Sickle cell disease: Only one road, but different pathways for inflammation

Detalhes bibliográficos
Autor(a) principal: Vilas-Boas, Wendell
Data de Publicação: 2012
Outros Autores: Cerqueira, Bruno Antonio Veloso, Pitanga, Thassila Nogueira, Seixas, Magda Oliveira, Menezes, Joelma, Souza, Cyntia Cajado de, Adorno, Elisângela Vitória, Goncalves, Marilda Souza
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/14098
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia do Sangue. São Paulo. SP, Brasil.
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spelling Vilas-Boas, WendellCerqueira, Bruno Antonio VelosoPitanga, Thassila NogueiraSeixas, Magda OliveiraMenezes, JoelmaSouza, Cyntia Cajado deAdorno, Elisângela VitóriaGoncalves, Marilda Souza2016-05-05T14:19:11Z2016-05-05T14:19:11Z2012VILAS-BOAS, Wendell et al. Sickle cell disease: Only one road, but different pathways for inflammation. Advances in Bioscience and Biotechnology, v. 3, p. 538-550, 2012.2156-8456https://www.arca.fiocruz.br/handle/icict/1409810.4236/abb.2012.324071engScientific Research PublishingSickle cell disease: Only one road, but different pathways for inflammationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia do Sangue. São Paulo. SP, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia do Sangue. São Paulo. SP, Brasil / Universidade Estadual de Santa Cruz. Ilhéus, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia do Sangue. São Paulo. SP, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia do Sangue. São Paulo. SP, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia do Sangue. São Paulo. SP, Brasil / Universidade Federal da Bahia. Faculdade de Farmacia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia do Sangue. São Paulo. SP, Brasil.Instituto Nacional de Ciência e Tecnologia do Sangue. São Paulo. SP, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia do Sangue. São Paulo. SP, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil.Sickle cell disease (SCD) is a genetic disorder charac- terized by a chronic inflammatory process, and new biomarkers have been studied as promising molecules for understanding the inflammation in its pathophy- siology. The hemolysis and the release of molecules associated to the hemoglobin (Hb) catabolism, such as free Hb, iron, and heme, generate an oxidant envi- ronment with production of reactive oxygen and ni- trogen species. The immune system plays a very im- portant role in the inflammation, with cells secreting pro-inflammatory cytokines and chemokines. There is also a nitric oxide (NO) resistance state, with an impaired NO bioactivity, leading to a vascular dys- function; activation of platelet, leukocytes, erythro- cytes, and endothelial cells, with expression of adhe- sion molecules and its ligands, and several receptors, that altogether participate at inflammatory process. During inflammation, there is an increase of dendritic cells (DCs) expressing toll like receptors (TLR), but the role of DCs and TLR in SCD pathogenesis is un-clear. Also, there are molecules contributing for en-hance the endothelium dysfunction, such as homo-cysteine that has been associated with vascular com-plications in the pathology of other diseases and it may contribute to the vascular complications pre-sented by SCD patients. Circulating microparticules (MPs) levels are augmented in several diseases and have been described in SCD, where cells membrane compounds are associated to cell’s thrombotic and coagulation state, such as tissue factor and phos-phatidylserine (PS), which may contribute to endo-thelial dysfunction. The knowledge of all these bio-markers may contribute to new therapeutic approach discover, improving SCD patient life quality.Sickle Cell DiseaseInflammationOxidative StressCells Activationinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/14098/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALVilas-Boas W Sickle cell....pdfVilas-Boas W Sickle cell....pdfapplication/pdf350003https://www.arca.fiocruz.br/bitstream/icict/14098/2/Vilas-Boas%20W%20Sickle%20cell....pdf79e235c0b9789d6e32decf101950f003MD52TEXTVilas-Boas W Sickle cell....pdf.txtVilas-Boas W Sickle cell....pdf.txtExtracted texttext/plain74059https://www.arca.fiocruz.br/bitstream/icict/14098/3/Vilas-Boas%20W%20Sickle%20cell....pdf.txt7470266856a96cd60c3c2a3642b4a943MD53icict/140982023-03-15 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dc.title.pt_BR.fl_str_mv Sickle cell disease: Only one road, but different pathways for inflammation
title Sickle cell disease: Only one road, but different pathways for inflammation
spellingShingle Sickle cell disease: Only one road, but different pathways for inflammation
Vilas-Boas, Wendell
Sickle Cell Disease
Inflammation
Oxidative Stress
Cells Activation
title_short Sickle cell disease: Only one road, but different pathways for inflammation
title_full Sickle cell disease: Only one road, but different pathways for inflammation
title_fullStr Sickle cell disease: Only one road, but different pathways for inflammation
title_full_unstemmed Sickle cell disease: Only one road, but different pathways for inflammation
title_sort Sickle cell disease: Only one road, but different pathways for inflammation
author Vilas-Boas, Wendell
author_facet Vilas-Boas, Wendell
Cerqueira, Bruno Antonio Veloso
Pitanga, Thassila Nogueira
Seixas, Magda Oliveira
Menezes, Joelma
Souza, Cyntia Cajado de
Adorno, Elisângela Vitória
Goncalves, Marilda Souza
author_role author
author2 Cerqueira, Bruno Antonio Veloso
Pitanga, Thassila Nogueira
Seixas, Magda Oliveira
Menezes, Joelma
Souza, Cyntia Cajado de
Adorno, Elisângela Vitória
Goncalves, Marilda Souza
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Vilas-Boas, Wendell
Cerqueira, Bruno Antonio Veloso
Pitanga, Thassila Nogueira
Seixas, Magda Oliveira
Menezes, Joelma
Souza, Cyntia Cajado de
Adorno, Elisângela Vitória
Goncalves, Marilda Souza
dc.subject.en.pt_BR.fl_str_mv Sickle Cell Disease
Inflammation
Oxidative Stress
Cells Activation
topic Sickle Cell Disease
Inflammation
Oxidative Stress
Cells Activation
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia do Sangue. São Paulo. SP, Brasil.
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2016-05-05T14:19:11Z
dc.date.available.fl_str_mv 2016-05-05T14:19:11Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv VILAS-BOAS, Wendell et al. Sickle cell disease: Only one road, but different pathways for inflammation. Advances in Bioscience and Biotechnology, v. 3, p. 538-550, 2012.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/14098
dc.identifier.issn.none.fl_str_mv 2156-8456
dc.identifier.doi.none.fl_str_mv 10.4236/abb.2012.324071
identifier_str_mv VILAS-BOAS, Wendell et al. Sickle cell disease: Only one road, but different pathways for inflammation. Advances in Bioscience and Biotechnology, v. 3, p. 538-550, 2012.
2156-8456
10.4236/abb.2012.324071
url https://www.arca.fiocruz.br/handle/icict/14098
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Scientific Research Publishing
publisher.none.fl_str_mv Scientific Research Publishing
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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