adfMD53icict/460872021-12-13 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dc.title.pt_BR.fl_str_mv |
Magnetic bead-based immunoassay allows rapid, inexpensive, and quantitative detection of human SARS-CoV‑2 antibodies |
title |
Magnetic bead-based immunoassay allows rapid, inexpensive, and quantitative detection of human SARS-CoV‑2 antibodies |
spellingShingle |
Magnetic bead-based immunoassay allows rapid, inexpensive, and quantitative detection of human SARS-CoV‑2 antibodies Huergo, Luciano F. COVID-19 ELISA SARS-CoV-2 Coronavirus Infections Enzyme-Linked Immunosorbent Assay Immunological Models Antibodies Methods Infecciones por Coronavirus Ensayo de Inmunoadsorción Enzimática Modelos Inmunológicos Anticuerpos Métodos Infections à coronavirus Test ELISA Modèles immunologiques Anticorps Méthodes Infecções por Coronavirus Ensaio de Imunoadsorção Enzimática Modelos Imunológicos Anticorpos Métodos |
title_short |
Magnetic bead-based immunoassay allows rapid, inexpensive, and quantitative detection of human SARS-CoV‑2 antibodies |
title_full |
Magnetic bead-based immunoassay allows rapid, inexpensive, and quantitative detection of human SARS-CoV‑2 antibodies |
title_fullStr |
Magnetic bead-based immunoassay allows rapid, inexpensive, and quantitative detection of human SARS-CoV‑2 antibodies |
title_full_unstemmed |
Magnetic bead-based immunoassay allows rapid, inexpensive, and quantitative detection of human SARS-CoV‑2 antibodies |
title_sort |
Magnetic bead-based immunoassay allows rapid, inexpensive, and quantitative detection of human SARS-CoV‑2 antibodies |
author |
Huergo, Luciano F. |
author_facet |
Huergo, Luciano F. Selim, Khaled A. Conzentino, Marcelo S. Gerhardt, Edileusa C. M. Santos, Adrian R. S. Wagner, Berenike Alford, Janette T. Deobald, Nelli Pedrosa, Fabio O. Souza, Emanuel Maltempi de Nogueira, Meri B. Raboni, Sônia M. Souto, Dênio Rego, Fabiane G. M. Zanette, Dalila Lucíola Aoki, Mateus Nóbrega Nardin, Jeanine M. Fornazari, Bruna Morales, Hugo M. P. Borges, Vânia A. Nelde, Annika Walz, Juliane S. Becker, Matthias Schneiderhan-Marra, Nicole Rothbauer, Ulrich Reis, Rodrigo A. Forchhammer, Karl |
author_role |
author |
author2 |
Selim, Khaled A. Conzentino, Marcelo S. Gerhardt, Edileusa C. M. Santos, Adrian R. S. Wagner, Berenike Alford, Janette T. Deobald, Nelli Pedrosa, Fabio O. Souza, Emanuel Maltempi de Nogueira, Meri B. Raboni, Sônia M. Souto, Dênio Rego, Fabiane G. M. Zanette, Dalila Lucíola Aoki, Mateus Nóbrega Nardin, Jeanine M. Fornazari, Bruna Morales, Hugo M. P. Borges, Vânia A. Nelde, Annika Walz, Juliane S. Becker, Matthias Schneiderhan-Marra, Nicole Rothbauer, Ulrich Reis, Rodrigo A. Forchhammer, Karl |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Huergo, Luciano F. Selim, Khaled A. Conzentino, Marcelo S. Gerhardt, Edileusa C. M. Santos, Adrian R. S. Wagner, Berenike Alford, Janette T. Deobald, Nelli Pedrosa, Fabio O. Souza, Emanuel Maltempi de Nogueira, Meri B. Raboni, Sônia M. Souto, Dênio Rego, Fabiane G. M. Zanette, Dalila Lucíola Aoki, Mateus Nóbrega Nardin, Jeanine M. Fornazari, Bruna Morales, Hugo M. P. Borges, Vânia A. Nelde, Annika Walz, Juliane S. Becker, Matthias Schneiderhan-Marra, Nicole Rothbauer, Ulrich Reis, Rodrigo A. Forchhammer, Karl |
dc.subject.other.pt_BR.fl_str_mv |
COVID-19 ELISA SARS-CoV-2 |
topic |
COVID-19 ELISA SARS-CoV-2 Coronavirus Infections Enzyme-Linked Immunosorbent Assay Immunological Models Antibodies Methods Infecciones por Coronavirus Ensayo de Inmunoadsorción Enzimática Modelos Inmunológicos Anticuerpos Métodos Infections à coronavirus Test ELISA Modèles immunologiques Anticorps Méthodes Infecções por Coronavirus Ensaio de Imunoadsorção Enzimática Modelos Imunológicos Anticorpos Métodos |
dc.subject.en.pt_BR.fl_str_mv |
Coronavirus Infections Enzyme-Linked Immunosorbent Assay Immunological Models Antibodies Methods |
dc.subject.es.pt_BR.fl_str_mv |
Infecciones por Coronavirus Ensayo de Inmunoadsorción Enzimática Modelos Inmunológicos Anticuerpos Métodos |
dc.subject.fr.pt_BR.fl_str_mv |
Infections à coronavirus Test ELISA Modèles immunologiques Anticorps Méthodes |
dc.subject.decs.pt_BR.fl_str_mv |
Infecções por Coronavirus Ensaio de Imunoadsorção Enzimática Modelos Imunológicos Anticorpos Métodos |
description |
Universidade Federal do Paraná. Setor Litoral. Matinhos. PR, Brasil. |
publishDate |
2021 |
dc.date.accessioned.fl_str_mv |
2021-02-16T18:51:28Z |
dc.date.available.fl_str_mv |
2021-02-16T18:51:28Z |
dc.date.issued.fl_str_mv |
2021 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
HUERGO, Luciano F. et al. Magnetic bead-based immunoassay allows rapid, inexpensive, and quantitative detection of human SARS-CoV‑2 antibodies. ACS Sensors, p. 1-6, 2021. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/46087 |
dc.identifier.issn.pt_BR.fl_str_mv |
2379-3694 |
dc.identifier.doi.pt_BR.fl_str_mv |
10.1021/acssensors.0c02544 |
identifier_str_mv |
HUERGO, Luciano F. et al. Magnetic bead-based immunoassay allows rapid, inexpensive, and quantitative detection of human SARS-CoV‑2 antibodies. ACS Sensors, p. 1-6, 2021. 2379-3694 10.1021/acssensors.0c02544 |
url |
https://www.arca.fiocruz.br/handle/icict/46087 |
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por |
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por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
American Chemical Society |
publisher.none.fl_str_mv |
American Chemical Society |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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