Non-target molecular network and putative genes of flavonoid biosynthesis in Erythrina velutina willd., a brazilian semiarid native woody plant
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/55824 |
Resumo: | Universidade Federal do Rio Grande do Norte. Departamento de Farmácia. Natal, RN, Brasil. |
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Chacon, Daisy SoteroSantos, Marlon Dias MarianoBonilauri, BernardoVilasboa, JohnatanCosta, Cibele Tesser daSilva, Ivanice Bezerra daTorres, Taffarel de MeloAraújo, Thiago Ferreira deRoque, Alan de AraújoPilon, Alan CesarSelegatto, Denise MedeirosFreire, Rafael TeixeiraReginaldo, Fernanda Priscila SantosVoigt, Eduardo LuizZuanazzi, José Angelo SilveiraScortecci, Kátia CastanhoCavalheiro, Alberto JoséLopes, Norberto PeporineFerreira, Leandro De SantisSantos, Leandro Vieira dosFontes, WagnerSousa, Marcelo Valle deCarvalho, Paulo CostaFett-Neto, Arthur GermanoGiordani, Raquel Brandt2022-11-29T15:11:36Z2022-11-29T15:11:36Z2022CHACON, Daisy Sotero et al. Non-target molecular network and putative genes of flavonoid biosynthesis in Erythrina velutina Willd., a Brazilian semiarid native woody plant. Front. Plant Sci, v. 13, n. 947558, p. 1–22, 2022.1664-462Xhttps://www.arca.fiocruz.br/handle/icict/5582410.3389/fpls.2022.947558porFrontiers MediaErythrina velutinCaatingaFlavonoidsTranscriptomePhenolic CompoundsPhytochemicalsFlavonoidesCompuestos FenólicosFitoquímicosFlavonoïdesComposés PhénoliquesComposés phytochimiquesErythrinaFlavonoidesTranscriptomaCompostos FenólicosCompostos FitoquímicosNon-target molecular network and putative genes of flavonoid biosynthesis in Erythrina velutina willd., a brazilian semiarid native woody plantinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio Grande do Norte. Departamento de Farmácia. Natal, RN, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Proteômica Estrutural e Computacional. Curitiba, PR, Brasil.Stanford Cardiovascular Institute. Stanford University School of Medicine. Stanford, CA, United States.Universidade Federal do Rio Grande do Sul. Centro de Biotecnologia e Departamento de Botânica. Laboratório de Fisiologia Vegetal. Porto Alegre, RS, Brasil.Universidade Federal do Rio Grande do Sul. Centro de Biotecnologia e Departamento de Botânica. Laboratório de Fisiologia Vegetal. Porto Alegre, RS, Brasil.Universidade Federal do Rio Grande do Norte. Departamento de Farmácia. Natal, RN, Brasil.Universidade Federal Rural do Semi-Árido. Núcleo de Bioinformática, Bioestatística e Biologia Computacional. Mossoró, RN, Brasil.Universidade Federal do Rio Grande do Norte. Departamento de Farmácia. Natal, RN, Brasil.Herbário do Parque das Dunas. Instituto de Desenvolvimento Sustentável e Meio Ambiente. Natal, RN, Brasil.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Departamento de Biomolecular. Ribeirão Preto, SP, Brasil.Zimmermann Group. European Molecular Biology Laboratory. Structural and Computational Biology Unit. Heidelberg, Germany.Signal and Information Processing for Sensing Systems. Institute for Bioengineering of Catalonia. Barcelona Institute of Science and Technology. Barcelona, Spain.Institute of Biology. Leiden University. Leiden, Netherlands.Universidade Federal do Rio Grande do Norte. Centro de Biociências. Departamento de Biologia Celular e Genética. Natal, RN, Brasil.Universidade Federal do Rio Grande do Sul. Laboratório de Farmacognosia. Porto Alegre, RS, Brasil.Universidade Federal do Rio Grande do Norte. Centro de Biociências. Departamento de Biologia Celular e Genética. Natal, RN, Brasil.Universidade Estadual de São Paulo. Instituto de Química. Araraquara, SP, Brasil.