Trypanosoma cruzi infection in neotropical wild carnivores (Mammalia: Carnivora): at the top of the T. cruzi transmission chain

Rocha, Fabiana Lopes; Roque, André Luiz Rodrigues; Lima, Juliane Saab de; Cheida, Carolina Carvalho; Lemos, Frederico Gemesio; Azevedo, Fernanda Cavalcanti de; Arrais, Ricardo Corassa; Bilac, Daniele; Herrera, Heitor Miraglia; Mourão, Guilherme; Jansen, Ana Maria

Trypanosoma cruzi infection in neotropical wild carnivores (Mammalia: Carnivora): at the top of the T. cruzi transmission chain

Detalhes bibliográficos
Autor(a) principal:	Rocha, Fabiana Lopes
Data de Publicação:	2013
Outros Autores:	Roque, André Luiz Rodrigues, Lima, Juliane Saab de, Cheida, Carolina Carvalho, Lemos, Frederico Gemesio, Azevedo, Fernanda Cavalcanti de, Arrais, Ricardo Corassa, Bilac, Daniele, Herrera, Heitor Miraglia, Mourão, Guilherme, Jansen, Ana Maria
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/11465
Resumo:	Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia de Tripanosomatídeos. Rio de Janeiro, RJ, Brasil / Instituto Brasileiro Para Medicina Da Conservação - Tríade. Recife, PE, Brasil / Programa de Conservação Mamíferos do Cerrado. Araguari, MG, Brasil.

