Age-dependent relevance of endogenous 5-lipoxygenase derivatives in anxiety-like behavior in mice

Detalhes bibliográficos
Autor(a) principal: Leo, Luciana Magalhães
Data de Publicação: 2014
Outros Autores: Corrêa, Suellen Almeida, Canetti, Cláudio de Azevedo, Amaral, Olavo Bohrer, Bozza, Fernando Augusto, Pamplona, Fabrício Alano
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/10448
Resumo: CNPq, FAPERJ
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spelling Leo, Luciana MagalhãesCorrêa, Suellen AlmeidaCanetti, Cláudio de AzevedoAmaral, Olavo BohrerBozza, Fernando AugustoPamplona, Fabrício Alano2015-05-21T18:14:39Z2015-05-21T18:14:39Z2014LEO, Luciana Magalhães et al. Age-dependent relevance of endogenous 5-lipoxygenase derivatives in anxiety-like behavior in mice. Plos One, v. 9, n. 1, p. 1-7, Jan. 2014.1932-6203https://www.arca.fiocruz.br/handle/icict/1044810.1371/journal.pone.00850091932-6203CNPq, FAPERJFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / D'Or Instituto de Ensino e Pesquisa. Rio de Janeiro, RJ, BrasilUniversidade Federal do Rio de Janeiro. Instituto de Bioquıímica Médica. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Centro Nacional de Bioimagem. Rio de Janeiro, RJ, BrasilUniversidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Bioquıímica Médica. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Centro Nacional de Bioimagem. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / D'Or Instituto de Ensino e Pesquisa. Rio de Janeiro, RJ, Brasil.D'Or Instituto de Ensino e Pesquisa. Rio de Janeiro, RJ, Brasil.When 5-lipoxygenase (5-LO) is inhibited, roughly half of the CNS effect of the prototypic endocannabinoid anandamide (AEA) is lost. Therefore, we decided to investigate whether inhibiting this enzyme would influence physiological functions classically described as being under control of the endocannabinoid system. Although 5-LO inhibition by MK-886 reduced lipoxin A4 levels in the brain, no effect was found in the elevated plus maze (EPM), even at the highest possible doses, via i.p. (10 mg/kg,) or i.c.v. (500 pmol/2 ml) routes. Accordingly, no alterations in anxiety-like behavior in the EPM test were observed in 5-LO KO mice. Interestingly, aged mice, which show reduced circulating lipoxin A4 levels, were sensitive to MK-886, displaying an anxiogenic-like state in response to treatment. Moreover, exogenous lipoxin A4 induced an anxiolytic-like profile in the EPM test. Our findings are in line with other reports showing no difference between FLAP KO or 5-LO KO and their control strains in adult mice, but increased anxiety-like behavior in aged mice. We also show for the first time that lipoxin A4 affects mouse behavior. In conclusion, we propose an age-dependent relevancy of endogenous 5-LO derivatives in the modulation of anxiety-like behavior, in addition to a potential for exogenous lipoxin A4 in producing an anxiolytic-like state.engPublic Library of ScienceAge-dependent relevance of endogenous 5-lipoxygenase derivatives in anxiety-like behavior in miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleArachidonate 5-lipoxygenaseLipoxinsAnxietyRats/physiologyAraquidonato 5-lipoxigenaseLipoxinasAnsiedadeRatos/fisiologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82352https://www.arca.fiocruz.br/bitstream/icict/10448/1/license.txtafbdf7d7a9bcf771a1cc7edf5f618413MD51ORIGINALAge-dependent relevance of endogenous 5-lipoxygenase derivatives in anxiety-like behavior in mice.pdfAge-dependent relevance of endogenous 5-lipoxygenase derivatives in anxiety-like behavior in mice.pdfapplication/pdf907684https://www.arca.fiocruz.br/bitstream/icict/10448/2/Age-dependent%20relevance%20of%20endogenous%205-lipoxygenase%20derivatives%20in%20anxiety-like%20behavior%20in%20mice.pdf69296a14cbac82dc806fb749cc54810aMD52TEXTAge-dependent