HTLV-1 decreases Th2 type of immune response in patients with strongyloidiasis.

Detalhes bibliográficos
Autor(a) principal: Porto, Maria Aurélia da Fonseca
Data de Publicação: 2001
Outros Autores: Neva, Franklin A, Bittencourt, Helito Mascarenhas, Lisboa, Waldir, Thompson, Robert, Alcantara, Luiz Carlos Júnior, Carvalho Filho, Edgar Marcelino
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/9487
Resumo: Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil
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spelling Porto, Maria Aurélia da FonsecaNeva, Franklin ABittencourt, Helito MascarenhasLisboa, WaldirThompson, RobertAlcantara, Luiz Carlos JúniorCarvalho Filho, Edgar Marcelino2015-02-11T14:09:32Z2015-02-11T14:09:32Z2001PORTO, A. F. et al. HTLV-1 decreases Th2 type of immune response in patients with strongyloidiasis. Parasite Immunology, v. 23, n. 9, p. 503-507, 20010141-9838https://www.arca.fiocruz.br/handle/icict/9487engWileyHTLV-1 decreases Th2 type of immune response in patients with strongyloidiasis.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilNational Institute of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Parasitic Diseases. Bethesda, MD, USAInstituto de Gastroenterologia e Hepatologia. Salvador, BA, BrasilServiço de Transfusão de Sangue. Salvador, BA, BrasilNational Institute of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Parasitic Diseases. Bethesda, MD, USAFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilEosinophils, immunoglobilin (Ig)E and cytokines have important roles in defence mechanisms against helminths. In this study, the influence of HTLV-1 infection, characterized by a Th1 type of immune response, was evaluated on the cytokine pattern and parasitic specific IgE response in patients with strongyloidiasis. Patients were divided into four groups: strongyloidiasis without HTLV-1 infection, strongyloidiasis with HTLV-1, HTLV-1 without strongyloidiasis and controls without either helminth infection or HTLV-1. The cytokine profile was determined in supernatants of mononuclear cells stimulated with Strongyloides stercoralis crude antigen and the parasite specific IgE was measured by ELISA. Patients coinfected with HTLV-1 had higher levels of interfron (IFN)-g and interleukin (IL)-10 (P , 0´05) and lower levels of IL-5 and IgE (P , 0´05) than patients with strongyloidiasis without HTLV-1. There was an inverse relationship between IFN-g and IL-5 (P 0´01; rs 2 0´37) and between IFN-g and parasite specific IgE (P 0´01; rs 2 0´39), and a direct relationship between IFN-g and IL-10 (P 0´04; rs 0´35). These data show that coinfection with HTLV-1 decreases IL-5 and IgE responses in patients with strongyloidiasis consistent with a relative switch from Th2 to Th1 response. Immunological responses such as these are important in the control of this helminthic infection.HTLV-1StrongyloidiasisIgES. stercoralisCitocinas/sangueInfecções por HTLV-I/imunologiaStrongyloides stercoralis/imunologiaEstrongiloidíase/imunologiaCélulas Th2/imunologiaAdultoAnimaisAnticorpos Anti-Helmínticos/sangueCélulas CultivadasCitocinas/biossínteseInfecções por HTLV-I/sangueVírus 1 Linfotrópico T Humano/imunologiaHumanosImunoglobulina E/sangueInterferon gama/sangueInterleucina-10/sangueLeucócitos Mononucleares/citologiaEstrongiloidíase/complicaçõesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/9487/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALPorto A F HTLV-1 Decrease....pdfPorto A F HTLV-1 Decrease....pdfapplication/pdf96066https://www.arca.fiocruz.br/bitstream/icict/9487/2/Porto%20A%20F%20HTLV-1%20Decrease....pdf9378824cadf34a92ec09dfd61d9944fcMD52TEXTPorto A F HTLV-1 Decrease....pdf.txtPorto A F HTLV-1 Decrease....pdf.txtExtracted texttext/plain25719https://www.arca.fiocruz.br/bitstream/icict/9487/3/Porto%20A%20F%20HTLV-1%20Decrease....pdf.txt9e8ea5caec2c26cdd948bd136f6ea016MD53icict/94872023-03-15 14:33:04.597oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:04Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv HTLV-1 decreases Th2 type of immune response in patients with strongyloidiasis.
title HTLV-1 decreases Th2 type of immune response in patients with strongyloidiasis.
spellingShingle HTLV-1 decreases Th2 type of immune response in patients with strongyloidiasis.
