Increased Frequency of Memory CD4+ T-Cell Responses in Individuals With Previously Treated Extrapulmonary Tuberculosis

Detalhes bibliográficos
Autor(a) principal: Duarte, Beatriz Barreto
Data de Publicação: 2020
Outros Autores: Sterling, Timothy R., Fiske, Christina T., Almeida, Alexandre, Nochowicz, Cynthia H., Smith, Rita M., Barnett, Louise, Warren, Christian, Blackman, Amondrea, Silva, Jose Roberto Lapa e, Andrade, Bruno de Bezerril, Kalams, Spyros A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/45972
Resumo: National Institutes of Health, NIAID 1R21AI127129-01 (SK); NIH U01 AI069923 (CCASAnet and RePORT-Brazil: LB, AB, JL, BA, TS), NIAID 1 P30AI110527-03 Tennessee Center for AIDS Research (TNCFAR) (CN, CW, SK, TS); Brazilian Research Council/CNPq 469607/2014-9 (AA, JL), K23AI091692 (CF). The work from BA was supported by the Intramural Research Program of Fundação Oswaldo Cruz. BA and JL are senior scientists from CNPq. The work from LB was supported by the National Institutes of Health (U01 AI069923). BB-D received a research fellowship from the Coordenação de Aperfeiçoamento de Pessoal de Nı́vel Superior (CAPES).
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spelling Duarte, Beatriz BarretoSterling, Timothy R.Fiske, Christina T.Almeida, AlexandreNochowicz, Cynthia H.Smith, Rita M.Barnett, LouiseWarren, ChristianBlackman, AmondreaSilva, Jose Roberto Lapa eAndrade, Bruno de BezerrilKalams, Spyros A.2021-02-05T13:11:29Z2021-02-05T13:11:29Z2020DUARTE, Beatriz Barreto et al. Increased Frequency of Memory CD4+ T-Cell Responses in Individuals With Previously Treated Extrapulmonary Tuberculosis. Frontiers in Immunology, v. 11, p. 1-9, 2020.1664-3224https://www.arca.fiocruz.br/handle/icict/4597210.3389/fimmu.2020.60533810.3389/fimmu.2020.605338National Institutes of Health, NIAID 1R21AI127129-01 (SK); NIH U01 AI069923 (CCASAnet and RePORT-Brazil: LB, AB, JL, BA, TS), NIAID 1 P30AI110527-03 Tennessee Center for AIDS Research (TNCFAR) (CN, CW, SK, TS); Brazilian Research Council/CNPq 469607/2014-9 (AA, JL), K23AI091692 (CF). The work from BA was supported by the Intramural Research Program of Fundação Oswaldo Cruz. BA and JL are senior scientists from CNPq. The work from LB was supported by the National Institutes of Health (U01 AI069923). BB-D received a research fellowship from the Coordenação de Aperfeiçoamento de Pessoal de Nı́vel Superior (CAPES).Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Universidade Salvador. Laureate Universities. Salvador, BA, Brasil / Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Rio de Janeiro, RJ, Brasil.Vanderbilt University Medical Center. Department of Medicine. Division of Infectious Diseases. Nashville, TN, United States, / Vanderbilt University Medical Center. Vanderbilt Tuberculosis Center. Nashville. TN, USA.Vanderbilt University Medical Center. Department of Medicine. Division of Infectious Diseases. Nashville, TN, United States, / Vanderbilt University Medical Center. Vanderbilt Tuberculosis Center. Nashville. TN, USA.Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Rio de Janeiro, RJ, Brasil.Vanderbilt University Medical Center. Department of Medicine. Division of Infectious Diseases. Nashville, TN, USA / Vanderbilt University Medical Center. Vanderbilt Tuberculosis Center. Nashville. TN, USA.Vanderbilt University Medical Center. Department of Medicine. Division of Infectious Diseases. Nashville, TN, USA / Vanderbilt University Medical Center. Vanderbilt Tuberculosis Center. Nashville. TN, USA.Vanderbilt University Medical Center. Department of Medicine. Division of Infectious Diseases. Nashville, TN, USA / Vanderbilt University Medical Center. Vanderbilt Tuberculosis Center. Nashville. TN, USA.Vanderbilt University Medical Center. Department of Medicine. Division of Infectious Diseases. Nashville, TN, USA / Vanderbilt University Medical Center. Vanderbilt Tuberculosis Center. Nashville. TN, USA.Vanderbilt University Medical Center. Department of Medicine. Division of Infectious Diseases. Nashville, TN, USA / Vanderbilt University Medical Center. Vanderbilt Tuberculosis Center. Nashville. TN, USA.Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Universidade Salvador. Laureate Universities. Salvador, BA, Brasil / Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Rio de Janeiro, RJ, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Centro Universitário Faculdades de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Curso de Medicina. Salvador, BA, Brasil.Vanderbilt University Medical Center. Department of Medicine. Division of Infectious Diseases. Nashville, TN, USA / Vanderbilt University Medical Center. Vanderbilt Tuberculosis Center. Nashville. TN, USA.Extrapulmonary TB (EPTB) occurs with increased frequency in persons with underlying immunodeficiency. Even after recovery from acute illness, differences in immune phenotype and activation persist. Studies defining characteristics of immune responses after recovery from extrapulmonary TB may provide insights into factors that increase TB risk. We performed two case-control studies (in the United States and Brazil) among HIVseronegative adults with previous EPTB (n = 9; 25), previous pulmonary TB (n = 7; 25), latent M. tuberculosis (Mtb) infection (n = 11; 25), and uninfected TB contacts (n = 10; 25). We assessed the frequency of dual CD4+ interferon-g and tumor necrosis factor-a responses after stimulation with overlapping Mtb peptides from ESAT-6 or CFP-10, or gamma-irradiated Mtb H37Rv, proliferative responses to Mtb antigens, T-regulatory cell (Treg) frequency and phenotype. In both study populations, individuals with prior EPTB had the highest frequency of intracellular cytokine-producing cells in response to Mtb antigens (p < 0.05; p <.0001). Persons with prior EPTB in Brazil had the highest levels of CD4 proliferation to Mtb antigens (p < 0.0001), and the highest expression of CD39 on Tregs (p < 0.0001). Individuals with treated EPTB maintained high frequencies of Mtbspecific memory responses and active Treg cells, suggesting that susceptibility to EPTB occurs despite the ability to develop and maintain enhanced adaptive immune responses.engFrontiers MediaTuberculoseCélulas TCitocinaCélulas T CD4TuberculosisExtrapulmonary tuberculosisMemory T-cell responses,CytokineCD4+ T cellIncreased Frequency of Memory CD4+ T-Cell Responses in Individuals With Previously Treated Extrapulmonary Tuberculosisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/45972/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALDuarte, Beatriz Barreto Increased....pdfDuarte, Beatriz Barreto 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dc.title.pt_BR.fl_str_mv Increased Frequency of Memory CD4+ T-Cell Responses in Individuals With Previously Treated Extrapulmonary Tuberculosis
title Increased Frequency of Memory CD4+ T-Cell Responses in Individuals With Previously Treated Extrapulmonary Tuberculosis
spellingShingle Increased Frequency of Memory CD4+ T-Cell Responses in Individuals With Previously Treated Extrapulmonary Tuberculosis
Duarte, Beatriz Barreto
Tuberculose
Células T
Citocina
Células T CD4
Tuberculosis
Extrapulmonary tuberculosis
Memory T-cell responses,
Cytokine
CD4+ T cell
title_short Increased Frequency of Memory CD4+ T-Cell Responses in Individuals With Previously Treated Extrapulmonary Tuberculosis
title_full Increased Frequency of Memory CD4+ T-Cell Responses in Individuals With Previously Treated Extrapulmonary Tuberculosis
title_fullStr Increased Frequency of Memory CD4+ T-Cell Responses in Individuals With Previously Treated Extrapulmonary Tuberculosis
title_full_unstemmed Increased Frequency of Memory CD4+ T-Cell Responses in Individuals With Previously Treated Extrapulmonary Tuberculosis
title_sort Increased Frequency of Memory CD4+ T-Cell Responses in Individuals With Previously Treated Extrapulmonary Tuberculosis
author Duarte, Beatriz Barreto
author_facet Duarte, Beatriz Barreto
Sterling, Timothy R.
