Cysteine proteases as digestive enzymes in parasitic helminths

Detalhes bibliográficos
Autor(a) principal: Caffrey, Conor R.
Data de Publicação: 2018
Outros Autores: Goupil, Louise, Rebello, Karina M., Dalton, John P., Smith, David
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/29452
Resumo: University of California San Diego. Skaggs School of Pharmacy and Pharmaceutical Sciences. Center for Discovery and Innovation in Parasitic DiseasesLa Jolla. Center for Discovery and Innovation in Parasitic Diseases. CA, USA.
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spelling Caffrey, Conor R.Goupil, LouiseRebello, Karina M.Dalton, John P.Smith, David2018-10-09T12:17:26Z2018-10-09T12:17:26Z2018CAFFREY, Conor R. et al. Cysteine proteases as digestive enzymes in parasitic helminths. PLoS Negl Trop Dis., v.12, n.8, e0005840, 20p, Aug. 2018.1935-2727https://www.arca.fiocruz.br/handle/icict/2945210.1371/journal.pntd.00058401935-2735engPublic Library of ScienceCisteína proteasesenzimas digestivashelmintos parasitasCysteine proteasesdigestive enzymesparasitic helminthsCysteine proteases as digestive enzymes in parasitic helminthsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversity of California San Diego. Skaggs School of Pharmacy and Pharmaceutical Sciences. Center for Discovery and Innovation in Parasitic DiseasesLa Jolla. Center for Discovery and Innovation in Parasitic Diseases. CA, USA.University of California San Diego. Skaggs School of Pharmacy and Pharmaceutical Sciences. Center for Discovery and Innovation in Parasitic DiseasesLa Jolla. Center for Discovery and Innovation in Parasitic Diseases. CA, USA / University of San Francisco. Department of Biology. San Francisco, CA, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxinologia. Rio de Janeiro, RJ. Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Estudos Integrados em Protozoologia. Rio de Janeiro, RJ, Brasil.Queen´s University Belfast. Medical Biology Centre. School of Biological Sciences. Belfast, United Kingdom.Queen´s University Belfast. Medical Biology Centre. School of Biological Sciences. Belfast, United Kingdom.We briefly review cysteine proteases (orthologs of mammalian cathepsins B, L, F, and C) that are expressed in flatworm and nematode parasites. Emphasis is placed on enzyme activities that have been functionally characterized, are associated with the parasite gut, and putatively contribute to degrading host proteins to absorbable nutrients [1-4]. Often, gut proteases are expressed as multigene families, as is the case with Fasciola [5] and Haemonchus [6], presumably expanding the range of substrates that can be degraded, not least during parasite migration through host tissues [5]. The application of the free-living planarian and Caenorhabditis elegans as investigative models for parasite cysteine proteases is discussed. Finally, because of their central nutritive contribution, targeting the component gut proteases with small-molecule chemical inhibitors and understanding their utility as vaccine candidates are active areas of research [7].info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/29452/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALkarina2_rebello_etal_IOC_2018.pdfkarina2_rebello_etal_IOC_2018.pdfapplication/pdf1284574https://www.arca.fiocruz.br/bitstream/icict/29452/2/karina2_rebello_etal_IOC_2018.pdf42a2f71d85facc371e10c5c43fa005b1MD52TEXTkarina2_rebello_etal_IOC_2018.pdf.txtkarina2_rebello_etal_IOC_2018.pdf.txtExtracted texttext/plain85457https://www.arca.fiocruz.br/bitstream/icict/29452/3/karina2_rebello_etal_IOC_2018.pdf.txtfbe1dd62df830650a9d4a2c6378b2b2fMD53icict/294522018-10-10 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dc.title.pt_BR.fl_str_mv Cysteine proteases as digestive enzymes in parasitic helminths
title Cysteine proteases as digestive enzymes in parasitic helminths
spellingShingle Cysteine proteases as digestive enzymes in parasitic helminths
Caffrey, Conor R.
Cisteína proteases
enzimas digestivas
helmintos parasitas
Cysteine proteases
digestive enzymes
parasitic helminths
title_short Cysteine proteases as digestive enzymes in parasitic helminths
title_full Cysteine proteases as digestive enzymes in parasitic helminths
title_fullStr Cysteine proteases as digestive enzymes in parasitic helminths
title_full_unstemmed Cysteine proteases as digestive enzymes in parasitic helminths
title_sort Cysteine proteases as digestive enzymes in parasitic helminths
author Caffrey, Conor R.
author_facet Caffrey, Conor R.
Goupil, Louise
Rebello, Karina M.
Dalton, John P.
Smith, David
author_role author
author2 Goupil, Louise
Rebello, Karina M.
Dalton, John P.
Smith, David
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Caffrey, Conor R.
Goupil, Louise
Rebello, Karina M.
Dalton, John P.
Smith, David
dc.subject.other.pt_BR.fl_str_mv Cisteína proteases
enzimas digestivas
helmintos parasitas
topic Cisteína proteases
enzimas digestivas
helmintos parasitas
Cysteine proteases
digestive enzymes
parasitic helminths
dc.subject.en.pt_BR.fl_str_mv Cysteine proteases
digestive enzymes
parasitic helminths
description University of California San Diego. Skaggs School of Pharmacy and Pharmaceutical Sciences. Center for Discovery and Innovation in Parasitic DiseasesLa Jolla. Center for Discovery and Innovation in Parasitic Diseases. CA, USA.
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-10-09T12:17:26Z
dc.date.available.fl_str_mv 2018-10-09T12:17:26Z
dc.date.issued.fl_str_mv 2018
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CAFFREY, Conor R. et al. Cysteine proteases as digestive enzymes in parasitic helminths. PLoS Negl Trop Dis., v.12, n.8, e0005840, 20p, Aug. 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/29452
dc.identifier.issn.pt_BR.fl_str_mv 1935-2727
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.0005840
dc.identifier.eissn.none.fl_str_mv 1935-2735
identifier_str_mv CAFFREY, Conor R. et al. Cysteine proteases as digestive enzymes in parasitic helminths. PLoS Negl Trop Dis., v.12, n.8, e0005840, 20p, Aug. 2018.
1935-2727
10.1371/journal.pntd.0005840
1935-2735
url https://www.arca.fiocruz.br/handle/icict/29452
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/29452/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/29452/2/karina2_rebello_etal_IOC_2018.pdf
https://www.arca.fiocruz.br/bitstream/icict/29452/3/karina2_rebello_etal_IOC_2018.pdf.txt
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