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Departamento de Biomolecular. Ribeirão Preto, SP, Brasil.Universidade Federal do Rio Grande do Norte. Departamento de Farmácia. Natal, RN, Brasil.Universidade de Campinas. Instituto de Biologia. Programa de Pós-Graduação em Genética e Biologia Molecular. Campinas, SP, Brasil.Universidade de Brasília. Departamento de Biologia Celular. Laboratório de Bioquímica e Química de Proteínas. Brasília, DF, Brasil.Universidade de Brasília. Departamento de Biologia Celular. Laboratório de Bioquímica e Química de Proteínas. Brasília, DF, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Proteômica Estrutural e Computacional. Curitiba, PR, Brasil.Universidade Federal do Rio Grande do Sul. Centro de Biotecnologia e Departamento de Botânica. Laboratório de Fisiologia Vegetal. Porto Alegre, RS, Brasil.Universidade Federal do Rio Grande do Norte. Departamento de Farmácia. Natal, RN, Brasil.Erythrina velutina is a Brazilian native tree of the Caatinga (a unique semiarid biome). It is widely used in traditional medicine showing anti-inflammatory and central nervous system modulating activities. The species is a rich source of specialized metabolites, mostly alkaloids and flavonoids. To date, genomic information, biosynthesis, and regulation of flavonoids remain unknown in this woody plant. As part of a larger ongoing research goal to better understand specialized metabolism in plants inhabiting the harsh condition of the Caatinga, the present study focused on this important class of bioactive phenolics. Leaves and seeds of plants growing in their natural habitat had their metabolic and proteomic profiles analyzed and integrated with transcriptome data. As a result, 96 metabolites (including 43 flavonoids) were annotated. Transcripts of the flavonoid pathway totaled 27, of which EvCHI, EvCHR, EvCHS, EvCYP75A and EvCYP75B1 were identified as putative main targets for modulating the accumulation of these metabolites. The highest correspondence of mRNA vs. protein was observed in the dierentially expressed transcripts. In addition, 394 candidate transcripts encoding for transcription factors distributed among the bHLH, ERF, and MYB families were annotated. Based on interaction network analyses, several putative genes of the flavonoid pathway and transcription factors were related, particularly TFs of the MYB family. Expression patterns of transcripts involved in flavonoid biosynthesis and those involved in responses to biotic and abiotic stresses were discussed in detail. Overall, these findings provide a base for the understanding of molecular and metabolic responses in this medicinally important species. Moreover, the identification of key regulatory targets for future studies aiming at bioactive metabolite production will be facilitated.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/55824/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALfpls-13-947558ok.pdffpls-13-947558ok.pdfapplication/pdf6217650https://www.arca.fiocruz.br/bitstream/icict/55824/2/fpls-13-947558ok.pdffe11b027bcc243389e06cb6da30d2616MD52icict/558242022-11-29 12:11:37.859oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-11-29T15:11:37Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.en_US.fl_str_mv |
Non-target molecular network and putative genes of flavonoid biosynthesis in Erythrina velutina willd., a brazilian semiarid native woody plant |
| title |
Non-target molecular network and putative genes of flavonoid biosynthesis in Erythrina velutina willd., a brazilian semiarid native woody plant |
| spellingShingle |
Non-target molecular network and putative genes of flavonoid biosynthesis in Erythrina velutina willd., a brazilian semiarid native woody plant Chacon, Daisy Sotero Erythrina velutin Caatinga Flavonoids Transcriptome Phenolic Compounds Phytochemicals Flavonoides Compuestos Fenólicos Fitoquímicos Flavonoïdes Composés Phénoliques Composés phytochimiques Erythrina Flavonoides Transcriptoma Compostos Fenólicos Compostos Fitoquímicos |
| title_short |
Non-target molecular network and putative genes of flavonoid biosynthesis in Erythrina velutina willd., a brazilian semiarid native woody plant |
| title_full |
Non-target molecular network and putative genes of flavonoid biosynthesis in Erythrina velutina willd., a brazilian semiarid native woody plant |
| title_fullStr |
Non-target molecular network and putative genes of flavonoid biosynthesis in Erythrina velutina willd., a brazilian semiarid native woody plant |
| title_full_unstemmed |
Non-target molecular network and putative genes of flavonoid biosynthesis in Erythrina velutina willd., a brazilian semiarid native woody plant |
