Characteristics of HIV seroconversions in ImPrEP, a large PrEP implementation study in Latin America
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , , , , |
| Tipo de documento: | Artigo de conferência |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/60912 |
Resumo: | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. |
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Hoagland, BrendaCaceres, F. C.Moreira, Ronaldo IsmérioKonda, K. A.Vega-Ramirez, H.Leite, I. C.Guanira, J. V.Bautista-Arredondo, S.Vermandere, H.Benedetti, Marcos RenatoPimenta, CristinaVeloso, Valdiléa G.Torres, Thiago SilvaGrinsztejn, Beatriz2023-10-25T15:26:55Z2023-10-25T15:26:55Z2023HOAGLAN, Brenda et al. Characteristics of HIV seroconversions in ImPrEP, a large PrEP implementation study in Latin America. In: IAS CONFERENCE ON HIV SCIENCE, 12., Brisbane, Australia. [Abstracts...]. Australia, 2023. 1 p.https://www.arca.fiocruz.br/handle/icict/60912engInternational AIDS SocietyHIVPrEPHomens que fazem sexo com homensMulheres transexuaisHIVPrEPMen who have sex with menTransgender womenCharacteristics of HIV seroconversions in ImPrEP, a large PrEP implementation study in Latin AmericaCaracterísticas das soroconversões do HIV em Imprep, um grande estudo de implementação de preparação na América Latinainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Universidad Peruana Cayetano Heredia. Lima, Peru.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Universidad Peruana Cayetano Heredia. Lima, Peru.Instituto Nacional de Psiquiatria Ramón de la Fuente Muñiz. Mexico City, Mexico.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sérgio Arouca. Rio de Janeiro, RJ, Brasil.Instituto Nacional de Psiquiatria Ramón de la Fuente Muñiz. Mexico City, Mexico.Instituto Nacional de Salud Pública. Cuernavaca, Mexico.Instituto Nacional de Salud Pública. Cuernavaca, Mexico.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Ministério da Saúde. Brasília, DF, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Background: Number of HIV cases continues to rise among young (18-30 years) gay, bisexual, and other men who have sex with men (MSM) and transgender women (TGW) in Latin America. ImPrEP was a PrEP implementation study conducted in Brazil, Peru, and Mexico. We describe characteristics of HIV seroconversions in ImPrEP by country. Methods: Eligible MSM and TGW (HIV-negative, =18 years, reporting 1+ risk criteria) were screened and enrolled on the same day and received a 30-day oral TDF/FTC PrEP supply. Follow-up visits were scheduled 4 weeks post-enrolment and quarterly thereafter. HIV rapid testing was performed at all visits. We compared demographic (at enrollment) and behaviour (last visit prior to seroconversion) characteristics using chi-square or exact tests for the contigency tables and Kruskal Wallis tests for medians. Results: From February 2018-June 2021, 9509 MSM/TGW were enrolled (Brazil: 3928 [41.3%]; Mexico: 3288 [24.6%]; Peru: 2293 [24.1%]); 104 were diagnosed with HIV during 12,185.25 person-years of follow-up. Overall, 76.0% were young, 82.7% non-white, and 71.3% completed secondary education or more. The median number of partners was 5 (IQR:2-15); 70.2%, 92.2% and 85.6% reported receptive condomless anal sex, inconsistent condom use and incomplete PrEP adherence, respectively. The median number of days between the first PrEP dispensation and HIV diagnosis was 360 days, higher in Brazil (541 days) and lower in Mexico (242 days). The median HIV viral load after diagnosis was 12,257 copies/mL, lower in Mexico (3680 copies/mL) and higher in Peru (50100 copies/mL). Viral mutations detected were: 1 (1.8%) K70 and 6 (10.5%) M184V/I (Table). Conclusions: We observed poor adherence among MSM and TGW who seroconverted during the ImPrEP study. Long-acting PrEP may be an appropriate strategy to overcome adherence barriers observed among young MSM and TGW in Latin America.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/60912/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCharacteristics_Brenda_Hoagland_2023.pdfCharacteristics_Brenda_Hoagland_2023.pdfapplication/pdf579169https://www.arca.fiocruz.br/bitstream/icict/60912/2/Characteristics_Brenda_Hoagland_2023.pdfcfe03edacf2a0223cc090cb4f367aaaaMD52icict/609122023-10-25 12:28:47.348oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-10-25T15:28:47Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.en_US.fl_str_mv |
