Experimental benznidazole treatment of Trypanosoma cruzi II strains isolated from children of the Jequitinhonha Valley, Minas Gerais, Brazil, with Chagas disease
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/12567 |
Resumo: | Universidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Núcleo de Pesquisas em Ciências Biológicas. Ouro Preto, MG, Brasil |
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Silva, Jaquelline Carla Valamiel de OliveiraAssis, Girley Francisco Machado deOliveira, Maykon TavaresPaiva, Nívia Carolina NogueiraAraújo, Márcio Sobreira SilvaCarneiro, Cláudia MartinsMartins Filho, Olindo AssisMartins, Helen RodriguesLana, Marta de2016-01-20T14:27:56Z2016-01-20T14:27:56Z2015SILVA, Jaquelline Carla Valamiel de Oliveira et al. Experimental benznidazole treatment of Trypanosoma cruzi II strains isolated from children of the Jequitinhonha Valley, Minas Gerais, Brazil, with Chagas disease. Mem Inst Oswaldo Cruz, Vol. 110, n. 1, p. 86-94, 2015.0074-0276https://www.arca.fiocruz.br/handle/icict/1256710.1590/0074-02760140260engFundação Oswaldo CruzExperimental benznidazole treatment of Trypanosoma cruzi II strains isolated from children of the Jequitinhonha Valley, Minas Gerais, Brazil, with Chagas diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Núcleo de Pesquisas em Ciências Biológicas. Ouro Preto, MG, BrasilUniversidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Núcleo de Pesquisas em Ciências Biológicas. Ouro Preto, MG, BrasilUniversidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Núcleo de Pesquisas em Ciências Biológicas. Ouro Preto, MG, BrasilUniversidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Núcleo de Pesquisas em Ciências Biológicas. Ouro Preto, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Belo Horizonte, MG, BrasilUniversidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Núcleo de Pesquisas em Ciências Biológicas. Ouro Preto, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Belo Horizonte, MG, BrasilUniversidade Federal dos Vales do Jequitinhonha e Mucuri. Faculdade de Ciências Biológicas e da Saúde. Departamento de Farmácia. Teófilo Otoni, MG, BrasilUniversidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Núcleo de Pesquisas em Ciências Biológicas. Ouro Preto, MG, Brasil/Universidade Federal de Ouro Preto. Escola de Farmácia. Departamento de Análises Clínicas. Ouro Preto, MG, BrasilTrypanosoma cruzi strains from distinct geographic areas show differences in drug resistance and association between parasites genetic and treatment response has been observed. Considering that benznidazole (BZ) can reduce the parasite burden and tissues damage, even in not cured animals and individuals, the goal is to assess the drug response to BZ of T. cruzi II strains isolated from children of the Jequitinhonha Valley, state of Minas Gerais, Brazil, before treatment. Mice infected and treated with BZ in both phases of infection were compared with the untreated and evaluated by fresh blood examination, haemoculture, polymerase chain reaction, conventional (ELISA) and non-conventional (FC-ALTA) serologies. In mice treated in the acute phase, a significant decrease in parasitaemia was observed for all strains. Positive parasitological and/or serological tests in animals treated during the acute and chronic (95.1-100%) phases showed that most of the strains were BZ resistant. However, beneficial effect was demonstrated because significant reduction (p < 0.05%) and/or suppression of parasitaemia was observed in mice infected with all strains (acute phase), associated to reduction/elimination of inflammation and fibrosis for two/eight strains. BZ offered some benefit, even in not cured animals, what suggest that BZ use may be recommended at least for recent chronic infection of the studied region.Trypanosoma cruzi IIbenznidazole responseacute and chronic phasesmurine modelJequitinhonha Valley - MG - Brazilinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/12567/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALExperimental benznidazole Chagas disease..pdfExperimental benznidazole Chagas disease..pdfapplication/pdf5919537https://www.arca.fiocruz.br/bitstream/icict/12567/2/Experimental%20benznidazole%20%20Chagas%20disease..pdfc442b6236a7b2c26315eb8b72af46462MD52TEXTExperimental benznidazole Chagas disease..pdf.txtExperimental benznidazole Chagas disease..pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Experimental benznidazole treatment of Trypanosoma cruzi II strains isolated from children of the Jequitinhonha Valley, Minas Gerais, Brazil, with Chagas disease |
