Cryptic population structure and transmission dynamics uncovered for Schistosoma mansoni populations by genetic analyses

Detalhes bibliográficos
Autor(a) principal: Long, Jeffrey C
Data de Publicação: 2022
Outros Autores: Taylor, Sarah E, Barbosa, Lucio M, Silva, Luciano Kalabric, Reis, Mitermayer G, Blanton, Ronald E
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/51526
Resumo: Supplementary Information: The online version contains supplementary material available at https://doi.org/10.1038/s41598-022-04776-0.
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spelling Long, Jeffrey CTaylor, Sarah EBarbosa, Lucio MSilva, Luciano KalabricReis, Mitermayer GBlanton, Ronald E2022-03-03T18:14:14Z2022-03-03T18:14:14Z2022LONG, Jeffrey C. et al. Cryptic population structure and transmission dynamics uncovered for Schistosoma mansoni populations by genetic analyses. Scientific Reports, v. 12, n. 1059, p. 1-12, 2022.2045-2322https://www.arca.fiocruz.br/handle/icict/5152610.1038/s41598-022-04776-02045-2322Supplementary Information: The online version contains supplementary material available at https://doi.org/10.1038/s41598-022-04776-0.National Institutes of Health, USA. Grant R01AI121330University of New Mexico. Department of Anthropology. Albuquerque, NM, USA.University of New Mexico. Department of Anthropology. Albuquerque, NM, USA.Tulane University. School of Public Health and Tropical Medicine. Department of Tropical Medicine. New Orleans, LA, USA.Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil / Yale University. Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, CT, USA.Patterns of diversity in pathogen genomes provide a window into the spatiotemporal spread of disease. In this study, we tested the hypothesis that Schistosoma mansoni parasites form genetic clusters that coincide with the communities of their human hosts. We also looked for genetic clustering of parasites at the sub-community level. Our data consists of 14 microsatellite DNA markers, typed from pooled DNA samples from N = 254 infected individuals living in three Brazilian communities. We found a one-to-one correspondence between genetic clusters found by K-means cluster analysis and communities when K = 3. These clusters are also easily identifed in a neighborjoining tree and principal coordinates plots. K-means analysis with K > 3 also reveals genetic clusters of parasites at the sub-community level. These sub-clusters also appear on the neighbor-joining tree and principal coordinates plots. A surprising fnding is a genetic relationship between subgroups in widely separated human communities. This connection suggests the existence of common transmission sites that have wide infuence. In summary, the genetic structure of S. mansoni in Brazil juxtaposes local isolation that is occasionally broken by long-range migration. Permanent eradication of schistosomes will require both local eforts and the identifcation of regional infection reservoirs.engNature ResearchEsquistossomose mansoniMortalidadeParasitosGenômicaSchistosomiasis mansoniMortalityParasitesGenomicsEsquistosomiasis mansoniMortalidadParásitosGenómicaSchistosomiase mansoniMortalitéParasitesGénomiqueEsquistossomose mansoniMortalidadeParasitosGenômicaCryptic population structure and transmission dynamics uncovered for Schistosoma mansoni populations by genetic analysesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/51526/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALLong, C. J. Crypitic....pdfLong, C. J. 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dc.title.en_US.fl_str_mv Cryptic population structure and transmission dynamics uncovered for Schistosoma mansoni populations by genetic analyses
title Cryptic population structure and transmission dynamics uncovered for Schistosoma mansoni populations by genetic analyses
spellingShingle Cryptic population structure and transmission dynamics uncovered for Schistosoma mansoni populations by genetic analyses
Long, Jeffrey C
Esquistossomose mansoni
Mortalidade
Parasitos
Genômica
Schistosomiasis mansoni
Mortality
Parasites
Genomics
Esquistosomiasis mansoni
Mortalidad
Parásitos
Genómica
Schistosomiase mansoni
Mortalité
Parasites
Génomique
Esquistossomose mansoni
Mortalidade
Parasitos
Genômica
title_short Cryptic population structure and transmission dynamics uncovered for Schistosoma mansoni populations by genetic analyses
title_full Cryptic population structure and transmission dynamics uncovered for Schistosoma mansoni populations by genetic analyses
title_fullStr Cryptic population structure and transmission dynamics uncovered for Schistosoma mansoni populations by genetic analyses
title_full_unstemmed Cryptic population structure and transmission dynamics uncovered for Schistosoma mansoni populations by genetic analyses
title_sort Cryptic population structure and transmission dynamics uncovered for Schistosoma mansoni populations by genetic analyses
author Long, Jeffrey C
author_facet Long, Jeffrey C
Taylor, Sarah E
Barbosa, Lucio M
Silva, Luciano Kalabric
Reis, Mitermayer G
Blanton, Ronald E
author_role author
author2 Taylor, Sarah E
Barbosa, Lucio M
Silva, Luciano Kalabric
Reis, Mitermayer G
Blanton, Ronald E
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Long, Jeffrey C
Taylor, Sarah E
Barbosa, Lucio M
Silva, Luciano Kalabric
Reis, Mitermayer G
Blanton, Ronald E
dc.subject.other.pt_BR.fl_str_mv Esquistossomose mansoni
Mortalidade
Parasitos
Genômica
topic Esquistossomose mansoni
Mortalidade
Parasitos
Genômica
Schistosomiasis mansoni
Mortality
Parasites
Genomics
Esquistosomiasis mansoni
Mortalidad
Parásitos
Genómica
Schistosomiase mansoni
Mortalité
Parasites
Génomique
Esquistossomose mansoni
Mortalidade
Parasitos
Genômica
dc.subject.en.en_US.fl_str_mv Schistosomiasis mansoni
Mortality
Parasites
Genomics
dc.subject.es.es_ES.fl_str_mv Esquistosomiasis mansoni
Mortalidad
Parásitos
Genómica
dc.subject.fr.fr_FR.fl_str_mv Schistosomiase mansoni
Mortalité
Parasites
Génomique
dc.subject.decs.pt_BR.fl_str_mv Esquistossomose mansoni
Mortalidade
Parasitos
Genômica
description Supplementary Information: The online version contains supplementary material available at https://doi.org/10.1038/s41598-022-04776-0.
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-03-03T18:14:14Z
dc.date.available.fl_str_mv 2022-03-03T18:14:14Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LONG, Jeffrey C. et al. Cryptic population structure and transmission dynamics uncovered for Schistosoma mansoni populations by genetic analyses. Scientific Reports, v. 12, n. 1059, p. 1-12, 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/51526
dc.identifier.issn.pt_BR.fl_str_mv 2045-2322
dc.identifier.doi.pt_BR.fl_str_mv 10.1038/s41598-022-04776-0
dc.identifier.eissn.pt_BR.fl_str_mv 2045-2322
identifier_str_mv LONG, Jeffrey C. et al. Cryptic population structure and transmission dynamics uncovered for Schistosoma mansoni populations by genetic analyses. Scientific Reports, v. 12, n. 1059, p. 1-12, 2022.
2045-2322
10.1038/s41598-022-04776-0
url https://www.arca.fiocruz.br/handle/icict/51526
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/51526/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/51526/2/Long%2c%20C.%20J.%20Crypitic....pdf
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