Individual responses to a single oral dose of albendazole indicate reduced efficacy against soil-transmitted helminths in an area with high drug pressure

Detalhes bibliográficos
Autor(a) principal: Walker, Martin
Data de Publicação: 2021
Outros Autores: Cools, Piet, Albonico, Marco, Ame, Shaali M, Ayana, Mio, Dana, Daniel, Keiser, Jennifer, Matoso, Leonardo Ferreira, Montresor, Antonio, Mekonnen, Zeleke, Oliveira, Rodrigo Corrêa de, Pinto, Simone Aparecida, Sayasone, Somphou, Vercruysse, Jozef, Vlaminck, Johnny, Levecke, Bruno
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/53146
Resumo: Department of Pathobiology and Population Sciences. Royal Veterinary College. Hatfield, United Kingdom/London Centre for Neglected Tropical Disease Research. Imperial College London. London, United Kingdom.
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spelling Walker, MartinCools, PietAlbonico, MarcoAme, Shaali MAyana, MioDana, DanielKeiser, JenniferMatoso, Leonardo FerreiraMontresor, AntonioMekonnen, ZelekeOliveira, Rodrigo Corrêa dePinto, Simone AparecidaSayasone, SomphouVercruysse, JozefVlaminck, JohnnyLevecke, Bruno2022-06-09T13:49:59Z2022-06-09T13:49:59Z2021WALKER, Martin et al. Individual responses to a single oral dose of albendazole indicate reduced efficacy against soil-transmitted helminths in an area with high drug pressure. Trial PLoS Negl Trop Dis., v. 15, n. 10, e0009888, 2021. doi: 10.1371/journal.pntd.0009888.1935-2735https://www.arca.fiocruz.br/handle/icict/5314610.1371/journal.pntd.0009888engPublic Library of ScienceAscaris lumbricoidesTrichuris trichiuraparasitas intestinaisIndividual responses to a single oral dose of albendazole indicate reduced efficacy against soil-transmitted helminths in an area with high drug pressureinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleDepartment of Pathobiology and Population Sciences. Royal Veterinary College. Hatfield, United Kingdom/London Centre for Neglected Tropical Disease Research. Imperial College London. London, United Kingdom.Department of Virology. Parasitology and Immunology. Ghent University. Merelbeke, Belgium.Center for Tropical Diseases. Sacro Cuore Don Calabria Hospital. Negrar, Italy/ Department of Life Sciences and Systems Biology. University of Turin. Turin, Italy.Laboratory Division. Public Health Laboratory-Ivo de Carneri. Chake Chake, United Republic of Tanzania.Jimma University Institute of Health. Jimma University. Jimma, Ethiopia.Jimma University Institute of Health. Jimma University. Jimma, Ethiopia.Department of Medical Parasitology and Infection Biology. Swiss Tropical and Public Health Institute. Basel, Switzerland/University of Basel. Basel, Switzerland.Laboratory of Molecular and Cellular Immunology. Institute René Rachou. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil/Nursing school. Federal University of Minas Gerais. Belo Horiozonte, MG, Brazil.Department of Control of Neglected Tropical Diseases. World Health Organization. Geneva, Switzerland.Jimma University Institute of Health. Jimma University. Jimma, Ethiopia.Laboratory of Molecular and Cellular Immunology. Institute René Rachou. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil.Laboratory of Molecular and Cellular Immunology. Institute René Rachou. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil.Lao Tropical and Public Health Institute. Ministry of Health. Vientiane, Lao People's Democratic Republic.Department of Virology. Parasitology and Immunology. Ghent University. Merelbeke, Belgium.Department of Virology. Parasitology and Immunology. Ghent University. Merelbeke, Belgium.Department of Virology. Parasitology and Immunology. Ghent University. Merelbeke, Belgium.Background: Albendazole (ALB) is administered annually to millions of children through global deworming programs targeting soil-transmitted helminths (STHs: Ascaris lumbricoides, Trichuris trichiura and hookworms, Necator americanus and Ancylostoma duodenale). However, due to the lack of large individual patient datasets collected using standardized protocols and the application of population-based statistical methods, little is known about factors that may affect individual responses to treatment. Methodology/principal findings: We re-analyzed 645 individual patient data from three standardized clinical trials designed to assess the efficacy of a single 400 mg oral dose of ALB against STHs in schoolchildren from different study sites, each with varying history of drug pressure based on duration of mass drug administration programs: Ethiopia, low; Lao People's Democratic Republic (PDR), moderate; Pemba Island (Tanzania), high. Using a Bayesian statistical modelling approach to estimate individual responses (individual egg reduction rates, ERRi), we found that efficacy was lower in Pemba Island, particularly for T. trichiura. For this STH, the proportion of participants with a satisfactory response (ERRi ≥50%), was 65% in Ethiopia, 61% in Lao PDR but only 29% in Pemba Island. There was a significant correlation between ERRi and infection intensity prior to drug administration (ERRi decreasing as a function of increasing infection intensity). Individual age and sex also affected the drug response, but these were of negligible clinical significance and not consistent across STHs and study sites. Conclusions/significance: We found decreased efficacy of ALB against all the STHs analyzed in Pemba Island (Tanzania), an area with high drug pressure. This does not indicate causality, as this association may also be partially explained by differences in infection intensity prior to drug administration. Notwithstanding, our results indicate that without alternative treatment regimens, program targets will not be achievable on Pemba Island because of inadequate efficacy of ALB.