Schistosoma mansoni reinfection: Analysis of risk factors by classification and regression tree (CART) modeling
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/25917 |
Resumo: | Universidade Federal de Minas Gerais. Escola de Enfermagem. Belo Horizonte, MG, Brazil/Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brazil/Fundação Oswaldo Cruz. |
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Oliveira, Andréa Gazzinelli Corrêa dePrado, Roberta OliveiraMatoso, Leonardo FerreiraVeloso, Braulio MirandaAndrade, GiseleKloos, HelmutBethony, Jeffrey MichaelAssunçao, Renato MartinsOliveira, Rodrigo Correa de2018-04-17T19:24:36Z2018-04-17T19:24:36Z2017GAZZINELLI, Andréa Gazzinelli Corrêa de et al. Schistosoma mansoni reinfection: Analysis of risk factors by classification and regression tree (CART) modeling. PLoS One, v. 12, n. 8, e0182197, 2017.1932-6203https://www.arca.fiocruz.br/handle/icict/2591710.1371/journal.pone.0182197engPublic Library of ScienceSchistosoma mansoniaspectos socioeconomicos na saudeesquistossomosecriançasSchistosoma mansoniSocioeconomic aspects of healthSchistosomiasisChildrenDecision treesBrazilSchoolsInfectious disease controlSchistosoma mansoni reinfection: Analysis of risk factors by classification and regression tree (CART) modelinginfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Escola de Enfermagem. Belo Horizonte, MG, Brazil/Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brazil/Fundação Oswaldo Cruz.Universidade Federal de Minas Gerais. Escola de Enfermagem. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Escola de Enfermagem. Belo Horizonte, MG, Brazil/Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brazil/Fundação Oswaldo Cruz.Universidade Federal de Minas Gerais. Instituto de Ciências Exatas. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Escola de Enfermagem. Belo Horizonte, MG, BrazilUniversity of California Medical Center. Department of Epidemiology and Biostatistics. San Francisco, CA, United States of AmericaGeorge Washington University. School of Medicine and Health Science. Microbiology, Immunology and Tropical Medicine. Washington DC, United States of AmericaUniversidade Federal de Minas Gerais. Instituto de Ciências Exatas. Belo Horizonte, MG, BrazilInstituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brazil/Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, BrazilPraziquantel (PZQ) is an effective chemotherapy for schistosomiasis mansoni and a mainstay for its control and potential elimination. However, it does not prevent against reinfection, which can occur rapidly in areas with active transmission. A guide to ranking the risk factors for Schistosoma mansoni reinfection would greatly contribute to prioritizing resources and focusing prevention and control measures to prevent rapid reinfection. The objective of the current study was to explore the relationship among the socioeconomic, demographic, and epidemiological factors that can influence reinfection by S. mansoni one year after successful treatment with PZQ in school-aged children in Northeastern Minas Gerais state Brazil. Parasitological, socioeconomic, demographic, and water contact information were surveyed in 506 S. mansoni-infected individuals, aged 6 to 15 years, resident in these endemic areas. Eligible individuals were treated with PZQ until they were determined to be negative by the absence of S. mansoni eggs in the feces on two consecutive days of Kato-Katz fecal thick smear. These individuals were surveyed again 12 months from the date of successful treatment with PZQ. A classification and regression tree modeling (CART) was then used to explore the relationship between socioeconomic, demographic, and epidemiological variables and their reinfection status. The most important risk factor identified for S. mansoni reinfection was their “heavy” infection at baseline. Additional analyses, excluding heavy infection status, showed that lower socioeconomic status and a lower level of education of the household head were also most important risk factors for S. mansoni reinfection. Our results provide an important contribution toward the control and possible elimination of schistosomiasis by identifying three major risk factors that can be used for targeted treatment and monitoring of reinfection. We suggest that control measures that target heavily infected children in the most economically disadvantaged households would be most beneficial to maintain the success of mass chemotherapy campaigns.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/25917/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALSchistosoma mansoni reinfection.pdfSchistosoma mansoni reinfection.pdfapplication/pdf2468100https://www.arca.fiocruz.br/bitstream/icict/25917/2/Schistosoma%20mansoni%20reinfection.pdf48481df7e3f8c50a01f1538e4286e1bfMD52TEXTSchistosoma mansoni reinfection.pdf.txtSchistosoma mansoni reinfection.pdf.txtExtracted texttext/plain52894https://www.arca.fiocruz.br/bitstream/icict/25917/3/Schistosoma%20mansoni%20reinfection.pdf.txt70076c3e6f8e2ed6b3f9c53fea8275dbMD53icict/259172019-06-19 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| dc.title.pt_BR.fl_str_mv |
