DETC-based bacterial cellulose bio-curatives for topical treatment of cutaneous leishmaniasis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/18118 |
Resumo: | CNPq. Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) (482193/2012-3), Fundação Oswaldo Cruz - Programa de Apoio a Pesquisas Estratégicas (FIOCRUZ-PAPES IV) (407437/2012-6) and Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). S.J.L, V.M.B and C.I.O are senior researchers CNPq. FSC received a fellowship from Coordenação de Amparo à Pesquisa e Ensino Superior (CAPES). |
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Celes, Fabiana SantanaTrovatti, ElianeCunha, Antonio Ricardo KhouriVan Weyenbergh, Johan Jozef Rosa MariaRibeiro, Sidney José LimaBorges, Valeria de MatosBarud, Hernane da SilvaOliveira, Camila Indiani de2017-03-22T16:38:38Z2017-03-22T16:38:38Z2016CELES, F. S. et al. DETC-based bacterial cellulose bio-curatives for topical treatment of cutaneous leishmaniasis. Scientific Reports, v. 6, p. 38330, 2016.2045-2322https://www.arca.fiocruz.br/handle/icict/1811810.1038/srep38330CNPq. Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) (482193/2012-3), Fundação Oswaldo Cruz - Programa de Apoio a Pesquisas Estratégicas (FIOCRUZ-PAPES IV) (407437/2012-6) and Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). S.J.L, V.M.B and C.I.O are senior researchers CNPq. FSC received a fellowship from Coordenação de Amparo à Pesquisa e Ensino Superior (CAPES).Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilUniversidade Estadual Paulista. Instituto de Química. Araraquara, SP, Brasil / Universidade de Araraquara-UNIARA. Araraquara, SP, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilRega Institute for Medical Research. Department of Microbiology and Immunology. K. U. Leuven, BelgiumUniversidade Estadual Paulista. Instituto de Química. Araraquara, SP, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilUniversidade Estadual Paulista. Instituto de Química. Araraquara, SP, Brasil / Universidade de Araraquara-UNIARA. Araraquara, SP, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Instituto de Investigação em Imunologia (iii). INCT. São Paulo, SP, BrasilThe treatment of leishmaniasis still relies on drugs with potentially serious adverse effects. Herein, we tested a topical formulation of bacterial cellulose (BC) membranes containing Diethyldithiocarbamate (DETC), a superoxide dismutase 1 inhibitor. Leishmania-infected macrophages exposed to BC-DETC resulted in parasite killing, without pronounced toxic effects to host cells. This outcome was associated with lower SOD1 activity and higher production of superoxide and cytokine mediators. Topical application of BC-DETC significantly decreased lesion size, parasite load and the inflammatory response at the infection site, as well as the production of both IFN-γ and TNF. Combination of topical BC-DETC plus intraperitoneal Sb(v) also significantly reduced disease development and parasite load. The leishmanicidal