B cells modulate T cells so as to favour T helper type 1 and CD8+ T-cell responses in the acute phase of Trypanosoma cruzi infection

Detalhes bibliográficos
Autor(a) principal: Cardillo, Fabíola
Data de Publicação: 2007
Outros Autores: Postol, Edilberto, Nihei, Jorge Sadao, Aroeira, Luiz S, Nomizo, Auro, Mengele Junior, José Orivaldo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/2748
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Chagas Experimental, Autoimunidade e Imunologia Celular. Laboratório Experimental Doença de Chagas. Salvador, BA, Brasil
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spelling Cardillo, FabíolaPostol, EdilbertoNihei, Jorge SadaoAroeira, Luiz SNomizo, AuroMengele Junior, José Orivaldo2011-07-06T17:31:24Z2011-07-06T17:31:24Z2007CARDILLO, F. et al. B cells modulate T cells so as to favour T helper type 1 and CD8+ T-cell responses in the acute phase of Trypanosoma cruzi infection. Immunology, v.122, n.4, p.584-595, 2007.0019-2805https://www.arca.fiocruz.br/handle/icict/274810.1111/j.1365-2567.2007.02677.xengTrypanosoma CruziCélulas BIFN-yMemóriaCD8Trypanosoma cruziB cellsIFN-yMemoryCD8Trypanosoma cruziLinfócitos BInterferon gamaMemóriaAntígenos CD8B cells modulate T cells so as to favour T helper type 1 and CD8+ T-cell responses in the acute phase of Trypanosoma cruzi infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Chagas Experimental, Autoimunidade e Imunologia Celular. Laboratório Experimental Doença de Chagas. Salvador, BA, BrasilInstituto do Coração. Universidade de São Paulo. Laboratório de Imunologia. São Paulo, SP, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Chagas Experimental, Autoimunidade e Imunologia Celular. Laboratório Experimental Doença de Chagas. Salvador, BA, BrasilHospital La Paz. Unidad de Investigacion. Madrid, ESP, EspanhaUniversidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Departamento de Análises Clínicas, Toxicologia e Bromatologia. São Paulo, SP, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Chagas Experimental, Autoimunidade e Imunologia Celular. Laboratório Experimental Doença de Chagas. Salvador, BA, BrasilIn this study, we have evaluated the production of pro- and anti-inflammatory cytokines and the formation of central and effector memory T cells in mice lacking mature B cells (muMT KO). The results show that Trypanosoma cruzi infection in C57Bl/6ml MT KO mice is intensified in relation to control mice and this exacerbation is related to low levels of inflammatory cytokines produced during the acute infection and the lower numbers of central and effector memory CD4+ and CD8+ T cells generated during the acute phase of the infection. In addition, a marked reduction in the CD8+ T-cell subpopulation was observed in muMT KO infected mice. In agreement to this, the degree of tissue parasitism was increased in muMT mice and the tissue inflammatory response was much less intense in the acute phase of the infection, consistent with a deficit in the generation of effector T cells. Flow cytometry analysis of the skeletal muscle inflammatory infiltrate showed a predominance of CD8+ CD45Rb low in B-cell-sufficient C57Bl/6 mice, whereas the preponderant cell type in muMT KO skeletal muscle inflammatory infiltrate was CD4+ T cells. In addition, CD8+ T cells found in skeletal muscle from muMT KO infected mice were less activated than in control B-cell sufficient infected mice. These results suggest that B cells may participate in the generation of effector/memory T cells. In addition and more importantly, B cells were crucial in the maintenance of central and effector memory CD8+ T cell, as well as the determination of the T cell cytokine functional pattern, and they may therefore account for critical aspects of the resistance to intracellular pathogens, such as T. cruzi.