Characteristics of HIV seroconversions in ImPrEP, a large PrEP implementation study in Latin America |
| dc.title.alternative.en_US.fl_str_mv |
Características das soroconversões do HIV em Imprep, um grande estudo de implementação de preparação na América Latina |
| title |
Characteristics of HIV seroconversions in ImPrEP, a large PrEP implementation study in Latin America |
| spellingShingle |
Characteristics of HIV seroconversions in ImPrEP, a large PrEP implementation study in Latin America Hoagland, Brenda HIV PrEP Homens que fazem sexo com homens Mulheres transexuais HIV PrEP Men who have sex with men Transgender women |
| title_short |
Characteristics of HIV seroconversions in ImPrEP, a large PrEP implementation study in Latin America |
| title_full |
Characteristics of HIV seroconversions in ImPrEP, a large PrEP implementation study in Latin America |
| title_fullStr |
Characteristics of HIV seroconversions in ImPrEP, a large PrEP implementation study in Latin America |
| title_full_unstemmed |
Characteristics of HIV seroconversions in ImPrEP, a large PrEP implementation study in Latin America |
| title_sort |
Characteristics of HIV seroconversions in ImPrEP, a large PrEP implementation study in Latin America |
| author |
Hoagland, Brenda |
| author_facet |
Hoagland, Brenda Caceres, F. C. Moreira, Ronaldo Ismério Konda, K. A. Vega-Ramirez, H. Leite, I. C. Guanira, J. V. Bautista-Arredondo, S. Vermandere, H. Benedetti, Marcos Renato Pimenta, Cristina Veloso, Valdiléa G. Torres, Thiago Silva Grinsztejn, Beatriz |
| author_role |
author |
| author2 |
Caceres, F. C. Moreira, Ronaldo Ismério Konda, K. A. Vega-Ramirez, H. Leite, I. C. Guanira, J. V. Bautista-Arredondo, S. Vermandere, H. Benedetti, Marcos Renato Pimenta, Cristina Veloso, Valdiléa G. Torres, Thiago Silva Grinsztejn, Beatriz |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Hoagland, Brenda Caceres, F. C. Moreira, Ronaldo Ismério Konda, K. A. Vega-Ramirez, H. Leite, I. C. Guanira, J. V. Bautista-Arredondo, S. Vermandere, H. Benedetti, Marcos Renato Pimenta, Cristina Veloso, Valdiléa G. Torres, Thiago Silva Grinsztejn, Beatriz |
| dc.subject.other.en_US.fl_str_mv |
HIV PrEP Homens que fazem sexo com homens Mulheres transexuais |
| topic |
HIV PrEP Homens que fazem sexo com homens Mulheres transexuais HIV PrEP Men who have sex with men Transgender women |
| dc.subject.en.en_US.fl_str_mv |
HIV PrEP Men who have sex with men Transgender women |
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Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. |
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2023 |
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2023-10-25T15:26:55Z |
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2023-10-25T15:26:55Z |
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2023 |
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HOAGLAN, Brenda et al. Characteristics of HIV seroconversions in ImPrEP, a large PrEP implementation study in Latin America. In: IAS CONFERENCE ON HIV SCIENCE, 12., Brisbane, Australia. [Abstracts...]. Australia, 2023. 1 p. |
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https://www.arca.fiocruz.br/handle/icict/60912 |
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HOAGLAN, Brenda et al. Characteristics of HIV seroconversions in ImPrEP, a large PrEP implementation study in Latin America. In: IAS CONFERENCE ON HIV SCIENCE, 12., Brisbane, Australia. [Abstracts...]. Australia, 2023. 1 p. |
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International AIDS Society |
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International AIDS Society |
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