Inosine triphosphatase allele frequency and association with ribavirin-induced anaemia in Brazilian patients receiving antiviral therapy for chronic hepatitis C
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/12636 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil. |
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Delvaux, NatháliaCosta, Vanessa Duarte daCosta, Maristella Matos daVillar, Livia MeloCoelho, Henrique Sérgio MoraesEsberard, Eliane Bordalo CathaláFlores, Priscila PolloMello, Carlos Eduardo BrandãoNogueira, Cristiane Alves VillelaAlmeida, Adilson José deLampe, Elisabeth2016-01-28T10:39:43Z2016-01-28T10:39:43Z2015DELVAUX, Nathália; et al. Inosine triphosphatase allele frequency and association with ribavirin-induced anaemia in Brazilian patients receiving antiviral therapy for chronic hepatitis C. Mem Inst Oswaldo Cruz, v.110, n.5, p.636-643, Aug. 2015.1678-8060https://www.arca.fiocruz.br/handle/icict/1263610.1590/0074-02760150104engFundação Oswaldo CruzInosine triphosphatase allele frequency and association with ribavirin-induced anaemia in Brazilian patients receiving antiviral therapy for chronic hepatitis Cinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Departamento de Hepatologia. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Hospital Universitário Antônio Pedro. Departamento de Gastroenterologia. Niterói, RJ, Brasil.Universidade Federal Fluminense. Hospital Universitário Antônio Pedro. Departamento de Gastroenterologia. Niterói, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffrée e Guinle. Departamento de Medicina Geral. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Departamento de Hepatologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil / Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffrée e Guinle. Departamento de Medicina Geral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil.Inosine triphosphatase (ITPA) single nucleotide polymorphisms (SNPs) are strongly associated with protection against ribavirin (RBV)-induced anaemia in European, American and Asian patients; however, there is a paucity of data for Brazilian patients. The aim of this study was to evaluate the ITPA SNP (rs7270101/rs1127354) frequency in healthy and hepatitis C virus (HCV)-infected patients from Brazil and the association with the development of severe anaemia during antiviral therapy. ITPA SNPs were determined in 200 HCV infected patients and 100 healthy individuals by sequencing. Biochemical parameters and haemoglobin (Hb) levels were analysed in 97 patients who underwent antiviral therapy. A combination of AArs7270101+CCrs1127354 (100% ITPase activity) was observed in 236/300 individuals. Anaemia was observed in 87.5% and 86.2% of treated patients with AA (rs7270101) and CC genotypes (rs1127354), respectively. Men with AA (rs7270101) showed a considerable reduction in Hb at week 12 compared to those with AC/CC (p = 0.1475). In women, there was no influence of genotype (p = 0.5295). For rs1127354, men with the CC genotype also showed a sudden reduction in Hb compared to those with AC. Allelic distribution of rs7270101 and rs1127354 shows high rates of the genotypes AA and CC, respectively, suggesting that the study population had a great propensity for developing RBV-induced anaemia. A progressive Hb reduction during treatment was observed; however, this reduction was greater in men at week 12 than in women.ITPAHepatitis CRibavirinAnaemiaBrazilHepatite CAnemiaRibavirinaBrasilinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/12636/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALelisabeth_lampe_etal_IOC_2015.pdfelisabeth_lampe_etal_IOC_2015.pdfapplication/pdf632287https://www.arca.fiocruz.br/bitstream/icict/12636/2/elisabeth_lampe_etal_IOC_2015.pdf39cd93beb016a0626e497bec365e7943MD52TEXTelisabeth_lampe_etal_IOC_2015.pdf.txtelisabeth_lampe_etal_IOC_2015.pdf.txtExtracted texttext/plain38609https://www.arca.fiocruz.br/bitstream/icict/12636/3/elisabeth_lampe_etal_IOC_2015.pdf.txt09bd2e178ea8841926651fd7d48c3e17MD53icict/126362023-09-05 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| dc.title.pt_BR.fl_str_mv |
