Genome-based survey of the SARS-CoV-2 BF. 7 variant from Asia

Detalhes bibliográficos
Autor(a) principal: Scarpa, Fabio
Data de Publicação: 2023
Outros Autores: Giovanetti, Marta, Azzena, Ilenia, Locci, Chiara, Casu, Marco, Fiori, Pier Luigi, Ciccozzi, Alessandra, Imperia, Elena, Bazzani, Liliana, Borsetti, Alessandra, Maruotti, Antonello, Pascarella, Stefano, Sanna, Daria, Ciccozzi, Massimo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/57947
Resumo: Department of Biomedical Sciences. University of Sassari. Sassari, Italy
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spelling Scarpa, FabioGiovanetti, MartaAzzena, IleniaLocci, ChiaraCasu, MarcoFiori, Pier LuigiCiccozzi, AlessandraImperia, ElenaBazzani, LilianaBorsetti, AlessandraMaruotti, AntonelloPascarella, StefanoSanna, DariaCiccozzi, Massimo2023-04-24T18:21:32Z2023-04-24T18:21:32Z2023SCARPA, Fábio et al. Genome-based survey of the SARS-CoV-2 BF. 7 variant from Asia. Journal of medical virology, v. 95, n. 4, e28714, 2023. doi.org/10.1002/jmv.287141096-9071https://www.arca.fiocruz.br/handle/icict/57947engSHOU-JIANG (SJ) GAOGenome-based survey of the SARS-CoV-2 BF. 7 variant from Asiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleDepartment of Biomedical Sciences. University of Sassari. Sassari, ItalyFundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil/Sciences and Technologies for Sustainable Development and One Health. University of Campus Bio‐Medico. Rome, ItalyDepartment of Biomedical Sciences. University of Sassari. Sassari, Italy/Department of Veterinary Medicine. University of Sassari. Sassari, ItalyDepartment of Biomedical Sciences. University of Sassari. Sassari, Italy/Department of Veterinary Medicine. University of Sassari. Sassari, ItalyDepartment of Veterinary Medicine. University of Sassari. Sassari, ItalyDepartment of Biomedical Sciences. University of Sassari. Sassari, Italy/Azienza Ospedaliera Universitaria. Sassari, ItalyUnit of Medical Statistics and Molecular Epidemiology. University Campus Bio‐Medico of Rome. Rome, ItalyUnit of Medical Statistics and Molecular Epidemiology. University Campus Bio‐Medico of Rome. Rome, Italy/Unit of Gastroenterology. Department of Medicine. University Campus Bio‐Medico of Rome. Rome, ItalySciences and Technologies for Sustainable Development and One Health. University of Campus Bio‐Medico. Rome, ItalyNational HIV/AIDS Research Center. Rome, Italy Istituto Superiore di Sanità. Rome, ItalyDepartment GEPLI. Libera Università Ss Maria Assunta. Rome, ItalyDepartment of Biochemical Sciences“A. Rossi Fanelli”. Sapienza Università di Roma. Rome, ItalyDepartment of Biomedical Sciences. University of Sassari. Sassari, ItalyUnit of Medical Statistics and Molecular Epidemiology. University Campus Bio‐Medico of Rome. Rome, ItalyThe SARS-CoV-2 BF.7 