Multi-centric prospective evaluation of rk39 rapid test and direct agglutination test for the diagnosis of visceral leishmaniasis in Brazil

Bibliographic Details
Main Author: Assis, Tália Santana Machado de
Publication Date: 2011
Other Authors: Braga, Alexandre Sérgio da Costa, Pedras, Mariana Junqueira, Oliveira, Edward José de, Barral, Aldina Maria Prado, Siqueira, Isadora Cristina de, Costa, Carlos Henrique Nery, Costa, Dorcas Lamounier, Holanda, Thiago Ayres, Soares, Vítor Yamashiro Rocha, Silva, Mauro Roberto Biá da, Caldas, Arlene de Jesus Mendes, Romero, Gustavo Adolfo Sierra, Rabello, Ana Lúcia Teles
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
Download full: https://www.arca.fiocruz.br/handle/icict/9289
Summary: Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Pesquisas Clínicas. Belo Horizonte, MG, Brasil
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spelling Assis, Tália Santana Machado deBraga, Alexandre Sérgio da CostaPedras, Mariana JunqueiraOliveira, Edward José deBarral, Aldina Maria PradoSiqueira, Isadora Cristina deCosta, Carlos Henrique NeryCosta, Dorcas LamounierHolanda, Thiago AyresSoares, Vítor Yamashiro RochaSilva, Mauro Roberto Biá daCaldas, Arlene de Jesus MendesRomero, Gustavo Adolfo SierraRabello, Ana Lúcia Teles2014-12-23T16:53:44Z2014-12-23T16:53:44Z2011ASSIS, T. S. M. et al. Multi-centric prospective evaluation of rk39 rapid test and direct agglutination test for the diagnosis of visceral leishmaniasis in Brazil. Transactions of the Royal Society of Tropical Medicine and Hygiene, v. 105, n. 2, p. 81-85, 2011.1878-3503https://www.arca.fiocruz.br/handle/icict/928910.1016/j.trstmh.2010.09.004engOxford University PressMulti-centric prospective evaluation of rk39 rapid test and direct agglutination test for the diagnosis of visceral leishmaniasis in Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Pesquisas Clínicas. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Pesquisas Clínicas. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Pesquisas Clínicas. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Pesquisas Clínicas. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital da Criança. Obras Sociais de Irmã Dulce. Salvador, BA, BrasilUniversidade Federal do Piauí. Teresina, PI, BrasilUniversidade Federal do Piauí. Teresina, PI, BrasilUniversidade Federal do Piauí. Teresina, PI, BrasilUniversidade Federal do Piauí. Teresina, PI, BrasilUniversidade Federal do Piauí. Teresina, PI, BrasilUniversidade Federal do Maranhão. São Luís, MA, BrasilUniversidade de Brasília. Brasília, DF, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Pesquisas Clínicas. Belo Horizonte, MG, BrasilThe diagnosis of visceral leishmaniasis (VL) is still a major problem in Brazil and several other countries where the disease is endemic. The use of an easy-to-use and interpret, sensitive, and specific method that requires no complex infrastructure or specialized professionals, such as direct agglutination test (DAT) and the rK39-based rapid immunochromatographic test may enhance the diagnosis of disease. This study evaluated the performance of a rapid test (DiaMed- IT-LEISH®) and the DAT for the diagnosis of VL in 213 parasitologically confirmed cases and 119 controls with clinical suspicion of VL and confirmation of another etiology. The sensitivities and specificities of the rapid test were 93% and 97%, respectively and those of the DAT were 90% and 96%, respectively. The positive predictive values of the rapid test and the DAT were 98% and 97%, respectively and the negative predictive values were 89% and 84%, respectively. The Kappa index showed agreement between both methods classified as substantial (0.77). This study showed that the DAT and the rapid test can be used to diagnose VL in Brazil, following a pilot study for implementation of the rapid test in the health servicesDirect agglutination testRapid test rK39Visceral leishmaniasisSensitivitySpecificity and diagnostic accuracyTestes de Aglutinação/normasLeishmaniose Visceral/diagnósticoKit de Reagentes para DiagnósticoAnimaisBrasil/epidemiologiaFemininoHumanosMasculinoPrevalênciaLeishmaniose Visceral/epidemiologiaEstudos ProspectivosPadrões de ReferênciaSensibilidade e Especificidadeinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/9289/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALAssis T S M Multi-centric prospective....pdfAssis T S M Multi-centric prospective....pdfapplication/pdf138158https://www.arca.fiocruz.br/bitstream/icict/9289/2/Assis%20T%20S%20M%20Multi-centric%20prospective....pdfb2acfec87df42a7da4cebe03cc315af3MD52TEXTAssis T S M Multi-centric prospective....pdf.txtAssis T S M Multi-centric prospective....pdf.txtExtracted texttext/plain26036https://www.arca.fiocruz.br/bitstream/icict/9289/3/Assis%20T%20S%20M%20Multi-centric%20prospective....pdf.txt3ca1236f6997751491143309af27307eMD53icict/92892023-03-15 14:32:53.503oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:53Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Multi-centric prospective evaluation of rk39 rapid test and direct agglutination test for the diagnosis of visceral leishmaniasis in Brazil