effect of BC-DETC was extended to human macrophages infected with L. braziliensis, highlighting the feasibility of BC-DETC as a topical formulation for chemotherapy of cutaneous leishmaniasis caused by L. braziliensis.engNature Publishing GroupLeishmaniaLeishmania braziliensisDrogasInfecçãoBiocurativosQuimioterapiaTratamentoLeishmaniaLeishmania braziliensisDrugsInfectionBio-curativeChemotherapyTreatmentDETC-based bacterial cellulose bio-curatives for topical treatment of cutaneous leishmaniasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/18118/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCeles FS DETC based....pdfCeles FS DETC based....pdfapplication/pdf1234264https://www.arca.fiocruz.br/bitstream/icict/18118/2/Celes%20FS%20DETC%20based....pdfef7607b2c04d4f19c048147a9aa88c5aMD52TEXTCeles FS DETC based....pdf.txtCeles FS DETC based....pdf.txtExtracted texttext/plain48705https://www.arca.fiocruz.br/bitstream/icict/18118/3/Celes%20FS%20DETC%20based....pdf.txt40db96cbbe96f956b617f8f4e95eed8cMD53icict/181182023-03-15 14:34:06.425oai:www.arca.fiocruz.br:icict/18118Q0VTU8ODTyBOw4NPIEVYQ0xVU0lWQSBERSBESVJFSVRPUyBBVVRPUkFJUwoKQW8gYWNlaXRhciBvcyBURVJNT1MgZSBDT05EScOHw5VFUyBkZXN0YSBDRVNTw4NPLCBvIEFVVE9SIGUvb3UgVElUVUxBUiBkZSBkaXJlaXRvcwphdXRvcmFpcyBzb2JyZSBhIE9CUkEgZGUgcXVlIHRyYXRhIGVzdGUgZG9jdW1lbnRvOgoKKDEpIENFREUgZSBUUkFOU0ZFUkUsIHRvdGFsIGUgZ3JhdHVpdGFtZW50ZSwgw6AgRklPQ1JVWiAtIEZVTkRBw4fDg08gT1NXQUxETyBDUlVaLCBlbQpjYXLDoXRlciBwZXJtYW5lbnRlLCBpcnJldm9nw6F2ZWwgZSBOw4NPIEVYQ0xVU0lWTywgdG9kb3Mgb3MgZGlyZWl0b3MgcGF0cmltb25pYWlzIE7Dg08KQ09NRVJDSUFJUyBkZSB1dGlsaXphw6fDo28gZGEgT0JSQSBhcnTDrXN0aWNhIGUvb3UgY2llbnTDrWZpY2EgaW5kaWNhZGEgYWNpbWEsIGluY2x1c2l2ZSBvcyBkaXJlaXRvcwpkZSB2b3ogZSBpbWFnZW0gdmluY3VsYWRvcyDDoCBPQlJBLCBkdXJhbnRlIHRvZG8gbyBwcmF6byBkZSBkdXJhw6fDo28gZG9zIGRpcmVpdG9zIGF1dG9yYWlzLCBlbQpxdWFscXVlciBpZGlvbWEgZSBlbSB0b2RvcyBvcyBwYcOtc2VzOwoKKDIpIEFDRUlUQSBxdWUgYSBjZXNzw6NvIHRvdGFsIG7Do28gZXhjbHVzaXZhLCBwZXJtYW5lbnRlIGUgaXJyZXZvZ8OhdmVsIGRvcyBkaXJlaXRvcyBhdXRvcmFpcwpwYXRyaW1vbmlhaXMgbsOjbyBjb21lcmNpYWlzIGRlIHV0aWxpemHDp8OjbyBkZSBxdWUgdHJhdGEgZXN0ZSBkb2N1bWVudG8gaW5jbHVpLCBleGVtcGxpZmljYXRpdmFtZW50ZSwKb3MgZGlyZWl0b3MgZGUgZGlzcG9uaWJpbGl6YcOnw6NvIGUgY29tdW5pY2HDp8OjbyBww7pibGljYSBkYSBPQlJBLCBlbSBxdWFscXVlciBtZWlvIG91IHZlw61jdWxvLAppbmNsdXNpdmUgZW0gUmVwb3NpdMOzcmlvcyBEaWdpdGFpcywgYmVtIGNvbW8gb3MgZGlyZWl0b3MgZGUgcmVwcm9kdcOnw6NvLCBleGliacOnw6NvLCBleGVjdcOnw6NvLApkZWNsYW1hw6fDo28sIHJlY2l0YcOnw6NvLCBleHBvc2nDp8OjbywgYXJxdWl2YW1lbnRvLCBpbmNsdXPDo28gZW0gYmFuY28gZGUgZGFkb3MsIHByZXNlcnZhw6fDo28sIGRpZnVzw6NvLApkaXN0cmlidWnDp8OjbywgZGl2dWxnYcOnw6NvLCBlbXByw6lzdGltbywgdHJhZHXDp8OjbywgZHVibGFnZW0sIGxlZ2VuZGFnZW0sIGluY2x1c8OjbyBlbSBub3ZhcyBvYnJhcyBvdQpjb2xldMOibmVhcywgcmV1dGlsaXphw6fDo28sIGVkacOnw6NvLCBwcm9kdcOnw6NvIGRlIG1hdGVyaWFsIGRpZMOhdGljbyBlIGN1cnNvcyBvdSBxdWFscXVlciBmb3JtYSBkZQp1dGlsaXphw6fDo28gbsOjbyBjb21lcmNpYWw7CgooMykgUkVDT05IRUNFIHF1ZSBhIGNlc3PDo28gYXF1aSBlc3BlY2lmaWNhZGEgY29uY2VkZSDDoCBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPCkNSVVogbyBkaXJlaXRvIGRlIGF1dG9yaXphciBxdWFscXVlciBwZXNzb2Eg4oCTIGbDrXNpY2Egb3UganVyw61kaWNhLCBww7pibGljYSBvdSBwcml2YWRhLCBuYWNpb25hbCBvdQplc3RyYW5nZWlyYSDigJMgYSBhY2Vzc2FyIGUgdXRpbGl6YXIgYW1wbGFtZW50ZSBhIE9CUkEsIHNlbSBleGNsdXNpdmlkYWRlLCBwYXJhIHF1YWlzcXVlcgpmaW5hbGlkYWRlcyBuw6NvIGNvbWVyY2lhaXM7CgooNCkgREVDTEFSQSBxdWUgYSBvYnJhIMOpIGNyaWHDp8OjbyBvcmlnaW5hbCBlIHF1ZSDDqSBvIHRpdHVsYXIgZG9zIGRpcmVpdG9zIGFxdWkgY2VkaWRvcyBlIGF1dG9yaXphZG9zLApyZXNwb25zYWJpbGl6YW5kby1zZSBpbnRlZ3JhbG1lbnRlIHBlbG8gY29udGXDumRvIGUgb3V0cm9zIGVsZW1lbnRvcyBxdWUgZmF6ZW0gcGFydGUgZGEgT0JSQSwKaW5jbHVzaXZlIG9zIGRpcmVpdG9zIGRlIHZveiBlIGltYWdlbSB2aW5jdWxhZG9zIMOgIE9CUkEsIG9icmlnYW5kby1zZSBhIGluZGVuaXphciB0ZXJjZWlyb3MgcG9yCmRhbm9zLCBiZW0gY29tbyBpbmRlbml6YXIgZSByZXNzYXJjaXIgYSBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPIENSVVogZGUKZXZlbnR1YWlzIGRlc3Blc2FzIHF1ZSB2aWVyZW0gYSBzdXBvcnRhciwgZW0gcmF6w6NvIGRlIHF1YWxxdWVyIG9mZW5zYSBhIGRpcmVpdG9zIGF1dG9yYWlzIG91CmRpcmVpdG9zIGRlIHZveiBvdSBpbWFnZW0sIHByaW5jaXBhbG1lbnRlIG5vIHF1ZSBkaXogcmVzcGVpdG8gYSBwbMOhZ2lvIGUgdmlvbGHDp8O1ZXMgZGUgZGlyZWl0b3M7CgooNSkgQUZJUk1BIHF1ZSBjb25oZWNlIGEgUG9sw610aWNhIEluc3RpdHVjaW9uYWwgZGUgQWNlc3NvIEFiZXJ0byBkYSBGSU9DUlVaIC0gRlVOREHDh8ODTwpPU1dBTERPIENSVVogZSBhcyBkaXJldHJpemVzIHBhcmEgbyBmdW5jaW9uYW1lbnRvIGRvIHJlcG9zaXTDs3JpbyBpbnN0aXR1Y2lvbmFsIEFSQ0EuCgpBIFBvbMOtdGljYSBJbnN0aXR1Y2lvbmFsIGRlIEFjZXNzbyBBYmVydG8gZGEgRklPQ1JVWiAtIEZVTkRBw4fDg08gT1NXQUxETyBDUlVaIHJlc2VydmEKZXhjbHVzaXZhbWVudGUgYW8gQVVUT1Igb3MgZGlyZWl0b3MgbW9yYWlzIGUgb3MgdXNvcyBjb21lcmNpYWlzIHNvYnJlIGFzIG9icmFzIGRlIHN1YSBhdXRvcmlhCmUvb3UgdGl0dWxhcmlkYWRlLCBzZW5kbyBvcyB0ZXJjZWlyb3MgdXN1w6FyaW9zIHJlc3BvbnPDoXZlaXMgcGVsYSBhdHJpYnVpw6fDo28gZGUgYXV0b3JpYSBlIG1hbnV0ZW7Dp8OjbwpkYSBpbnRlZ3JpZGFkZSBkYSBPQlJBIGVtIHF1YWxxdWVyIHV0aWxpemHDp8Ojby4KCkEgUG9sw610aWNhIEluc3RpdHVjaW9uYWwgZGUgQWNlc3NvIEFiZXJ0byBkYSBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPIENSVVoKcmVzcGVpdGEgb3MgY29udHJhdG9zIGUgYWNvcmRvcyBwcmVleGlzdGVudGVzIGRvcyBBdXRvcmVzIGNvbSB0ZXJjZWlyb3MsIGNhYmVuZG8gYW9zIEF1dG9yZXMKaW5mb3JtYXIgw6AgSW5zdGl0dWnDp8OjbyBhcyBjb25kacOnw7VlcyBlIG91dHJhcyByZXN0cmnDp8O1ZXMgaW1wb3N0YXMgcG9yIGVzdGVzIGluc3RydW1lbnRvcy4KRepositório 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| dc.title.pt_BR.fl_str_mv |
DETC-based bacterial cellulose bio-curatives for topical treatment of cutaneous leishmaniasis |
| title |
DETC-based bacterial cellulose bio-curatives for topical treatment of cutaneous leishmaniasis |
| spellingShingle |
DETC-based bacterial cellulose bio-curatives for topical treatment of cutaneous leishmaniasis Celes, Fabiana Santana Leishmania Leishmania braziliensis Drogas Infecção Biocurativos Quimioterapia Tratamento Leishmania Leishmania braziliensis Drugs Infection Bio-curative Chemotherapy Treatment |
| title_short |
DETC-based bacterial cellulose bio-curatives for topical treatment of cutaneous leishmaniasis |
| title_full |
DETC-based bacterial cellulose bio-curatives for topical treatment of cutaneous leishmaniasis |
| title_fullStr |
