Polymorphisms in B Cell Co-Stimulatory Genes Are Associated with IgG Antibody Responses against Blood–Stage Proteins of Plasmodium vivax

Bibliographic Details
Main Author: Cassiano, Gustavo Capatti
Publication Date: 2016
Other Authors: Furini, Adriana Antonia Cruz, Capobianco, Marcela Petrolini, Melo, Luciane Moreno Storti, Cunha, Maristela Gomes da, Kano, Flora Satiko, Carvalho, Luzia Helena, Soares, Irene da Silva, Santos, Sidney Emanuel Batista dos, Póvoa, Marinete Marins, Machado, Ricardo Luiz Dantas
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
Download full: https://www.arca.fiocruz.br/handle/icict/15010
Summary: Universidade Estadual Paulista. Departamento de Biologia. São José do Rio Preto, SP, Brasil
id CRUZ_906865ea668e958f9019a0c6f0f4e09c
oai_identifier_str oai:www.arca.fiocruz.br:icict/15010
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Cassiano, Gustavo CapattiFurini, Adriana Antonia CruzCapobianco, Marcela PetroliniMelo, Luciane Moreno StortiCunha, Maristela Gomes daKano, Flora SatikoCarvalho, Luzia HelenaSoares, Irene da SilvaSantos, Sidney Emanuel Batista dosPóvoa, Marinete MarinsMachado, Ricardo Luiz Dantas2016-07-20T17:49:33Z2016-07-20T17:49:33Z2016Cassiano, Gustavo Capatti et al. Polymorphisms in B Cell Co-Stimulatory Genes Are Associated with IgG Antibody Responses against Blood–Stage Proteins of Plasmodium vivax. PLoS One, vol. 11, n. 2, p. e0149581, 20161932-6203https://www.arca.fiocruz.br/handle/icict/1501010.1371/journal.pone.0149581engPublic Library of SciencePolymorphisms in B Cell Co-Stimulatory Genes Are Associated with IgG Antibody Responses against Blood–Stage Proteins of Plasmodium vivaxinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Estadual Paulista. Departamento de Biologia. São José do Rio Preto, SP, BrasilFaculdade de Medicina. Departamento de Dermatologia, Doenças Infecciosas e Parasitarias. São José do Rio Preto, SP, BrasilUniversidade Estadual Paulista. Departamento de Biologia. São José do Rio Preto, SP, BrasilUniversidade Federal de Sergipe. Departamento de Biologia. Aracaju, SE, BrasilUniversidade Federal do Pará. Instituto de Ciencias Biologicas. Laboratório f Microbiologia e Imunologia. Belém, PA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratorio de Malaria. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratorio de Malaria. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratorio de Malaria. Belo Horizonte, MG, BrasilUniversidade de São Paulo. Faculdade de Ciencias Farmaceuticas. Departamento de Analises Toxicologicas e Clinicas. São Paulo, SP, BrasilUniversidade Federal do Pará. Laboratorio de Genetica Medica e Humana. Belém, PA, BrazilFundação Oswaldo Cruz. Instituto Evandro Chagas.Departamento de Parasitologia. Laboratorio de Pesquisa Básica em Malaria. Belém, PA, BrasilUniversidade Estadual Paulista. Departamento de Biologia. São José do Rio Preto, SP, Brasil/ Fundação Oswaldo Cruz. Instituto Evandro Chagas.Departamento de Parasitologia. Laboratorio de Pesquisa Básica em Malaria. Belém, PA, BrasilThe development of an effective immune response can help decrease mortality from malaria and its clinical symptoms. However, this mechanism is complex and has significant inter-individual variation, most likely owing to the genetic contribution of the human host. Therefore, this study aimed to investigate the influence of polymorphisms in genes involved in the costimulation of B-lymphocytes in the naturally acquired humoral immune response against proteins of the asexual stage of Plasmodium vivax. A total of 319 individuals living in an area of malaria transmission in the Brazilian Amazon were genotyped for four SNPs in the genes CD40, CD40L, BLYS and CD86. In addition, IgG antibodies against P. vivax apical membrane antigen 1 (PvAMA-1), Duffy binding protein (PvDBP) and merozoite surface protein 1 (PvMSP-119) were detected by ELISA. The SNP BLYS -871C>T was associated with the frequency of IgG responders to PvAMA-1 and PvMSP-119. The SNP CD40 -1C>T was associated with the IgG response against PvDBP, whereas IgG antibody titers against PvMSP-119 were influenced by the polymorphism CD86 +1057G>A. These data may help to elucidate the immunological aspects of vivax malaria and consequently assist in the design of malaria vaccinesAntibodies, Protozoan/immunologyAntigens, CD/geneticsAntigens, CD/immunologyImmunoglobulin G/immunologyMalaria, Vivax/geneticsMalaria, Vivax/immunologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/15010/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALve_Cassiano_Gustavo_Polymorphisms_CPqRR_2016.PDFve_Cassiano_Gustavo_Polymorphisms_CPqRR_2016.PDFapplication/pdf1919155https://www.arca.fiocruz.br/bitstream/icict/15010/2/ve_Cassiano_Gustavo_Polymorphisms_CPqRR_2016.PDF7b126cea1b5944636f3c8cc75665d756MD52TEXTve_Cassiano_Gustavo_Polymorphisms_CPqRR_2016.PDF.txtve_Cassiano_Gustavo_Polymorphisms_CPqRR_2016.PDF.txtExtracted texttext/plain53635https://www.arca.fiocruz.br/bitstream/icict/15010/3/ve_Cassiano_Gustavo_Polymorphisms_CPqRR_2016.PDF.txtc2f722665bac37bff53c472fea64b8d1MD53icict/150102019-06-19 10:13:30.282oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-06-19T13:13:30Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Polymorphisms in B Cell Co-Stimulatory Genes Are Associated with IgG Antibody Responses against Blood–Stage Proteins of Plasmodium vivax
