Serological and molecular characterization of hepatitis B virus infection in chronic kidney disease patients from Rio de Janeiro, Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/53563 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil. |
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Villar, Livia MeloFraga, Ketlyn AraujoMendonça, Ana Carolina da FonsecaMiguel, Juliana CustódioSilva, Elisangela Ferreira daBarbosa, Jakeline RibeiroSousa, Paulo Sérgio Fonseca deLewis-Ximenez, Lia LauraMello, Francisco Campello do Amaral2022-06-28T17:54:48Z2022-06-28T17:54:48Z2022VILLAR, Livia Melo et al. Serological and molecular characterization of hepatitis B virus infection in chronic kidney disease patients from Rio de Janeiro, Brazil. The Brazilian Journal of Infection Diseases, v. 26, n.3, p. 1 - 8, 2022.1413-8670https://www.arca.fiocruz.br/handle/icict/5356310.1016/j.bjid.2022.102371engElsevier EspañaHepatite BEpidemiologiaVariabilidade genéticaDoença renal crônicaHemodiáliseHepatitis BEpidemiologyGenetic variabilityChronic kidney diseaseHemodialysisSerological and molecular characterization of hepatitis B virus infection in chronic kidney disease patients from Rio de Janeiro, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil.Chronic kidney disease (CKD) patients undergoing hemodialysis (HD) are more vulnerable to blood-borne viral infections due to frequent invasive procedures. Hepatitis B virus (HBV) infection in this cohort of patients has been a matter of concern worldwide. The objective of this cross-sectional study was to evaluate the frequency of serological markers for hepatitis B, and the occurrence of overt and occult HBV infection (OBI) and its molecular characterization in serum samples from 644 CKD patients in HD units located in Rio de Janeiro, Brazil, from 2013 to 2017. HBV DNA was investigated in HBsAg reactive and “anti-HBc alone” samples to determine infecting genotypes and genetic relatedness between sequences. The prevalence of serological markers HBsAg+, anti-HBc alone, anti-HBc+/anti-HBs+, anti-HBs+, anti- HBc/anti-HBs/HBsAg were 5.9%, 2.8%, 30.7%, 26.6%, 34.0%, respectively. HBV DNA was detected in 39.5% (15/38) of the HBsAg+ and in 5/18 (27.8%) of the “anti-HBc alone” individuals, indicating a high prevalence of OBI within this group. We found a higher prevalence of HBV/A1 (65%), followed by HBV/D3 (20%), and HBV/A2 (15%). BayesianMCC tree with a highly supported clade, genetic distance comparison, and identical nucleotide sequences suggested a nosocomial spread of HBV in some units. The high prevalence of HBV infection and low number of individuals immune to infection reinforces the need for vaccination in this group. The presence of closely related strains in the same HD unit reinforces the importance of continuous improvement of safety control measures and laboratory surveillance of serological markers to prevent the risk of infection and transmission of HBV.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/53563/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALLiviaMVilar_KetlynAFraga_etal_IOC_2022.pdfLiviaMVilar_KetlynAFraga_etal_IOC_2022.pdfapplication/pdf985628https://www.arca.fiocruz.br/bitstream/icict/53563/2/LiviaMVilar_KetlynAFraga_etal_IOC_2022.pdf5aba334fe13f51352e9769c4a1bed9c6MD52icict/535632022-06-28 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| dc.title.pt_BR.fl_str_mv |
Serological and molecular characterization of hepatitis B virus infection in chronic kidney disease patients from Rio de Janeiro, Brazil |
| title |
Serological and molecular characterization of hepatitis B virus infection in chronic kidney disease patients from Rio de Janeiro, Brazil |
| spellingShingle |
Serological and molecular characterization of hepatitis B virus infection in chronic kidney disease patients from Rio de Janeiro, Brazil Villar, Livia Melo Hepatite B Epidemiologia Variabilidade genética Doença renal crônica Hemodiálise Hepatitis B Epidemiology Genetic variability Chronic kidney disease Hemodialysis |
| title_short |
Serological and molecular characterization of hepatitis B virus infection in chronic kidney disease patients from Rio de Janeiro, Brazil |
| title_full |
Serological and molecular characterization of hepatitis B virus infection in chronic kidney disease patients from Rio de Janeiro, Brazil |
| title_fullStr |
Serological and molecular characterization of hepatitis B virus infection in chronic kidney disease patients from Rio de Janeiro, Brazil |
| title_full_unstemmed |
Serological and molecular characterization of hepatitis B virus infection in chronic kidney disease patients from Rio de Janeiro, Brazil |
| title_sort |
Serological and molecular characterization of hepatitis B virus infection in chronic kidney disease patients from Rio de Janeiro, Brazil |
| author |
Villar, Livia Melo |
| author_facet |
Villar, Livia Melo Fraga, Ketlyn Araujo Mendonça, Ana Carolina da Fonseca Miguel, Juliana Custódio Silva, Elisangela Ferreira da Barbosa, Jakeline Ribeiro Sousa, Paulo Sérgio Fonseca de Lewis-Ximenez, Lia Laura Mello, Francisco Campello do Amaral |
| author_role |
author |
| author2 |
Fraga, Ketlyn Araujo Mendonça, Ana Carolina da Fonseca Miguel, Juliana Custódio Silva, Elisangela Ferreira da Barbosa, Jakeline Ribeiro Sousa, Paulo Sérgio Fonseca de Lewis-Ximenez, Lia Laura Mello, Francisco Campello do Amaral |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Villar, Livia Melo Fraga, Ketlyn Araujo Mendonça, Ana Carolina da Fonseca Miguel, Juliana Custódio Silva, Elisangela Ferreira da Barbosa, Jakeline Ribeiro Sousa, Paulo Sérgio Fonseca de Lewis-Ximenez, Lia Laura Mello, Francisco Campello do Amaral |
| dc.subject.other.pt_BR.fl_str_mv |
Hepatite B Epidemiologia Variabilidade genética Doença renal crônica Hemodiálise |
| topic |
Hepatite B Epidemiologia Variabilidade genética Doença renal crônica Hemodiálise Hepatitis B Epidemiology Genetic variability Chronic kidney disease Hemodialysis |
| dc.subject.en.pt_BR.fl_str_mv |
Hepatitis B Epidemiology Genetic variability Chronic kidney disease Hemodialysis |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil. |
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2022 |
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2022-06-28T17:54:48Z |
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2022-06-28T17:54:48Z |
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2022 |
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info:eu-repo/semantics/article |
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VILLAR, Livia Melo et al. Serological and molecular characterization of hepatitis B virus infection in chronic kidney disease patients from Rio de Janeiro, Brazil. The Brazilian Journal of Infection Diseases, v. 26, n.3, p. 1 - 8, 2022. |
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https://www.arca.fiocruz.br/handle/icict/53563 |
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1413-8670 |
| dc.identifier.doi.none.fl_str_mv |
10.1016/j.bjid.2022.102371 |
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VILLAR, Livia Melo et al. Serological and molecular characterization of hepatitis B virus infection in chronic kidney disease patients from Rio de Janeiro, Brazil. The Brazilian Journal of Infection Diseases, v. 26, n.3, p. 1 - 8, 2022. 1413-8670 10.1016/j.bjid.2022.102371 |
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