Timing of HIV diagnosis relative to pregnancy and postpartum HIV care continuum outcomes among Latin American women, 2000 to 2017
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/47831 |
Resumo: | Vanderbilt University School of Medicine. Nashville, TN, USA. |
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Yohannes, Nathaniel T.Jenkins, Cathy A.Clouse, KateCortés, Claudia P.Cordero, Fernando MejíaPadgett, DenisRouzier, VanessaFriedman, Ruth K.McGowan, Catherine C.Shepherd, Bryan E.Rebeiro, Peter F.2021-06-22T12:33:46Z2021-06-22T12:33:46Z2021YOHANNES, Nathaniel T. et al. Timing of HIV diagnosis relative to pregnancy and postpartum HIV care continuum outcomes among Latin American women, 2000 to 2017. Journal of the International AIDS Society, v. 24, n. 5, p. 1-8, 20211758-2652https://www.arca.fiocruz.br/handle/icict/4783110.1002/jia2.25740engWileyTiming of HIV diagnosis relative to pregnancy and postpartum HIV care continuum outcomes among Latin American women, 2000 to 2017info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleVanderbilt University School of Medicine. Nashville, TN, USA.Vanderbilt University Medical Center. Department of Biostatistics. Nashville, TN, USA.Vanderbilt University Medical Center. Department of Medicine. Division of Infectious Diseases. Nashville, TN, USA / Vanderbilt University School of Nursing. Nashville, TN, USA.Fundación Arriaran y Clínica Santa María. Santiago, Chile.Universidad Peruana Cayetano Heredia. Instituto de Medicina Tropical Alexander von Humboldt. Lima, Peru.Instituto Hondureño de Seguridad Social & Hospital Escuela Universitario. Tegucigalpa, Honduras.Groupe Haitien d'Etudes du Sarcome de Kaposi et des Infections Opportunistes. Port-au-Prince, Haiti.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Vanderbilt University Medical Center. Department of Medicine. Division of Infectious Diseases. Nashville, TN, USA.Vanderbilt University Medical Center. Department of Biostatistics. Nashville, TN, USA.Vanderbilt University Medical Center. Department of Biostatistics. Nashville, TN, USA / Vanderbilt University Medical Center. Department of Medicine. Division of Infectious Diseases. Nashville, TN, USA.Background: HIV incidence among women of reproductive age and vertical HIV transmission rates remain high in Latin America. We, therefore, quantified HIV care continuum barriers and outcomes among pregnant women living with HIV (WLWH) in Latin America. Methods: WLWH (aged ≥16 years) enrolling at Caribbean, Central and South America network for HIV epidemiology (CCASAnet) sites from 2000 to 2017 who had HIV diagnosis, pregnancy and delivery dates contributed. Logistic regression produced adjusted odds ratios (aOR) and 95% confidence intervals (CI) for retention in care (≥2 visits ≥3 months apart) and virological suppression (viral load <200 copies/mL) 12 months after pregnancy outcome. Cumulative incidences of loss to follow-up (LTFU) postpartum were estimated using Cox regression. Evidence of HIV status at pregnancy confirmation was the exposure. Covariates included pregnancy outcome (born alive vs. others); AIDS diagnosis prior to delivery; CD4, age, HIV-1 RNA and cART regimen at first delivery and CCASAnet country. Results: Among 579 WLWH, median postpartum follow-up was 4.34 years (IQR 1.91, 7.35); 459 (79%) were HIV-diagnosed before pregnancy confirmation, 445 (77%) retained in care and 259 (45%) virologically suppressed at 12 months of postpartum. Cumulative incidence of LTFU was 21% by 12 months and 40% by five years postpartum. Those HIV-diagnosed during pregnancy had lower odds of retention (aOR = 0.58, 95% CI: 0.35 to 0.97) and virological suppression (aOR = 0.50, 95% CI: 0.31 to 0.82) versus those HIV-diagnosed before. Conclusion: HIV diagnosis during pregnancy was associated with poorer 12-month retention and virological suppression. Young women should be tested and linked to HIV care earlier to narrow these disparities.HIV care continuumHIV epidemiologyLatin America and the Caribbean (Region)RetentionVertical transmissionWomeninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/47831/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALTiming_Ruth_Friedman_etal_INI_2021.pdfTiming_Ruth_Friedman_etal_INI_2021.pdfapplication/pdf218502https://www.arca.fiocruz.br/bitstream/icict/47831/2/Timing_Ruth_Friedman_etal_INI_2021.pdff005fc461f12492b134f34b4bcfb6840MD52TEXTTiming_Ruth_Friedman_etal_INI_2021.pdf.txtTiming_Ruth_Friedman_etal_INI_2021.pdf.txtExtracted texttext/plain41595https://www.arca.fiocruz.br/bitstream/icict/47831/3/Timing_Ruth_Friedman_etal_INI_2021.pdf.txt7c00368871ab986a5a95b969ce890c12MD53icict/478312021-06-23 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| dc.title.pt_BR.fl_str_mv |
