An evaluation of p16(INK4a) expression in cervical intraepithelial neoplasia specimens, including women with HIV-1
| Autor(a) principal: | |
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| Data de Publicação: | 2012 |
| Outros Autores: | , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/5865 |
Resumo: | FAPERJ, CAPES. |
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Nicol, Alcina F.Golub, Jonathan E.Silva, José R. Lapa eCunha, Cynthia Braga daAmaro Filho, Sérgio MenezesOliveira, Nathalia S.Menezes, WillkerAndrade, Cecília Vianna deRussomano, Fábio BastosTristão, AparecidaGrinsztejn, BeatrizFriedman, Ruth KhaliliOliveira, Marcia P.Pires, AndreaNuovo, Gerard J.2012-11-26T11:26:08Z2012-11-26T11:26:08Z2012NICOL, Alcina F et al. An evaluation of p16INK4a expression in cervical intraepithelial neoplasia specimens, including women with HIV-1. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 107, n. 5, p. 571-577, Aug. 2012.https://www.arca.fiocruz.br/handle/icict/586510.1590/S0074-02762012000500001FAPERJ, CAPES.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, BrasilJohns Hopkins Bloomberg School of Public Health. Baltimore, MD, USA / Johns Hopkins School of Medicine, Baltimore, MD, USAUniversidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Laboratório Multidisciplinar. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Departamento de Doenças Infecciosas. Rio de Janeiro, RJ, Brasilundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasilundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasilundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, BrasilJohns Hopkins School of Medicine, Baltimore, MD, USAJohns Hopkins School of Medicine, Baltimore, MD, USAFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, BrasilFonte Medicina Diagnóstica. Niterói, RJ, Brasil / Universidade Federal Fluminense, Niterói, RJ, Brasil9Comprehensive Cancer Center. Ohio State University. Columbus, OH, USAAlthough several studies have evaluated the role of p16INK4a as a diagnostic marker of cervical intraepithelial neoplasia (CIN) and its association with disease progression, studies regarding the role of p16INK4a in human immunodeficiency virus (HIV)-infected patients remain scarce. The present study was designed to determine the potential utility of p16INK4a as a diagnostic marker for CIN and invasive cervical cancer in HIV-positive and negative cervical specimens. An immunohistochemical analysis of p16INK4a was performed in 326 cervical tissue microarray specimens. Performance indicators were calculated and compared using receiving operating characteristics curve (ROC)/area under the curve. In HIV-1-negative women, the percentage of cells that was positive for p16INK4a expression was significantly correlated with the severity of CIN (p < 0.0001). A ROC curve with a cut-off value of 55.28% resulted in a sensitivity of 89%, a specificity of 81%, a positive predictive value of 91% and a negative predictive value of 78%. HIV-seropositive women exhibited decreased expression of p16INK4a in CIN2-3 specimens compared with HIV-negative specimens (p = 0.031). The ROC data underscore the potential utility of p16INK4a under defined conditions as a diagnostic marker for CIN 2-3 staging and invasive cervical cancer. HIV-1 infection, however, is associated with relatively reduced p16INK4a expression in CIN 2-3.engInstituto Oswaldo CruzBranca M, Ciotti M, Santini D, Di Bonito L, Giorgi C, Benedetto A, Paba P, Favalli C, Costa S, Agarossi A, Alderisio M, Syrjänen K 2004. p16(INK4A) expression is related to grade of cin and high-risk human papillomavirus but does not predict virus clearance after conization or disease outcome. Int J Gynecol Pathol 23: 354-365.Eng J 2005. Receiver operating characteristic analysis: a primer. Acad Radiol 12: 909-916.Fan J, Upadhye S, Worster A 2006. Understanding receiver operating characteristic (ROC) curves. CJEM 8: 19-20.Galgano MT, Castle PE, Atkins KA, Brix WK, Nassau SR, Stoler MH 2010. Using biomarkers as objective standards in the diagnosis of cervical biopsies. Am J Surg Pathol 34: 1077-1087.Guedes AC, Brenna SM, Coelho SA, Martinez EZ, Syrjanen KJ, Zeferino