Alterations in the lipid profiles and circulating liver enzymes in individuals infected by Schistosoma mansoni

Detalhes bibliográficos
Autor(a) principal: Silva, Fabiana Letícia da
Data de Publicação: 2018
Outros Autores: Del-Rei, Rodrigo Pimenta, Fraga, Deborah Bittencourt Mothé, Leony, Leonardo Maia, Souza, Alina Maria Gonzaga Carlos de, Santos, Fred Luciano Neves
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/31384
Resumo: Gonçalo Moniz Institute (Fiocruz-BA).
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spelling Silva, Fabiana Letícia daDel-Rei, Rodrigo PimentaFraga, Deborah Bittencourt MothéLeony, Leonardo MaiaSouza, Alina Maria Gonzaga Carlos deSantos, Fred Luciano Neves2019-02-01T18:11:28Z2019-02-01T18:11:28Z2018SILVA, F. L. et al. Alterations in the lipid profiles and circulating liver enzymes in individuals infected by Schistosoma mansoni. Revista da Sociedade Brasileira de Medicina Tropical, v. 51, n. 6, p. 795-801, 2018.0037-8682https://www.arca.fiocruz.br/handle/icict/3138410.1590/0037-8682-0113-2018Gonçalo Moniz Institute (Fiocruz-BA).Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Análise de Sistemas de Informações em Saúde. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Interação Parasito-Hospedeiro e Epidemiologia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil.Grupo Promedica. Laboratório Datalab. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil.Portal hypertension and periportal fibrosis commonly occur in severe Schistosoma mansoni infection. Changes in lipid profile and elevated levels of circulating liver enzymes have also been described in infected individuals. The present study sought to assess the alterations in laboratory parameters associated with liver disorder in individuals infected by S. mansoni who visited a private routine laboratory service. Levels of circulating liver enzymes (gamma-glutamyl transferase [γ-GT], aspartate transaminase [AST], alanine transaminase [ALT], and alkaline phosphatase [ALP]) and a lipid panel (total cholesterol [COL], high-density lipoprotein [HDL], low-density lipoprotein [LDL], very low-density lipoprotein [VLDL], and triglycerides [TRI]) were evaluated in both infected and non-infected individuals and relative risk was used to measure associations. Methods: Data were collected for analysis from a total of 1,078 cases identified in 379,600 individuals who submitted samples to the Datalab Laboratory (Salvador, Bahia) between 2004 and 2008. Results: S. mansoni infection led to increased circulating levels of γ-GT in both women and men, AST (women), and ALP (men). S. mansoni infection was a protective factor against increased levels of TRI, CHO, and VLDL for individuals aged 19 years or older. The results of our analysis indicate that alterations in lipid metabolism and circulating liver enzymes in asymptomatic S. mansoni-infected individuals might be attributed to eggs lodged in the hepatic sinusoids. Conclusions: Parasitological testing for S. mansoni should be indicated in endemic areas when this pattern of alterations is detected.engSociedade Brasileira de Medicina TropicalSchistosoma mansoniAlterações bioquímicasEnzimas hepáticasColesterolTriglicerídeosSchistosoma mansoniBiochemical changesLiver enzymesCholesterolTriglyceridesAlterations in the lipid profiles and circulating liver enzymes in individuals infected by Schistosoma mansoniinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31384/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSILVA, F.L. Alterations in lipid profile...2018.pdfSILVA, F.L. Alterations in lipid profile...2018.pdfapplication/pdf2734859https://www.arca.fiocruz.br/bitstream/icict/31384/2/SILVA%2c%20F.L.%20Alterations%20in%20lipid%20profile...2018.pdf8b8fe8385076ecbba9e7c3b334824b27MD52TEXTSILVA, F.L. Alterations in lipid profile...2018.pdf.txtSILVA, F.L. 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dc.title.pt_BR.fl_str_mv Alterations in the lipid profiles and circulating liver enzymes in individuals infected by Schistosoma mansoni
title Alterations in the lipid profiles and circulating liver enzymes in individuals infected by Schistosoma mansoni
spellingShingle Alterations in the lipid profiles and circulating liver enzymes in individuals infected by Schistosoma mansoni
Silva, Fabiana Letícia da
Schistosoma mansoni
Alterações bioquímicas
Enzimas hepáticas
Colesterol
Triglicerídeos
Schistosoma mansoni
Biochemical changes
Liver enzymes
Cholesterol
Triglycerides
title_short Alterations in the lipid profiles and circulating liver enzymes in individuals infected by Schistosoma mansoni
title_full Alterations in the lipid profiles and circulating liver enzymes in individuals infected by Schistosoma mansoni
title_fullStr Alterations in the lipid profiles and circulating liver enzymes in individuals infected by Schistosoma mansoni
title_full_unstemmed Alterations in the lipid profiles and circulating liver enzymes in individuals infected by Schistosoma mansoni
title_sort Alterations in the lipid profiles and circulating liver enzymes in individuals infected by Schistosoma mansoni
author Silva, Fabiana Letícia da
author_facet Silva, Fabiana Letícia da
Del-Rei, Rodrigo Pimenta
Fraga, Deborah Bittencourt Mothé
Leony, Leonardo Maia
Souza, Alina Maria Gonzaga Carlos de
Santos, Fred Luciano Neves
author_role author
author2 Del-Rei, Rodrigo Pimenta
Fraga, Deborah Bittencourt Mothé
Leony, Leonardo Maia
Souza, Alina Maria Gonzaga Carlos de
Santos, Fred Luciano Neves
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, Fabiana Letícia da
Del-Rei, Rodrigo Pimenta
Fraga, Deborah Bittencourt Mothé
Leony, Leonardo Maia
Souza, Alina Maria Gonzaga Carlos de
Santos, Fred Luciano Neves
dc.subject.other.pt_BR.fl_str_mv Schistosoma mansoni
Alterações bioquímicas
Enzimas hepáticas
Colesterol
Triglicerídeos
topic Schistosoma mansoni
Alterações bioquímicas
Enzimas hepáticas
Colesterol
Triglicerídeos
Schistosoma mansoni
Biochemical changes
Liver enzymes
Cholesterol
Triglycerides
dc.subject.en.pt_BR.fl_str_mv Schistosoma mansoni
Biochemical changes
Liver enzymes
Cholesterol
Triglycerides
description Gonçalo Moniz Institute (Fiocruz-BA).
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2019-02-01T18:11:28Z
dc.date.available.fl_str_mv 2019-02-01T18:11:28Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, F. L. et al. Alterations in the lipid profiles and circulating liver enzymes in individuals infected by Schistosoma mansoni. Revista da Sociedade Brasileira de Medicina Tropical, v. 51, n. 6, p. 795-801, 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/31384
dc.identifier.issn.pt_BR.fl_str_mv 0037-8682
dc.identifier.doi.none.fl_str_mv 10.1590/0037-8682-0113-2018
identifier_str_mv SILVA, F. L. et al. Alterations in the lipid profiles and circulating liver enzymes in individuals infected by Schistosoma mansoni. Revista da Sociedade Brasileira de Medicina Tropical, v. 51, n. 6, p. 795-801, 2018.
0037-8682
10.1590/0037-8682-0113-2018
url https://www.arca.fiocruz.br/handle/icict/31384
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical
publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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