Metadados do item

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spelling	Rocha, Fabiana LopesRoque, André Luiz RodriguesLima, Juliane Saab deCheida, Carolina CarvalhoLemos, Frederico GemesioAzevedo, Fernanda Cavalcanti deArrais, Ricardo CorassaBilac, DanieleHerrera, Heitor MiragliaMourão, GuilhermeJansen, Ana Maria2015-08-19T13:49:15Z2015-08-19T13:49:15Z2013ROCHA, Fabiana Lopes et al. Trypanosoma cruzi infection in neotropical wild carnivores (Mammalia: Carnivora): at the top of the T. cruzi transmission chain. PLoS ONE, v. 8, n. 7, p. 1-12, 4 July 2013.1932-6203https://www.arca.fiocruz.br/handle/icict/1146510.1371/journal.pone.00674631932-6203engPublic Library of ScienceInfecção por Trypanosoma cruziCarnívoros Selvagens NeotropicaisMamíferos: CarnívorosT. cruzi Cadeia de TransmissãoTrypanosoma cruzi InfectionNeotropical Wild CarnivoresMammalia: CarnivoraT. cruzi Transmission ChainTrypanosoma cruziMamíferosCarnívorosTrypanosoma cruzi infection in neotropical wild carnivores (Mammalia: Carnivora): at the top of the T. cruzi transmission chaininfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia de Tripanosomatídeos. Rio de Janeiro, RJ, Brasil / Instituto Brasileiro Para Medicina Da Conservação - Tríade. Recife, PE, Brasil / Programa de Conservação Mamíferos do Cerrado. Araguari, MG, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia de Tripanosomatídeos. Rio de Janeiro, RJ, Brasil.Universidade Federal de Mato Grosso do Sul. Instituto de Biociências. Programa de Pós-Graduação em Ecologia e Conservação. Campo Grande, MS, Brasil.Instituto de Pesquisas Cananéia. Programa de Pesquisa em Vida Selvagem. Projeto Carnívoros. Cananéia, SP, Brasil.Programa de Conservação Mamíferos do Cerrado. Araguari, MG, Brasil / Universidade Federal de Goiás. Departamento de Ciências Biológicas. Catalão, GO, Brasil.Programa de Conservação Mamíferos do Cerrado. Araguari, MG, Brasil.Programa de Conservação Mamíferos do Cerrado. Araguari, MG, Brasil / Universidade de São Paulo. Departamento de Medicina Preventiva e Saúde Animal. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia de Tripanosomatídeos. Rio de Janeiro, RJ, Brasil.Universidade Católica Dom Bosco. Campo Grande, MS, Brasil.Embrapa Pantanal. Empresa Brasileira de Pesquisa Agropecuária. Laboratório de Vida Selvagem. Corumbá, MS, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia de Tripanosomatídeos. Rio de Janeiro, RJ, Brasil.Little is known on the role played by Neotropical wild carnivores in the Trypanosoma cruzi transmission cycles. We investigated T. cruzi infection in wild carnivores from three sites in Brazil through parasitological and serological tests. The seven carnivore species examined were infected by T. cruzi, but high parasitemias detectable by hemoculture were found only in two Procyonidae species. Genotyping by Mini-exon gene, PCR-RFLP (1f8/Akw21I) and kDNA genomic targets revealed that the raccoon (Procyon cancrivorus) harbored TcI and the coatis (Nasua nasua) harbored TcI, TcII, TcIII-IV and Trypanosoma rangeli, in single and mixed infections, besides four T. cruzi isolates that displayed odd band patterns in the Mini-exon assay. These findings corroborate the coati can be a bioaccumulator of T. cruzi Discrete Typing Units (DTU) and may act as a transmission hub, a connection point joining sylvatic transmission cycles within terrestrial and arboreal mammals and vectors. Also, the odd band patterns observed in coatis’ isolates reinforce that T. cruzi diversity might be much higher than currently acknowledged. Additionally, we assembled our data with T. cruzi infection on Neotropical carnivores’ literature records to provide a comprehensive analysis of the infection patterns among distinct carnivore species, especially considering their ecological traits and phylogeny. Altogether, fifteen Neotropical carnivore species were found naturally infected by T. cruzi. Species diet was associated with T. cruzi infection rates, supporting the hypothesis that predator-prey links are important mechanisms for T. cruzi maintenance and dispersion in the wild. Distinct T. cruzi infection patterns across carnivore species and study sites were notable. Musteloidea species consistently exhibit high parasitemias in different studies which indicate their high infectivity potential. Mesocarnivores that feed on both invertebrates and mammals, including the coati, a host that can be bioaccumulator of T. cruzi DTU’s, seem to take place at the top of the T. cruzi transmission chain.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/11465/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALfabiana_rocha_etal_IOC-2013.pdfapplication/pdf7997141https://www.arca.fiocruz.br/bitstream/icict/11465/2/fabiana_rocha_etal_IOC-2013.pdf4c775f9a5ca87f1b13332fbbeff45911MD52TEXTfabiana_rocha_etal_IOC-2013.pdf.txtfabiana_rocha_etal_IOC-2013.pdf.txtExtracted texttext/plain69252https://www.arca.fiocruz.br/bitstream/icict/11465/3/fabiana_rocha_etal_IOC-2013.pdf.txt6a6a7250793324e6b2fc0629fd8c4a7bMD53icict/114652023-09-14 15:46:28.82oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-09-14T18:46:28Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv	Trypanosoma cruzi infection in neotropical wild carnivores (Mammalia: Carnivora): at the top of the T. cruzi transmission chain
