Clinical Predictive Model of Multidrug Resistance in Neutropenic Cancer Patients with Bloodstream Infection Due to Pseudomonas aeruginosa
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/45044 |
Resumo: | Infectious Disease Department. Bellvitge University Hospital. University of Barcelona, Barcelona, Spain / Institut Català of Oncologia. Hospital Duran. Reynals, Barcelona, Spain / Spanish Network for Resaerch in Infection Diseases. Instituto de Salud Carlos III. Madrid, Spain. |
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Gudiol, C.Albasanz-Puig, A.Laporte-Amargòs, J.Pallarés, N.Mussetti, A.Ruiz-Camps, I.Puerta-Alcade, P.Abdala, EdsonOitolini, C.Akova, M.Montejo, M.Mikulska, M.Martin-Dávila, P.Herrera, F.Gasch, O.Drgona, L.Morales, H. PazBrunel, A.-S.Garcia, E.Isler, B.Kern, W. V.Morales, I.Maestro--dela Calle, G.Montero, M.Kanj, S. S.Sipahi, O. R.Calik, S.Mpaquez-Gómez, I.Marin, J. I.Gomes, M. Z. R.Hemmatti, P.Peghin, M.Pozo, J. L. delÝanez, L.Tilley, R.Manzur, A.Novo, A.Carrtalá, J.2020-12-18T18:20:07Z2020-12-18T18:20:07Z2020GUDIOL, C. et al. Clinical predective model of multidrug resistence in neutrophenic cancer patients with bloodstream infection due to Pseudomonas aeruginosa. Antimicrobial Agents of Chemotherapy, v. 64, n. 4, e02494-19, p. 1-12, Apr. 2020.0066-4804https://www.arca.fiocruz.br/handle/icict/4504410.1128/AAC.02494-191098-659610.1128/AAC02494-19engAmerican Society for MicrobiologyResistente a multidrogaPseudomas aeroginosaBacteremiaInfecção por bloostreamCâncerFatores de riscoModelo pré-indecisoMultirdrug resistantPseudomas aeroginosaBacteremiaBloostream infectionCancerRisk factorsPredective modelClinical Predictive Model of Multidrug Resistance in Neutropenic Cancer Patients with Bloodstream Infection Due to Pseudomonas aeruginosainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInfectious Disease Department. Bellvitge University Hospital. University of Barcelona, Barcelona, Spain / Institut Català of Oncologia. Hospital Duran. Reynals, Barcelona, Spain / Spanish Network for Resaerch in Infection Diseases. Instituto de Salud Carlos III. Madrid, Spain.Infectious Disease Department. Bellvitge University Hospital. University of Barcelona, Barcelona, Spain / Spanish Network for Resaerch in Infection Diseases. Instituto de Salud Carlos III. Madrid, Spain.Infectious Disease Department. Bellvitge University Hospital. University of Barcelona, Barcelona, Spain / Statistics Advisory Service. Institute of Biomedical Research of Bellvitge. Barcelona, Spain.Haematology Department. Institut Catalá d`Oncologia. Hospital Duran i Reynals. IDIBELL, Barcelona, Spain.Infectious Disease Department. Vall d`Hebron. University Hospital, Barcelona, Spain / Institut Català of Oncologia. Hospital Duran. Reynals, Barcelona, Spain / Spanish Network for Resaerch in Infection Diseases. Instituto de Salud Carlos III. Madrid, Spain.Infectious Disease Department. Hospital Clinic i Provincial. Barcelona, Spain / Institut Català of Oncologia. Hospital Duran. Reynals, Barcelona, Spain / Spanish Network for Resaerch in Infection Diseases. Instituto de Salud Carlos III. Madrid, Spain.Universidade de São Paulo. Faculdade de Medicina. Instituto de Câncer do Estado de São Paulo. São Paulo, SP, Brasil.Unit of Infectious and Tropical Diseases. IRCCS San Raffaele Scientific Institute. Milan, Italy.Department of Infectious Disease. Hacettepe University School of Medicine. Ankara, Turkey.Infectious Diseases Unit. Cruces University Hospital. Bilbao, Spain.Division of Infection Diseases. University of Genoa (DISSAL) and Ospedale Policlinico san Martino. Genoa, Italy.Infection Diseases Department. Ramon y Cajal Hospital. Madrid, Spain /Institut Català of Oncologia. Hospital Duran. Reynals, Barcelona, Spain / Spanish Network for Resaerch in Infection