A Global comparative evaluation of commercial immunochromatographic rapid diagnostic tests for visceral leishmaniasis

Detalhes bibliográficos
Autor(a) principal: Cunningham, Jane
Data de Publicação: 2012
Outros Autores: Hasker, Epco, Das, Pradeep, Safi, Sayda El, Goto, Hiro, Mondal, Dinesh, Mbuchi, Margaret, Mukhtar, Maowia, Rabello, Ana Lúcia Teles, Rijal, Suman, Sundar, Shyam, Wasunna, Monique, Adams, Emily, Menten, Joris, Peeling, Rosanna, Boelaert, Marleen
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7426
Resumo: UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases; and Institute of Tropical Medicine Antwerp through the Third Framework Agreement with the Belgian Directorate-General for Development Cooperation.
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spelling Cunningham, JaneHasker, EpcoDas, PradeepSafi, Sayda ElGoto, HiroMondal, DineshMbuchi, MargaretMukhtar, MaowiaRabello, Ana Lúcia TelesRijal, SumanSundar, ShyamWasunna, MoniqueAdams, EmilyMenten, JorisPeeling, RosannaBoelaert, Marleen2014-03-19T17:26:12Z2014-03-19T17:26:12Z2012CUNNINGHAM, Jane et al. A Global comparative evaluation of commercial immunochromatographic rapid diagnostic tests for visceral leishmaniasis. Clinical Infectious Diseases. 2012, vol.55, n.10, pp. 1312-1319.1058-4838https://www.arca.fiocruz.br/handle/icict/7426UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases; and Institute of Tropical Medicine Antwerp through the Third Framework Agreement with the Belgian Directorate-General for Development Cooperation.World Health Organization Special Programme for Research and Training in Tropical Diseases. Geneva, SwitzerlandInstitute of Tropical Medicine. Antwerp, BelgiumRajendra Memorial Research Institute of Medical Science. Patna, IndiaUniversity of Khartoum. Department of Medical Microbiology and Parasitology. SudanInstituto de Medicina Tropical de São Paulo Laboratório de Soroepidemiologia e Imunobiologia. São Paulo, SP, BrazilInternational Centre for Diarrhoeal Disease Research. Dhaka, BangladeshKenya Medical Research Institute. NairobiUniversity of Khartoum. Institute Endemic Diseases. Sudanfundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrazilB. P. Koirala Institute of Health Sciences. Dharan, NepalBanaras Hindu University. Varanasi, IndiaKenya Medical Research Institute. NairobiRoyal Tropical Institute/Koninklijk Instituut voor de Tropen. Amsterdam, NetherlandsInstitute of Tropical Medicine. Antwerp, BelgiumLondon School of Hygiene and Tropical Medicine. London, United KingdomInstitute of Tropical Medicine. Antwerp, BelgiumBackground. Poor access to diagnosis stymies control of visceral leishmaniasis (VL). Antibody-detecting rapid diagnostic tests (RDTs) can be performed in peripheral health settings. However, there are many brands available and published reports of variable accuracy. Methods. Commercial VL RDTs containing bound rK39 or rKE16 antigen were evaluated using archived human sera from confirmed VL cases (n = 750) and endemic non-VL controls (n = 754) in the Indian subcontinent (ISC), Brazil, and East Africa to assess sensitivity and specificity with 95% confidence intervals. A subset of RDTs were also evaluated after 60 days’ heat incubation (37°C, 45°C). Interlot and interobserver variability was assessed. Results. All test brands performed well against ISC panels (sensitivity range, 92.8%–100%; specificity range, 96%–100%); however, sensitivity was lower against Brazil and East African panels (61.5%–91% and 36.8%–87.2%, respectively). Specificity was consistently > 95% in Brazil and ranged between 90.8% and 98% in East Africa. Performance of some products was adversely affected by high temperatures. Agreement between lots and readers was good to excellent (κ > 0.73–0.99). Conclusions. Diagnostic accuracy of VL RDTs varies between the major endemic regions. Many tests performed well and showed good heat stability in the ISC; however, reduced sensitivity against Brazilian and East African panels suggests that in these regions, used alone, several RDTs are inadequate for excluding a VL diagnosis. More research is needed to assess ease of use and to compare performance