Factors associated with anti-phenolic glycolipid-I seropositivity among the household contacts of leprosy cases

Detalhes bibliográficos
Autor(a) principal: Carvalho, Ana Paula Mendes
Data de Publicação: 2015
Outros Autores: Fabri, Angélica da Conceição Oliveira Coelho, Oliveira, Rodrigo Corrêa de, Lana, Francisco Carlos Félix
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/50982
Resumo: CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO
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spelling Carvalho, Ana Paula MendesFabri, Angélica da Conceição Oliveira CoelhoOliveira, Rodrigo Corrêa deLana, Francisco Carlos Félix2022-02-02T11:41:10Z2022-02-02T11:41:10Z2015CARVALHO, Ana Paula Mendes et al. Factors associated with anti-phenolic glycolipid-I seropositivity among the household contacts of leprosy cases. BMC Infectious Diseases, v. 15, 219, 2015.1471-2334https://www.arca.fiocruz.br/handle/icict/5098210.1186/s12879-015-0955-3CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOUniversidade Federal de Minas Gerais. Escola de Enfermagem. Postgraduate Program in Nursing. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Escola de Enfermagem. Postgraduate Program in Nursing. Belo Horizonte, MG, Brasil/Universidade Federal de Juiz de Fora. Faculdade de Enfermagem. Department of Basic Nursing. Juiz de Fora, MG, Brasil.Universidade Federal de Minas Gerais. Escola de Enfermagem. Postgraduate Program in Nursing. Belo Horizonte, MG, Brasil./Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratory of Cellular and Molecular Immunology. Belo Horizonte, MG, Brasil/ Universidade Federal de Ouro Preto. Núcleo de Pesquisas em Ciências Biológicas. Laboratory of Immunology. Ouro Preto, MG, Brasil/ Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Belo Horizonte, Brasil.Universidade Federal de Minas Gerais. Escola de Enfermagem. Postgraduate Program in Nursing. Belo Horizonte, MG, Brasil/ Universidade Federal de Minas Gerais. Escola de Enfermagem. Department of Maternal and Child Nursing and Public Health. Belo Horizonte, MG, Brasil.Background: The diagnosis of leprosy is based on clinical symptoms of the disease, which may not be sufficient to ensure early diagnosis. The development of effective tools for the early detection of infection, such as rapid tests that can be applied by non-specialists for early-stage leprosy identification, has been considered a research priority and may contribute to overcoming the complications associated with late diagnosis. The aim of this study was to analyze the factors associated with anti-phenolic glycolipid-I (PGL-I) seropositivity among the household contacts of leprosy cases. Methods: A cross-sectional study of individuals from the northeastern municipalities of the state of Minas Gerais, Brazil, was performed. Anti-PGL-I seropositivity was evaluated by assessing specific antibody production using the ML Flow test. A Poisson regression with a robust error variance was used to evaluate the relationship between anti-PGL-I seropositivity and the independent variables investigated. Results: The overall anti-PGL-I seropositivity was 13.5 %, and among the contacts of leprosy cases that were classified as paucibacillary or multibacillary, it was 8.4 and 17.3 %, respectively. The factors associated with the variation of anti-PGL-I seropositivity among the study population were the presence of signs suggestive of leprosy (PR = 3.68; 95 % CI: 1.56-8.71), the operational leprosy classification (PR = 2.17; 95 % CI: 1.22-3.86) and grade 1 (PR = 1.83; 95 % CI: 1.02-3.26) or grade 2 disability (PR = 2.42; 95 % CI: 1.02-5.47) of the index leprosy case. Conclusions: The presence of signs suggestive of leprosy and the operational classification of leprosy cases were associated with anti-PGL-I seropositivity. The serological tests available for leprosy are not considered to be diagnostic tests but can be used as auxiliary assessments in combination with clinical parameters to identify exposed individuals at high risk of developing leprosy and those exhibiting the initial stages of this diseaseengBioMed CentralFactors associated with anti-phenolic glycolipid-I seropositivity among the household contacts of leprosy casesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleAntigens, Bacterial / immunologyLeprosy, Paucibacillary / epidemiologyGlycolipids / metabolismBrazil / epidemiologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/50982/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALFactors associated with anti-phenolic glycolipid-I.pdfFactors associated with anti-phenolic glycolipid-I.pdfapplication/pdf7223968https://www.arca.fiocruz.br/bitstream/icict/50982/2/Factors%20associated%20with%20anti-phenolic%20glycolipid-I.pdf348e2e0286fc79f35ae39f10a6dbef05MD52icict/509822022-02-02 08:41:10.939oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-02-02T11:41:10Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Factors associated with anti-phenolic glycolipid-I seropositivity among the household contacts of leprosy cases
title Factors associated with anti-phenolic glycolipid-I seropositivity among the household contacts of leprosy cases
spellingShingle Factors associated with anti-phenolic glycolipid-I seropositivity among the household contacts of leprosy cases
Carvalho, Ana Paula Mendes
Antigens, Bacterial / immunology
Leprosy, Paucibacillary / epidemiology
Glycolipids / metabolism
Brazil / epidemiology
title_short Factors associated with anti-phenolic glycolipid-I seropositivity among the household contacts of leprosy cases
title_full Factors associated with anti-phenolic glycolipid-I seropositivity among the household contacts of leprosy cases
title_fullStr Factors associated with anti-phenolic glycolipid-I seropositivity among the household contacts of leprosy cases
title_full_unstemmed Factors associated with anti-phenolic glycolipid-I seropositivity among the household contacts of leprosy cases
title_sort Factors associated with anti-phenolic glycolipid-I seropositivity among the household contacts of leprosy cases
author Carvalho, Ana Paula Mendes
author_facet Carvalho, Ana Paula Mendes
Fabri, Angélica da Conceição Oliveira Coelho
Oliveira, Rodrigo Corrêa de
Lana, Francisco Carlos Félix
author_role author
author2 Fabri, Angélica da Conceição Oliveira Coelho
Oliveira, Rodrigo Corrêa de
Lana, Francisco Carlos Félix
author2_role author
author
author
dc.contributor.author.fl_str_mv Carvalho, Ana Paula Mendes
Fabri, Angélica da Conceição Oliveira Coelho
Oliveira, Rodrigo Corrêa de
Lana, Francisco Carlos Félix
dc.subject.en.pt_BR.fl_str_mv Antigens, Bacterial / immunology
Leprosy, Paucibacillary / epidemiology
Glycolipids / metabolism
Brazil / epidemiology
topic Antigens, Bacterial / immunology
Leprosy, Paucibacillary / epidemiology
Glycolipids / metabolism
Brazil / epidemiology
description CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2022-02-02T11:41:10Z
dc.date.available.fl_str_mv 2022-02-02T11:41:10Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv CARVALHO, Ana Paula Mendes et al. Factors associated with anti-phenolic glycolipid-I seropositivity among the household contacts of leprosy cases. BMC Infectious Diseases, v. 15, 219, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/50982
dc.identifier.issn.pt_BR.fl_str_mv 1471-2334
dc.identifier.doi.none.fl_str_mv 10.1186/s12879-015-0955-3
identifier_str_mv CARVALHO, Ana Paula Mendes et al. Factors associated with anti-phenolic glycolipid-I seropositivity among the household contacts of leprosy cases. BMC Infectious Diseases, v. 15, 219, 2015.
1471-2334
10.1186/s12879-015-0955-3
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dc.publisher.none.fl_str_mv BioMed Central
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