Epigenetic control of gene function in schistosomes: a source of therapeutic targets?

Detalhes bibliográficos
Autor(a) principal: Cabezas-Cruz, Alejandro
Data de Publicação: 2014
Outros Autores: Lancelot, Julien, Caby, Stéphanie, Oliveira, Guilherme Correa de, Pierce, Raymond John
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/9805
Resumo: Université de Lille. Institut National de la Santé et de la Recherche Médicale. Centre National de la Recherche Scientifique. Institut Pasteur de Lille. Center for Infection and Immunity of Lille. Lille, France
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spelling Cabezas-Cruz, AlejandroLancelot, JulienCaby, StéphanieOliveira, Guilherme Correa dePierce, Raymond John2015-03-23T13:37:47Z2015-03-23T13:37:47Z2014CABEZAS-CRUZ, Alejandro et al, Epigenetic control of gene function in schistosomes: a source of therapeutic targets? Front Genet, v. 5, p. 317, 2014.1664-8021https://www.arca.fiocruz.br/handle/icict/980510.3389/fgene.2014.00317engUniversity of Alabama at BirminghamEpigenetic control of gene function in schistosomes: a source of therapeutic targets?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversité de Lille. Institut National de la Santé et de la Recherche Médicale. Centre National de la Recherche Scientifique. Institut Pasteur de Lille. Center for Infection and Immunity of Lille. Lille, FranceUniversité de Lille. Institut National de la Santé et de la Recherche Médicale. Centre National de la Recherche Scientifique. Institut Pasteur de Lille. Center for Infection and Immunity of Lille. Lille, FranceUniversité de Lille. Institut National de la Santé et de la Recherche Médicale. Centre National de la Recherche Scientifique. Institut Pasteur de Lille. Center for Infection and Immunity of Lille. Lille, FranceFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Centro de Excelencia em Bioinformatica. Grupo de Biologia e Genômica Computational. Instituto Nacional de Ciencia e Tecnologia em Doenças Tropicais. Belo Horizonte, MG, BrazilUniversité de Lille. Institut National de la Santé et de la Recherche Médicale. Centre National de la Recherche Scientifique. Institut Pasteur de Lille. Center for Infection and Immunity of Lille. Lille, FranceThe discovery of the epigenetic regulation of gene expression has revolutionized both our understanding of how genomes function and approaches to the therapy of numerous pathologies. Schistosomes are metazoan parasites and as such utilize most, if not all the epigenetic mechanisms in play in their vertebrate hosts: histone variants, histone tail modifications, non-coding RNA and, perhaps, DNA methylation. Moreover, we are acquiring an increasing understanding of the ways in which these mechanisms come into play during the complex schistosome developmental program. In turn, interest in the actors involved in epigenetic mechanisms, particularly the enzymes that carry out epigenetic modifications of histones or nucleic acid, as therapeutic targets has been stimulated by the finding that their inhibitors exert profound effects, not only on survival, but also on the reproductive function of Schistosoma mansoni. Here, we review our current knowledge, and what we can infer, about the role of epigenetic mechanisms in schistosome development, differentiation and survival. We will consider which epigenetic actors can be targeted for drug discovery and what strategies can be employed to develop potent, selective inhibitors as drugs to cure schistosomiasis.epigeneticsschistosomedrug discoveryhistone modifying enzymesDNA methylationmicroRNAsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82352https://www.arca.fiocruz.br/bitstream/icict/9805/1/license.txtafbdf7d7a9bcf771a1cc7edf5f618413MD51ORIGINAL2014_163.pdf2014_163.pdfapplication/pdf2498080https://www.arca.fiocruz.br/bitstream/icict/9805/2/2014_163.pdf0900e8fc49da4f3a4f3f4e056602fdeeMD52TEXT2014_163.pdf.txt2014_163.pdf.txtExtracted texttext/plain74026https://www.arca.fiocruz.br/bitstream/icict/9805/3/2014_163.pdf.txtd727e2401193f4f4610a735a232f9c1eMD53icict/98052022-02-01 10:40:09.788oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-02-01T13:40:09Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Epigenetic control of gene function in schistosomes: a source of therapeutic targets?
title Epigenetic control of gene function in schistosomes: a source of therapeutic targets?
spellingShingle Epigenetic control of gene function in schistosomes: a source of therapeutic targets?
Cabezas-Cruz, Alejandro
epigenetics
schistosome
drug discovery
histone modifying enzymes
DNA methylation
microRNAs
title_short Epigenetic control of gene function in schistosomes: a source of therapeutic targets?
title_full Epigenetic control of gene function in schistosomes: a source of therapeutic targets?
title_fullStr Epigenetic control of gene function in schistosomes: a source of therapeutic targets?
title_full_unstemmed Epigenetic control of gene function in schistosomes: a source of therapeutic targets?
title_sort Epigenetic control of gene function in schistosomes: a source of therapeutic targets?
author Cabezas-Cruz, Alejandro
author_facet Cabezas-Cruz, Alejandro
Lancelot, Julien
Caby, Stéphanie
Oliveira, Guilherme Correa de
Pierce, Raymond John
author_role author
author2 Lancelot, Julien
Caby, Stéphanie
Oliveira, Guilherme Correa de
Pierce, Raymond John
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Cabezas-Cruz, Alejandro
Lancelot, Julien
Caby, Stéphanie
Oliveira, Guilherme Correa de
Pierce, Raymond John
dc.subject.en.pt_BR.fl_str_mv epigenetics
schistosome
drug discovery
histone modifying enzymes
DNA methylation
microRNAs
topic epigenetics
schistosome
drug discovery
histone modifying enzymes
DNA methylation
microRNAs
description Université de Lille. Institut National de la Santé et de la Recherche Médicale. Centre National de la Recherche Scientifique. Institut Pasteur de Lille. Center for Infection and Immunity of Lille. Lille, France
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-03-23T13:37:47Z
dc.date.available.fl_str_mv 2015-03-23T13:37:47Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CABEZAS-CRUZ, Alejandro et al, Epigenetic control of gene function in schistosomes: a source of therapeutic targets? Front Genet, v. 5, p. 317, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/9805
dc.identifier.issn.none.fl_str_mv 1664-8021
dc.identifier.doi.none.fl_str_mv 10.3389/fgene.2014.00317
identifier_str_mv CABEZAS-CRUZ, Alejandro et al, Epigenetic control of gene function in schistosomes: a source of therapeutic targets? Front Genet, v. 5, p. 317, 2014.
1664-8021
10.3389/fgene.2014.00317
url https://www.arca.fiocruz.br/handle/icict/9805
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv University of Alabama at Birmingham
publisher.none.fl_str_mv University of Alabama at Birmingham
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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