Leishmaniasis treatment: update of possibilities for drug repurposing
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/28846 |
Resumo: | Inclui tabela - Species pathogenic to human, occurrence and clinical manifestation. |
| id |
CRUZ_9c4993d5348e8ee7f6ab476eb842f0f6 |
|---|---|
| oai_identifier_str |
oai:www.arca.fiocruz.br:icict/28846 |
| network_acronym_str |
CRUZ |
| network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| repository_id_str |
2135 |
| spelling |
Andrade Neto, Valter VianaCunha Junior, Edezio FerreiraFaioes, Viviane dos SantosMartins, Thais PereiraSilva, Raphaela LopesLeon, Leonor LauraSantos, Eduardo Caio Torres2018-09-18T12:23:40Z2018-09-18T12:23:40Z2018ANDRADE NETO, Valter Viana et al. Leishmaniasis treatment: update of possibilities for drug repurposing. Frontiers in Bioscience, v. 23, p. 967-996, Jan. 2018.1093-9946https://www.arca.fiocruz.br/handle/icict/28846Inclui tabela - Species pathogenic to human, occurrence and clinical manifestation.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquimica de Tripanosomatideos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquimica de Tripanosomatideos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquimica de Tripanosomatideos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquimica de Tripanosomatideos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquimica de Tripanosomatideos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquimica de Tripanosomatideos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquimica de Tripanosomatideos. Rio de Janeiro, RJ, Brasil.The leishmaniases represent a public health problem in under-developed countries and are considered a neglected disease by the World Health Organization (WHO). They are cuased by Leishmania parasites with different clinical manifestations. Currently, there is no vaccine, and treatment is in-efficient and is associated with both serious side effects often leading to resistance to the parasites. Thus, it is essential to search for new treatment strategies, such as drug repurposing, i.e., the use of drugs that are already used for other diseases. The discovery of new clinical applications for approved drugs is strategic for lowering the cost of drug discovery since human toxicity assays are already conducted. Here, we review a broad analysis of the different aspects of this approach for anti-leishmanial treatment.engFrontiers in BioScienceLeishmanioseReposicionamento de MedicamentosTratamentoRevisãoLeishmaniasisTreatmentDrug RepurposingReviewLeishmaniasis treatment: update of possibilities for drug repurposinginfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/28846/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALvalter_andradeneto_etal_IOC_2018.pd.pdfvalter_andradeneto_etal_IOC_2018.pd.pdfapplication/pdf2144279https://www.arca.fiocruz.br/bitstream/icict/28846/2/valter_andradeneto_etal_IOC_2018.pd.pdfec5d5f365d4f82408968a31ea87c16f0MD52valter_andradeneto_etal_IOC_2018_Tables.pdfvalter_andradeneto_etal_IOC_2018_Tables.pdfTablesapplication/pdf112863https://www.arca.fiocruz.br/bitstream/icict/28846/4/valter_andradeneto_etal_IOC_2018_Tables.pdfb7b05438e51f723a544e57d6d24d109bMD54TEXTvalter_andradeneto_etal_IOC_2018.pd.pdf.txtvalter_andradeneto_etal_IOC_2018.pd.pdf.txtExtracted texttext/plain109638https://www.arca.fiocruz.br/bitstream/icict/28846/3/valter_andradeneto_etal_IOC_2018.pd.pdf.txtf2bdd2a5aa904093c3eee8968e5768b7MD53valter_andradeneto_etal_IOC_2018_Tables.pdf.txtvalter_andradeneto_etal_IOC_2018_Tables.pdf.txtExtracted texttext/plain1344https://www.arca.fiocruz.br/bitstream/icict/28846/5/valter_andradeneto_etal_IOC_2018_Tables.pdf.txt9891585c836619a8abb42fb3721be2d2MD55icict/288462023-09-05 10:30:46.552oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-09-05T13:30:46Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Leishmaniasis treatment: update of possibilities for drug repurposing |