variant represents one of the most recent subvariant under monitoring. At the beginning of the 2023 it caused several concerns especially in Asia because of a resurge in COVID-19 cases. Here we perform a genome-based integrative approach on SARS-CoV-2 BF.7 to shed light on this emerging lineage and produce some consideration on its real dangerousness. Both genetic and structural data suggest that this new variant currently does not show evidence of an high expansion capability. It is very common in Asia, but it appears less virulent than other Omicron variants as proved by its relatively low evolutionary rate (5.62 × 10−4 subs/sites/years). The last plateau has been reached around December 14, 2022 and then the genetic variability, and thus the viral population size, no longer increased. As already seen for several previous variants, the features that may be theoretically related to advantages are due to genetic drift that allows to the virus a constant adaptability to the host, but is not strictly connected to a fitness advantage. These results have further pointed that the genome-based monitoring must continue uninterruptedly to be prepared and well documented on the real situation.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/57947/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALGenome-based survey of the SARS-CoV-2 BF. 7 variant from Asia.pdfGenome-based survey of the SARS-CoV-2 BF. 7 variant from Asia.pdfapplication/pdf3434418https://www.arca.fiocruz.br/bitstream/icict/57947/2/Genome-based%20survey%20of%20the%20SARS-CoV-2%20BF.%207%20variant%20from%20Asia.pdfd732a7a7be3836ea8d7df4d4a09dee6fMD52icict/579472023-04-24 15:21:33.105oai:www.arca.fiocruz.br:icict/57947Q0VTU8ODTyBOw4NPIEVYQ0xVU0lWQSBERSBESVJFSVRPUyBBVVRPUkFJUwoKQW8gYWNlaXRhciBvcyBURVJNT1MgZSBDT05EScOHw5VFUyBkZXN0YSBDRVNTw4NPLCBvIEFVVE9SIGUvb3UgVElUVUxBUiBkZSBkaXJlaXRvcwphdXRvcmFpcyBzb2JyZSBhIE9CUkEgZGUgcXVlIHRyYXRhIGVzdGUgZG9jdW1lbnRvOgoKKDEpIENFREUgZSBUUkFOU0ZFUkUsIHRvdGFsIGUgZ3JhdHVpdGFtZW50ZSwgw6AgRklPQ1JVWiAtIEZVTkRBw4fDg08gT1NXQUxETyBDUlVaLCBlbQpjYXLDoXRlciBwZXJtYW5lbnRlLCBpcnJldm9nw6F2ZWwgZSBOw4NPIEVYQ0xVU0lWTywgdG9kb3Mgb3MgZGlyZWl0b3MgcGF0cmltb25pYWlzIE7Dg08KQ09NRVJDSUFJUyBkZSB1dGlsaXphw6fDo28gZGEgT0JSQSBhcnTDrXN0aWNhIGUvb3UgY2llbnTDrWZpY2EgaW5kaWNhZGEgYWNpbWEsIGluY2x1c2l2ZSBvcyBkaXJlaXRvcwpkZSB2b3ogZSBpbWFnZW0gdmluY3VsYWRvcyDDoCBPQlJBLCBkdXJhbnRlIHRvZG8gbyBwcmF6byBkZSBkdXJhw6fDo28gZG9zIGRpcmVpdG9zIGF1dG9yYWlzLCBlbQpxdWFscXVlciBpZGlvbWEgZSBlbSB0b2RvcyBvcyBwYcOtc2VzOwoKKDIpIEFDRUlUQSBxdWUgYSBjZXNzw6NvIHRvdGFsIG7Do28gZXhjbHVzaXZhLCBwZXJtYW5lbnRlIGUgaXJyZXZvZ8OhdmVsIGRvcyBkaXJlaXRvcyBhdXRvcmFpcwpwYXRyaW1vbmlhaXMgbsOjbyBjb21lcmNpYWlzIGRlIHV0aWxpemHDp8OjbyBkZSBxdWUgdHJhdGEgZXN0ZSBkb2N1bWVudG8gaW5jbHVpLCBleGVtcGxpZmljYXRpdmFtZW50ZSwKb3MgZGlyZWl0b3MgZGUgZGlzcG9uaWJpbGl6YcOnw6NvIGUgY29tdW