title Polymorphisms in B Cell Co-Stimulatory Genes Are Associated with IgG Antibody Responses against Blood–Stage Proteins of Plasmodium vivax
spellingShingle Polymorphisms in B Cell Co-Stimulatory Genes Are Associated with IgG Antibody Responses against Blood–Stage Proteins of Plasmodium vivax
Cassiano, Gustavo Capatti
Antibodies, Protozoan/immunology
Antigens, CD/genetics
Antigens, CD/immunology
Immunoglobulin G/immunology
Malaria, Vivax/genetics
Malaria, Vivax/immunology
title_short Polymorphisms in B Cell Co-Stimulatory Genes Are Associated with IgG Antibody Responses against Blood–Stage Proteins of Plasmodium vivax
title_full Polymorphisms in B Cell Co-Stimulatory Genes Are Associated with IgG Antibody Responses against Blood–Stage Proteins of Plasmodium vivax
title_fullStr Polymorphisms in B Cell Co-Stimulatory Genes Are Associated with IgG Antibody Responses against Blood–Stage Proteins of Plasmodium vivax
title_full_unstemmed Polymorphisms in B Cell Co-Stimulatory Genes Are Associated with IgG Antibody Responses against Blood–Stage Proteins of Plasmodium vivax
title_sort Polymorphisms in B Cell Co-Stimulatory Genes Are Associated with IgG Antibody Responses against Blood–Stage Proteins of Plasmodium vivax
author Cassiano, Gustavo Capatti
author_facet Cassiano, Gustavo Capatti
Furini, Adriana Antonia Cruz
Capobianco, Marcela Petrolini
Melo, Luciane Moreno Storti
Cunha, Maristela Gomes da
Kano, Flora Satiko
Carvalho, Luzia Helena
Soares, Irene da Silva
Santos, Sidney Emanuel Batista dos
Póvoa, Marinete Marins
Machado, Ricardo Luiz Dantas
author_role author
author2 Furini, Adriana Antonia Cruz
Capobianco, Marcela Petrolini
Melo, Luciane Moreno Storti
Cunha, Maristela Gomes da
Kano, Flora Satiko
Carvalho, Luzia Helena
Soares, Irene da Silva
Santos, Sidney Emanuel Batista dos
Póvoa, Marinete Marins
Machado, Ricardo Luiz Dantas
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cassiano, Gustavo Capatti
Furini, Adriana Antonia Cruz
Capobianco, Marcela Petrolini
Melo, Luciane Moreno Storti
Cunha, Maristela Gomes da
Kano, Flora Satiko
Carvalho, Luzia Helena
Soares, Irene da Silva
Santos, Sidney Emanuel Batista dos
Póvoa, Marinete Marins
Machado, Ricardo Luiz Dantas
dc.subject.en.pt_BR.fl_str_mv Antibodies, Protozoan/immunology
Antigens, CD/genetics
Antigens, CD/immunology
Immunoglobulin G/immunology
Malaria, Vivax/genetics
Malaria, Vivax/immunology
topic Antibodies, Protozoan/immunology
Antigens, CD/genetics
Antigens, CD/immunology
Immunoglobulin G/immunology
Malaria, Vivax/genetics
Malaria, Vivax/immunology
description Universidade Estadual Paulista. Departamento de Biologia. São José do Rio Preto, SP, Brasil
publishDate 2016
dc.date.accessioned.fl_str_mv 2016-07-20T17:49:33Z
dc.date.available.fl_str_mv 2016-07-20T17:49:33Z
dc.date.issued.fl_str_mv 2016
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv Cassiano, Gustavo Capatti et al. Polymorphisms in B Cell Co-Stimulatory Genes Are Associated with IgG Antibody Responses against Blood–Stage Proteins of Plasmodium vivax. PLoS One, vol. 11, n. 2, p. e0149581, 2016
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/15010
dc.identifier.issn.pt_BR.fl_str_mv 1932-6203
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pone.0149581
identifier_str_mv Cassiano, Gustavo Capatti et al. Polymorphisms in B Cell Co-Stimulatory Genes Are Associated with IgG Antibody Responses against Blood–Stage Proteins of Plasmodium vivax. PLoS One, vol. 11, n. 2, p. e0149581, 2016
1932-6203
10.1371/journal.pone.0149581
url https://www.arca.fiocruz.br/handle/icict/15010
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/15010/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/15010/2/ve_Cassiano_Gustavo_Polymorphisms_CPqRR_2016.PDF
https://www.arca.fiocruz.br/bitstream/icict/15010/3/ve_Cassiano_Gustavo_Polymorphisms_CPqRR_2016.PDF.txt
bitstream.checksum.fl_str_mv 5a560609d32a3863062d77ff32785d58
7b126cea1b5944636f3c8cc75665d756
c2f722665bac37bff53c472fea64b8d1
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1798324760378081280

Similar Items