LC 2007. p16(INK4a) expression does not predict the outcome of cervical intraepithelial neoplasia grade 2. Int J Gynecol Cancer 17: 1099-1103.Gupta N, Srinivasan R, Rajwanshi A 2010. Functional biomarkers in cervical precancer: an overview. Diagn Cytopathol 38: 618-623.Kreuter A, Jesse M, Potthoff A, Brockmeyer NH, Gambichler T, Stucker M, Bechara FG, Pfister H, Wieland U 2010. Expression of proliferative biomarkers in anal intraepithelial neoplasia of HIV-positive men. J Am Acad Dermatol 63: 490-498.McLaughlin-Drubin ME, Crum CP, Munger K 2011. Human papillomavirus E7 oncoprotein induces KDM6A and KDM6B histone demethylase expression and causes epigenetic reprogramming. Proc Natl Acad Sci USA 108: 2130-2135.Nicol AF, Fernandes AT, Grinsztejn B, Russomano F, Tristao A, Perez M de A, Nuovo GJ, Martinez-Maza O, Bonecini-Almeida M da G 2005. Distribution of immune cell subsets and cytokine- producing cells in the uterine cervix of human papillomavirus (HPV)-infected women: influence of HIV-1 coinfection. Diagn Mol Pathol 14: 39-47.Nicol AF, Nuovo GJ, Salomao-Estevez A, Grinsztejn B, Tristao A, Russomano F, Lapa ESJR, Oliveira MP, Pirmez C 2008a. Im- Immune factors involved in the cervical immune response in the HIV/HPV co-infection. J Clin Pathol 61: 84-88.Nicol AF, Pires AR, de Souza SR, Nuovo GJ, Grinsztejn B, Tristao A, Russomano FB, Velasque L, Lapa e Silva JR, Pirmez C 2008b. Cell-cycle and suppressor proteins expression in uterine cervix in HIV/HPV co-infection: comparative study by tissue micro-array (TMA). BMC Cancer 8: 289.Nuovo GJ 2010. In situ detection of microRNAs in paraffin embedded, formalin fixed tissues and the co-localization of their putative targets. Methods 52: 307-315.Nuovo GJ, Pedemonte BM 1990. Human papillomavirus types and recurrent genital warts. JAMA 263: 1223-1226.Pinto AP, Schlecht NF, Woo TY, Crum CP, Cibas ES 2008. Bio-Biomarker (ProEx C, p16(INK4A) and MiB-1) distinction of high- grade squamous intraepithelial lesion from its mimics. Mod Pathol 21: 1067-1074.Pires AR, Andreiuolo F da M, de Souza SR 2006. TMA for all: a new method for the construction of tissue microarrays without recipient paraffin block using custom-built needles. Diagn Pathol 1: 14.Queiroz C, Silva TC, Alves VA, Villa LL, Costa MC, Travassos AG, Filho JB, Studart E, Cheto T, de Freitas LA 2006. P16(INK4a) expression as a potential prognostic marker in cervical pre-neoplastic and neoplastic lesions. Pathol Res Pract 202: 77-83.Tringler B, Gup CJ, Singh M, Groshong S, Shroyer AL, Heinz DE, Shroyer KR 2004. Evaluation of p16INK4a and pRb expression in cervical squamous and glandular neoplasia. Hum Pathol 35: 689-696.Valasoulis G, Tsoumpou I, Founta C, Kyrgiou M, Dalkalitsis N, Nasioutziki M, Kassanos D, Paraskevaidis E, Karakitsos P 2011. The role of p16(INK4a) immunostaining in the risk assessment of women with LSIL cytology: a prospective pragmatic study. Eur J Gynaecol Oncol 32: 150-152.Wang SS, Trunk M, Schiffman M, Herrero R, Sherman ME, Burk RD, Hildesheim A, Bratti MC, Wright T, Rodriguez AC, Chen S, Reichert A, von Knebel Doeberitz C, Ridder R, von Knebel Doeberitz M 2004. Validation of p16INK4a as a marker of oncogenic human papillomavirus infection in cervical biopsies from a population-based cohort in Costa Rica. Cancer Epidemiol Biomarkers Prev 13: 1355-1360Wentzensen N, Bergeron C, Cas F, Eschenbach D, Vinokurova S, von Knebel Doeberitz M 2005. Evaluation of a nuclear score for p16INK4a-stained cervical squamous cells in liquid-based cytology samples. 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| dc.title.pt_BR.fl_str_mv |
An evaluation of p16(INK4a) expression in cervical intraepithelial neoplasia specimens, including women with HIV-1 |
| title |
An evaluation of p16(INK4a) expression in cervical intraepithelial neoplasia specimens, including women with HIV-1 |
| spellingShingle |
An evaluation of p16(INK4a) expression in cervical intraepithelial neoplasia specimens, including women with HIV-1 Nicol, Alcina F. CIN p16INK4a HPV HIV TMA ROC Neoplasia Intra-Epitelial Cervical Genes p16 Sondas de DNA de HPV HIV |
| title_short |