Porto, Maria Aurélia da Fonseca
HTLV-1
Strongyloidiasis
IgE
S. stercoralis
Citocinas/sangue
Infecções por HTLV-I/imunologia
Strongyloides stercoralis/imunologia
Estrongiloidíase/imunologia
Células Th2/imunologia
Adulto
Animais
Anticorpos Anti-Helmínticos/sangue
Células Cultivadas
Citocinas/biossíntese
Infecções por HTLV-I/sangue
Vírus 1 Linfotrópico T Humano/imunologia
Humanos
Imunoglobulina E/sangue
Interferon gama/sangue
Interleucina-10/sangue
Leucócitos Mononucleares/citologia
Estrongiloidíase/complicações
title_short HTLV-1 decreases Th2 type of immune response in patients with strongyloidiasis.
title_full HTLV-1 decreases Th2 type of immune response in patients with strongyloidiasis.
title_fullStr HTLV-1 decreases Th2 type of immune response in patients with strongyloidiasis.
title_full_unstemmed HTLV-1 decreases Th2 type of immune response in patients with strongyloidiasis.
title_sort HTLV-1 decreases Th2 type of immune response in patients with strongyloidiasis.
author Porto, Maria Aurélia da Fonseca
author_facet Porto, Maria Aurélia da Fonseca
Neva, Franklin A
Bittencourt, Helito Mascarenhas
Lisboa, Waldir
Thompson, Robert
Alcantara, Luiz Carlos Júnior
Carvalho Filho, Edgar Marcelino
author_role author
author2 Neva, Franklin A
Bittencourt, Helito Mascarenhas
Lisboa, Waldir
Thompson, Robert
Alcantara, Luiz Carlos Júnior
Carvalho Filho, Edgar Marcelino
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Porto, Maria Aurélia da Fonseca
Neva, Franklin A
Bittencourt, Helito Mascarenhas
Lisboa, Waldir
Thompson, Robert
Alcantara, Luiz Carlos Júnior
Carvalho Filho, Edgar Marcelino
dc.subject.en.pt_BR.fl_str_mv HTLV-1
Strongyloidiasis
IgE
S. stercoralis
topic HTLV-1
Strongyloidiasis
IgE
S. stercoralis
Citocinas/sangue
Infecções por HTLV-I/imunologia
Strongyloides stercoralis/imunologia
Estrongiloidíase/imunologia
Células Th2/imunologia
Adulto
Animais
Anticorpos Anti-Helmínticos/sangue
Células Cultivadas
Citocinas/biossíntese
Infecções por HTLV-I/sangue
Vírus 1 Linfotrópico T Humano/imunologia
Humanos
Imunoglobulina E/sangue
Interferon gama/sangue
Interleucina-10/sangue
Leucócitos Mononucleares/citologia
Estrongiloidíase/complicações
dc.subject.decs.pt_BR.fl_str_mv Citocinas/sangue
Infecções por HTLV-I/imunologia
Strongyloides stercoralis/imunologia
Estrongiloidíase/imunologia
Células Th2/imunologia
Adulto
Animais
Anticorpos Anti-Helmínticos/sangue
Células Cultivadas
Citocinas/biossíntese
Infecções por HTLV-I/sangue
Vírus 1 Linfotrópico T Humano/imunologia
Humanos
Imunoglobulina E/sangue
Interferon gama/sangue
Interleucina-10/sangue
Leucócitos Mononucleares/citologia
Estrongiloidíase/complicações
description Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil
publishDate 2001
dc.date.issued.fl_str_mv 2001
dc.date.accessioned.fl_str_mv 2015-02-11T14:09:32Z
dc.date.available.fl_str_mv 2015-02-11T14:09:32Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PORTO, A. F. et al. HTLV-1 decreases Th2 type of immune response in patients with strongyloidiasis. Parasite Immunology, v. 23, n. 9, p. 503-507, 2001
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/9487
dc.identifier.issn.none.fl_str_mv 0141-9838
identifier_str_mv PORTO, A. F. et al. HTLV-1 decreases Th2 type of immune response in patients with strongyloidiasis. Parasite Immunology, v. 23, n. 9, p. 503-507, 2001
0141-9838
url https://www.arca.fiocruz.br/handle/icict/9487
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
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