Schistosoma mansoni reinfection: Analysis of risk factors by classification and regression tree (CART) modeling |
| title |
Schistosoma mansoni reinfection: Analysis of risk factors by classification and regression tree (CART) modeling |
| spellingShingle |
Schistosoma mansoni reinfection: Analysis of risk factors by classification and regression tree (CART) modeling Oliveira, Andréa Gazzinelli Corrêa de Schistosoma mansoni aspectos socioeconomicos na saude esquistossomose crianças Schistosoma mansoni Socioeconomic aspects of health Schistosomiasis Children Decision trees Brazil Schools Infectious disease control |
| title_short |
Schistosoma mansoni reinfection: Analysis of risk factors by classification and regression tree (CART) modeling |
| title_full |
Schistosoma mansoni reinfection: Analysis of risk factors by classification and regression tree (CART) modeling |
| title_fullStr |
Schistosoma mansoni reinfection: Analysis of risk factors by classification and regression tree (CART) modeling |
| title_full_unstemmed |
Schistosoma mansoni reinfection: Analysis of risk factors by classification and regression tree (CART) modeling |
| title_sort |
Schistosoma mansoni reinfection: Analysis of risk factors by classification and regression tree (CART) modeling |
| author |
Oliveira, Andréa Gazzinelli Corrêa de |
| author_facet |
Oliveira, Andréa Gazzinelli Corrêa de Prado, Roberta Oliveira Matoso, Leonardo Ferreira Veloso, Braulio Miranda Andrade, Gisele Kloos, Helmut Bethony, Jeffrey Michael Assunçao, Renato Martins Oliveira, Rodrigo Correa de |
| author_role |
author |
| author2 |
Prado, Roberta Oliveira Matoso, Leonardo Ferreira Veloso, Braulio Miranda Andrade, Gisele Kloos, Helmut Bethony, Jeffrey Michael Assunçao, Renato Martins Oliveira, Rodrigo Correa de |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Oliveira, Andréa Gazzinelli Corrêa de Prado, Roberta Oliveira Matoso, Leonardo Ferreira Veloso, Braulio Miranda Andrade, Gisele Kloos, Helmut Bethony, Jeffrey Michael Assunçao, Renato Martins Oliveira, Rodrigo Correa de |
| dc.subject.other.pt_BR.fl_str_mv |
Schistosoma mansoni aspectos socioeconomicos na saude esquistossomose crianças |
| topic |
Schistosoma mansoni aspectos socioeconomicos na saude esquistossomose crianças Schistosoma mansoni Socioeconomic aspects of health Schistosomiasis Children Decision trees Brazil Schools Infectious disease control |
| dc.subject.en.pt_BR.fl_str_mv |
Schistosoma mansoni Socioeconomic aspects of health Schistosomiasis Children Decision trees Brazil Schools Infectious disease control |
| description |
Universidade Federal de Minas Gerais. Escola de Enfermagem. Belo Horizonte, MG, Brazil/Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brazil/Fundação Oswaldo Cruz. |
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2017 |
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2017 |
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2018-04-17T19:24:36Z |
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2018-04-17T19:24:36Z |
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info:eu-repo/semantics/publishedVersion |
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GAZZINELLI, Andréa Gazzinelli Corrêa de et al. Schistosoma mansoni reinfection: Analysis of risk factors by classification and regression tree (CART) modeling. PLoS One, v. 12, n. 8, e0182197, 2017. |
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https://www.arca.fiocruz.br/handle/icict/25917 |
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1932-6203 |
| dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pone.0182197 |
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GAZZINELLI, Andréa Gazzinelli Corrêa de et al. Schistosoma mansoni reinfection: Analysis of risk factors by classification and regression tree (CART) modeling. PLoS One, v. 12, n. 8, e0182197, 2017. 1932-6203 10.1371/journal.pone.0182197 |
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