Higher values of triglycerides:HDL-cholesterol ratio hallmark disease severity in children and adolescents with sickle cell anemia
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/37019 |
Resumo: | Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB) under the number 020/201 – Research Program: Shared Health Management – (PPSUS) of Bahia award number: EFP00006943. This study was also financed in part by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) (Finance Code 001). The work of B.B.A. was supported by a grant from NIH (U01AI115940). B.B.A. is a senior scientist of the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Brazil (Bolsa de Produtividade). M.B.A. and P.S.S.M. were supported by PhD fellowships from the Fundac¸ão de Amparo à Pesquisa do Estado da Bahia (FAPESB). |
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Teixeira, Rozana SantosArriaga Gutiérrez, María BelenRamos, Regina TerseFerreira, Tatiane AnunciaçãoMachado, Vinícius RamosLago, M. R. RissattoMattos, Paulo Sérgio de Morais da SilveiraBoa-Sorte, NeyLadeia, Ana Marice TeixeiraAndrade, Bruno de Bezerril2019-11-13T12:46:29Z2019-11-13T12:46:29Z2019TEIXEIRA, Rozana Santos et al. Higher values of triglycerides:HDL-cholesterol ratio hallmark disease severity in children and adolescents with sickle cell anemia. Brazilian Journal of Medical and Biological Research, v. 52, n. 10, p. 1-9, 2019.0100-879Xhttps://www.arca.fiocruz.br/handle/icict/3701910.1590/1414-431X20198833Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB) under the number 020/201 – Research Program: Shared Health Management – (PPSUS) of Bahia award number: EFP00006943. This study was also financed in part by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) (Finance Code 001). The work of B.B.A. was supported by a grant from NIH (U01AI115940). B.B.A. is a senior scientist of the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Brazil (Bolsa de Produtividade). M.B.A. and P.S.S.M. were supported by PhD fellowships from the Fundac¸ão de Amparo à Pesquisa do Estado da Bahia (FAPESB).Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Departamento de Pediatria. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Medicina. Departamento de Pediatria. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Medicina. Departamento de Pediatria. Salvador, BA, Brasil.Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Universidade Estadual da Bahia. Departamento de Ciências da Vida.Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil.Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Universidade Estadual da Bahia. Departamento de Ciências da Vida.Salvador, BA, Brasil.Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil / Universidade Salvador. Laureate International Universities. Salvador, BA, Brasil.Dyslipidemia has been described in sickle cell anemia (SCA) but its association with increased disease severity is unknown. Here, we examined 55 children and adolescents with SCA as well as 41 healthy controls to test the association between the lipid profiles in peripheral blood and markers of hemolysis, inflammation, endothelial function, and SCA-related clinical outcomes. SCA patients exhibited lower levels of total cholesterol (P<0.001), low-density lipoprotein cholesterol (LDL-c) (P<0.001), and high-density lipoprotein cholesterol (HDL-c) (P<0.001), while displaying higher triglyceride (TG) levels and TG/HDL-c ratio values (P<0.001). TG/HDL-c values were positively correlated with lactate dehydrogenase (P=0.047), leukocyte count (P=0.006), and blood flow velocity in the right (P=0.02) and left (P=0.05) cerebral artery, while being negatively correlated with hemoglobin levels (P<0.04). Acute chest syndrome (ACS) and vaso-occlusive events (VOE) were more frequent in SCA patients exhibiting higher TG/HDL-c values (odds ratio: 3.77, P=0.027). Multivariate logistic regression analysis confirmed independent associations between elevated TG/HDL-c values and SCA. Thus, children and adolescents with SCA exhibited a lipid profile associated with hemolysis and inflammatory parameters, with increased risk of ACS and VOE. TG/HDL-c is a potential biomarker of severity of disease.porAssociação Brasileira de Divulgação CientíficaDoença falciformeLipoproteínasColesterolTriglicerídeosHidroxiureiaFunção endotelialSickle cell diseaseLipoproteinsCholesterolTriglyceridesHydroxyureaEndothelial functionHigher values of triglycerides:HDL-cholesterol ratio hallmark disease severity in children and adolescents with sickle cell anemiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/37019/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALTeixeira, S.R. Higher....pdfTeixeira, S.R. Higher....pdfapplication/pdf541994https://www.arca.fiocruz.br/bitstream/icict/37019/2/Teixeira%2c%20S.R.%20Higher....pdf9a12a9e1a81f69328d79a10349021f56MD52TEXTTeixeira, S.R. 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dc.title.pt_BR.fl_str_mv |