title	Trypanosoma cruzi infection in neotropical wild carnivores (Mammalia: Carnivora): at the top of the T. cruzi transmission chain
spellingShingle	Trypanosoma cruzi infection in neotropical wild carnivores (Mammalia: Carnivora): at the top of the T. cruzi transmission chain Rocha, Fabiana Lopes Infecção por Trypanosoma cruzi Carnívoros Selvagens Neotropicais Mamíferos: Carnívoros T. cruzi Cadeia de Transmissão Trypanosoma cruzi Infection Neotropical Wild Carnivores Mammalia: Carnivora T. cruzi Transmission Chain Trypanosoma cruzi Mamíferos Carnívoros
title_short	Trypanosoma cruzi infection in neotropical wild carnivores (Mammalia: Carnivora): at the top of the T. cruzi transmission chain
title_full	Trypanosoma cruzi infection in neotropical wild carnivores (Mammalia: Carnivora): at the top of the T. cruzi transmission chain
title_fullStr	Trypanosoma cruzi infection in neotropical wild carnivores (Mammalia: Carnivora): at the top of the T. cruzi transmission chain
title_full_unstemmed	Trypanosoma cruzi infection in neotropical wild carnivores (Mammalia: Carnivora): at the top of the T. cruzi transmission chain
title_sort	Trypanosoma cruzi infection in neotropical wild carnivores (Mammalia: Carnivora): at the top of the T. cruzi transmission chain
author	Rocha, Fabiana Lopes
author_facet	Rocha, Fabiana Lopes Roque, André Luiz Rodrigues Lima, Juliane Saab de Cheida, Carolina Carvalho Lemos, Frederico Gemesio Azevedo, Fernanda Cavalcanti de Arrais, Ricardo Corassa Bilac, Daniele Herrera, Heitor Miraglia Mourão, Guilherme Jansen, Ana Maria
author_role	author
author2	Roque, André Luiz Rodrigues Lima, Juliane Saab de Cheida, Carolina Carvalho Lemos, Frederico Gemesio Azevedo, Fernanda Cavalcanti de Arrais, Ricardo Corassa Bilac, Daniele Herrera, Heitor Miraglia Mourão, Guilherme Jansen, Ana Maria
author2_role	author author author author author author author author author author
dc.contributor.author.fl_str_mv	Rocha, Fabiana Lopes Roque, André Luiz Rodrigues Lima, Juliane Saab de Cheida, Carolina Carvalho Lemos, Frederico Gemesio Azevedo, Fernanda Cavalcanti de Arrais, Ricardo Corassa Bilac, Daniele Herrera, Heitor Miraglia Mourão, Guilherme Jansen, Ana Maria
dc.subject.other.pt_BR.fl_str_mv	Infecção por Trypanosoma cruzi Carnívoros Selvagens Neotropicais Mamíferos: Carnívoros T. cruzi Cadeia de Transmissão
topic	Infecção por Trypanosoma cruzi Carnívoros Selvagens Neotropicais Mamíferos: Carnívoros T. cruzi Cadeia de Transmissão Trypanosoma cruzi Infection Neotropical Wild Carnivores Mammalia: Carnivora T. cruzi Transmission Chain Trypanosoma cruzi Mamíferos Carnívoros
dc.subject.en.en_US.fl_str_mv	Trypanosoma cruzi Infection Neotropical Wild Carnivores Mammalia: Carnivora T. cruzi Transmission Chain
dc.subject.decs.pt_BR.fl_str_mv	Trypanosoma cruzi Mamíferos Carnívoros
description	Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia de Tripanosomatídeos. Rio de Janeiro, RJ, Brasil / Instituto Brasileiro Para Medicina Da Conservação - Tríade. Recife, PE, Brasil / Programa de Conservação Mamíferos do Cerrado. Araguari, MG, Brasil.
publishDate	2013
dc.date.issued.fl_str_mv	2013
dc.date.accessioned.fl_str_mv	2015-08-19T13:49:15Z
dc.date.available.fl_str_mv	2015-08-19T13:49:15Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	ROCHA, Fabiana Lopes et al. Trypanosoma cruzi infection in neotropical wild carnivores (Mammalia: Carnivora): at the top of the T. cruzi transmission chain. PLoS ONE, v. 8, n. 7, p. 1-12, 4 July 2013.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/11465
dc.identifier.issn.none.fl_str_mv	1932-6203
dc.identifier.doi.none.fl_str_mv	10.1371/journal.pone.0067463
dc.identifier.eissn.none.fl_str_mv	1932-6203
identifier_str_mv	ROCHA, Fabiana Lopes et al. Trypanosoma cruzi infection in neotropical wild carnivores (Mammalia: Carnivora): at the top of the T. cruzi transmission chain. PLoS ONE, v. 8, n. 7, p. 1-12, 4 July 2013. 1932-6203 10.1371/journal.pone.0067463
url	https://www.arca.fiocruz.br/handle/icict/11465
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Public Library of Science
publisher.none.fl_str_mv	Public Library of Science
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
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reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
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Trypanosoma cruzi infection in neotropical wild carnivores (Mammalia: Carnivora): at the top of the T. cruzi transmission chain

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