Evaluation of monocyte subsets and markers of activation in leprosy reactions.

Detalhes bibliográficos
Autor(a) principal: Shibuya, Mayume
Data de Publicação: 2018
Outros Autores: Bergheme, Giovana, Passos, Sara Timoteo, Queiroz, Ivonete, Rêgo, Jamile, Carvalho, Lucas Pedreira de, Machado, Paulo Roberto Lima
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/30673
Resumo: Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais (INCT-DT), Brazil.
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spelling Shibuya, MayumeBergheme, GiovanaPassos, Sara TimoteoQueiroz, IvoneteRêgo, JamileCarvalho, Lucas Pedreira deMachado, Paulo Roberto Lima2018-12-18T16:51:46Z2018-12-18T16:51:46Z2018SHIBUYA, M. et al. Evaluation of monocyte subsets and markers of activation in leprosy reactions. Microbes and Infection, oct. 2018.1286-4579https://www.arca.fiocruz.br/handle/icict/3067310.1016/j.micinf.2018.10.003Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais (INCT-DT), Brazil.Federal University of Bahia. P os-Graduação em Ciências da Saúde. Salvador, BA, Brasil.Federal University of Bahia. P os-Graduação em Ciências da Saúde. Salvador, BA, Brasil.Federal University of Bahia. P os-Graduação em Ciências da Saúde. Salvador, BA, Brasil / Federal University of Bahia. Hospital Universit ario Professor Edgard Santos. Immunology Service. Salvador, BA, Brazil.Federal University of Bahia. P os-Graduação em Ciências da Saúde. Salvador, BA, Brasil.Federal University of Bahia. P os-Graduação em Ciências da Saúde. Salvador, BA, Brasil / Federal University of Bahia. Hospital Universit ario Professor Edgard Santos. Immunology Service. Salvador, BA, Brazil.Federal University of Bahia. P os-Graduação em Ciências da Saúde. Salvador, BA, Brasil / Federal University of Bahia. Hospital Universit ario Professor Edgard Santos. Immunology Service. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Federal University of Bahia. P os-Graduação em Ciências da Saúde. Salvador, BA, Brasil / Federal University of Bahia. Hospital Universit ario Professor Edgard Santos. Immunology Service. Salvador, BA, Brazil.Understanding host immune pathways associated with tissue damage during reactions are of upmost importance to the development of immune intervention strategies. The participation of monocytes in leprosy reactions was evaluated by determining the frequency of monocyte subsets and the degree of cellular activation through the expression of MHCII and the co-stimulatory molecules CD40, CD80, CD86. Leprosy subjects with or without reactions were included in this cross-sectional study. Peripheral blood mononuclear cell were isolated and stained ex vivo to determine monocyte subsets and the degree of cellular activation by flow cytometry. Intermediate monocytes were increased in leprosy patients with reactions when compared to patients without reactions. Although no difference was detected in the frequency of monocyte subsets between type 1 and 2 reactions, the expression of CD80 was increased in monocytes from patients with type 1 reactions and CD40 was higher in paucibacillary subjects presenting type 1 reactions. Moreover, CD86 and MHC II expression were higher in intermediate monocytes when compared to the other subsets in leprosy reaction types 1 and 2. Intermediate monocyte activation with CD86 and MHCII expression is involved with both type 1 and 2 reactions, whereas CD80 and CD40 expression is related to type 1 reactions.engElsevierHanseníaseReações de lepraMonócitosMoléculas co-estimulatóriasLeprosyLeprosy reactionsMonocytesCo-stimulatory moleculesEvaluation of monocyte subsets and markers of activation in leprosy reactions.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/30673/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALShibuya M. Evaluation of monocyte subsets...2018.pdfShibuya M. 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dc.title.pt_BR.fl_str_mv Evaluation of monocyte subsets and markers of activation in leprosy reactions.
title Evaluation of monocyte subsets and markers of activation in leprosy reactions.
spellingShingle Evaluation of monocyte subsets and markers of activation in leprosy reactions.
Shibuya, Mayume
Hanseníase
Reações de lepra
Monócitos
Moléculas co-estimulatórias
Leprosy
Leprosy reactions
Monocytes
Co-stimulatory molecules
title_short Evaluation of monocyte subsets and markers of activation in leprosy reactions.
title_full Evaluation of monocyte subsets and markers of activation in leprosy reactions.
title_fullStr Evaluation of monocyte subsets and markers of activation in leprosy reactions.
title_full_unstemmed Evaluation of monocyte subsets and markers of activation in leprosy reactions.
title_sort Evaluation of monocyte subsets and markers of activation in leprosy reactions.
author Shibuya, Mayume
author_facet Shibuya, Mayume
Bergheme, Giovana
Passos, Sara Timoteo
Queiroz, Ivonete
Rêgo, Jamile
Carvalho, Lucas Pedreira de
Machado, Paulo Roberto Lima
author_role author
author2 Bergheme, Giovana
Passos, Sara Timoteo
Queiroz, Ivonete
Rêgo, Jamile
Carvalho, Lucas Pedreira de
Machado, Paulo Roberto Lima
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Shibuya, Mayume
Bergheme, Giovana
Passos, Sara Timoteo
Queiroz, Ivonete
Rêgo, Jamile
Carvalho, Lucas Pedreira de
Machado, Paulo Roberto Lima
dc.subject.other.pt_BR.fl_str_mv Hanseníase
Reações de lepra
Monócitos
Moléculas co-estimulatórias
topic Hanseníase
Reações de lepra
Monócitos
Moléculas co-estimulatórias
Leprosy
Leprosy reactions
Monocytes
Co-stimulatory molecules
dc.subject.en.pt_BR.fl_str_mv Leprosy
Leprosy reactions
Monocytes
Co-stimulatory molecules
description Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais (INCT-DT), Brazil.
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-12-18T16:51:46Z
dc.date.available.fl_str_mv 2018-12-18T16:51:46Z
dc.date.issued.fl_str_mv 2018
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SHIBUYA, M. et al. Evaluation of monocyte subsets and markers of activation in leprosy reactions. Microbes and Infection, oct. 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/30673
dc.identifier.issn.pt_BR.fl_str_mv 1286-4579
dc.identifier.doi.none.fl_str_mv 10.1016/j.micinf.2018.10.003
identifier_str_mv SHIBUYA, M. et al. Evaluation of monocyte subsets and markers of activation in leprosy reactions. Microbes and Infection, oct. 2018.
1286-4579
10.1016/j.micinf.2018.10.003
url https://www.arca.fiocruz.br/handle/icict/30673
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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instacron_str FIOCRUZ
institution FIOCRUZ
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