title Multi-centric prospective evaluation of rk39 rapid test and direct agglutination test for the diagnosis of visceral leishmaniasis in Brazil
spellingShingle Multi-centric prospective evaluation of rk39 rapid test and direct agglutination test for the diagnosis of visceral leishmaniasis in Brazil
Assis, Tália Santana Machado de
Direct agglutination test
Rapid test rK39
Visceral leishmaniasis
Sensitivity
Specificity and diagnostic accuracy
Testes de Aglutinação/normas
Leishmaniose Visceral/diagnóstico
Kit de Reagentes para Diagnóstico
Animais
Brasil/epidemiologia
Feminino
Humanos
Masculino
Prevalência
Leishmaniose Visceral/epidemiologia
Estudos Prospectivos
Padrões de Referência
Sensibilidade e Especificidade
title_short Multi-centric prospective evaluation of rk39 rapid test and direct agglutination test for the diagnosis of visceral leishmaniasis in Brazil
title_full Multi-centric prospective evaluation of rk39 rapid test and direct agglutination test for the diagnosis of visceral leishmaniasis in Brazil
title_fullStr Multi-centric prospective evaluation of rk39 rapid test and direct agglutination test for the diagnosis of visceral leishmaniasis in Brazil
title_full_unstemmed Multi-centric prospective evaluation of rk39 rapid test and direct agglutination test for the diagnosis of visceral leishmaniasis in Brazil
title_sort Multi-centric prospective evaluation of rk39 rapid test and direct agglutination test for the diagnosis of visceral leishmaniasis in Brazil
author Assis, Tália Santana Machado de
author_facet Assis, Tália Santana Machado de
Braga, Alexandre Sérgio da Costa
Pedras, Mariana Junqueira
Oliveira, Edward José de
Barral, Aldina Maria Prado
Siqueira, Isadora Cristina de
Costa, Carlos Henrique Nery
Costa, Dorcas Lamounier
Holanda, Thiago Ayres
Soares, Vítor Yamashiro Rocha
Silva, Mauro Roberto Biá da
Caldas, Arlene de Jesus Mendes
Romero, Gustavo Adolfo Sierra
Rabello, Ana Lúcia Teles
author_role author
author2 Braga, Alexandre Sérgio da Costa
Pedras, Mariana Junqueira
Oliveira, Edward José de
Barral, Aldina Maria Prado
Siqueira, Isadora Cristina de
Costa, Carlos Henrique Nery
Costa, Dorcas Lamounier
Holanda, Thiago Ayres
Soares, Vítor Yamashiro Rocha
Silva, Mauro Roberto Biá da
Caldas, Arlene de Jesus Mendes
Romero, Gustavo Adolfo Sierra
Rabello, Ana Lúcia Teles
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Assis, Tália Santana Machado de
Braga, Alexandre Sérgio da Costa
Pedras, Mariana Junqueira
Oliveira, Edward José de
Barral, Aldina Maria Prado
Siqueira, Isadora Cristina de
Costa, Carlos Henrique Nery
Costa, Dorcas Lamounier
Holanda, Thiago Ayres
Soares, Vítor Yamashiro Rocha
Silva, Mauro Roberto Biá da
Caldas, Arlene de Jesus Mendes
Romero, Gustavo Adolfo Sierra
Rabello, Ana Lúcia Teles
dc.subject.en.pt_BR.fl_str_mv Direct agglutination test
Rapid test rK39
Visceral leishmaniasis
Sensitivity
Specificity and diagnostic accuracy
topic Direct agglutination test
Rapid test rK39
Visceral leishmaniasis
Sensitivity
Specificity and diagnostic accuracy
Testes de Aglutinação/normas
Leishmaniose Visceral/diagnóstico
Kit de Reagentes para Diagnóstico
Animais
Brasil/epidemiologia
Feminino
Humanos
Masculino
Prevalência
Leishmaniose Visceral/epidemiologia
Estudos Prospectivos
Padrões de Referência
Sensibilidade e Especificidade
dc.subject.decs.pt_BR.fl_str_mv Testes de Aglutinação/normas
Leishmaniose Visceral/diagnóstico
Kit de Reagentes para Diagnóstico
Animais
Brasil/epidemiologia
Feminino
Humanos
Masculino
Prevalência
Leishmaniose Visceral/epidemiologia
Estudos Prospectivos
Padrões de Referência
Sensibilidade e Especificidade
description Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Pesquisas Clínicas. Belo Horizonte, MG, Brasil
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2014-12-23T16:53:44Z
dc.date.available.fl_str_mv 2014-12-23T16:53:44Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ASSIS, T. S. M. et al. Multi-centric prospective evaluation of rk39 rapid test and direct agglutination test for the diagnosis of visceral leishmaniasis in Brazil. Transactions of the Royal Society of Tropical Medicine and Hygiene, v. 105, n. 2, p. 81-85, 2011.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/9289
dc.identifier.issn.none.fl_str_mv 1878-3503
dc.identifier.doi.none.fl_str_mv 10.1016/j.trstmh.2010.09.004
identifier_str_mv ASSIS, T. S. M. et al. Multi-centric prospective evaluation of rk39 rapid test and direct agglutination test for the diagnosis of visceral leishmaniasis in Brazil. Transactions of the Royal Society of Tropical Medicine and Hygiene, v. 105, n. 2, p. 81-85, 2011.
1878-3503
10.1016/j.trstmh.2010.09.004
url https://www.arca.fiocruz.br/handle/icict/9289
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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