DETC-based bacterial cellulose bio-curatives for topical treatment of cutaneous leishmaniasis |
| title_full_unstemmed |
DETC-based bacterial cellulose bio-curatives for topical treatment of cutaneous leishmaniasis |
| title_sort |
DETC-based bacterial cellulose bio-curatives for topical treatment of cutaneous leishmaniasis |
| author |
Celes, Fabiana Santana |
| author_facet |
Celes, Fabiana Santana Trovatti, Eliane Cunha, Antonio Ricardo Khouri Van Weyenbergh, Johan Jozef Rosa Maria Ribeiro, Sidney José Lima Borges, Valeria de Matos Barud, Hernane da Silva Oliveira, Camila Indiani de |
| author_role |
author |
| author2 |
Trovatti, Eliane Cunha, Antonio Ricardo Khouri Van Weyenbergh, Johan Jozef Rosa Maria Ribeiro, Sidney José Lima Borges, Valeria de Matos Barud, Hernane da Silva Oliveira, Camila Indiani de |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Celes, Fabiana Santana Trovatti, Eliane Cunha, Antonio Ricardo Khouri Van Weyenbergh, Johan Jozef Rosa Maria Ribeiro, Sidney José Lima Borges, Valeria de Matos Barud, Hernane da Silva Oliveira, Camila Indiani de |
| dc.subject.other.pt_BR.fl_str_mv |
Leishmania Leishmania braziliensis Drogas Infecção Biocurativos Quimioterapia Tratamento |
| topic |
Leishmania Leishmania braziliensis Drogas Infecção Biocurativos Quimioterapia Tratamento Leishmania Leishmania braziliensis Drugs Infection Bio-curative Chemotherapy Treatment |
| dc.subject.en.pt_BR.fl_str_mv |
Leishmania Leishmania braziliensis Drugs Infection Bio-curative Chemotherapy Treatment |
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CNPq. Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) (482193/2012-3), Fundação Oswaldo Cruz - Programa de Apoio a Pesquisas Estratégicas (FIOCRUZ-PAPES IV) (407437/2012-6) and Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). S.J.L, V.M.B and C.I.O are senior researchers CNPq. FSC received a fellowship from Coordenação de Amparo à Pesquisa e Ensino Superior (CAPES). |
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2016 |
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2016 |
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2017-03-22T16:38:38Z |
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2017-03-22T16:38:38Z |
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CELES, F. S. et al. DETC-based bacterial cellulose bio-curatives for topical treatment of cutaneous leishmaniasis. Scientific Reports, v. 6, p. 38330, 2016. |
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https://www.arca.fiocruz.br/handle/icict/18118 |
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2045-2322 |
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10.1038/srep38330 |
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CELES, F. S. et al. DETC-based bacterial cellulose bio-curatives for topical treatment of cutaneous leishmaniasis. Scientific Reports, v. 6, p. 38330, 2016. 2045-2322 10.1038/srep38330 |
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