Diseases. Instituto de Salud Carlos III. Madrid, Spain.Infectious Diseases Section, Depatment of Medicine. Centro de Educación Médica e Investigaciones Clinicas (CEMIC). Buenos Aires, Argentina.Institut Català of Oncologia. Hospital Duran. Reynals, Barcelona, Spain / Spanish Network for Resaerch in Infection Diseases. Instituto de Salud Carlos III. Madrid, Spain.Oncohematology Department. Comenius University and National Cancer Institute. Bratislava, Slovakia.Infectious Diseases Department. Hospital Erasto Gaerther. Curitiba, PR, Brasil.Infectious Diseases Department. Department of Medicine. Lausanne University Hospital (CHUV). Laussane, Switzerland.Haematology Department. Reina Sofia University Hospital-IMiBIC-UCO, Córdoba, Spain.Department of Infectious Diseases and Clincal Microbiology. Istanbul Education and Research Hospital. Istanbul, Turkey.Division of Infectious Diseases. Department of Medicine II. University of Freiburg Medical Center and Faculty of Medicine. Freiburg, Germany.Energency Clinical Unit and Infection Diseases Division. Hospital Universitario Virgem Macarena. Seville, Spain / Institut Català of Oncologia. Hospital Duran. Reynals, Barcelona, Spain / Spanish Network for Resaerch in Infection Diseases. Instituto de Salud Carlos III. Madrid, Spain.Infecton Diseases Unit. Instituto de Investigación Hospital 12 de Octubre (i+12). 12 Octuber University Hospital. School of Medicine. Universidad Complutense, Madrid, Spain.Infecton Diseases services, Hospital del Mar, Infectious Pathology and Antimicrobial Resaerch Group (IPAR), Institut Hospital del Mar Investigaciones Mèdiques (IMIM). Universitat Autonoma de Barcelona, (UAB), CEXS Universitat Pompeu Fabra, Barcelona, Spain / Institut Català of Oncologia. Hospital Duran. Reynals, Barcelona, Spain / Spanish Network for Resaerch in Infection Diseases. Instituto de Salud Carlos III. Madrid, Spain..Infection Disease Division. American University of Beirut Medical Center. Beirut, Lebanon.Ege University Faculty of Medicine. Izmem Turkey.University of health Science Izmir Bozyaka Training and Research Hospital. Izmir, Turkey.Infection Diseases Department. Hospital Regional de Málaga. Malága, Spiian.Infection Diseases and Clincal Microbiology.Department. Clinica Maraya, Pereira, Colombia / Critical Care and Clinical Microbiology. Manizales, Colombia.Hospital Federal de Servidores do Estado. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Department of hematology, Oncology amd Pallaitive Care. Kilinikum Ernst von Bergmann, Academic Teaching Hospital of Charité. University Medical School, Berlin, Germany.Instituto de Ciencias e Innovación en Medicina. Facultad de Medicina Clinica alemanha, Universidad del Desarolo. Santiago de Chile, Chile / Millennium Initiative for Colaborative Research on Bacterial Resistance (MICROB-R). Santiago de Chile. Chile.Infectious Diseases Clinic. Department of Medicine. University of Udine and Azienda Sanitaria Universitaria integrata. Udine, Italy.Infectious Diseases and Microbiology Unit. Navarra University Clinic. Pamplona, Spain.Haematology Department. Marques del Valdecilla University Hospital. Santander, Spain.Microbiology Department. University Hospitals Plymouth NHS Trust, Plymouth, United Kingdom.Infectious Diseases and Microbiology Unit. Navarra University Clinic. Pamplona, Spain.Haematology Department. Son Espases University Hospital. Palma de Mallorca, Spain.Infectious Disease Department. Bellvitge University Hospital. University of Barcelona, Barcelona, Spain / Spanish Network for Resaerch in Infection Diseases. Instituto de Salud Carlos III. Madrid, Spain.Background: We aimed to assess the rate and predictive factors of bloodstream infection (BSI) due to multidrug-resistant (MDR) Pseudomonas aeruginosa (PA) in neutropenic cancer patients. Methods: We performed