Timing of HIV diagnosis relative to pregnancy and postpartum HIV care continuum outcomes among Latin American women, 2000 to 2017 |
| title |
Timing of HIV diagnosis relative to pregnancy and postpartum HIV care continuum outcomes among Latin American women, 2000 to 2017 |
| spellingShingle |
Timing of HIV diagnosis relative to pregnancy and postpartum HIV care continuum outcomes among Latin American women, 2000 to 2017 Yohannes, Nathaniel T. HIV care continuum HIV epidemiology Latin America and the Caribbean (Region) Retention Vertical transmission Women |
| title_short |
Timing of HIV diagnosis relative to pregnancy and postpartum HIV care continuum outcomes among Latin American women, 2000 to 2017 |
| title_full |
Timing of HIV diagnosis relative to pregnancy and postpartum HIV care continuum outcomes among Latin American women, 2000 to 2017 |
| title_fullStr |
Timing of HIV diagnosis relative to pregnancy and postpartum HIV care continuum outcomes among Latin American women, 2000 to 2017 |
| title_full_unstemmed |
Timing of HIV diagnosis relative to pregnancy and postpartum HIV care continuum outcomes among Latin American women, 2000 to 2017 |
| title_sort |
Timing of HIV diagnosis relative to pregnancy and postpartum HIV care continuum outcomes among Latin American women, 2000 to 2017 |
| author |
Yohannes, Nathaniel T. |
| author_facet |
Yohannes, Nathaniel T. Jenkins, Cathy A. Clouse, Kate Cortés, Claudia P. Cordero, Fernando Mejía Padgett, Denis Rouzier, Vanessa Friedman, Ruth K. McGowan, Catherine C. Shepherd, Bryan E. Rebeiro, Peter F. |
| author_role |
author |
| author2 |
Jenkins, Cathy A. Clouse, Kate Cortés, Claudia P. Cordero, Fernando Mejía Padgett, Denis Rouzier, Vanessa Friedman, Ruth K. McGowan, Catherine C. Shepherd, Bryan E. Rebeiro, Peter F. |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Yohannes, Nathaniel T. Jenkins, Cathy A. Clouse, Kate Cortés, Claudia P. Cordero, Fernando Mejía Padgett, Denis Rouzier, Vanessa Friedman, Ruth K. McGowan, Catherine C. Shepherd, Bryan E. Rebeiro, Peter F. |
| dc.subject.en.pt_BR.fl_str_mv |
HIV care continuum HIV epidemiology Latin America and the Caribbean (Region) Retention Vertical transmission Women |
| topic |
HIV care continuum HIV epidemiology Latin America and the Caribbean (Region) Retention Vertical transmission Women |
| description |
Vanderbilt University School of Medicine. Nashville, TN, USA. |
| publishDate |
2021 |
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2021-06-22T12:33:46Z |
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2021-06-22T12:33:46Z |
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2021 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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YOHANNES, Nathaniel T. et al. Timing of HIV diagnosis relative to pregnancy and postpartum HIV care continuum outcomes among Latin American women, 2000 to 2017. Journal of the International AIDS Society, v. 24, n. 5, p. 1-8, 2021 |
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https://www.arca.fiocruz.br/handle/icict/47831 |
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1758-2652 |
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10.1002/jia2.25740 |
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YOHANNES, Nathaniel T. et al. Timing of HIV diagnosis relative to pregnancy and postpartum HIV care continuum outcomes among Latin American women, 2000 to 2017. Journal of the International AIDS Society, v. 24, n. 5, p. 1-8, 2021 1758-2652 10.1002/jia2.25740 |
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Wiley |
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