Altered ex vivo expression of caspase 8, caspase 9 and Bcl-2 is associated with the T-cell hyporreactivity of paracoccidioidomycosis patients

Detalhes bibliográficos
Autor(a) principal: Cacere, Camila R.
Data de Publicação: 2009
Outros Autores: Mendes-Giannini, Maria J. S., Valle, Antonio Carlos F. do, Duarte, Alberto J. S., Benard, Gil
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/38839
Resumo: 2020-06-26
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spelling Cacere, Camila R.Mendes-Giannini, Maria J. S.Valle, Antonio Carlos F. doDuarte, Alberto J. S.Benard, Gil2019-12-26T14:11:59Z2019-12-26T14:11:59Z2009CACERE, Camila R. et al. Altered ex vivo expression of caspase 8, caspase 9, and Bcl-2 is associated with T-cell hyporeactivity in patients with paracoccidioidomycosis. Clinical and Vaccine Immunology, v. 16, n. 6, p. 953-955, June 2009.1556-6811https://www.arca.fiocruz.br/handle/icict/3883910.1128/CVI.00071-091556-679XengAmerican Society for MicrobiologyAltered ex vivo expression of caspase 8, caspase 9 and Bcl-2 is associated with the T-cell hyporreactivity of paracoccidioidomycosis patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-06-26University of São Paulo. Medical School. Laboratory of Dermatology and Immunodeficiencies. São Paulo, SP, Brazil.São Paulo State University. Faculty of Pharmaceutical Sciences. Clinical Pathology Department. Araraquara, SP, Brazil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.University of São Paulo. Medical School. Laboratory of Dermatology and Immunodeficiencies. São Paulo, SP, Brazil.University of São Paulo. Medical School. Laboratory of Dermatology and Immunodeficiencies. São Paulo, SP, Brazil / University of São Paulo. Medical School. Clinics Hospital. Division of Infectious Diseases. Systemic Mycoses Outpatient Unit. São Paulo, SP, Brazil.To better understand the T-cell hyporesponsiveness of patients with paracoccidioidomycosis, we tested the hypothesis that the T cells were committed to apoptosis. We show here that T cells of patients with paracoccidioidomycosis overexpress caspase 9 and caspase 8 but express low Bcl-2 levels and that interleukin-2 was unable to revert the hyporesponsiveness. These data suggest that the T cells would in vivo be driven to a tolerant state and apoptosis.ParacoccidioidomycosisT-cellinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/38839/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Cacere_Camila_etal_INI_2009.pdfve_Cacere_Camila_etal_INI_2009.pdfapplication/pdf376886https://www.arca.fiocruz.br/bitstream/icict/38839/2/ve_Cacere_Camila_etal_INI_2009.pdf31e6a4b1edafef37f28e660d26de3bceMD52TEXTve_Cacere_Camila_etal_INI_2009.pdf.txtve_Cacere_Camila_etal_INI_2009.pdf.txtExtracted texttext/plain16965https://www.arca.fiocruz.br/bitstream/icict/38839/3/ve_Cacere_Camila_etal_INI_2009.pdf.txt1dcbc30d4578b86a05771c330ec9fc68MD53icict/388392021-03-24 16:32:33.685oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-03-24T19:32:33Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Altered ex vivo expression of caspase 8, caspase 9 and Bcl-2 is associated with the T-cell hyporreactivity of paracoccidioidomycosis patients
title Altered ex vivo expression of caspase 8, caspase 9 and Bcl-2 is associated with the T-cell hyporreactivity of paracoccidioidomycosis patients
spellingShingle Altered ex vivo expression of caspase 8, caspase 9 and Bcl-2 is associated with the T-cell hyporreactivity of paracoccidioidomycosis patients
Cacere, Camila R.
Paracoccidioidomycosis
T-cell
title_short Altered ex vivo expression of caspase 8, caspase 9 and Bcl-2 is associated with the T-cell hyporreactivity of paracoccidioidomycosis patients
title_full Altered ex vivo expression of caspase 8, caspase 9 and Bcl-2 is associated with the T-cell hyporreactivity of paracoccidioidomycosis patients
title_fullStr Altered ex vivo expression of caspase 8, caspase 9 and Bcl-2 is associated with the T-cell hyporreactivity of paracoccidioidomycosis patients
title_full_unstemmed Altered ex vivo expression of caspase 8, caspase 9 and Bcl-2 is associated with the T-cell hyporreactivity of paracoccidioidomycosis patients
title_sort Altered ex vivo expression of caspase 8, caspase 9 and Bcl-2 is associated with the T-cell hyporreactivity of paracoccidioidomycosis patients
author Cacere, Camila R.
author_facet Cacere, Camila R.
Mendes-Giannini, Maria J. S.
Valle, Antonio Carlos F. do
Duarte, Alberto J. S.
Benard, Gil
author_role author
author2 Mendes-Giannini, Maria J. S.
Valle, Antonio Carlos F. do
Duarte, Alberto J. S.
Benard, Gil
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Cacere, Camila R.
Mendes-Giannini, Maria J. S.
Valle, Antonio Carlos F. do
Duarte, Alberto J. S.
Benard, Gil
dc.subject.en.pt_BR.fl_str_mv Paracoccidioidomycosis
T-cell
topic Paracoccidioidomycosis
T-cell
description 2020-06-26
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2019-12-26T14:11:59Z
dc.date.available.fl_str_mv 2019-12-26T14:11:59Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CACERE, Camila R. et al. Altered ex vivo expression of caspase 8, caspase 9, and Bcl-2 is associated with T-cell hyporeactivity in patients with paracoccidioidomycosis. Clinical and Vaccine Immunology, v. 16, n. 6, p. 953-955, June 2009.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/38839
dc.identifier.issn.pt_BR.fl_str_mv 1556-6811
dc.identifier.doi.none.fl_str_mv 10.1128/CVI.00071-09
dc.identifier.eissn.none.fl_str_mv 1556-679X
identifier_str_mv CACERE, Camila R. et al. Altered ex vivo expression of caspase 8, caspase 9, and Bcl-2 is associated with T-cell hyporeactivity in patients with paracoccidioidomycosis. Clinical and Vaccine Immunology, v. 16, n. 6, p. 953-955, June 2009.
1556-6811
10.1128/CVI.00071-09
1556-679X
url https://www.arca.fiocruz.br/handle/icict/38839
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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