Pharmacological Properties of Riparin IV in Models of Pain and Inflammation
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/18064 |
Resumo: | Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Fundação Oswaldo Cruz (FIOCRUZ). |
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Nascimento, Olívia AzevêdoSanto, Renan Fernandes do EspíritoOpretzka, Luíza Carolina FrançaBarbosa Filho, José MariaGutierrez, Stanley Juan ChavezVillarreal, Cristiane FloraSoares, Milena Botelho Pereira2017-03-16T17:14:05Z2017-03-16T17:14:05Z2016NASCIMENTO, O. A. et al. Pharmacological Properties of Riparin IV in Models of Pain and Inflammation. Molecules, v. 21, p. 1757, 2016.1420-3049https://www.arca.fiocruz.br/handle/icict/1806410.3390/molecules21121757Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Fundação Oswaldo Cruz (FIOCRUZ).Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, BrasilUniversidade Federal da Paraíba. Laboratório de Tecnologia Farmacêutica. João Pessoa, PB, BrasilUniversidade Federal do Piauí. Departamento de Bioquímica e Farmacologia. Teresina, PI, BrasilUniversidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, BrasilRiparins, natural alkaloids of the alkamide group, can be synthesized by simple methods, enhancing their potential application in pharmaceutical development. Here, the pharmacological properties of riparins were investigated in in vitro and in vivo assays of pain and inflammation in Swiss mice. Inflammatory mediators were measured by radioimmunoassay and Real-Time PCR. Riparins I, II, III and IV (1.56-100 mg/kg; ip) produced dose-related antinociceptive effects in the formalin test, exhibiting ED50 values of 22.93, 114.2, 31.05 and 6.63 mg/kg, respectively. Taking the greater potency as steering parameter, riparin IV was further investigated. Riparin IV did not produce antinociceptive effect on the tail flick, suggesting that its antinociception is not a centrally-mediated action. In fact, riparin IV (1.56-25 mg/kg) produced dose-related antinociceptive and antiedematogenic effects on the complete Freund's adjuvant (CFA)-induced paw inflammation in mice. During CFA-induced inflammation, riparin IV did not modulate either the production of cytokines, TNF-α and IL-10, or COX-2 mRNA expression. On the other hand, riparin IV decreased the PGE₂ levels in the inflamed paw. In in vitro assays, riparin IV did not exhibit suppressive activities in activated macrophages. These results indicate, for the first time, that riparin IV induces antinociceptive and anti-inflammatory effects, possibly through the inhibition of prostanoid production.engMDPIAnti-inflamatóriosAntinocicepçãoPGE2CitocinasRiparinasAnti-inflammatoryAntinociceptionPGE2CytokinesRiparinsPharmacological Properties of Riparin IV in Models of Pain and Inflammationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/18064/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALNascimento OA Pharmacological ....pdfNascimento OA Pharmacological ....pdfapplication/pdf1543204https://www.arca.fiocruz.br/bitstream/icict/18064/2/Nascimento%20OA%20Pharmacological%20....pdf62ff0f3c4a1831446c9052206ab3c303MD52TEXTNascimento OA Pharmacological 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| dc.title.pt_BR.fl_str_mv |
Pharmacological Properties of Riparin IV in Models of Pain and Inflammation |
| title |
Pharmacological Properties of Riparin IV in Models of Pain and Inflammation |
| spellingShingle |
Pharmacological Properties of Riparin IV in Models of Pain and Inflammation Nascimento, Olívia Azevêdo Anti-inflamatórios Antinocicepção PGE2 Citocinas Riparinas Anti-inflammatory Antinociception PGE2 Cytokines Riparins |
| title_short |
Pharmacological Properties of Riparin IV in Models of Pain and Inflammation |
| title_full |
Pharmacological Properties of Riparin IV in Models of Pain and Inflammation |
| title_fullStr |
Pharmacological Properties of Riparin IV in Models of Pain and Inflammation |
| title_full_unstemmed |
Pharmacological Properties of Riparin IV in Models of Pain and Inflammation |
| title_sort |
Pharmacological Properties of Riparin IV in Models of Pain and Inflammation |
| author |
Nascimento, Olívia Azevêdo |
| author_facet |
Nascimento, Olívia Azevêdo Santo, Renan Fernandes do Espírito Opretzka, Luíza Carolina França Barbosa Filho, José Maria Gutierrez, Stanley Juan Chavez Villarreal, Cristiane Flora Soares, Milena Botelho Pereira |
| author_role |
author |
| author2 |
Santo, Renan Fernandes do Espírito Opretzka, Luíza Carolina França Barbosa Filho, José Maria Gutierrez, Stanley Juan Chavez Villarreal, Cristiane Flora Soares, Milena Botelho Pereira |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Nascimento, Olívia Azevêdo Santo, Renan Fernandes do Espírito Opretzka, Luíza Carolina França Barbosa Filho, José Maria Gutierrez, Stanley Juan Chavez Villarreal, Cristiane Flora Soares, Milena Botelho Pereira |
| dc.subject.other.pt_BR.fl_str_mv |
Anti-inflamatórios Antinocicepção PGE2 Citocinas Riparinas |
| topic |
Anti-inflamatórios Antinocicepção PGE2 Citocinas Riparinas Anti-inflammatory Antinociception PGE2 Cytokines Riparins |
| dc.subject.en.pt_BR.fl_str_mv |
Anti-inflammatory Antinociception PGE2 Cytokines Riparins |
| description |
Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Fundação Oswaldo Cruz (FIOCRUZ). |
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2016 |
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2016 |
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2017-03-16T17:14:05Z |
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2017-03-16T17:14:05Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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NASCIMENTO, O. A. et al. Pharmacological Properties of Riparin IV in Models of Pain and Inflammation. Molecules, v. 21, p. 1757, 2016. |
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https://www.arca.fiocruz.br/handle/icict/18064 |
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1420-3049 |
| dc.identifier.doi.none.fl_str_mv |
10.3390/molecules21121757 |
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NASCIMENTO, O. A. et al. Pharmacological Properties of Riparin IV in Models of Pain and Inflammation. Molecules, v. 21, p. 1757, 2016. 1420-3049 10.3390/molecules21121757 |
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MDPI |
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