Diabetes Downregulates Allergen-Induced Airway Inflammation in Mice
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/28718 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil. |
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Carvalho, Vinicius F.Barreto, Emiliano O.Arantes, Ana Carolina S.Serra, Magda F.Ferreira, Tatiana Paula T.Jannini-Sá, Yago A. P.Hogaboam, Cory M.Martins, Marco A.Silva, Patrícia M. R.2018-09-13T11:41:59Z2018-09-13T11:41:59Z2018CARVALHO, Vinicius F. et al. Diabetes Downregulates Allergen-Induced Airway Inflammation in Mice. Mediators of Inflammation, Volume 2018, Article ID 6150843, 11p, 2018.0962-9351https://www.arca.fiocruz.br/handle/icict/2871810.1155/2018/61508431466-1861engHindawi Publishing CorporationDiabetesInflamaçãoVias aéreasCamundongosDiabetesInflammationAirwayMiceDiabetes Downregulates Allergen-Induced Airway Inflammation in Miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil.Universidade Federal de Alagoas. Maceió, AL, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil.Cedars-Sinai Medical Center. Los Angeles, CA, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil.Previous studies described that allergic diseases, including asthma, occur less often than expected in patients with type 1 diabetes. Here, we investigated the influence of diabetes on allergic airway inflammation in a model of experimental asthma in mice. Diabetes was induced by intravenous injection of alloxan into 12 h-fasted A/J mice, followed by subcutaneous sensitization with ovalbumin (OVA) and aluminum hydroxide (Al(OH)3), on days 5 and 19 after diabetes induction. Animals were intranasally challenged with OVA (25 μg), from day 24 to day 26. Alloxan-induced diabetes significantly attenuated airway inflammation as attested by the lower number of total leukocytes in the bronchoalveolar lavage fluid, mainly neutrophils and eosinophils. Suppression of eosinophil infiltration in the peribronchiolar space and generation of eosinophilotactic mediators, such as CCL-11/eotaxin, CCL-3/MIP-1α, and IL-5, were noted in the lungs of diabetic sensitized mice. In parallel, reduction of airway hyperreactivity (AHR) to methacholine, mucus production, and serum IgE levels was also noted under diabetic conditions. Our findings show that alloxan diabetes caused attenuation of lung allergic inflammatory response in A/J mice, by a mechanism possibly associated with downregulation of IgE antibody production.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/28718/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALanacarolina_arantes_etal_IOC_2018.pdfanacarolina_arantes_etal_IOC_2018.pdfapplication/pdf4071354https://www.arca.fiocruz.br/bitstream/icict/28718/2/anacarolina_arantes_etal_IOC_2018.pdfc6b9d12167748ddbf75f4c67e47643d0MD52TEXTanacarolina_arantes_etal_IOC_2018.pdf.txtanacarolina_arantes_etal_IOC_2018.pdf.txtExtracted texttext/plain49144https://www.arca.fiocruz.br/bitstream/icict/28718/3/anacarolina_arantes_etal_IOC_2018.pdf.txta8a357d400b44cb9f2cc4396f1a78654MD53icict/287182018-09-14 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| dc.title.pt_BR.fl_str_mv |
Diabetes Downregulates Allergen-Induced Airway Inflammation in Mice |
| title |
Diabetes Downregulates Allergen-Induced Airway Inflammation in Mice |
| spellingShingle |
Diabetes Downregulates Allergen-Induced Airway Inflammation in Mice Carvalho, Vinicius F. Diabetes Inflamação Vias aéreas Camundongos Diabetes Inflammation Airway Mice |
| title_short |
Diabetes Downregulates Allergen-Induced Airway Inflammation in Mice |
| title_full |
Diabetes Downregulates Allergen-Induced Airway Inflammation in Mice |
| title_fullStr |
Diabetes Downregulates Allergen-Induced Airway Inflammation in Mice |
| title_full_unstemmed |
Diabetes Downregulates Allergen-Induced Airway Inflammation in Mice |
| title_sort |
Diabetes Downregulates Allergen-Induced Airway Inflammation in Mice |
| author |
Carvalho, Vinicius F. |
| author_facet |
Carvalho, Vinicius F. Barreto, Emiliano O. Arantes, Ana Carolina S. Serra, Magda F. Ferreira, Tatiana Paula T. Jannini-Sá, Yago A. P. Hogaboam, Cory M. Martins, Marco A. Silva, Patrícia M. R. |
| author_role |
author |
| author2 |
Barreto, Emiliano O. Arantes, Ana Carolina S. Serra, Magda F. Ferreira, Tatiana Paula T. Jannini-Sá, Yago A. P. Hogaboam, Cory M. Martins, Marco A. Silva, Patrícia M. R. |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Carvalho, Vinicius F. Barreto, Emiliano O. Arantes, Ana Carolina S. Serra, Magda F. Ferreira, Tatiana Paula T. Jannini-Sá, Yago A. P. Hogaboam, Cory M. Martins, Marco A. Silva, Patrícia M. R. |
| dc.subject.other.pt_BR.fl_str_mv |
Diabetes Inflamação Vias aéreas Camundongos |
| topic |
Diabetes Inflamação Vias aéreas Camundongos Diabetes Inflammation Airway Mice |
| dc.subject.en.pt_BR.fl_str_mv |
Diabetes Inflammation Airway Mice |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil. |
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2018 |
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2018-09-13T11:41:59Z |
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2018-09-13T11:41:59Z |
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2018 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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CARVALHO, Vinicius F. et al. Diabetes Downregulates Allergen-Induced Airway Inflammation in Mice. Mediators of Inflammation, Volume 2018, Article ID 6150843, 11p, 2018. |
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https://www.arca.fiocruz.br/handle/icict/28718 |
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0962-9351 |
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10.1155/2018/6150843 |
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1466-1861 |
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CARVALHO, Vinicius F. et al. Diabetes Downregulates Allergen-Induced Airway Inflammation in Mice. Mediators of Inflammation, Volume 2018, Article ID 6150843, 11p, 2018. 0962-9351 10.1155/2018/6150843 1466-1861 |
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Hindawi Publishing Corporation |
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Hindawi Publishing Corporation |
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