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/53146/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALIndividual responses to a single oral dose of albendazole indicate reduced.pdfIndividual responses to a single oral dose of albendazole indicate reduced.pdfapplication/pdf676576https://www.arca.fiocruz.br/bitstream/icict/53146/2/Individual%20responses%20to%20a%20single%20oral%20dose%20of%20albendazole%20indicate%20reduced.pdf2867230c7731b811ebd18acb842e9a84MD52icict/531462022-06-09 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dc.title.pt_BR.fl_str_mv Individual responses to a single oral dose of albendazole indicate reduced efficacy against soil-transmitted helminths in an area with high drug pressure
title Individual responses to a single oral dose of albendazole indicate reduced efficacy against soil-transmitted helminths in an area with high drug pressure
spellingShingle Individual responses to a single oral dose of albendazole indicate reduced efficacy against soil-transmitted helminths in an area with high drug pressure
Walker, Martin
Ascaris lumbricoides
Trichuris trichiura
parasitas intestinais
title_short Individual responses to a single oral dose of albendazole indicate reduced efficacy against soil-transmitted helminths in an area with high drug pressure
title_full Individual responses to a single oral dose of albendazole indicate reduced efficacy against soil-transmitted helminths in an area with high drug pressure
title_fullStr Individual responses to a single oral dose of albendazole indicate reduced efficacy against soil-transmitted helminths in an area with high drug pressure
title_full_unstemmed Individual responses to a single oral dose of albendazole indicate reduced efficacy against soil-transmitted helminths in an area with high drug pressure
title_sort Individual responses to a single oral dose of albendazole indicate reduced efficacy against soil-transmitted helminths in an area with high drug pressure
author Walker, Martin
author_facet Walker, Martin
Cools, Piet
Albonico, Marco
Ame, Shaali M
Ayana, Mio
Dana, Daniel
Keiser, Jennifer
Matoso, Leonardo Ferreira
Montresor, Antonio
Mekonnen, Zeleke
Oliveira, Rodrigo Corrêa de
Pinto, Simone Aparecida
Sayasone, Somphou
Vercruysse, Jozef
Vlaminck, Johnny
Levecke, Bruno
author_role author
author2 Cools, Piet
Albonico, Marco
Ame, Shaali M
Ayana, Mio
Dana, Daniel
Keiser, Jennifer
Matoso, Leonardo Ferreira
Montresor, Antonio
Mekonnen, Zeleke
Oliveira, Rodrigo Corrêa de
Pinto, Simone Aparecida
Sayasone, Somphou
Vercruysse, Jozef
Vlaminck, Johnny
Levecke, Bruno
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Walker, Martin
Cools, Piet
Albonico, Marco
Ame, Shaali M
Ayana, Mio
Dana, Daniel
Keiser, Jennifer
Matoso, Leonardo Ferreira
Montresor, Antonio
Mekonnen, Zeleke
Oliveira, Rodrigo Corrêa de
Pinto, Simone Aparecida
Sayasone, Somphou
Vercruysse, Jozef
Vlaminck, Johnny
Levecke, Bruno
dc.subject.other.pt_BR.fl_str_mv Ascaris lumbricoides
Trichuris trichiura
parasitas intestinais
topic Ascaris lumbricoides
Trichuris trichiura
parasitas intestinais
description Department of Pathobiology and Population Sciences. Royal Veterinary College. Hatfield, United Kingdom/London Centre for Neglected Tropical Disease Research. Imperial College London. London, United Kingdom.
publishDate 2021
dc.date.issued.fl_str_mv 2021
dc.date.accessioned.fl_str_mv 2022-06-09T13:49:59Z
dc.date.available.fl_str_mv 2022-06-09T13:49:59Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv WALKER, Martin et al. Individual responses to a single oral dose of albendazole indicate reduced efficacy against soil-transmitted helminths in an area with high drug pressure. Trial PLoS Negl Trop Dis., v. 15, n. 10, e0009888, 2021. doi: 10.1371/journal.pntd.0009888.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/53146
dc.identifier.issn.pt_BR.fl_str_mv 1935-2735
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.0009888
identifier_str_mv WALKER, Martin et al. Individual responses to a single oral dose of albendazole indicate reduced efficacy against soil-transmitted helminths in an area with high drug pressure. Trial PLoS Negl Trop Dis., v. 15, n. 10, e0009888, 2021. doi: 10.1371/journal.pntd.0009888.
1935-2735
10.1371/journal.pntd.0009888
url https://www.arca.fiocruz.br/handle/icict/53146
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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institution FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/53146/1/license.txt
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