Higher values of triglycerides:HDL-cholesterol ratio hallmark disease severity in children and adolescents with sickle cell anemia |
title |
Higher values of triglycerides:HDL-cholesterol ratio hallmark disease severity in children and adolescents with sickle cell anemia |
spellingShingle |
Higher values of triglycerides:HDL-cholesterol ratio hallmark disease severity in children and adolescents with sickle cell anemia Teixeira, Rozana Santos Doença falciforme Lipoproteínas Colesterol Triglicerídeos Hidroxiureia Função endotelial Sickle cell disease Lipoproteins Cholesterol Triglycerides Hydroxyurea Endothelial function |
title_short |
Higher values of triglycerides:HDL-cholesterol ratio hallmark disease severity in children and adolescents with sickle cell anemia |
title_full |
Higher values of triglycerides:HDL-cholesterol ratio hallmark disease severity in children and adolescents with sickle cell anemia |
title_fullStr |
Higher values of triglycerides:HDL-cholesterol ratio hallmark disease severity in children and adolescents with sickle cell anemia |
title_full_unstemmed |
Higher values of triglycerides:HDL-cholesterol ratio hallmark disease severity in children and adolescents with sickle cell anemia |
title_sort |
Higher values of triglycerides:HDL-cholesterol ratio hallmark disease severity in children and adolescents with sickle cell anemia |
author |
Teixeira, Rozana Santos |
author_facet |
Teixeira, Rozana Santos Arriaga Gutiérrez, María Belen Ramos, Regina Terse Ferreira, Tatiane Anunciação Machado, Vinícius Ramos Lago, M. R. Rissatto Mattos, Paulo Sérgio de Morais da Silveira Boa-Sorte, Ney Ladeia, Ana Marice Teixeira Andrade, Bruno de Bezerril |
author_role |
author |
author2 |
Arriaga Gutiérrez, María Belen Ramos, Regina Terse Ferreira, Tatiane Anunciação Machado, Vinícius Ramos Lago, M. R. Rissatto Mattos, Paulo Sérgio de Morais da Silveira Boa-Sorte, Ney Ladeia, Ana Marice Teixeira Andrade, Bruno de Bezerril |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Teixeira, Rozana Santos Arriaga Gutiérrez, María Belen Ramos, Regina Terse Ferreira, Tatiane Anunciação Machado, Vinícius Ramos Lago, M. R. Rissatto Mattos, Paulo Sérgio de Morais da Silveira Boa-Sorte, Ney Ladeia, Ana Marice Teixeira Andrade, Bruno de Bezerril |
dc.subject.other.pt_BR.fl_str_mv |
Doença falciforme Lipoproteínas Colesterol Triglicerídeos Hidroxiureia Função endotelial |
topic |
Doença falciforme Lipoproteínas Colesterol Triglicerídeos Hidroxiureia Função endotelial Sickle cell disease Lipoproteins Cholesterol Triglycerides Hydroxyurea Endothelial function |
dc.subject.en.pt_BR.fl_str_mv |
Sickle cell disease Lipoproteins Cholesterol Triglycerides Hydroxyurea Endothelial function |
description |
Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB) under the number 020/201 – Research Program: Shared Health Management – (PPSUS) of Bahia award number: EFP00006943. This study was also financed in part by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) (Finance Code 001). The work of B.B.A. was supported by a grant from NIH (U01AI115940). B.B.A. is a senior scientist of the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Brazil (Bolsa de Produtividade). M.B.A. and P.S.S.M. were supported by PhD fellowships from the Fundac¸ão de Amparo à Pesquisa do Estado da Bahia (FAPESB). |
publishDate |
2019 |
dc.date.accessioned.fl_str_mv |
2019-11-13T12:46:29Z |
dc.date.available.fl_str_mv |
2019-11-13T12:46:29Z |
dc.date.issued.fl_str_mv |
2019 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
TEIXEIRA, Rozana Santos et al. Higher values of triglycerides:HDL-cholesterol ratio hallmark disease severity in children and adolescents with sickle cell anemia. Brazilian Journal of Medical and Biological Research, v. 52, n. 10, p. 1-9, 2019. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/37019 |
dc.identifier.issn.pt_BR.fl_str_mv |
0100-879X |
dc.identifier.doi.none.fl_str_mv |
10.1590/1414-431X20198833 |
identifier_str_mv |
TEIXEIRA, Rozana Santos et al. Higher values of triglycerides:HDL-cholesterol ratio hallmark disease severity in children and adolescents with sickle cell anemia. Brazilian Journal of Medical and Biological Research, v. 52, n. 10, p. 1-9, 2019. 0100-879X 10.1590/1414-431X20198833 |
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https://www.arca.fiocruz.br/handle/icict/37019 |
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Associação Brasileira de Divulgação Científica |
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Associação Brasileira de Divulgação Científica |
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