Toward precision medicine of breast cancer

Bibliographic Details
Main Author: Carels, Nicolas
Publication Date: 2016
Other Authors: Spinassé, Lizânia Borges, Tilli, Tatiana Martins, Tuszynski, Jack A.
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
Download full: https://www.arca.fiocruz.br/handle/icict/23750
Summary: Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Laboratório de Modelagem de Sistemas Biológicos. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia de Inovação em Doenças Negligenciadas. Rio de Janeiro, RJ, Brasil.
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spelling Carels, NicolasSpinassé, Lizânia BorgesTilli, Tatiana MartinsTuszynski, Jack A.2017-12-22T13:15:03Z2017-12-22T13:15:03Z2016Carels et al. Toward precision medicine of breast cancer. Theor Biol Med Model, v. 13, n. 7, 2016.1742-4682https://www.arca.fiocruz.br/handle/icict/2375010.1186/s12976-016-0035-4engBioMed Centralcâncer de mamamedicina de precisãoToward precision medicine of breast cancerinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Laboratório de Modelagem de Sistemas Biológicos. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia de Inovação em Doenças Negligenciadas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Laboratório de Modelagem de Sistemas Biológicos. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia de Inovação em Doenças Negligenciadas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Laboratório de Modelagem de Sistemas Biológicos. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia de Inovação em Doenças Negligenciadas. Rio de Janeiro, RJ, Brasil.University of Alberta. Faculty of Medicine & Dentistry. Department of Physics. Department of Oncology. Edmonton, Alberta, Canada.In this review, we report on breast cancer's molecular features and on how high throughput technologies are helping in understanding the dynamics of tumorigenesis and cancer progression with the aim of developing precision medicine methods. We first address the current state of the art in breast cancer therapies and challenges in order to progress towards its cure. Then, we show how the interaction of high-throughput technologies with in silico modeling has led to set up useful inferences for promising strategies of target-specific therapies with low secondary effect incidence for patients. Finally, we discuss the challenge of pharmacogenetics in the clinical practice of cancer therapy. All these issues are explored within the context of precision medicine.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83101https://www.arca.fiocruz.br/bitstream/icict/23750/1/license.txt425ef259bcb460998407fbfed7c102d0MD51ORIGINALCarels_etal_2016.pdfCarels_etal_2016.pdfapplication/pdf1791253https://www.arca.fiocruz.br/bitstream/icict/23750/2/Carels_etal_2016.pdf50b62516c34481941599770d288b65aeMD52TEXTCarels_etal_2016.pdf.txtCarels_etal_2016.pdf.txtExtracted texttext/plain177112https://www.arca.fiocruz.br/bitstream/icict/23750/3/Carels_etal_2016.pdf.txtdfaf6530e19c4df19b3727ce3a1a16faMD53icict/237502023-02-23 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dc.title.pt_BR.fl_str_mv Toward precision medicine of breast cancer
title Toward precision medicine of breast cancer
spellingShingle Toward precision medicine of breast cancer
Carels, Nicolas
câncer de mama
medicina de precisão
title_short Toward precision medicine of breast cancer
title_full Toward precision medicine of breast cancer
title_fullStr Toward precision medicine of breast cancer
title_full_unstemmed Toward precision medicine of breast cancer
title_sort Toward precision medicine of breast cancer
author Carels, Nicolas
author_facet Carels, Nicolas
Spinassé, Lizânia Borges
Tilli, Tatiana Martins
Tuszynski, Jack A.
author_role author
author2 Spinassé, Lizânia Borges
Tilli, Tatiana Martins
Tuszynski, Jack A.
author2_role author
author
author
dc.contributor.author.fl_str_mv Carels, Nicolas
Spinassé, Lizânia Borges
Tilli, Tatiana Martins
Tuszynski, Jack A.
dc.subject.other.pt_BR.fl_str_mv câncer de mama
medicina de precisão
topic câncer de mama
medicina de precisão
description Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Laboratório de Modelagem de Sistemas Biológicos. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia de Inovação em Doenças Negligenciadas. Rio de Janeiro, RJ, Brasil.
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2017-12-22T13:15:03Z
dc.date.available.fl_str_mv 2017-12-22T13:15:03Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv Carels et al. Toward precision medicine of breast cancer. Theor Biol Med Model, v. 13, n. 7, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/23750
dc.identifier.issn.pt_BR.fl_str_mv 1742-4682
dc.identifier.eissn.none.fl_str_mv 10.1186/s12976-016-0035-4
identifier_str_mv Carels et al. Toward precision medicine of breast cancer. Theor Biol Med Model, v. 13, n. 7, 2016.
1742-4682
10.1186/s12976-016-0035-4
url https://www.arca.fiocruz.br/handle/icict/23750
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/23750/1/license.txt
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