| title |
Experimental benznidazole treatment of Trypanosoma cruzi II strains isolated from children of the Jequitinhonha Valley, Minas Gerais, Brazil, with Chagas disease |
| spellingShingle |
Experimental benznidazole treatment of Trypanosoma cruzi II strains isolated from children of the Jequitinhonha Valley, Minas Gerais, Brazil, with Chagas disease Silva, Jaquelline Carla Valamiel de Oliveira Trypanosoma cruzi II benznidazole response acute and chronic phases murine model Jequitinhonha Valley - MG - Brazil |
| title_short |
Experimental benznidazole treatment of Trypanosoma cruzi II strains isolated from children of the Jequitinhonha Valley, Minas Gerais, Brazil, with Chagas disease |
| title_full |
Experimental benznidazole treatment of Trypanosoma cruzi II strains isolated from children of the Jequitinhonha Valley, Minas Gerais, Brazil, with Chagas disease |
| title_fullStr |
Experimental benznidazole treatment of Trypanosoma cruzi II strains isolated from children of the Jequitinhonha Valley, Minas Gerais, Brazil, with Chagas disease |
| title_full_unstemmed |
Experimental benznidazole treatment of Trypanosoma cruzi II strains isolated from children of the Jequitinhonha Valley, Minas Gerais, Brazil, with Chagas disease |
| title_sort |
Experimental benznidazole treatment of Trypanosoma cruzi II strains isolated from children of the Jequitinhonha Valley, Minas Gerais, Brazil, with Chagas disease |
| author |
Silva, Jaquelline Carla Valamiel de Oliveira |
| author_facet |
Silva, Jaquelline Carla Valamiel de Oliveira Assis, Girley Francisco Machado de Oliveira, Maykon Tavares Paiva, Nívia Carolina Nogueira Araújo, Márcio Sobreira Silva Carneiro, Cláudia Martins Martins Filho, Olindo Assis Martins, Helen Rodrigues Lana, Marta de |
| author_role |
author |
| author2 |
Assis, Girley Francisco Machado de Oliveira, Maykon Tavares Paiva, Nívia Carolina Nogueira Araújo, Márcio Sobreira Silva Carneiro, Cláudia Martins Martins Filho, Olindo Assis Martins, Helen Rodrigues Lana, Marta de |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Silva, Jaquelline Carla Valamiel de Oliveira Assis, Girley Francisco Machado de Oliveira, Maykon Tavares Paiva, Nívia Carolina Nogueira Araújo, Márcio Sobreira Silva Carneiro, Cláudia Martins Martins Filho, Olindo Assis Martins, Helen Rodrigues Lana, Marta de |
| dc.subject.en.pt_BR.fl_str_mv |
Trypanosoma cruzi II benznidazole response acute and chronic phases murine model Jequitinhonha Valley - MG - Brazil |
| topic |
Trypanosoma cruzi II benznidazole response acute and chronic phases murine model Jequitinhonha Valley - MG - Brazil |
| description |
Universidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Núcleo de Pesquisas em Ciências Biológicas. Ouro Preto, MG, Brasil |
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2015 |
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2015 |
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2016-01-20T14:27:56Z |
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2016-01-20T14:27:56Z |
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SILVA, Jaquelline Carla Valamiel de Oliveira et al. Experimental benznidazole treatment of Trypanosoma cruzi II strains isolated from children of the Jequitinhonha Valley, Minas Gerais, Brazil, with Chagas disease. Mem Inst Oswaldo Cruz, Vol. 110, n. 1, p. 86-94, 2015. |
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https://www.arca.fiocruz.br/handle/icict/12567 |
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0074-0276 |
| dc.identifier.doi.none.fl_str_mv |
10.1590/0074-02760140260 |
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SILVA, Jaquelline Carla Valamiel de Oliveira et al. Experimental benznidazole treatment of Trypanosoma cruzi II strains isolated from children of the Jequitinhonha Valley, Minas Gerais, Brazil, with Chagas disease. Mem Inst Oswaldo Cruz, Vol. 110, n. 1, p. 86-94, 2015. 0074-0276 10.1590/0074-02760140260 |
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