T-cell responses associated with resistance to Leishmania infection in individuals from endemic areas for Leishmania (Viannia) braziliensis

Detalhes bibliográficos
Autor(a) principal: Bittar, Rita C.
Data de Publicação: 2007
Outros Autores: Nogueira, Ricardo S., Gonçalves, Ricardo Vieira, Ribeiro, Vanessa Pinho, Mattos, Marise S., Oliveira Neto, Manoel Paes, Coutinho, Sergio G., Cruz, Alda M. da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/44579
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.
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spelling Bittar, Rita C.Nogueira, Ricardo S.Gonçalves, Ricardo VieiraRibeiro, Vanessa PinhoMattos, Marise S.Oliveira Neto, Manoel PaesCoutinho, Sergio G.Cruz, Alda M. da2020-11-22T19:58:36Z2020-11-22T19:58:36Z2007BITTAR, Rita C. et al. T-cell responses associated with resistance to Leishmania infection in individuals from endemic areas for Leishmania (Viannia) braziliensis. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 102, n. 5, p. 625-630, Aug. 2007.0074-0276https://www.arca.fiocruz.br/handle/icict/4457910.1590/S0074-027620070050000691678-8060engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.Leishmania (Viannia) braziliensisInfecção assintomáticaLeishmaniose curadaCitocinasSubconjuntos de células TImunidade a longo prazoAsymptomatic infectionLeishmania (Viannia) braziliensisCured leishmaniasisCytokinesT-cell subsetsLong term immunityT-cell responses associated with resistance to Leishmania infection in individuals from endemic areas for Leishmania (Viannia) braziliensisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Subclinical or asymptomatic infection is documented in individuals living in endemic areas for leishmaniasis suggesting that the development of an appropriate immune response can control parasite replication and maintain tissue integrity. A low morbidity indicates that intrinsic factors could favor resistance to Leishmania infection. Herein, leishmanial T-cell responses induced in subjects with low susceptibility to leishmaniasis as asymptomatic subjects were compared to those observed in cured cutaneous leishmaniasis (CCL) patients, who controlled the disease after antimonial therapy. All of them have shown maintenance of specific long-term immune responses characterized by expansion of higher proportions of CD4+ as compared to CD8+ Leishmania reactive T-lymphocytes. Asymptomatic subjects had lower indexes of in vitro Leishmania induced lymphoproliferative responses and interferon-gamma (IFN-γ) production in comparison to CCL patients. On the other hand, interleukin (IL-10) production was much higher in asymptomatics than in CCL, while no differences in IL-5 levels were found. In conclusion, long lived T-cell responses achieved by asymptomatic individuals differed from those who had developed symptomatic leishmaniasis in terms of intensity of lymphocyte activation (proliferation or IFN-γ) and regulatory mechanisms (IL-10). The absence of the disease in asymptomatics could be explained by their intrinsic ability to create a balance between immunoregulatory (IL-10) and effector cytokines (IFN-γ), leading to parasite destruction without producing skin tissue damage. The establishment of profiles of cell-mediated immune responses associated with resistance against Leishmania infection is likely to make new inroads into understanding the long-lived immune protection against the disease.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/44579/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALRitaCBittar_AldaMCruz_etal_IOC_2007.pdfRitaCBittar_AldaMCruz_etal_IOC_2007.pdfapplication/pdf159465https://www.arca.fiocruz.br/bitstream/icict/44579/2/RitaCBittar_AldaMCruz_etal_IOC_2007.pdfcd44419e0b6bd74334608505a7763fb5MD52TEXTRitaCBittar_AldaMCruz_etal_IOC_2007.pdf.txtRitaCBittar_AldaMCruz_etal_IOC_2007.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv T-cell responses associated with resistance to Leishmania infection in individuals from endemic areas for Leishmania (Viannia) braziliensis
title T-cell responses associated with resistance to Leishmania infection in individuals from endemic areas for Leishmania (Viannia) braziliensis
spellingShingle T-cell responses associated with resistance to Leishmania infection in individuals from endemic areas for Leishmania (Viannia) braziliensis
Bittar, Rita C.
Leishmania (Viannia) braziliensis
Infecção assintomática
Leishmaniose curada
Citocinas
Subconjuntos de células T
Imunidade a longo prazo
Asymptomatic infection
Leishmania (Viannia) braziliensis
Cured leishmaniasis
Cytokines
T-cell subsets
Long term immunity
title_short T-cell responses associated with resistance to Leishmania infection in individuals from endemic areas for Leishmania (Viannia) braziliensis
title_full T-cell responses associated with resistance to Leishmania infection in individuals from endemic areas for Leishmania (Viannia) braziliensis
title_fullStr T-cell responses associated with resistance to Leishmania infection in individuals from endemic areas for Leishmania (Viannia) braziliensis
title_full_unstemmed T-cell responses associated with resistance to Leishmania infection in individuals from endemic areas for Leishmania (Viannia) braziliensis
title_sort T-cell responses associated with resistance to Leishmania infection in individuals from endemic areas for Leishmania (Viannia) braziliensis
author Bittar, Rita C.
author_facet Bittar, Rita C.
Nogueira, Ricardo S.
Gonçalves, Ricardo Vieira
Ribeiro, Vanessa Pinho
Mattos, Marise S.
Oliveira Neto, Manoel Paes
Coutinho, Sergio G.
Cruz, Alda M. da
author_role author
author2 Nogueira, Ricardo S.
Gonçalves, Ricardo Vieira
Ribeiro, Vanessa Pinho
Mattos, Marise S.
Oliveira Neto, Manoel Paes
Coutinho, Sergio G.
Cruz, Alda M. da
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Bittar, Rita C.
Nogueira, Ricardo S.
Gonçalves, Ricardo Vieira
Ribeiro, Vanessa Pinho
Mattos, Marise S.
Oliveira Neto, Manoel Paes
Coutinho, Sergio G.
Cruz, Alda M. da
dc.subject.other.pt_BR.fl_str_mv Leishmania (Viannia) braziliensis
Infecção assintomática
Leishmaniose curada
Citocinas
Subconjuntos de células T
Imunidade a longo prazo
topic Leishmania (Viannia) braziliensis
Infecção assintomática
Leishmaniose curada
Citocinas
Subconjuntos de células T
Imunidade a longo prazo
Asymptomatic infection
Leishmania (Viannia) braziliensis
Cured leishmaniasis
Cytokines
T-cell subsets
Long term immunity
dc.subject.en.pt_BR.fl_str_mv Asymptomatic infection
Leishmania (Viannia) braziliensis
Cured leishmaniasis
Cytokines
T-cell subsets
Long term immunity
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.
publishDate 2007
dc.date.issued.fl_str_mv 2007
dc.date.accessioned.fl_str_mv 2020-11-22T19:58:36Z
dc.date.available.fl_str_mv 2020-11-22T19:58:36Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv BITTAR, Rita C. et al. T-cell responses associated with resistance to Leishmania infection in individuals from endemic areas for Leishmania (Viannia) braziliensis. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 102, n. 5, p. 625-630, Aug. 2007.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/44579
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/S0074-02762007005000069
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv BITTAR, Rita C. et al. T-cell responses associated with resistance to Leishmania infection in individuals from endemic areas for Leishmania (Viannia) braziliensis. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 102, n. 5, p. 625-630, Aug. 2007.
0074-0276
10.1590/S0074-02762007005000069
1678-8060
url https://www.arca.fiocruz.br/handle/icict/44579
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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