a multicenter, retrospective cohort study including onco-hematological neutropenic patients with BSI due to PA conducted across 34 centers in 12 countries from January 2006 to May 2018. A mixed logistic regression model was used to estimate a model to predict multidrug resistance of the causative pathogens. Results: Of a total of 1217 episodes of BSI due to PA, 309 episodes (25.4%) were caused by MDR strains. The rate of multidrug resistance increased significantly over the study period (p=0.033). Predictors of MDRPA BSI were prior therapy with piperacillin/tazobactam (odds ratio [OR], 3.48; 95% confidence interval [CI], 2.29-5.30), prior antipseudomonal carbapenem use (OR, 2.53; 95% CI, 1.65-3.87), fluoroquinolone prophylaxis (OR, 2.99; 95% CI, 1.92-4.64), underlying hematological disease (OR, 2.09 95% CI, 1.26-3.44) and the presence of a urinary catheter (OR, 2.54; 95% CI, 1.65-3.91), whereas older age (OR, 0.98; 95% CI, 0.97-0.99) was found to be protective. Conclusions: Our prediction model achieves good discrimination and calibration, thereby identifying neutropenic patients at higher risk of BSI due to MDRPA. The application of this model using a web-based calculator may be a simple strategy to identify high-risk patients, who may benefit from the early administration of a broad-spectrum antibiotic coverage against MDR strains according to the local susceptibility patterns, thus avoiding the use of broad-spectrum antibiotics in patients at low risk of resistance.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/45044/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMZR-Gomes_etal_IOC_2020.pdfMZR-Gomes_etal_IOC_2020.pdfapplication/pdf700540https://www.arca.fiocruz.br/bitstream/icict/45044/2/MZR-Gomes_etal_IOC_2020.pdfa23923221ef7e7df0ebd40c34e1a3dc1MD52TEXTMZR-Gomes_etal_IOC_2020.pdf.txtMZR-Gomes_etal_IOC_2020.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Clinical Predictive Model of Multidrug Resistance in Neutropenic Cancer Patients with Bloodstream Infection Due to Pseudomonas aeruginosa |
| title |
Clinical Predictive Model of Multidrug Resistance in Neutropenic Cancer Patients with Bloodstream Infection Due to Pseudomonas aeruginosa |
| spellingShingle |
Clinical Predictive Model of Multidrug Resistance in Neutropenic Cancer Patients with Bloodstream Infection Due to Pseudomonas aeruginosa Gudiol, C. Resistente a multidroga Pseudomas aeroginosa Bacteremia Infecção por bloostream Câncer Fatores de risco Modelo pré-indeciso Multirdrug resistant Pseudomas aeroginosa Bacteremia Bloostream infection Cancer Risk factors Predective model |
| title_short |
Clinical Predictive Model of Multidrug Resistance in Neutropenic Cancer Patients with Bloodstream Infection Due to Pseudomonas aeruginosa |
| title_full |
Clinical Predictive Model of Multidrug Resistance in Neutropenic Cancer Patients with Bloodstream Infection Due to Pseudomonas aeruginosa |
| title_fullStr |
Clinical Predictive Model of Multidrug Resistance in Neutropenic Cancer Patients with Bloodstream Infection Due to Pseudomonas aeruginosa |
| title_full_unstemmed |
Clinical Predictive Model of Multidrug Resistance in Neutropenic Cancer Patients with Bloodstream Infection Due to Pseudomonas aeruginosa |
| title_sort |
Clinical Predictive Model of Multidrug Resistance in Neutropenic Cancer Patients with Bloodstream Infection Due to Pseudomonas aeruginosa |
| author |
Gudiol, C. |
| author_facet |
Gudiol, C. Albasanz-Puig, A. Laporte-Amargòs, J. Pallarés, N. Mussetti, A. Ruiz-Camps, I. Puerta-Alcade, P. Abdala, Edson Oitolini, C. Akova, M. Montejo, M. Mikulska, M. Martin-Dávila, P. Herrera, F. Gasch, O. Drgona, L. Morales, H. Paz Brunel, A.-S. Garcia, E. Isler, B. Kern, W. V. Morales, I. Maestro--dela Calle, G. Montero, M. Kanj, S. S. Sipahi, O. R. Calik, S. Mpaquez-Gómez, I. Marin, J. I. Gomes, M. Z. R. Hemmatti, P. Peghin, M. Pozo, J. L. del Ýanez, L. Tilley, R. Manzur, A. Novo, A. Carrtalá, J. |
