Plasmodium berghei ANKA infection induces thymocyte apoptosis and thymocyte depletion in CBA mice

Detalhes bibliográficos
Autor(a) principal: Carvalho, Leonardo José de Moura
Data de Publicação: 2006
Outros Autores: Cruz, Maria de Fátima Ferreira da, Daniel-Ribeiro, Cláudio Tadeu, Machado, Marcelo Pelajo, Lenzi, Henrique Leonel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/4054
http://dx.doi.org/10.1590/S0074-02762006000500007
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Pesquisas em Malária. Rio de Janeiro, RJ, Brasil
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spelling Carvalho, Leonardo José de MouraCruz, Maria de Fátima Ferreira daDaniel-Ribeiro, Cláudio TadeuMachado, Marcelo PelajoLenzi, Henrique Leonel2012-05-10T14:20:48Z2012-05-10T14:20:48Z2006CARVALHO, L. J. M. et al. Plasmodium berghei ANKA infection induces thymocyte apoptosis and thymocyte depletion in CBA mice. Memórias do Instituto Oswaldo Cruz, v.101, n.5, p. 523-528, 2006.0074-0276https://www.arca.fiocruz.br/handle/icict/4054http://dx.doi.org/10.1590/S0074-02762006000500007engFundação Oswaldo Cruz. Instituto Oswaldo CruzPlasmodium berghei ANKA infection induces thymocyte apoptosis and thymocyte depletion in CBA miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Pesquisas em Malária. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Pesquisas em Malária. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Pesquisas em Malária. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.Immune responses to malaria infections are characterized by strong T and B cell activation, which, in addition of potentially causing immunopathology, are of poor efficacy against the infection. It is possible that the thymus is involved in the origin of immunopathological reactions and a target during malaria infections. This work was developed in an attempt to further clarify these points. We studied the sequential changes in the thymus of CBA mice infected with Plasmodium berghei ANKA, a model in which 60-90% of the infected animals develop cerebral malaria. During the acute phase of infection, different degrees of thymocyte apoptosis were recorded: (1) starry-sky pattern of diffuse apoptosis with maintenance of cortical-medullary structure; (2) intense apoptosis with cortical atrophy, with absence of large cells; (3) severe cortical thymocyte depletion, resulting in cortical-medullary inversion. In the latter, only residual clusters of small thymocytes were observed within the framework of epithelial cells. The intensity of thymus alterations could not be associated with the degree of parasitemia, the expression of clinical signs of cerebral malaria or intensity of brain lesions. The implications of these events for malaria immunity and pathology are discussed.MalariaPlasmodium bergheiThymusMiceMaláriaPlasmodium bergheiTimoCamundongosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALANKA.pdfANKA.pdfapplication/pdf1292520https://www.arca.fiocruz.br/bitstream/icict/4054/1/ANKA.pdf5dba12422698e3ed0184fad9c22ea1caMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81648https://www.arca.fiocruz.br/bitstream/icict/4054/2/license.txte095249ac7cacefbfe39684dfe45e706MD52TEXTANKA.pdf.txtANKA.pdf.txtExtracted texttext/plain23215https://www.arca.fiocruz.br/bitstream/icict/4054/5/ANKA.pdf.txt0d9e709ea149c4b412e0117309375e75MD55THUMBNAILANKA.pdf.jpgANKA.pdf.jpgGenerated Thumbnailimage/jpeg2321https://www.arca.fiocruz.br/bitstream/icict/4054/4/ANKA.pdf.jpgdd501aef6184b22e241e8a9c57cba8f4MD54icict/40542020-07-17 16:12:26.273oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352020-07-17T19:12:26Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Plasmodium berghei ANKA infection induces thymocyte apoptosis and thymocyte depletion in CBA mice
title Plasmodium berghei ANKA infection induces thymocyte apoptosis and thymocyte depletion in CBA mice
spellingShingle Plasmodium berghei ANKA infection induces thymocyte apoptosis and thymocyte depletion in CBA mice
Carvalho, Leonardo José de Moura
Malaria
Plasmodium berghei
Thymus
Mice
Malária
Plasmodium berghei
Timo
Camundongos
title_short Plasmodium berghei ANKA infection induces thymocyte apoptosis and thymocyte depletion in CBA mice
title_full Plasmodium berghei ANKA infection induces thymocyte apoptosis and thymocyte depletion in CBA mice
title_fullStr Plasmodium berghei ANKA infection induces thymocyte apoptosis and thymocyte depletion in CBA mice
title_full_unstemmed Plasmodium berghei ANKA infection induces thymocyte apoptosis and thymocyte depletion in CBA mice
title_sort Plasmodium berghei ANKA infection induces thymocyte apoptosis and thymocyte depletion in CBA mice
author Carvalho, Leonardo José de Moura
author_facet Carvalho, Leonardo José de Moura
Cruz, Maria de Fátima Ferreira da
Daniel-Ribeiro, Cláudio Tadeu
Machado, Marcelo Pelajo
Lenzi, Henrique Leonel
author_role author
author2 Cruz, Maria de Fátima Ferreira da
Daniel-Ribeiro, Cláudio Tadeu
Machado, Marcelo Pelajo
Lenzi, Henrique Leonel
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Carvalho, Leonardo José de Moura
Cruz, Maria de Fátima Ferreira da
Daniel-Ribeiro, Cláudio Tadeu
Machado, Marcelo Pelajo
Lenzi, Henrique Leonel
dc.subject.en.pt_BR.fl_str_mv Malaria
Plasmodium berghei
Thymus
Mice
topic Malaria
Plasmodium berghei
Thymus
Mice
Malária
Plasmodium berghei
Timo
Camundongos
dc.subject.decs.pt_BR.fl_str_mv Malária
Plasmodium berghei
Timo
Camundongos
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Pesquisas em Malária. Rio de Janeiro, RJ, Brasil
publishDate 2006
dc.date.issued.fl_str_mv 2006
dc.date.accessioned.fl_str_mv 2012-05-10T14:20:48Z
dc.date.available.fl_str_mv 2012-05-10T14:20:48Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CARVALHO, L. J. M. et al. Plasmodium berghei ANKA infection induces thymocyte apoptosis and thymocyte depletion in CBA mice. Memórias do Instituto Oswaldo Cruz, v.101, n.5, p. 523-528, 2006.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/4054
dc.identifier.issn.none.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv http://dx.doi.org/10.1590/S0074-02762006000500007
identifier_str_mv CARVALHO, L. J. M. et al. Plasmodium berghei ANKA infection induces thymocyte apoptosis and thymocyte depletion in CBA mice. Memórias do Instituto Oswaldo Cruz, v.101, n.5, p. 523-528, 2006.
0074-0276
url https://www.arca.fiocruz.br/handle/icict/4054
http://dx.doi.org/10.1590/S0074-02762006000500007
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
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