relevance of endogenous 5-lipoxygenase derivatives in anxiety-like behavior in mice.pdf.txtAge-dependent relevance of endogenous 5-lipoxygenase derivatives in anxiety-like behavior in mice.pdf.txtExtracted texttext/plain28837https://www.arca.fiocruz.br/bitstream/icict/10448/3/Age-dependent%20relevance%20of%20endogenous%205-lipoxygenase%20derivatives%20in%20anxiety-like%20behavior%20in%20mice.pdf.txt79ac490417ba80acfcab513911c1bf41MD53icict/104482019-09-10 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dc.title.pt_BR.fl_str_mv Age-dependent relevance of endogenous 5-lipoxygenase derivatives in anxiety-like behavior in mice
title Age-dependent relevance of endogenous 5-lipoxygenase derivatives in anxiety-like behavior in mice
spellingShingle Age-dependent relevance of endogenous 5-lipoxygenase derivatives in anxiety-like behavior in mice
Leo, Luciana Magalhães
Arachidonate 5-lipoxygenase
Lipoxins
Anxiety
Rats/physiology
Araquidonato 5-lipoxigenase
Lipoxinas
Ansiedade
Ratos/fisiologia
title_short Age-dependent relevance of endogenous 5-lipoxygenase derivatives in anxiety-like behavior in mice
title_full Age-dependent relevance of endogenous 5-lipoxygenase derivatives in anxiety-like behavior in mice
title_fullStr Age-dependent relevance of endogenous 5-lipoxygenase derivatives in anxiety-like behavior in mice
title_full_unstemmed Age-dependent relevance of endogenous 5-lipoxygenase derivatives in anxiety-like behavior in mice
title_sort Age-dependent relevance of endogenous 5-lipoxygenase derivatives in anxiety-like behavior in mice
author Leo, Luciana Magalhães
author_facet Leo, Luciana Magalhães
Corrêa, Suellen Almeida
Canetti, Cláudio de Azevedo
Amaral, Olavo Bohrer
Bozza, Fernando Augusto
Pamplona, Fabrício Alano
author_role author
author2 Corrêa, Suellen Almeida
Canetti, Cláudio de Azevedo
Amaral, Olavo Bohrer
Bozza, Fernando Augusto
Pamplona, Fabrício Alano
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Leo, Luciana Magalhães
Corrêa, Suellen Almeida
Canetti, Cláudio de Azevedo
Amaral, Olavo Bohrer
Bozza, Fernando Augusto
Pamplona, Fabrício Alano
dc.subject.en.pt_BR.fl_str_mv Arachidonate 5-lipoxygenase
Lipoxins
Anxiety
Rats/physiology
topic Arachidonate 5-lipoxygenase
Lipoxins
Anxiety
Rats/physiology
Araquidonato 5-lipoxigenase
Lipoxinas
Ansiedade
Ratos/fisiologia
dc.subject.decs.pt_BR.fl_str_mv Araquidonato 5-lipoxigenase
Lipoxinas
Ansiedade
Ratos/fisiologia
description CNPq, FAPERJ
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-05-21T18:14:39Z
dc.date.available.fl_str_mv 2015-05-21T18:14:39Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LEO, Luciana Magalhães et al. Age-dependent relevance of endogenous 5-lipoxygenase derivatives in anxiety-like behavior in mice. Plos One, v. 9, n. 1, p. 1-7, Jan. 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/10448
dc.identifier.issn.none.fl_str_mv 1932-6203
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pone.0085009
dc.identifier.eissn.none.fl_str_mv 1932-6203
identifier_str_mv LEO, Luciana Magalhães et al. Age-dependent relevance of endogenous 5-lipoxygenase derivatives in anxiety-like behavior in mice. Plos One, v. 9, n. 1, p. 1-7, Jan. 2014.
1932-6203
10.1371/journal.pone.0085009
url https://www.arca.fiocruz.br/handle/icict/10448
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/10448/1/license.txt
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https://www.arca.fiocruz.br/bitstream/icict/10448/3/Age-dependent%20relevance%20of%20endogenous%205-lipoxygenase%20derivatives%20in%20anxiety-like%20behavior%20in%20mice.pdf.txt
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