| author_role |
author |
| author2 |
Albasanz-Puig, A. Laporte-Amargòs, J. Pallarés, N. Mussetti, A. Ruiz-Camps, I. Puerta-Alcade, P. Abdala, Edson Oitolini, C. Akova, M. Montejo, M. Mikulska, M. Martin-Dávila, P. Herrera, F. Gasch, O. Drgona, L. Morales, H. Paz Brunel, A.-S. Garcia, E. Isler, B. Kern, W. V. Morales, I. Maestro--dela Calle, G. Montero, M. Kanj, S. S. Sipahi, O. R. Calik, S. Mpaquez-Gómez, I. Marin, J. I. Gomes, M. Z. R. Hemmatti, P. Peghin, M. Pozo, J. L. del Ýanez, L. Tilley, R. Manzur, A. Novo, A. Carrtalá, J. |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Gudiol, C. Albasanz-Puig, A. Laporte-Amargòs, J. Pallarés, N. Mussetti, A. Ruiz-Camps, I. Puerta-Alcade, P. Abdala, Edson Oitolini, C. Akova, M. Montejo, M. Mikulska, M. Martin-Dávila, P. Herrera, F. Gasch, O. Drgona, L. Morales, H. Paz Brunel, A.-S. Garcia, E. Isler, B. Kern, W. V. Morales, I. Maestro--dela Calle, G. Montero, M. Kanj, S. S. Sipahi, O. R. Calik, S. Mpaquez-Gómez, I. Marin, J. I. Gomes, M. Z. R. Hemmatti, P. Peghin, M. Pozo, J. L. del Ýanez, L. Tilley, R. Manzur, A. Novo, A. Carrtalá, J. |
| dc.subject.other.pt_BR.fl_str_mv |
Resistente a multidroga Pseudomas aeroginosa Bacteremia Infecção por bloostream Câncer Fatores de risco Modelo pré-indeciso |
| topic |
Resistente a multidroga Pseudomas aeroginosa Bacteremia Infecção por bloostream Câncer Fatores de risco Modelo pré-indeciso Multirdrug resistant Pseudomas aeroginosa Bacteremia Bloostream infection Cancer Risk factors Predective model |
| dc.subject.en.pt_BR.fl_str_mv |
Multirdrug resistant Pseudomas aeroginosa Bacteremia Bloostream infection Cancer Risk factors Predective model |
| description |
Infectious Disease Department. Bellvitge University Hospital. University of Barcelona, Barcelona, Spain / Institut Català of Oncologia. Hospital Duran. Reynals, Barcelona, Spain / Spanish Network for Resaerch in Infection Diseases. Instituto de Salud Carlos III. Madrid, Spain. |
| publishDate |
2020 |
| dc.date.accessioned.fl_str_mv |
2020-12-18T18:20:07Z |
| dc.date.available.fl_str_mv |
2020-12-18T18:20:07Z |
| dc.date.issued.fl_str_mv |
2020 |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
GUDIOL, C. et al. Clinical predective model of multidrug resistence in neutrophenic cancer patients with bloodstream infection due to Pseudomonas aeruginosa. Antimicrobial Agents of Chemotherapy, v. 64, n. 4, e02494-19, p. 1-12, Apr. 2020. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/45044 |
| dc.identifier.issn.pt_BR.fl_str_mv |
0066-4804 |
| dc.identifier.doi.pt_BR.fl_str_mv |
10.1128/AAC.02494-19 |
| dc.identifier.eissn.none.fl_str_mv |
1098-6596 10.1128/AAC02494-19 |
| identifier_str_mv |
GUDIOL, C. et al. Clinical predective model of multidrug resistence in neutrophenic cancer patients with bloodstream infection due to Pseudomonas aeruginosa. Antimicrobial Agents of Chemotherapy, v. 64, n. 4, e02494-19, p. 1-12, Apr. 2020. 0066-4804 10.1128/AAC.02494-19 1098-6596 10.1128/AAC02494-19 |
| url |
https://www.arca.fiocruz.br/handle/icict/45044 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
American Society for Microbiology |
| publisher.none.fl_str_mv |
American Society for Microbiology |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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Repositório Institucional da FIOCRUZ (ARCA) |
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Repositório Institucional da FIOCRUZ (ARCA) |
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Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
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repositorio.arca@fiocruz.br |
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