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALCardillo_Postol_Nihei_etal.pdfCardillo_Postol_Nihei_etal.pdfapplication/pdf691051https://www.arca.fiocruz.br/bitstream/icict/2748/1/Cardillo_Postol_Nihei_etal.pdf40699b46678a946d46434bcc773ed3f9MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81648https://www.arca.fiocruz.br/bitstream/icict/2748/2/license.txte095249ac7cacefbfe39684dfe45e706MD52TEXTCardillo_Postol_Nihei_etal.pdf.txtCardillo_Postol_Nihei_etal.pdf.txtExtracted texttext/plain52235https://www.arca.fiocruz.br/bitstream/icict/2748/5/Cardillo_Postol_Nihei_etal.pdf.txt8243402bb862fe4a78490c586c2fb86bMD55THUMBNAILCardillo_Postol_Nihei_etal.pdf.jpgCardillo_Postol_Nihei_etal.pdf.jpgGenerated Thumbnailimage/jpeg2375https://www.arca.fiocruz.br/bitstream/icict/2748/4/Cardillo_Postol_Nihei_etal.pdf.jpg88698614eeb63808a285e028ab5b52b3MD54icict/27482023-03-15 14:33:00.989oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv B cells modulate T cells so as to favour T helper type 1 and CD8+ T-cell responses in the acute phase of Trypanosoma cruzi infection
title B cells modulate T cells so as to favour T helper type 1 and CD8+ T-cell responses in the acute phase of Trypanosoma cruzi infection
spellingShingle B cells modulate T cells so as to favour T helper type 1 and CD8+ T-cell responses in the acute phase of Trypanosoma cruzi infection
Cardillo, Fabíola
Trypanosoma Cruzi
Células B
IFN-y
Memória
CD8
Trypanosoma cruzi
B cells
IFN-y
Memory
CD8
Trypanosoma cruzi
Linfócitos B
Interferon gama
Memória
Antígenos CD8
title_short B cells modulate T cells so as to favour T helper type 1 and CD8+ T-cell responses in the acute phase of Trypanosoma cruzi infection
title_full B cells modulate T cells so as to favour T helper type 1 and CD8+ T-cell responses in the acute phase of Trypanosoma cruzi infection
title_fullStr B cells modulate T cells so as to favour T helper type 1 and CD8+ T-cell responses in the acute phase of Trypanosoma cruzi infection
title_full_unstemmed B cells modulate T cells so as to favour T helper type 1 and CD8+ T-cell responses in the acute phase of Trypanosoma cruzi infection
title_sort B cells modulate T cells so as to favour T helper type 1 and CD8+ T-cell responses in the acute phase of Trypanosoma cruzi infection
author Cardillo, Fabíola
author_facet Cardillo, Fabíola
Postol, Edilberto
Nihei, Jorge Sadao
Aroeira, Luiz S
Nomizo, Auro
Mengele Junior, José Orivaldo
author_role author
author2 Postol, Edilberto
Nihei, Jorge Sadao
Aroeira, Luiz S
Nomizo, Auro
Mengele Junior, José Orivaldo
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Cardillo, Fabíola
Postol, Edilberto
Nihei, Jorge Sadao
Aroeira, Luiz S
Nomizo, Auro
Mengele Junior, José Orivaldo
dc.subject.other.pt_BR.fl_str_mv Trypanosoma Cruzi
Células B
IFN-y
Memória
CD8
topic Trypanosoma Cruzi
Células B
IFN-y
Memória
CD8
Trypanosoma cruzi
B cells
IFN-y
Memory
CD8
Trypanosoma cruzi
Linfócitos B
Interferon gama
Memória
Antígenos CD8
dc.subject.en.pt_BR.fl_str_mv Trypanosoma cruzi
B cells
IFN-y
Memory
CD8
dc.subject.decs.pt_BR.fl_str_mv Trypanosoma cruzi
Linfócitos B
Interferon gama
Memória
Antígenos CD8
description Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Chagas Experimental, Autoimunidade e Imunologia Celular. Laboratório Experimental Doença de Chagas. Salvador, BA, Brasil
publishDate 2007
dc.date.issued.fl_str_mv 2007
dc.date.accessioned.fl_str_mv 2011-07-06T17:31:24Z
dc.date.available.fl_str_mv 2011-07-06T17:31:24Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CARDILLO, F. et al. B cells modulate T cells so as to favour T helper type 1 and CD8+ T-cell responses in the acute phase of Trypanosoma cruzi infection. Immunology, v.122, n.4, p.584-595, 2007.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/2748
dc.identifier.issn.none.fl_str_mv 0019-2805
dc.identifier.doi.none.fl_str_mv 10.1111/j.1365-2567.2007.02677.x
identifier_str_mv CARDILLO, F. et al. B cells modulate T cells so as to favour T helper type 1 and CD8+ T-cell responses in the acute phase of Trypanosoma cruzi infection. Immunology, v.122, n.4, p.584-595, 2007.
0019-2805
10.1111/j.1365-2567.2007.02677.x
url https://www.arca.fiocruz.br/handle/icict/2748
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instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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