Biological activities of the essential oil from the leaves of Lantana montevidensis (Spreng) Briq. in mice

Detalhes bibliográficos
Autor(a) principal: Oliveira, Maria Rayane Correia de
Data de Publicação: 2021
Outros Autores: Silva, Maria Gabriely de Lima, Alcântara, Isabel Sousa, Ribeiro Filho, Jaime, Tintino, Cícera Datiane de Morais Oliveira, Magalhães, Francisco Ernani Alves, Martins, Anita Oliveira Brito Pereira Bezerra, Pessoa, Renata Torres, Duarte, Antonia Eliene, Costa, José Galberto Martins da, Lima, Sidney Gonçalo de, Coutinho, Henrique Douglas Melo, Capasso, Raffaele, Menezes, Irwin Rose Alencar de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/46589
Resumo: Ribeiro Filho, Jaime. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. “Documento protegido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
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spelling Oliveira, Maria Rayane Correia deSilva, Maria Gabriely de LimaAlcântara, Isabel SousaRibeiro Filho, JaimeTintino, Cícera Datiane de Morais OliveiraMagalhães, Francisco Ernani AlvesMartins, Anita Oliveira Brito Pereira BezerraPessoa, Renata TorresDuarte, Antonia ElieneCosta, José Galberto Martins daLima, Sidney Gonçalo deCoutinho, Henrique Douglas MeloCapasso, RaffaeleMenezes, Irwin Rose Alencar de2021-04-09T13:51:39Z2021-04-09T13:51:39Z2021OLIVEIRA, Maria Rayane Correia de et al. Biological activities of the essential oil from the leaves of Lantana montevidensis (Spreng) Briq. in mice. Environment, Development and Sustainability, 2021.1387-585Xhttps://www.arca.fiocruz.br/handle/icict/4658910.1007/s10668-021-01281-8Ribeiro Filho, Jaime. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. “Documento protegido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES)—Finance Code 001, Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico (FUNCAP)—Finance Code BPI and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Financiadora de Estudos e Projetos—Brasil (FINEP).Regional University of Cariri. Laboratory of Pharmacology and Molecular Chemistry. Department of Biological Chemistry. Crato, CE, Brazil.Regional University of Cariri. Laboratory of Pharmacology and Molecular Chemistry. Department of Biological Chemistry. Crato, CE, Brazil.Regional University of Cariri. Laboratory of Pharmacology and Molecular Chemistry. Department of Biological Chemistry. Crato, CE, Brazil.Regional University of Cariri. Laboratory of Pharmacology and Molecular Chemistry. Department of Biological Chemistry. Crato, CE, Brazil.Federal University of Pernambuco. Laboratory of Pharmacotoxicological Prospecting of Bioactive Products. Department of Antibiotics. Recife, PE, Brazil.State University of Ceará. Center of Education, Sciences and Technology of the Inhamuns Region. Laboratory of Bioprospecting of Natural Products and Biotechnology. Tauá, CE, Brazil.Regional University of Cariri. Laboratory of Pharmacology and Molecular Chemistry. Department of Biological Chemistry. Crato, CE, Brazil.Regional University of Cariri. Laboratory of Pharmacology and Molecular Chemistry. Department of Biological Chemistry. Crato, CE, Brazil.Center for Biological and Health Sciences. Department of Biological Sciences. Crato, CE, Brazil.Regional University of Cariri. Laboratory of Prospecting of Natural Products, Department of Biological Chemistry. Crato, CE, Brazil.Federal University of Piauí. Center for Natural Sciences. Laboratory of Organic Geochemistry. Teresina, PI, Brazil.Regional University of Cariri. , Department of Biological Chemistry. Laboratory of Microbiology and Molecular Biology. Crato, CE, Brazil.University of Naples Federico II. Department of Agricultural Sciences. Portici, Italy.Regional University of Cariri. Laboratory of Pharmacology and Molecular Chemistry. Department of Biological Chemistry. Crato, CE, Brazil.This work aimed to analyze the chemical composition and evaluate the anti-inflammatory and antinociceptive properties of the essential oil obtained from the leaves of Lantana montevidensis (OEFLM) in mice. The chemical composition of the OEFLM was analyzed by GC–MS, and its effects on the central nervous system were determined by the open field and rotarod tests. The antinociceptive and anti-inflammatory screenings were conducted using the formalin test, as well as the acetic acid-induced abdominal contortion assay. The antinociceptive activity was assessed by the tail-flick and hot plate tests. The systemic anti-inflammatory activity was determined using models of paw edema induced by carrageenan, dextran, histamine, or arachidonic acid. The effects of the essential oil on vascular permeability and granuloma formation were also investigated. The chemical composition of the OEFLM revealed the presence of valencene (17.93%), bicyclogermacrene (16.35%), trans-caryophyllene (12.84%) and germacrene D (12.18%). The