An evaluation of p16(INK4a) expression in cervical intraepithelial neoplasia specimens, including women with HIV-1 |
| title_full |
An evaluation of p16(INK4a) expression in cervical intraepithelial neoplasia specimens, including women with HIV-1 |
| title_fullStr |
An evaluation of p16(INK4a) expression in cervical intraepithelial neoplasia specimens, including women with HIV-1 |
| title_full_unstemmed |
An evaluation of p16(INK4a) expression in cervical intraepithelial neoplasia specimens, including women with HIV-1 |
| title_sort |
An evaluation of p16(INK4a) expression in cervical intraepithelial neoplasia specimens, including women with HIV-1 |
| author |
Nicol, Alcina F. |
| author_facet |
Nicol, Alcina F. Golub, Jonathan E. Silva, José R. Lapa e Cunha, Cynthia Braga da Amaro Filho, Sérgio Menezes Oliveira, Nathalia S. Menezes, Willker Andrade, Cecília Vianna de Russomano, Fábio Bastos Tristão, Aparecida Grinsztejn, Beatriz Friedman, Ruth Khalili Oliveira, Marcia P. Pires, Andrea Nuovo, Gerard J. |
| author_role |
author |
| author2 |
Golub, Jonathan E. Silva, José R. Lapa e Cunha, Cynthia Braga da Amaro Filho, Sérgio Menezes Oliveira, Nathalia S. Menezes, Willker Andrade, Cecília Vianna de Russomano, Fábio Bastos Tristão, Aparecida Grinsztejn, Beatriz Friedman, Ruth Khalili Oliveira, Marcia P. Pires, Andrea Nuovo, Gerard J. |
| author2_role |
author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Nicol, Alcina F. Golub, Jonathan E. Silva, José R. Lapa e Cunha, Cynthia Braga da Amaro Filho, Sérgio Menezes Oliveira, Nathalia S. Menezes, Willker Andrade, Cecília Vianna de Russomano, Fábio Bastos Tristão, Aparecida Grinsztejn, Beatriz Friedman, Ruth Khalili Oliveira, Marcia P. Pires, Andrea Nuovo, Gerard J. |
| dc.subject.en.pt_BR.fl_str_mv |
CIN p16INK4a HPV HIV TMA ROC |
| topic |
CIN p16INK4a HPV HIV TMA ROC Neoplasia Intra-Epitelial Cervical Genes p16 Sondas de DNA de HPV HIV |
| dc.subject.decs.pt_BR.fl_str_mv |
Neoplasia Intra-Epitelial Cervical Genes p16 Sondas de DNA de HPV HIV |
| description |
FAPERJ, CAPES. |
| publishDate |
2012 |
| dc.date.accessioned.fl_str_mv |
2012-11-26T11:26:08Z |
| dc.date.available.fl_str_mv |
2012-11-26T11:26:08Z |
| dc.date.issued.fl_str_mv |
2012 |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
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article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
NICOL, Alcina F et al. An evaluation of p16INK4a expression in cervical intraepithelial neoplasia specimens, including women with HIV-1. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 107, n. 5, p. 571-577, Aug. 2012. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/5865 |
| dc.identifier.doi.none.fl_str_mv |
10.1590/S0074-02762012000500001 |
| identifier_str_mv |
NICOL, Alcina F et al. An evaluation of p16INK4a expression in cervical intraepithelial neoplasia specimens, including women with HIV-1. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 107, n. 5, p. 571-577, Aug. 2012. 10.1590/S0074-02762012000500001 |
| url |
https://www.arca.fiocruz.br/handle/icict/5865 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.isbasedon.pt_BR.fl_str_mv |
Branca M, Ciotti M, Santini D, Di Bonito L, Giorgi C, Benedetto A, Paba P, Favalli C, Costa S, Agarossi A, Alderisio M, Syrjänen K 2004. p16(INK4A) expression is related to grade of cin and high-risk human papillomavirus but does not predict virus clearance after conization or disease outcome. Int J Gynecol Pathol 23: 354-365. Eng J 2005. Receiver operating characteristic analysis: a primer. Acad Radiol 12: 909-916. Fan J, Upadhye S, Worster A 2006. Understanding receiver operating characteristic (ROC) curves. CJEM 8: 19-20. Galgano MT, Castle PE, Atkins KA, Brix WK, Nassau SR, Stoler MH 2010. Using biomarkers as objective standards in the diagnosis of cervical biopsies. Am J Surg Pathol 34: 1077-1087. Guedes AC, Brenna SM, Coelho SA, Martinez EZ, Syrjanen KJ, Zeferino LC 2007. p16(INK4a) expression does not predict the outcome of cervical intraepithelial neoplasia grade 2. Int J Gynecol Cancer 17: 1099-1103. Gupta N, Srinivasan R, Rajwanshi A 2010. Functional biomarkers in cervical precancer: an overview. Diagn Cytopathol 38: 