Inflammasome Genetic Variants Are Associated with Protection to Clinical Severity of COVID-19 among Patients from Rio de Janeiro, Brazil
| Autor(a) principal: | |
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| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/55097 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. |
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Sá, Nathalia Beatriz Ramos deGoulart, Milena NeiraAlves, Marcelo RibeiroPerazzo, HugoGeraldo, Kim MattosRibeiro, Maria Pia DinizCardoso, Sandra WagnerGrinsztejn, BeatrizVeloso, Valdiléa G.Capão, ArturSiqueira, Marilda MendonçaBezerra, Ohanna Cavalcanti de LimaGarcia, Cristiana CoutoGomes, Larissa RodriguesCazote, Andressa da SilvaAlmeida, Dalziza Victalina deGiacoia-Gripp, Carmem Beatriz WagnerCôrtes, Fernanda HeloiseMorgado, Mariza Gonçalves2022-10-11T12:06:48Z2022-10-11T12:06:48Z2022SÁ, Nathalia Beatriz Ramos de et al. Inflammasome Genetic Variants Are Associated with Protection to Clinical Severity of COVID-19 among Patients from Rio de Janeiro, Brazil. BioMed Research International, v. 2022, Article 9082455, p. 1-15, 2022.2314-6133https://www.arca.fiocruz.br/handle/icict/5509710.1155/2022/9082455engHindawiCOVID-19Variantes genéticas do inflamassomaProteçãoGravidade clínicaPacientesBrasilCOVID-19Inflammasome Genetic VariantsProtectionClinical Severity of COVID-19PatientsBrazilInflammasome Genetic Variants Are Associated with Protection to Clinical Severity of COVID-19 among Patients from Rio de Janeiro, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratório e do Sarampo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratório e do Sarampo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratório e do Sarampo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratório e do Sarampo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Instituto Nacional de Ciência e Tecnologia para Inovação em Doenças da População Negligenciadas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.COVID-19 has a broad spectrum of clinical manifestations, from asymptomatic or mild/moderate symptoms to severe symptoms and death. The mechanisms underlying its clinical evolution are still unclear. Upon SARS-CoV-2 infection, host factors, such as the inflammasome system, are activated by the presence of the virus inside host cells. The search for COVID-19 risk factors is of relevance for clinical management. In this study, we investigated the impact of inflammasome single-nucleotide polymorphisms (SNPs) in SARS-CoV-2-infected individuals with distinct severity profiles at clinical presentation. Patients were divided into two groups according to disease severity at clinical presentation based on the WHO Clinical Progression Scale. Group 1 included patients with mild/moderate disease (WHO< 6; n = 76), and group 2 included patients with severe/critical COVID-19 (WHO≥ 6; n = 357). Inpatients with moderate to severe/critical profiles were recruited and followed-up at Hospital Center for COVID-19 Pandemic – National Institute of Infectology (INI)/FIOCRUZ, RJ, Brazil, from June 2020 to March 2021. Patients with mild disease were recruited at Oswaldo Cruz Institute (IOC)/FIOCRUZ, RJ, Brazil, in August 2020. Genotyping of 11 inflammasome SNPs was determined by real-time PCR. Protection and risk estimation were performed using unconditional logistic regression models. Significant differences in NLRP3 rs1539019 and CARD8 rs2043211 were observed between the two groups. Protection against disease severity was associated with the A/A genotype (ORadj = 0:36; P = 0:032), allele A (ORadj = 0:93; P = 0:010), or carrier-A (ORadj = 0:45; P = 0:027) in the NLRP3 rs1539019 polymorphism; A/T genotype (ORadj = 0:5; P = 0:045), allele T (ORadj = 0:93; P = 0:018), or carrier-T (ORadj = 0:48; P = 0:029) in the CARD8 rs2043211 polymorphism; and the A-C-G-C-C (ORadj = 0:11; P = 0:018), A-C-G-C-G (ORadj = 0:23; P = 0:003), C-C-G-C-C (ORadj = 0:37; P = 0:021), and C-T-G-A-C (ORadj = 0:04; P = 0:0473) in NLRP3 genetic haplotype variants. No significant associations were observed for the other polymorphisms. To the best of our knowledge, this is the first study demonstrating an association between CARD8 and NLRP3 inflammasome genetic variants and protection against COVID-19 severity, contributing to the discussion of the impact of inflammasomes on COVID-19 outcomes.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/55097/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALNathaliaSa_CristianaGarcia_etal_IOC_2022.pdfNathaliaSa_CristianaGarcia_etal_IOC_2022.pdfapplication/pdf588014https://www.arca.fiocruz.br/bitstream/icict/55097/2/NathaliaSa_CristianaGarcia_etal_IOC_2022.pdf17e63cfee4c2743c94e79cbca14daaaaMD52icict/550972023-11-13 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| dc.title.en_US.fl_str_mv |