Fiske, Christina T.
Almeida, Alexandre
Nochowicz, Cynthia H.
Smith, Rita M.
Barnett, Louise
Warren, Christian
Blackman, Amondrea
Silva, Jose Roberto Lapa e
Andrade, Bruno de Bezerril
Kalams, Spyros A.
author_role author
author2 Sterling, Timothy R.
Fiske, Christina T.
Almeida, Alexandre
Nochowicz, Cynthia H.
Smith, Rita M.
Barnett, Louise
Warren, Christian
Blackman, Amondrea
Silva, Jose Roberto Lapa e
Andrade, Bruno de Bezerril
Kalams, Spyros A.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Duarte, Beatriz Barreto
Sterling, Timothy R.
Fiske, Christina T.
Almeida, Alexandre
Nochowicz, Cynthia H.
Smith, Rita M.
Barnett, Louise
Warren, Christian
Blackman, Amondrea
Silva, Jose Roberto Lapa e
Andrade, Bruno de Bezerril
Kalams, Spyros A.
dc.subject.other.pt_BR.fl_str_mv Tuberculose
Células T
Citocina
Células T CD4
topic Tuberculose
Células T
Citocina
Células T CD4
Tuberculosis
Extrapulmonary tuberculosis
Memory T-cell responses,
Cytokine
CD4+ T cell
dc.subject.en.pt_BR.fl_str_mv Tuberculosis
Extrapulmonary tuberculosis
Memory T-cell responses,
Cytokine
CD4+ T cell
description National Institutes of Health, NIAID 1R21AI127129-01 (SK); NIH U01 AI069923 (CCASAnet and RePORT-Brazil: LB, AB, JL, BA, TS), NIAID 1 P30AI110527-03 Tennessee Center for AIDS Research (TNCFAR) (CN, CW, SK, TS); Brazilian Research Council/CNPq 469607/2014-9 (AA, JL), K23AI091692 (CF). The work from BA was supported by the Intramural Research Program of Fundação Oswaldo Cruz. BA and JL are senior scientists from CNPq. The work from LB was supported by the National Institutes of Health (U01 AI069923). BB-D received a research fellowship from the Coordenação de Aperfeiçoamento de Pessoal de Nı́vel Superior (CAPES).
publishDate 2020
dc.date.issued.fl_str_mv 2020
dc.date.accessioned.fl_str_mv 2021-02-05T13:11:29Z
dc.date.available.fl_str_mv 2021-02-05T13:11:29Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv DUARTE, Beatriz Barreto et al. Increased Frequency of Memory CD4+ T-Cell Responses in Individuals With Previously Treated Extrapulmonary Tuberculosis. Frontiers in Immunology, v. 11, p. 1-9, 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/45972
dc.identifier.issn.pt_BR.fl_str_mv 1664-3224
dc.identifier.doi.pt_BR.fl_str_mv 10.3389/fimmu.2020.605338
dc.identifier.eissn.none.fl_str_mv 10.3389/fimmu.2020.605338
identifier_str_mv DUARTE, Beatriz Barreto et al. Increased Frequency of Memory CD4+ T-Cell Responses in Individuals With Previously Treated Extrapulmonary Tuberculosis. Frontiers in Immunology, v. 11, p. 1-9, 2020.
1664-3224
10.3389/fimmu.2020.605338
url https://www.arca.fiocruz.br/handle/icict/45972
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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instacron_str FIOCRUZ
institution FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
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