administration of OEFLM at the dose of 2000 mg/Kg caused no evident toxicity. While OEFLM (25, 50, 100, and 200 mg/kg) did not present significant anxiolytic-loke or sedative effects, it showed promising antinociceptive and anti-inflammatory activities. The results of this study indicate that the OEFLM has analgesic and anti-inflammatory activities in animal models by inhibiting acute and chronic inflammation.engSpringerLantanaInflamaçãoÁcido AraquidônicoHistaminaCamundongosEssential oil ·Lantana montevidensis ·Anti-inflammatory activity ·Antinociceptive activityBiological activities of the essential oil from the leaves of Lantana montevidensis (Spreng) Briq. in miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/46589/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALOliveira, Maria Rayne C Biological Activities ....pdfOliveira, Maria Rayne C Biological Activities 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dc.title.pt_BR.fl_str_mv Biological activities of the essential oil from the leaves of Lantana montevidensis (Spreng) Briq. in mice
title Biological activities of the essential oil from the leaves of Lantana montevidensis (Spreng) Briq. in mice
spellingShingle Biological activities of the essential oil from the leaves of Lantana montevidensis (Spreng) Briq. in mice
Oliveira, Maria Rayane Correia de
Lantana
Inflamação
Ácido Araquidônico
Histamina
Camundongos
Essential oil ·
Lantana montevidensis ·
Anti-inflammatory activity ·
Antinociceptive activity
title_short Biological activities of the essential oil from the leaves of Lantana montevidensis (Spreng) Briq. in mice
title_full Biological activities of the essential oil from the leaves of Lantana montevidensis (Spreng) Briq. in mice
title_fullStr Biological activities of the essential oil from the leaves of Lantana montevidensis (Spreng) Briq. in mice
title_full_unstemmed Biological activities of the essential oil from the leaves of Lantana montevidensis (Spreng) Briq. in mice
title_sort Biological activities of the essential oil from the leaves of Lantana montevidensis (Spreng) Briq. in mice
author Oliveira, Maria Rayane Correia de
author_facet Oliveira, Maria Rayane Correia de
Silva, Maria Gabriely de Lima
Alcântara, Isabel Sousa
Ribeiro Filho, Jaime
Tintino, Cícera Datiane de Morais Oliveira
Magalhães, Francisco Ernani Alves
Martins, Anita Oliveira Brito Pereira Bezerra
Pessoa, Renata Torres
Duarte, Antonia Eliene
Costa, José Galberto Martins da
Lima, Sidney Gonçalo de
Coutinho, Henrique Douglas Melo
Capasso, Raffaele
Menezes, Irwin Rose Alencar de
author_role author
author2 Silva, Maria Gabriely de Lima
Alcântara, Isabel Sousa
Ribeiro Filho, Jaime
Tintino, Cícera Datiane de Morais Oliveira
Magalhães, Francisco Ernani Alves
Martins, Anita Oliveira Brito Pereira Bezerra
Pessoa, Renata Torres
Duarte, Antonia Eliene
Costa, José Galberto Martins da
Lima, Sidney Gonçalo de
Coutinho, Henrique Douglas Melo
Capasso, Raffaele
Menezes, Irwin Rose Alencar de
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Oliveira, Maria Rayane Correia de
Silva, Maria Gabriely de Lima
Alcântara, Isabel Sousa
Ribeiro Filho, Jaime
Tintino, Cícera Datiane de Morais Oliveira
Magalhães, Francisco Ernani Alves
Martins, Anita Oliveira Brito Pereira Bezerra
Pessoa, Renata Torres
Duarte, Antonia Eliene
Costa, José Galberto Martins da
Lima, Sidney Gonçalo de
Coutinho, Henrique Douglas Melo
Capasso, Raffaele
Menezes, Irwin Rose Alencar de
dc.subject.other.pt_BR.fl_str_mv Lantana
Inflamação
Ácido Araquidônico
Histamina
Camundongos
topic Lantana
Inflamação
Ácido Araquidônico
Histamina
Camundongos
Essential oil ·
Lantana montevidensis ·
Anti-inflammatory activity ·
Antinociceptive activity
dc.subject.en.pt_BR.fl_str_mv Essential oil ·
Lantana montevidensis ·
Anti-inflammatory activity ·
Antinociceptive activity
description Ribeiro Filho, Jaime. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. “Documento protegido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-04-09T13:51:39Z
dc.date.available.fl_str_mv 2021-04-09T13:51:39Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv OLIVEIRA, Maria Rayane Correia de et al. Biological activities of the essential oil from the leaves of Lantana montevidensis (Spreng) Briq. in mice. Environment, Development and Sustainability, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/46589
dc.identifier.issn.pt_BR.fl_str_mv 1387-585X
dc.identifier.eissn.none.fl_str_mv 10.1007/s10668-021-01281-8
identifier_str_mv OLIVEIRA, Maria Rayane Correia de et al. Biological activities of the essential oil from the leaves of Lantana montevidensis (Spreng) Briq. in mice. Environment, Development and Sustainability, 2021.
1387-585X
10.1007/s10668-021-01281-8
url https://www.arca.fiocruz.br/handle/icict/46589
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
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