Inflammasome Genetic Variants Are Associated with Protection to Clinical Severity of COVID-19 among Patients from Rio de Janeiro, Brazil |
| title |
Inflammasome Genetic Variants Are Associated with Protection to Clinical Severity of COVID-19 among Patients from Rio de Janeiro, Brazil |
| spellingShingle |
Inflammasome Genetic Variants Are Associated with Protection to Clinical Severity of COVID-19 among Patients from Rio de Janeiro, Brazil Sá, Nathalia Beatriz Ramos de COVID-19 Variantes genéticas do inflamassoma Proteção Gravidade clínica Pacientes Brasil COVID-19 Inflammasome Genetic Variants Protection Clinical Severity of COVID-19 Patients Brazil |
| title_short |
Inflammasome Genetic Variants Are Associated with Protection to Clinical Severity of COVID-19 among Patients from Rio de Janeiro, Brazil |
| title_full |
Inflammasome Genetic Variants Are Associated with Protection to Clinical Severity of COVID-19 among Patients from Rio de Janeiro, Brazil |
| title_fullStr |
Inflammasome Genetic Variants Are Associated with Protection to Clinical Severity of COVID-19 among Patients from Rio de Janeiro, Brazil |
| title_full_unstemmed |
Inflammasome Genetic Variants Are Associated with Protection to Clinical Severity of COVID-19 among Patients from Rio de Janeiro, Brazil |
| title_sort |
Inflammasome Genetic Variants Are Associated with Protection to Clinical Severity of COVID-19 among Patients from Rio de Janeiro, Brazil |
| author |
Sá, Nathalia Beatriz Ramos de |
| author_facet |
Sá, Nathalia Beatriz Ramos de Goulart, Milena Neira Alves, Marcelo Ribeiro Perazzo, Hugo Geraldo, Kim Mattos Ribeiro, Maria Pia Diniz Cardoso, Sandra Wagner Grinsztejn, Beatriz Veloso, Valdiléa G. Capão, Artur Siqueira, Marilda Mendonça Bezerra, Ohanna Cavalcanti de Lima Garcia, Cristiana Couto Gomes, Larissa Rodrigues Cazote, Andressa da Silva Almeida, Dalziza Victalina de Giacoia-Gripp, Carmem Beatriz Wagner Côrtes, Fernanda Heloise Morgado, Mariza Gonçalves |
| author_role |
author |
| author2 |
Goulart, Milena Neira Alves, Marcelo Ribeiro Perazzo, Hugo Geraldo, Kim Mattos Ribeiro, Maria Pia Diniz Cardoso, Sandra Wagner Grinsztejn, Beatriz Veloso, Valdiléa G. Capão, Artur Siqueira, Marilda Mendonça Bezerra, Ohanna Cavalcanti de Lima Garcia, Cristiana Couto Gomes, Larissa Rodrigues Cazote, Andressa da Silva Almeida, Dalziza Victalina de Giacoia-Gripp, Carmem Beatriz Wagner Côrtes, Fernanda Heloise Morgado, Mariza Gonçalves |
| author2_role |
author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Sá, Nathalia Beatriz Ramos de Goulart, Milena Neira Alves, Marcelo Ribeiro Perazzo, Hugo Geraldo, Kim Mattos Ribeiro, Maria Pia Diniz Cardoso, Sandra Wagner Grinsztejn, Beatriz Veloso, Valdiléa G. Capão, Artur Siqueira, Marilda Mendonça Bezerra, Ohanna Cavalcanti de Lima Garcia, Cristiana Couto Gomes, Larissa Rodrigues Cazote, Andressa da Silva Almeida, Dalziza Victalina de Giacoia-Gripp, Carmem Beatriz Wagner Côrtes, Fernanda Heloise Morgado, Mariza Gonçalves |
| dc.subject.other.en_US.fl_str_mv |
COVID-19 Variantes genéticas do inflamassoma Proteção Gravidade clínica Pacientes Brasil |
| topic |
COVID-19 Variantes genéticas do inflamassoma Proteção Gravidade clínica Pacientes Brasil COVID-19 Inflammasome Genetic Variants Protection Clinical Severity of COVID-19 Patients Brazil |
| dc.subject.en.en_US.fl_str_mv |
COVID-19 Inflammasome Genetic Variants Protection Clinical Severity of COVID-19 Patients Brazil |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. |
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2022 |
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2022-10-11T12:06:48Z |
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2022-10-11T12:06:48Z |
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2022 |
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SÁ, Nathalia Beatriz Ramos de et al. Inflammasome Genetic Variants Are Associated with Protection to Clinical Severity of COVID-19 among Patients from Rio de Janeiro, Brazil. BioMed Research International, v. 2022, Article 9082455, p. 1-15, 2022. |
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https://www.arca.fiocruz.br/handle/icict/55097 |
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2314-6133 |
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10.1155/2022/9082455 |
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SÁ, Nathalia Beatriz Ramos de et al. Inflammasome Genetic Variants Are Associated with Protection to Clinical Severity of COVID-19 among Patients from Rio de Janeiro, Brazil. BioMed Research International, v. 2022, Article 9082455, p. 1-15, 2022. 2314-6133 10.1155/2022/9082455 |
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