| title |
Leishmaniasis treatment: update of possibilities for drug repurposing |
| spellingShingle |
Leishmaniasis treatment: update of possibilities for drug repurposing Andrade Neto, Valter Viana Leishmaniose Reposicionamento de Medicamentos Tratamento Revisão Leishmaniasis Treatment Drug Repurposing Review |
| title_short |
Leishmaniasis treatment: update of possibilities for drug repurposing |
| title_full |
Leishmaniasis treatment: update of possibilities for drug repurposing |
| title_fullStr |
Leishmaniasis treatment: update of possibilities for drug repurposing |
| title_full_unstemmed |
Leishmaniasis treatment: update of possibilities for drug repurposing |
| title_sort |
Leishmaniasis treatment: update of possibilities for drug repurposing |
| author |
Andrade Neto, Valter Viana |
| author_facet |
Andrade Neto, Valter Viana Cunha Junior, Edezio Ferreira Faioes, Viviane dos Santos Martins, Thais Pereira Silva, Raphaela Lopes Leon, Leonor Laura Santos, Eduardo Caio Torres |
| author_role |
author |
| author2 |
Cunha Junior, Edezio Ferreira Faioes, Viviane dos Santos Martins, Thais Pereira Silva, Raphaela Lopes Leon, Leonor Laura Santos, Eduardo Caio Torres |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Andrade Neto, Valter Viana Cunha Junior, Edezio Ferreira Faioes, Viviane dos Santos Martins, Thais Pereira Silva, Raphaela Lopes Leon, Leonor Laura Santos, Eduardo Caio Torres |
| dc.subject.other.pt_BR.fl_str_mv |
Leishmaniose Reposicionamento de Medicamentos Tratamento Revisão |
| topic |
Leishmaniose Reposicionamento de Medicamentos Tratamento Revisão Leishmaniasis Treatment Drug Repurposing Review |
| dc.subject.en.pt_BR.fl_str_mv |
Leishmaniasis Treatment Drug Repurposing Review |
| description |
Inclui tabela - Species pathogenic to human, occurrence and clinical manifestation. |
| publishDate |
2018 |
| dc.date.accessioned.fl_str_mv |
2018-09-18T12:23:40Z |
| dc.date.available.fl_str_mv |
2018-09-18T12:23:40Z |
| dc.date.issued.fl_str_mv |
2018 |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
ANDRADE NETO, Valter Viana et al. Leishmaniasis treatment: update of possibilities for drug repurposing. Frontiers in Bioscience, v. 23, p. 967-996, Jan. 2018. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/28846 |
| dc.identifier.issn.pt_BR.fl_str_mv |
1093-9946 |
| identifier_str_mv |
ANDRADE NETO, Valter Viana et al. Leishmaniasis treatment: update of possibilities for drug repurposing. Frontiers in Bioscience, v. 23, p. 967-996, Jan. 2018. 1093-9946 |
| url |
https://www.arca.fiocruz.br/handle/icict/28846 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Frontiers in BioScience |
| publisher.none.fl_str_mv |
Frontiers in BioScience |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
| instacron_str |
FIOCRUZ |
| institution |
FIOCRUZ |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/28846/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/28846/2/valter_andradeneto_etal_IOC_2018.pd.pdf https://www.arca.fiocruz.br/bitstream/icict/28846/4/valter_andradeneto_etal_IOC_2018_Tables.pdf https://www.arca.fiocruz.br/bitstream/icict/28846/3/valter_andradeneto_etal_IOC_2018.pd.pdf.txt https://www.arca.fiocruz.br/bitstream/icict/28846/5/valter_andradeneto_etal_IOC_2018_Tables.pdf.txt |
| bitstream.checksum.fl_str_mv |
5a560609d32a3863062d77ff32785d58 ec5d5f365d4f82408968a31ea87c16f0 b7b05438e51f723a544e57d6d24d109b f2bdd2a5aa904093c3eee8968e5768b7 9891585c836619a8abb42fb3721be2d2 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1798324783355527168 |