Impact of environment and social gradient on Leptospira infection in urban slums
| Autor(a) principal: | |
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| Data de Publicação: | 2008 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/2775 |
Resumo: | The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript |
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Reis, Renato BarbosaRibeiro, Guilherme de SousaFelzemburgh, Ridalva Dias MartinsSantana, Francisco SMohr, SharifMelendez, Astrid X. T. OQueiroz, AdrianoSantos, Andréia Carvalho dosRavines, Romy RTassinari, Wagner SCarvalho, Marilia SáReis, Mitermayer Galvão dosKo, Albert Icksang2011-07-26T17:31:52Z2011-07-26T17:31:52Z2008REIS, R. B. et al. Impact of environment and social gradient on Leptospira infection in urban slums. PLoS Neglected Tropical Diseases, v.2, n.4, p.e228, 2008.1935-2735https://www.arca.fiocruz.br/handle/icict/277510.1371/journal.pntd.0000228The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscriptThis work was supported by the US National Institutes of Health (grants NIAID R01 AI052473, FIC D43 TW00919), Brazilian National Research Council (grants 300861/1996, 473082/2004, 420067/2005, 305723/2006, 150176/2007), and Oswaldo Cruz Foundation (grant 0250.250.102Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Escola Nacional da Saúde Pública. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Escola Nacional da Saúde Pública. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Escola Nacional da Saúde Pública. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilLeptospirosis has become an urban health problem as slum settlements have expanded worldwide. Efforts to identify interventions for urban leptospirosis have been hampered by the lack of population-based information on Leptospira transmission determinants. The aim of the study was to estimate the prevalence of Leptospira infection and identify risk factors for infection in the urban slum setting.We performed a community-based survey of 3,171 slum residents from Salvador, Brazil. Leptospira agglutinating antibodies were measured as a marker for prior infection. Poisson regression models evaluated the association between the presence of Leptospira antibodies and environmental attributes obtained from Geographical Information System surveys and indicators of socioeconomic status and exposures for individuals. Overall prevalence of Leptospira antibodies was 15.4% (95% confidence interval [CI], 14.0-16.8). Households of subjects with Leptospira antibodies clustered in squatter areas at the bottom of valleys. The risk of acquiring Leptospira antibodies was associated with household environmental factors such as residence in flood-risk regions with open sewers (prevalence ratio [PR] 1.42, 95% CI 1.14-1.75) and proximity to accumulated refuse (1.43, 1.04-1.88), sighting rats (1.32, 1.10-1.58), and the presence of chickens (1.26, 1.05-1.51). Furthermore, low income and black race (1.25, 1.03-1.50) were independent risk factors. An increase of US$1 per day in per capita household income was associated with an 11% (95% CI 5%-18%) decrease in infection risk.Deficiencies in the sanitation infrastructure where slum inhabitants reside were found to be environmental sources of Leptospira transmission. Even after controlling for environmental factors, differences in socioeconomic status contributed to the risk of Leptospira infection, indicating that effective prevention of leptospirosis may need to address the social factors that produce unequal health outcomes among slum residents, in addition to improving sanitation.engImpact of environment and social gradient on Leptospira infection in urban slumsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleLeptospiroseFatores SocioeconômicosPobrezaAnticorpos Antibacterianosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALP Impact of Environment and Social Gradient.pdfP Impact of Environment and Social Gradient.pdfapplication/pdf473037https://www.arca.fiocruz.br/bitstream/icict/2775/1/P%20Impact%20of%20Environment%20and%20Social%20Gradient.pdfe9e4b234b7ca112afb7169abbd2f77dfMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81648https://www.arca.fiocruz.br/bitstream/icict/2775/2/license.txte095249ac7cacefbfe39684dfe45e706MD52TEXTP Impact of Environment and Social Gradient.pdf.txtP Impact of Environment and Social Gradient.pdf.txtExtracted texttext/plain53511https://www.arca.fiocruz.br/bitstream/icict/2775/5/P%20Impact%20of%20Environment%20and%20Social%20Gradient.pdf.txt129557b1c74fa844199a35a65c13672eMD55THUMBNAILP Impact of Environment and Social Gradient.pdf.jpgP Impact of Environment and Social Gradient.pdf.jpgGenerated Thumbnailimage/jpeg2194https://www.arca.fiocruz.br/bitstream/icict/2775/4/P%20Impact%20of%20Environment%20and%20Social%20Gradient.pdf.jpg87c48cd14aafba6d3f81ae57905b0f5fMD54icict/27752023-03-15 14:33:01.334oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:01Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Impact of environment and social gradient on Leptospira infection in urban slums |
| title |
Impact of environment and social gradient on Leptospira infection in urban slums |
| spellingShingle |
Impact of environment and social gradient on Leptospira infection in urban slums Reis, Renato Barbosa Leptospirose Fatores Socioeconômicos Pobreza Anticorpos Antibacterianos |
| title_short |
Impact of environment and social gradient on Leptospira infection in urban slums |
| title_full |
Impact of environment and social gradient on Leptospira infection in urban slums |
| title_fullStr |
Impact of environment and social gradient on Leptospira infection in urban slums |
| title_full_unstemmed |
Impact of environment and social gradient on Leptospira infection in urban slums |
| title_sort |
Impact of environment and social gradient on Leptospira infection in urban slums |
| author |
Reis, Renato Barbosa |
| author_facet |
Reis, Renato Barbosa Ribeiro, Guilherme de Sousa Felzemburgh, Ridalva Dias Martins Santana, Francisco S Mohr, Sharif Melendez, Astrid X. T. O Queiroz, Adriano Santos, Andréia Carvalho dos Ravines, Romy R Tassinari, Wagner S Carvalho, Marilia Sá Reis, Mitermayer Galvão dos Ko, Albert Icksang |
| author_role |
author |
| author2 |
Ribeiro, Guilherme de Sousa Felzemburgh, Ridalva Dias Martins Santana, Francisco S Mohr, Sharif Melendez, Astrid X. T. O Queiroz, Adriano Santos, Andréia Carvalho dos Ravines, Romy R Tassinari, Wagner S Carvalho, Marilia Sá Reis, Mitermayer Galvão dos Ko, Albert Icksang |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Reis, Renato Barbosa Ribeiro, Guilherme de Sousa Felzemburgh, Ridalva Dias Martins Santana, Francisco S Mohr, Sharif Melendez, Astrid X. T. O Queiroz, Adriano Santos, Andréia Carvalho dos Ravines, Romy R Tassinari, Wagner S Carvalho, Marilia Sá Reis, Mitermayer Galvão dos Ko, Albert Icksang |
| dc.subject.decs.pt_BR.fl_str_mv |
Leptospirose Fatores Socioeconômicos Pobreza Anticorpos Antibacterianos |
| topic |
Leptospirose Fatores Socioeconômicos Pobreza Anticorpos Antibacterianos |
| description |
The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript |
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2008 |
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2008 |
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2011-07-26T17:31:52Z |
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2011-07-26T17:31:52Z |
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REIS, R. B. et al. Impact of environment and social gradient on Leptospira infection in urban slums. PLoS Neglected Tropical Diseases, v.2, n.4, p.e228, 2008. |
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10.1371/journal.pntd.0000228 |
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REIS, R. B. et al. Impact of environment and social gradient on Leptospira infection in urban slums. PLoS Neglected Tropical Diseases, v.2, n.4, p.e228, 2008. 1935-2735 10.1371/journal.pntd.0000228 |
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