Antinociceptive activity of Stephanolepis hispidus skin aqueous extract depends partly on opioid system activation
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2013 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/8667 http://dx.doi.org/10.3390/md11041221 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. |
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Carvalho, ViniciusFernandes, LohengrinConde, Taline RamosZamith, Helena Pereira da SilvaSilva, Ronald SantosSurrage, AndreaFrutuoso, ValberFaria Neto, Hugo Caire de CastroAmendoeira, Fábio Coelho2014-10-23T15:28:15Z2014-10-23T15:28:15Z2013CARVALHO, V. et al. Antinociceptive activity of Stephanolepis hispidus skin aqueous extract depends partly on opioid system activation. Marine Drugs, v. 11, n. 4, p. 1221-1234, abr. 2013.1221–1234https://www.arca.fiocruz.br/handle/icict/8667http://dx.doi.org/10.3390/md11041221engMDPI AGStephanolepis hispidusPele de PeixeAntinociceptivosProdutos MarinhosPeixe-porcoStephanolepis hispidusFish SkinAntinociceptiveMarine ProductsPlanehead FilefishPeixesAnalgésicosAntinociceptive activity of Stephanolepis hispidus skin aqueous extract depends partly on opioid system activationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Instituto de Estudos do Mar Almirante Paulo Moreira. Departamento de Oceanografia. Divisão de Ecosistemas Marinhos. Arraial do Cabo, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Departamento de Farmacologia e Toxicologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Departamento de Farmacologia e Toxicologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Departamento de Farmacologia e Toxicologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Departamento de Farmacologia e Toxicologia. Rio de Janeiro, RJ, Brasil.Stephanolepis hispidus is one of the most common filefish species in Brazil. Its skin is traditionally used as a complementary treatment for inflammatory disorders. However, there are very few studies on chemical and pharmacological properties using the skin of this fish. This study was undertaken in order to investigate the effect of aqueous crude extract of S. hispidus skin (SAE) in different nociception models. Here, we report that intraperitoneal administration of SAE inhibited the abdominal constrictions induced by acetic acid in mice. In addition to the effect seen in the abdominal constriction model, SAE was also able to inhibit the hyperalgesia induced by carrageenan and prostaglandin E2 (PGE2) in mice. This potent antinociceptive effect was observed in the hot plate model too, but not in tail-flick test. Naloxone, an opioid receptor antagonist, was able to block the antinociceptive effect of SAE in the abdominal constriction and hot plate models. In addition, SAE did not present cytotoxic or genotoxic effect in human peripheral blood cells. Our results suggest that aqueous crude extract from S. hispidus skin has antinociceptive activity in close relationship with the partial activation of opioid receptors in the nervous system. Moreover, aqueous crude extract from S. hispidus skin does not present toxicity and is therefore endowed with the potential for pharmacological control of pain.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8667/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALMar_Drugs_11_1221-1234.pdfMar_Drugs_11_1221-1234.pdfapplication/pdf182058https://www.arca.fiocruz.br/bitstream/icict/8667/2/Mar_Drugs_11_1221-1234.pdf2901e090d0e728bd217d6d7d3c839433MD52TEXTMar_Drugs_11_1221-1234.pdf.txtMar_Drugs_11_1221-1234.pdf.txtExtracted texttext/plain35607https://www.arca.fiocruz.br/bitstream/icict/8667/3/Mar_Drugs_11_1221-1234.pdf.txt89be3d955c66a74f32eaf5c1ddbe383cMD53icict/86672018-04-06 08:43:54.354oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-04-06T11:43:54Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.en.fl_str_mv |
Antinociceptive activity of Stephanolepis hispidus skin aqueous extract depends partly on opioid system activation |
| title |
Antinociceptive activity of Stephanolepis hispidus skin aqueous extract depends partly on opioid system activation |
| spellingShingle |
Antinociceptive activity of Stephanolepis hispidus skin aqueous extract depends partly on opioid system activation Carvalho, Vinicius Stephanolepis hispidus Pele de Peixe Antinociceptivos Produtos Marinhos Peixe-porco Stephanolepis hispidus Fish Skin Antinociceptive Marine Products Planehead Filefish Peixes Analgésicos |
| title_short |
Antinociceptive activity of Stephanolepis hispidus skin aqueous extract depends partly on opioid system activation |
| title_full |
Antinociceptive activity of Stephanolepis hispidus skin aqueous extract depends partly on opioid system activation |
| title_fullStr |
Antinociceptive activity of Stephanolepis hispidus skin aqueous extract depends partly on opioid system activation |
| title_full_unstemmed |
Antinociceptive activity of Stephanolepis hispidus skin aqueous extract depends partly on opioid system activation |
| title_sort |
Antinociceptive activity of Stephanolepis hispidus skin aqueous extract depends partly on opioid system activation |
| author |
Carvalho, Vinicius |
| author_facet |
Carvalho, Vinicius Fernandes, Lohengrin Conde, Taline Ramos Zamith, Helena Pereira da Silva Silva, Ronald Santos Surrage, Andrea Frutuoso, Valber Faria Neto, Hugo Caire de Castro Amendoeira, Fábio Coelho |
| author_role |
author |
| author2 |
Fernandes, Lohengrin Conde, Taline Ramos Zamith, Helena Pereira da Silva Silva, Ronald Santos Surrage, Andrea Frutuoso, Valber Faria Neto, Hugo Caire de Castro Amendoeira, Fábio Coelho |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Carvalho, Vinicius Fernandes, Lohengrin Conde, Taline Ramos Zamith, Helena Pereira da Silva Silva, Ronald Santos Surrage, Andrea Frutuoso, Valber Faria Neto, Hugo Caire de Castro Amendoeira, Fábio Coelho |
| dc.subject.other.pt_BR.fl_str_mv |
Stephanolepis hispidus Pele de Peixe Antinociceptivos Produtos Marinhos Peixe-porco |
| topic |
Stephanolepis hispidus Pele de Peixe Antinociceptivos Produtos Marinhos Peixe-porco Stephanolepis hispidus Fish Skin Antinociceptive Marine Products Planehead Filefish Peixes Analgésicos |
| dc.subject.en.en.fl_str_mv |
Stephanolepis hispidus Fish Skin Antinociceptive Marine Products Planehead Filefish |
| dc.subject.decs.pt_BR.fl_str_mv |
Peixes Analgésicos |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. |
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2013 |
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2013 |
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2014-10-23T15:28:15Z |
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2014-10-23T15:28:15Z |
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CARVALHO, V. et al. Antinociceptive activity of Stephanolepis hispidus skin aqueous extract depends partly on opioid system activation. Marine Drugs, v. 11, n. 4, p. 1221-1234, abr. 2013. |
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https://www.arca.fiocruz.br/handle/icict/8667 |
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1221–1234 |
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http://dx.doi.org/10.3390/md11041221 |
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CARVALHO, V. et al. Antinociceptive activity of Stephanolepis hispidus skin aqueous extract depends partly on opioid system activation. Marine Drugs, v. 11, n. 4, p. 1221-1234, abr. 2013. 1221–1234 |
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