Physiological and morphological aspects of Aedes aegypti developing larvae: effects of the chitin synthesis inhibitor novaluron
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/18452 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil / Instituto de Biologia do Exército. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular, Rio de Janeiro, RJ, Brasil. |
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Farnesi, Luana C.Brito, José M.Linss, Jutta G.Pelajo-Machado, MarceloValle, DeniseRezende, Gustavo L.2017-04-15T15:27:21Z2017-04-15T15:27:21Z2012FARNESI, Luana C. et al. Physiological and Morphological Aspects of Aedes aegypti Developing Larvae: Effects of the Chitin Synthesis Inhibitor Novaluron. Plos One, v.7, n.1, e30363, Jan. 2012.1932-6203https://www.arca.fiocruz.br/handle/icict/1845210.1371/journal.pone.0030363engPublic Library of ScienceAedes aegyptiAspectos fisiológicosAspectos morfológicosLarvasInibidorNovaluronAedes aegyptiLarvaephysiological aspectsmorphological aspectsinhibitorNovaluronPhysiological and morphological aspects of Aedes aegypti developing larvae: effects of the chitin synthesis inhibitor novaluroninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil / Instituto de Biologia do Exército. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular, Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil / Instituto de Biologia do Exército. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular, Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil / Instituto de Biologia do Exército. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular, Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil / Instituto de Biologia do Exército. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular, Rio de Janeiro, RJ, Brasil.Population control of the dengue vector mosquito, Aedes aegypti, is difficult due to many reasons, one being the development of resistance to neurotoxic insecticides employed. The biosynthesis of chitin, a major constituent of insect cuticle, is a novel target for population control. Novaluron is a benzoylphenylurea (BPU) that acts as a chitin synthesis inhibitor, already used against mosquitoes. However, information regarding BPU effects on immature mosquito stages and physiological parameters related with mosquito larval development are scarce. A set of physiological parameters were recorded in control developing larvae and novaluron was administered continuously to Ae. aegypti larvae, since early third instar. Larval instar period duration was recorded from third instar until pupation. Chitin content was measured during third and fourth instars. Fourth instars were processed histochemically at the mesothorax region, stained with hematoxylin and eosin (HE) for assessment of internal tissues, and labeled with WGA-FITC to reveal chitinized structures. In control larvae: i) there is a chitin content increase during both third and fourth instars where late third instars contain more chitin than early fourth instars; ii) thoracic organs and a continuous cuticle, closely associated with the underlying epidermis were observed; iii) chitin was continuously present throughout integument cuticle. Novaluron treatment inhibited adult emergence, induced immature mortality, altered adult sex ratio and caused delay in larval development. Moreover, novaluron: i) significantly affected chitin content during larval development; ii) induced a discontinuous and altered cuticle in some regions while epidermis was often thinner or missing; iii) rendered chitin cuticle presence discontinuous and less evident. In both control and novaluron larvae, chitin was present in the peritrophic matrix. This study showed quantitatively and qualitatively evidences of novaluron effects on Ae. aegypti larval development. To our knowledge, this is the first report describing histological alterations produced by a BPU in immature vector mosquitoes.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/18452/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALluana1_farnesi_etal_IOC_2012.pdfluana1_farnesi_etal_IOC_2012.pdfapplication/pdf3642923https://www.arca.fiocruz.br/bitstream/icict/18452/2/luana1_farnesi_etal_IOC_2012.pdfbf2294b45a2852b4fcb4457cfc0e8ff1MD52TEXTluana1_farnesi_etal_IOC_2012.pdf.txtluana1_farnesi_etal_IOC_2012.pdf.txtExtracted texttext/plain49518https://www.arca.fiocruz.br/bitstream/icict/18452/3/luana1_farnesi_etal_IOC_2012.pdf.txt8956255e661f2878b4249a6c798c950cMD53icict/184522018-08-15 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dc.title.pt_BR.fl_str_mv |
Physiological and morphological aspects of Aedes aegypti developing larvae: effects of the chitin synthesis inhibitor novaluron |
title |
Physiological and morphological aspects of Aedes aegypti developing larvae: effects of the chitin synthesis inhibitor novaluron |
spellingShingle |
Physiological and morphological aspects of Aedes aegypti developing larvae: effects of the chitin synthesis inhibitor novaluron Farnesi, Luana C. Aedes aegypti Aspectos fisiológicos Aspectos morfológicos Larvas Inibidor Novaluron Aedes aegypti Larvae physiological aspects morphological aspects inhibitor Novaluron |
title_short |
Physiological and morphological aspects of Aedes aegypti developing larvae: effects of the chitin synthesis inhibitor novaluron |
title_full |
Physiological and morphological aspects of Aedes aegypti developing larvae: effects of the chitin synthesis inhibitor novaluron |
title_fullStr |
Physiological and morphological aspects of Aedes aegypti developing larvae: effects of the chitin synthesis inhibitor novaluron |
title_full_unstemmed |
Physiological and morphological aspects of Aedes aegypti developing larvae: effects of the chitin synthesis inhibitor novaluron |
title_sort |
Physiological and morphological aspects of Aedes aegypti developing larvae: effects of the chitin synthesis inhibitor novaluron |
author |
Farnesi, Luana C. |
author_facet |
Farnesi, Luana C. Brito, José M. Linss, Jutta G. Pelajo-Machado, Marcelo Valle, Denise Rezende, Gustavo L. |
author_role |
author |
author2 |
Brito, José M. Linss, Jutta G. Pelajo-Machado, Marcelo Valle, Denise Rezende, Gustavo L. |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Farnesi, Luana C. Brito, José M. Linss, Jutta G. Pelajo-Machado, Marcelo Valle, Denise Rezende, Gustavo L. |
dc.subject.other.pt_BR.fl_str_mv |
Aedes aegypti Aspectos fisiológicos Aspectos morfológicos Larvas Inibidor Novaluron |
topic |
Aedes aegypti Aspectos fisiológicos Aspectos morfológicos Larvas Inibidor Novaluron Aedes aegypti Larvae physiological aspects morphological aspects inhibitor Novaluron |
dc.subject.en.pt_BR.fl_str_mv |
Aedes aegypti Larvae physiological aspects morphological aspects inhibitor Novaluron |
description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil / Instituto de Biologia do Exército. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular, Rio de Janeiro, RJ, Brasil. |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012 |
dc.date.accessioned.fl_str_mv |
2017-04-15T15:27:21Z |
dc.date.available.fl_str_mv |
2017-04-15T15:27:21Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
FARNESI, Luana C. et al. Physiological and Morphological Aspects of Aedes aegypti Developing Larvae: Effects of the Chitin Synthesis Inhibitor Novaluron. Plos One, v.7, n.1, e30363, Jan. 2012. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/18452 |
dc.identifier.issn.pt_BR.fl_str_mv |
1932-6203 |
dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pone.0030363 |
identifier_str_mv |
FARNESI, Luana C. et al. Physiological and Morphological Aspects of Aedes aegypti Developing Larvae: Effects of the Chitin Synthesis Inhibitor Novaluron. Plos One, v.7, n.1, e30363, Jan. 2012. 1932-6203 10.1371/journal.pone.0030363 |
url |
https://www.arca.fiocruz.br/handle/icict/18452 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Public Library of Science |
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Public Library of Science |
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