using whole blood instead of serum and in patients coinfected with human immunodeficiency virusengInfectious Diseases Society of AmericaA Global comparative evaluation of commercial immunochromatographic rapid diagnostic tests for visceral leishmaniasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlevisceral leishmaniasisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALGlobal comparative evaluation of commercial immunochromatographic rapid diagnostic tests for visceral leishmaniasis.pdfGlobal comparative evaluation of commercial immunochromatographic rapid diagnostic tests for visceral leishmaniasis.pdfapplication/pdf115009https://www.arca.fiocruz.br/bitstream/icict/7426/1/Global%20comparative%20evaluation%20of%20commercial%20immunochromatographic%20rapid%20diagnostic%20tests%20for%20visceral%20leishmaniasis.pdfedc14bc9578d116420ea76cd5e24474dMD51LICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv A Global comparative evaluation of commercial immunochromatographic rapid diagnostic tests for visceral leishmaniasis
title A Global comparative evaluation of commercial immunochromatographic rapid diagnostic tests for visceral leishmaniasis
spellingShingle A Global comparative evaluation of commercial immunochromatographic rapid diagnostic tests for visceral leishmaniasis
Cunningham, Jane
visceral leishmaniasis
title_short A Global comparative evaluation of commercial immunochromatographic rapid diagnostic tests for visceral leishmaniasis
title_full A Global comparative evaluation of commercial immunochromatographic rapid diagnostic tests for visceral leishmaniasis
title_fullStr A Global comparative evaluation of commercial immunochromatographic rapid diagnostic tests for visceral leishmaniasis
title_full_unstemmed A Global comparative evaluation of commercial immunochromatographic rapid diagnostic tests for visceral leishmaniasis
title_sort A Global comparative evaluation of commercial immunochromatographic rapid diagnostic tests for visceral leishmaniasis
author Cunningham, Jane
author_facet Cunningham, Jane
Hasker, Epco
Das, Pradeep
Safi, Sayda El
Goto, Hiro
Mondal, Dinesh
Mbuchi, Margaret
Mukhtar, Maowia
Rabello, Ana Lúcia Teles
Rijal, Suman
Sundar, Shyam
Wasunna, Monique
Adams, Emily
Menten, Joris
Peeling, Rosanna
Boelaert, Marleen
author_role author
author2 Hasker, Epco
Das, Pradeep
Safi, Sayda El
Goto, Hiro
Mondal, Dinesh
Mbuchi, Margaret
Mukhtar, Maowia
Rabello, Ana Lúcia Teles
Rijal, Suman
Sundar, Shyam
Wasunna, Monique
Adams, Emily
Menten, Joris
Peeling, Rosanna
Boelaert, Marleen
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cunningham, Jane
Hasker, Epco
Das, Pradeep
Safi, Sayda El
Goto, Hiro
Mondal, Dinesh
Mbuchi, Margaret
Mukhtar, Maowia
Rabello, Ana Lúcia Teles
Rijal, Suman
Sundar, Shyam
Wasunna, Monique
Adams, Emily
Menten, Joris
Peeling, Rosanna
Boelaert, Marleen
dc.subject.en.pt_BR.fl_str_mv visceral leishmaniasis
topic visceral leishmaniasis
description UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases; and Institute of Tropical Medicine Antwerp through the Third Framework Agreement with the Belgian Directorate-General for Development Cooperation.
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2014-03-19T17:26:12Z
dc.date.available.fl_str_mv 2014-03-19T17:26:12Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CUNNINGHAM, Jane et al. A Global comparative evaluation of commercial immunochromatographic rapid diagnostic tests for visceral leishmaniasis. Clinical Infectious Diseases. 2012, vol.55, n.10, pp. 1312-1319.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7426
dc.identifier.issn.none.fl_str_mv 1058-4838
identifier_str_mv CUNNINGHAM, Jane et al. A Global comparative evaluation of commercial immunochromatographic rapid diagnostic tests for visceral leishmaniasis. Clinical Infectious Diseases. 2012, vol.55, n.10, pp. 1312-1319.
1058-4838
url https://www.arca.fiocruz.br/handle/icict/7426
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Infectious Diseases Society of America
publisher.none.fl_str_mv Infectious Diseases Society of America
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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