618-623. Kreuter A, Jesse M, Potthoff A, Brockmeyer NH, Gambichler T, Stucker M, Bechara FG, Pfister H, Wieland U 2010. Expression of proliferative biomarkers in anal intraepithelial neoplasia of HIV-positive men. J Am Acad Dermatol 63: 490-498. McLaughlin-Drubin ME, Crum CP, Munger K 2011. Human papillomavirus E7 oncoprotein induces KDM6A and KDM6B histone demethylase expression and causes epigenetic reprogramming. Proc Natl Acad Sci USA 108: 2130-2135. Nicol AF, Fernandes AT, Grinsztejn B, Russomano F, Tristao A, Perez M de A, Nuovo GJ, Martinez-Maza O, Bonecini-Almeida M da G 2005. Distribution of immune cell subsets and cytokine- producing cells in the uterine cervix of human papillomavirus (HPV)-infected women: influence of HIV-1 coinfection. Diagn Mol Pathol 14: 39-47. Nicol AF, Nuovo GJ, Salomao-Estevez A, Grinsztejn B, Tristao A, Russomano F, Lapa ESJR, Oliveira MP, Pirmez C 2008a. Im- Immune factors involved in the cervical immune response in the HIV/HPV co-infection. J Clin Pathol 61: 84-88. Nicol AF, Pires AR, de Souza SR, Nuovo GJ, Grinsztejn B, Tristao A, Russomano FB, Velasque L, Lapa e Silva JR, Pirmez C 2008b. Cell-cycle and suppressor proteins expression in uterine cervix in HIV/HPV co-infection: comparative study by tissue micro-array (TMA). BMC Cancer 8: 289. Nuovo GJ 2010. In situ detection of microRNAs in paraffin embedded, formalin fixed tissues and the co-localization of their putative targets. Methods 52: 307-315. Nuovo GJ, Pedemonte BM 1990. Human papillomavirus types and recurrent genital warts. JAMA 263: 1223-1226. Pinto AP, Schlecht NF, Woo TY, Crum CP, Cibas ES 2008. Bio-Biomarker (ProEx C, p16(INK4A) and MiB-1) distinction of high- grade squamous intraepithelial lesion from its mimics. Mod Pathol 21: 1067-1074. Pires AR, Andreiuolo F da M, de Souza SR 2006. TMA for all: a new method for the construction of tissue microarrays without recipient paraffin block using custom-built needles. Diagn Pathol 1: 14. Queiroz C, Silva TC, Alves VA, Villa LL, Costa MC, Travassos AG, Filho JB, Studart E, Cheto T, de Freitas LA 2006. P16(INK4a) expression as a potential prognostic marker in cervical pre-neoplastic and neoplastic lesions. Pathol Res Pract 202: 77-83. Tringler B, Gup CJ, Singh M, Groshong S, Shroyer AL, Heinz DE, Shroyer KR 2004. Evaluation of p16INK4a and pRb expression in cervical squamous and glandular neoplasia. Hum Pathol 35: 689-696. Valasoulis G, Tsoumpou I, Founta C, Kyrgiou M, Dalkalitsis N, Nasioutziki M, Kassanos D, Paraskevaidis E, Karakitsos P 2011. The role of p16(INK4a) immunostaining in the risk assessment of women with LSIL cytology: a prospective pragmatic study. Eur J Gynaecol Oncol 32: 150-152. Wang SS, Trunk M, Schiffman M, Herrero R, Sherman ME, Burk RD, Hildesheim A, Bratti MC, Wright T, Rodriguez AC, Chen S, Reichert A, von Knebel Doeberitz C, Ridder R, von Knebel Doeberitz M 2004. Validation of p16INK4a as a marker of oncogenic human papillomavirus infection in cervical biopsies from a population-based cohort in Costa Rica. Cancer Epidemiol Biomarkers Prev 13: 1355-1360 Wentzensen N, Bergeron C, Cas F, Eschenbach D, Vinokurova S, von Knebel Doeberitz M 2005. Evaluation of a nuclear score for p16INK4a-stained cervical squamous cells in liquid-based cytology samples. Cancer 105: 461-467. |
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Instituto Oswaldo Cruz |
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Instituto Oswaldo Cruz |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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FIOCRUZ |
| institution |
FIOCRUZ |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/5865/1/An_evaluation_of_p16_2012_107_5.pdf https://www.arca.fiocruz.br/bitstream/icict/5865/2/license.txt https://www.arca.fiocruz.br/bitstream/icict/5865/5/An_evaluation_of_p16_2012_107_5.pdf.txt https://www.arca.fiocruz.br/bitstream/icict/5865/4/An_evaluation_of_p16_2012_107_5.pdf.jpg |
| bitstream.checksum.fl_str_mv |
fb810821aa889971f95b1a19c85d8601 06db3f0df647fd9ddff657403bbe0ee2 ad69b8b6737a3eedfc85b4c9a94b55a4 d5e74a65f576a3f920c35eede218c943 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1798324801427734528 |