Inosine triphosphatase allele frequency and association with ribavirin-induced anaemia in Brazilian patients receiving antiviral therapy for chronic hepatitis C |
| title |
Inosine triphosphatase allele frequency and association with ribavirin-induced anaemia in Brazilian patients receiving antiviral therapy for chronic hepatitis C |
| spellingShingle |
Inosine triphosphatase allele frequency and association with ribavirin-induced anaemia in Brazilian patients receiving antiviral therapy for chronic hepatitis C Delvaux, Nathália ITPA Hepatitis C Ribavirin Anaemia Brazil Hepatite C Anemia Ribavirina Brasil |
| title_short |
Inosine triphosphatase allele frequency and association with ribavirin-induced anaemia in Brazilian patients receiving antiviral therapy for chronic hepatitis C |
| title_full |
Inosine triphosphatase allele frequency and association with ribavirin-induced anaemia in Brazilian patients receiving antiviral therapy for chronic hepatitis C |
| title_fullStr |
Inosine triphosphatase allele frequency and association with ribavirin-induced anaemia in Brazilian patients receiving antiviral therapy for chronic hepatitis C |
| title_full_unstemmed |
Inosine triphosphatase allele frequency and association with ribavirin-induced anaemia in Brazilian patients receiving antiviral therapy for chronic hepatitis C |
| title_sort |
Inosine triphosphatase allele frequency and association with ribavirin-induced anaemia in Brazilian patients receiving antiviral therapy for chronic hepatitis C |
| author |
Delvaux, Nathália |
| author_facet |
Delvaux, Nathália Costa, Vanessa Duarte da Costa, Maristella Matos da Villar, Livia Melo Coelho, Henrique Sérgio Moraes Esberard, Eliane Bordalo Cathalá Flores, Priscila Pollo Mello, Carlos Eduardo Brandão Nogueira, Cristiane Alves Villela Almeida, Adilson José de Lampe, Elisabeth |
| author_role |
author |
| author2 |
Costa, Vanessa Duarte da Costa, Maristella Matos da Villar, Livia Melo Coelho, Henrique Sérgio Moraes Esberard, Eliane Bordalo Cathalá Flores, Priscila Pollo Mello, Carlos Eduardo Brandão Nogueira, Cristiane Alves Villela Almeida, Adilson José de Lampe, Elisabeth |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Delvaux, Nathália Costa, Vanessa Duarte da Costa, Maristella Matos da Villar, Livia Melo Coelho, Henrique Sérgio Moraes Esberard, Eliane Bordalo Cathalá Flores, Priscila Pollo Mello, Carlos Eduardo Brandão Nogueira, Cristiane Alves Villela Almeida, Adilson José de Lampe, Elisabeth |
| dc.subject.en.pt_BR.fl_str_mv |
ITPA Hepatitis C Ribavirin Anaemia Brazil |
| topic |
ITPA Hepatitis C Ribavirin Anaemia Brazil Hepatite C Anemia Ribavirina Brasil |
| dc.subject.decs.pt_BR.fl_str_mv |
Hepatite C Anemia Ribavirina Brasil |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil. |
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2015 |
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2015 |
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2016-01-28T10:39:43Z |
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2016-01-28T10:39:43Z |
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info:eu-repo/semantics/article |
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DELVAUX, Nathália; et al. Inosine triphosphatase allele frequency and association with ribavirin-induced anaemia in Brazilian patients receiving antiviral therapy for chronic hepatitis C. Mem Inst Oswaldo Cruz, v.110, n.5, p.636-643, Aug. 2015. |
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https://www.arca.fiocruz.br/handle/icict/12636 |
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1678-8060 |
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10.1590/0074-02760150104 |
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DELVAUX, Nathália; et al. Inosine triphosphatase allele frequency and association with ribavirin-induced anaemia in Brazilian patients receiving antiviral therapy for chronic hepatitis C. Mem Inst Oswaldo Cruz, v.110, n.5, p.636-643, Aug. 2015. 1678-8060 10.1590/0074-02760150104 |
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