5pY2HDp8OjbyBww7pibGljYSBkYSBPQlJBLCBlbSBxdWFscXVlciBtZWlvIG91IHZlw61jdWxvLAppbmNsdXNpdmUgZW0gUmVwb3NpdMOzcmlvcyBEaWdpdGFpcywgYmVtIGNvbW8gb3MgZGlyZWl0b3MgZGUgcmVwcm9kdcOnw6NvLCBleGliacOnw6NvLCBleGVjdcOnw6NvLApkZWNsYW1hw6fDo28sIHJlY2l0YcOnw6NvLCBleHBvc2nDp8OjbywgYXJxdWl2YW1lbnRvLCBpbmNsdXPDo28gZW0gYmFuY28gZGUgZGFkb3MsIHByZXNlcnZhw6fDo28sIGRpZnVzw6NvLApkaXN0cmlidWnDp8OjbywgZGl2dWxnYcOnw6NvLCBlbXByw6lzdGltbywgdHJhZHXDp8OjbywgZHVibGFnZW0sIGxlZ2VuZGFnZW0sIGluY2x1c8OjbyBlbSBub3ZhcyBvYnJhcyBvdQpjb2xldMOibmVhcywgcmV1dGlsaXphw6fDo28sIGVkacOnw6NvLCBwcm9kdcOnw6NvIGRlIG1hdGVyaWFsIGRpZMOhdGljbyBlIGN1cnNvcyBvdSBxdWFscXVlciBmb3JtYSBkZQp1dGlsaXphw6fDo28gbsOjbyBjb21lcmNpYWw7CgooMykgUkVDT05IRUNFIHF1ZSBhIGNlc3PDo28gYXF1aSBlc3BlY2lmaWNhZGEgY29uY2VkZSDDoCBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPCkNSVVogbyBkaXJlaXRvIGRlIGF1dG9yaXphciBxdWFscXVlciBwZXNzb2Eg4oCTIGbDrXNpY2Egb3UganVyw61kaWNhLCBww7pibGljYSBvdSBwcml2YWRhLCBuYWNpb25hbCBvdQplc3RyYW5nZWlyYSDigJMgYSBhY2Vzc2FyIGUgdXRpbGl6YXIgYW1wbGFtZW50ZSBhIE9CUkEsIHNlbSBleGNsdXNpdmlkYWRlLCBwYXJhIHF1YWlzcXVlcgpmaW5hbGlkYWRlcyBuw6NvIGNvbWVyY2lhaXM7CgooNCkgREVDTEFSQSBxdWUgYSBvYnJhIMOpIGNyaWHDp8OjbyBvcmlnaW5hbCBlIHF1ZSDDqSBvIHRpdHVsYXIgZG9zIGRpcmVpdG9zIGFxdWkgY2VkaWRvcyBlIGF1dG9yaXphZG9zLApyZXNwb25zYWJpbGl6YW5kby1zZSBpbnRlZ3JhbG1lbnRlIHBlbG8gY29udGXDumRvIGUgb3V0cm9zIGVsZW1lbnRvcyBxdWUgZmF6ZW0gcGFydGUgZGEgT0JSQSwKaW5jbHVzaXZlIG9zIGRpcmVpdG9zIGRlIHZveiBlIGltYWdlbSB2aW5jdWxhZG9zIMOgIE9CUkEsIG9icmlnYW5kby1zZSBhIGluZGVuaXphciB0ZXJjZWlyb3MgcG9yCmRhbm9zLCBiZW0gY29tbyBpbmRlbml6YXIgZSByZXNzYXJjaXIgYSBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPIENSVVogZGUKZXZlbnR1YWlzIGRlc3Blc2FzIHF1ZSB2aWVyZW0gYSBzdXBvcnRhciwgZW0gcmF6w6NvIGRlIHF1YWxxdWVyIG9mZW5zYSBhIGRpcmVpdG9zIGF1dG9yYWlzIG91CmRpcmVpdG9zIGRlIHZveiBvdSBpbWFnZW0sIHByaW5jaXBhbG1lbnRlIG5vIHF1ZSBkaXogcmVzcGVpdG8gYSBwbMOhZ2lvIGUgdmlvbGHDp8O1ZXMgZGUgZGlyZWl0b3M7CgooNSkgQUZJUk1BIHF1ZSBjb25oZWNlIGEgUG9sw610aWNhIEluc3RpdHVjaW9uYWwgZGUgQWNlc3NvIEFiZXJ0byBkYSBGSU9DUlVaIC0gRlVOREHDh8ODTwpPU1dBTERPIENSVVogZSBhcyBkaXJldHJpemVzIHBhcmEgbyBmdW5jaW9uYW1lbnRvIGRvIHJlcG9zaXTDs3JpbyBpbnN0aXR1Y2lvbmFsIEFSQ0EuCgpBIFBvbMOtdGljYSBJbnN0aXR1Y2lvbmFsIGRlIEFjZXNzbyBBYmVydG8gZGEgRklPQ1JVWiAtIEZVTkRBw4fDg08gT1NXQUxETyBDUlVaIHJlc2VydmEKZXhjbHVzaXZhbWVudGUgYW8gQVVUT1Igb3MgZGlyZWl0b3MgbW9yYWlzIGUgb3MgdXNvcyBjb21lcmNpYWlzIHNvYnJlIGFzIG9icmFzIGRlIHN1YSBhdXRvcmlhCmUvb3UgdGl0dWxhcmlkYWRlLCBzZW5kbyBvcyB0ZXJjZWlyb3MgdXN1w6FyaW9zIHJlc3BvbnPDoXZlaXMgcGVsYSBhdHJpYnVpw6fDo28gZGUgYXV0b3JpYSBlIG1hbnV0ZW7Dp8OjbwpkYSBpbnRlZ3JpZGFkZSBkYSBPQlJBIGVtIHF1YWxxdWVyIHV0aWxpemHDp8Ojby4KCkEgUG9sw610aWNhIEluc3RpdHVjaW9uYWwgZGUgQWNlc3NvIEFiZXJ0byBkYSBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPIENSVVoKcmVzcGVpdGEgb3MgY29udHJhdG9zIGUgYWNvcmRvcyBwcmVleGlzdGVudGVzIGRvcyBBdXRvcmVzIGNvbSB0ZXJjZWlyb3MsIGNhYmVuZG8gYW9zIEF1dG9yZXMKaW5mb3JtYXIgw6AgSW5zdGl0dWnDp8OjbyBhcyBjb25kacOnw7VlcyBlIG91dHJhcyByZXN0cmnDp8O1ZXMgaW1wb3N0YXMgcG9yIGVzdGVzIGluc3RydW1lbnRvcy4KRepositório 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dc.title.en_US.fl_str_mv Genome-based survey of the SARS-CoV-2 BF. 7 variant from Asia