| title_sort |
Non-target molecular network and putative genes of flavonoid biosynthesis in Erythrina velutina willd., a brazilian semiarid native woody plant |
| author |
Chacon, Daisy Sotero |
| author_facet |
Chacon, Daisy Sotero Santos, Marlon Dias Mariano Bonilauri, Bernardo Vilasboa, Johnatan Costa, Cibele Tesser da Silva, Ivanice Bezerra da Torres, Taffarel de Melo Araújo, Thiago Ferreira de Roque, Alan de Araújo Pilon, Alan Cesar Selegatto, Denise Medeiros Freire, Rafael Teixeira Reginaldo, Fernanda Priscila Santos Voigt, Eduardo Luiz Zuanazzi, José Angelo Silveira Scortecci, Kátia Castanho Cavalheiro, Alberto José Lopes, Norberto Peporine Ferreira, Leandro De Santis Santos, Leandro Vieira dos Fontes, Wagner Sousa, Marcelo Valle de Carvalho, Paulo Costa Fett-Neto, Arthur Germano Giordani, Raquel Brandt |
| author_role |
author |
| author2 |
Santos, Marlon Dias Mariano Bonilauri, Bernardo Vilasboa, Johnatan Costa, Cibele Tesser da Silva, Ivanice Bezerra da Torres, Taffarel de Melo Araújo, Thiago Ferreira de Roque, Alan de Araújo Pilon, Alan Cesar Selegatto, Denise Medeiros Freire, Rafael Teixeira Reginaldo, Fernanda Priscila Santos Voigt, Eduardo Luiz Zuanazzi, José Angelo Silveira Scortecci, Kátia Castanho Cavalheiro, Alberto José Lopes, Norberto Peporine Ferreira, Leandro De Santis Santos, Leandro Vieira dos Fontes, Wagner Sousa, Marcelo Valle de Carvalho, Paulo Costa Fett-Neto, Arthur Germano Giordani, Raquel Brandt |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Chacon, Daisy Sotero Santos, Marlon Dias Mariano Bonilauri, Bernardo Vilasboa, Johnatan Costa, Cibele Tesser da Silva, Ivanice Bezerra da Torres, Taffarel de Melo Araújo, Thiago Ferreira de Roque, Alan de Araújo Pilon, Alan Cesar Selegatto, Denise Medeiros Freire, Rafael Teixeira Reginaldo, Fernanda Priscila Santos Voigt, Eduardo Luiz Zuanazzi, José Angelo Silveira Scortecci, Kátia Castanho Cavalheiro, Alberto José Lopes, Norberto Peporine Ferreira, Leandro De Santis Santos, Leandro Vieira dos Fontes, Wagner Sousa, Marcelo Valle de Carvalho, Paulo Costa Fett-Neto, Arthur Germano Giordani, Raquel Brandt |
| dc.subject.other.en_US.fl_str_mv |
Erythrina velutin Caatinga |
| topic |
Erythrina velutin Caatinga Flavonoids Transcriptome Phenolic Compounds Phytochemicals Flavonoides Compuestos Fenólicos Fitoquímicos Flavonoïdes Composés Phénoliques Composés phytochimiques Erythrina Flavonoides Transcriptoma Compostos Fenólicos Compostos Fitoquímicos |
| dc.subject.en.en_US.fl_str_mv |
Flavonoids Transcriptome Phenolic Compounds Phytochemicals |
| dc.subject.es.en_US.fl_str_mv |
Flavonoides Compuestos Fenólicos Fitoquímicos |
| dc.subject.fr.en_US.fl_str_mv |
Flavonoïdes Composés Phénoliques Composés phytochimiques |
| dc.subject.decs.en_US.fl_str_mv |
Erythrina Flavonoides Transcriptoma Compostos Fenólicos Compostos Fitoquímicos |
| description |
Universidade Federal do Rio Grande do Norte. Departamento de Farmácia. Natal, RN, Brasil. |
| publishDate |
2022 |
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2022-11-29T15:11:36Z |
| dc.date.available.fl_str_mv |
2022-11-29T15:11:36Z |
| dc.date.issued.fl_str_mv |
2022 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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| dc.identifier.citation.fl_str_mv |
CHACON, Daisy Sotero et al. Non-target molecular network and putative genes of flavonoid biosynthesis in Erythrina velutina Willd., a Brazilian semiarid native woody plant. Front. Plant Sci, v. 13, n. 947558, p. 1–22, 2022. |
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https://www.arca.fiocruz.br/handle/icict/55824 |
| dc.identifier.issn.en_US.fl_str_mv |
1664-462X |
| dc.identifier.doi.none.fl_str_mv |
10.3389/fpls.2022.947558 |
| identifier_str_mv |
CHACON, Daisy Sotero et al. Non-target molecular network and putative genes of flavonoid biosynthesis in Erythrina velutina Willd., a Brazilian semiarid native woody plant. Front. Plant Sci, v. 13, n. 947558, p. 1–22, 2022. 1664-462X 10.3389/fpls.2022.947558 |
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Frontiers Media |
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