title Genome-based survey of the SARS-CoV-2 BF. 7 variant from Asia
spellingShingle Genome-based survey of the SARS-CoV-2 BF. 7 variant from Asia
Scarpa, Fabio
title_short Genome-based survey of the SARS-CoV-2 BF. 7 variant from Asia
title_full Genome-based survey of the SARS-CoV-2 BF. 7 variant from Asia
title_fullStr Genome-based survey of the SARS-CoV-2 BF. 7 variant from Asia
title_full_unstemmed Genome-based survey of the SARS-CoV-2 BF. 7 variant from Asia
title_sort Genome-based survey of the SARS-CoV-2 BF. 7 variant from Asia
author Scarpa, Fabio
author_facet Scarpa, Fabio
Giovanetti, Marta
Azzena, Ilenia
Locci, Chiara
Casu, Marco
Fiori, Pier Luigi
Ciccozzi, Alessandra
Imperia, Elena
Bazzani, Liliana
Borsetti, Alessandra
Maruotti, Antonello
Pascarella, Stefano
Sanna, Daria
Ciccozzi, Massimo
author_role author
author2 Giovanetti, Marta
Azzena, Ilenia
Locci, Chiara
Casu, Marco
Fiori, Pier Luigi
Ciccozzi, Alessandra
Imperia, Elena
Bazzani, Liliana
Borsetti, Alessandra
Maruotti, Antonello
Pascarella, Stefano
Sanna, Daria
Ciccozzi, Massimo
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Scarpa, Fabio
Giovanetti, Marta
Azzena, Ilenia
Locci, Chiara
Casu, Marco
Fiori, Pier Luigi
Ciccozzi, Alessandra
Imperia, Elena
Bazzani, Liliana
Borsetti, Alessandra
Maruotti, Antonello
Pascarella, Stefano
Sanna, Daria
Ciccozzi, Massimo
description Department of Biomedical Sciences. University of Sassari. Sassari, Italy
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-04-24T18:21:32Z
dc.date.available.fl_str_mv 2023-04-24T18:21:32Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SCARPA, Fábio et al. Genome-based survey of the SARS-CoV-2 BF. 7 variant from Asia. Journal of medical virology, v. 95, n. 4, e28714, 2023. doi.org/10.1002/jmv.28714
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/57947
dc.identifier.issn.en_US.fl_str_mv 1096-9071
identifier_str_mv SCARPA, Fábio et al. Genome-based survey of the SARS-CoV-2 BF. 7 variant from Asia. Journal of medical virology, v. 95, n. 4, e28714, 2023. doi.org/10.1002/jmv.28714
1096-9071
url https://www.arca.fiocruz.br/handle/icict/57947
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv SHOU-JIANG (SJ) GAO
publisher.none.fl_str_mv SHOU-JIANG (SJ) GAO
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/57947/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/57947/2/Genome-based%20survey%20of%20the%20SARS-CoV-2%20BF.%207%20variant%20from%20Asia.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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