Expression of infection-related genes in parasites and host during murine experimental infection with Leishmania (Leishmania) amazonensis

Detalhes bibliográficos
Autor(a) principal: Pereira, Bernardo Acácio Santini
Data de Publicação: 2012
Outros Autores: Britto, Constança, Alves, Carlos Roberto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/16221
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil.
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spelling Pereira, Bernardo Acácio SantiniBritto, ConstançaAlves, Carlos Roberto2016-10-13T16:05:42Z2016-10-13T16:05:42Z2012PEREIRA, Bernardo Acácio Santini; BRITTO, Constança; ALVES, Carlos Roberto. Expression of infection-related genes in parasites and host during murine experimental infection with Leishmania (Leishmania) amazonensis. Microbial Pathogenesis, v.52, n.2, p.101-108, Feb. 2012..0882-4010https://www.arca.fiocruz.br/handle/icict/1622110.1016/j.micpath.2011.11.0041096-1208engElsevierRoedoresProteasesExpressão genéticaLeishmaniaModelo animalComplexo de Histocompatibilidade (MHC)Leishmania sppAnimal modelGene expressionRodentMHCProteaseExpression of infection-related genes in parasites and host during murine experimental infection with Leishmania (Leishmania) amazonensisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil.Leishmania parasites are able to interfere with host immune responses on many levels, as T cell responses balance, as observed in the murine model of infection. In the present study, we analyzed genes expression in both host and parasite during the progression of infection. Host genes associated to T-lymphocytes responses, MHC classes I and II, as well as parasite enzymes genes, cysteine-proteinases (CP) B and C, were examined in mice along evolution of infection by Leishmania (Leishmania) amazonensis. Murine strains with distinct levels of susceptibility to infection presented different patterns of MHC genes expression: MHC class I genes tend to have higher expression levels in CBA mice, whereas MHC class II genes expression predominates in BALB/c mice. CPB genes expression in the parasites was shown to predominate over CPC in both mice strains tested. Understanding genes expression patterns during infection may lead to new and more efficient treatments for leishmaniasis.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/16221/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALcarlos _alves_etal_IOC_2012.pdfcarlos _alves_etal_IOC_2012.pdfapplication/pdf355760https://www.arca.fiocruz.br/bitstream/icict/16221/2/carlos%20_alves_etal_IOC_2012.pdf570be3aa22f2ffbd282c80cf2275e2cdMD52TEXTcarlos _alves_etal_IOC_2012.pdf.txtcarlos _alves_etal_IOC_2012.pdf.txtExtracted texttext/plain44678https://www.arca.fiocruz.br/bitstream/icict/16221/3/carlos%20_alves_etal_IOC_2012.pdf.txtf7de51e944626091f745423121f15303MD53icict/162212018-04-02 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dc.title.pt_BR.fl_str_mv Expression of infection-related genes in parasites and host during murine experimental infection with Leishmania (Leishmania) amazonensis
title Expression of infection-related genes in parasites and host during murine experimental infection with Leishmania (Leishmania) amazonensis
spellingShingle Expression of infection-related genes in parasites and host during murine experimental infection with Leishmania (Leishmania) amazonensis
Pereira, Bernardo Acácio Santini
Roedores
Proteases
Expressão genética
Leishmania
Modelo animal
Complexo de Histocompatibilidade (MHC)
Leishmania spp
Animal model
Gene expression
Rodent
MHC
Protease
title_short Expression of infection-related genes in parasites and host during murine experimental infection with Leishmania (Leishmania) amazonensis
title_full Expression of infection-related genes in parasites and host during murine experimental infection with Leishmania (Leishmania) amazonensis
title_fullStr Expression of infection-related genes in parasites and host during murine experimental infection with Leishmania (Leishmania) amazonensis
title_full_unstemmed Expression of infection-related genes in parasites and host during murine experimental infection with Leishmania (Leishmania) amazonensis
title_sort Expression of infection-related genes in parasites and host during murine experimental infection with Leishmania (Leishmania) amazonensis
author Pereira, Bernardo Acácio Santini
author_facet Pereira, Bernardo Acácio Santini
Britto, Constança
Alves, Carlos Roberto
author_role author
author2 Britto, Constança
Alves, Carlos Roberto
author2_role author
author
dc.contributor.author.fl_str_mv Pereira, Bernardo Acácio Santini
Britto, Constança
Alves, Carlos Roberto
dc.subject.other.pt_BR.fl_str_mv Roedores
Proteases
Expressão genética
Leishmania
Modelo animal
Complexo de Histocompatibilidade (MHC)
topic Roedores
Proteases
Expressão genética
Leishmania
Modelo animal
Complexo de Histocompatibilidade (MHC)
Leishmania spp
Animal model
Gene expression
Rodent
MHC
Protease
dc.subject.en.pt_BR.fl_str_mv Leishmania spp
Animal model
Gene expression
Rodent
MHC
Protease
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil.
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2016-10-13T16:05:42Z
dc.date.available.fl_str_mv 2016-10-13T16:05:42Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PEREIRA, Bernardo Acácio Santini; BRITTO, Constança; ALVES, Carlos Roberto. Expression of infection-related genes in parasites and host during murine experimental infection with Leishmania (Leishmania) amazonensis. Microbial Pathogenesis, v.52, n.2, p.101-108, Feb. 2012..
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/16221
dc.identifier.issn.pt_BR.fl_str_mv 0882-4010
dc.identifier.doi.none.fl_str_mv 10.1016/j.micpath.2011.11.004
dc.identifier.eissn.none.fl_str_mv 1096-1208
identifier_str_mv PEREIRA, Bernardo Acácio Santini; BRITTO, Constança; ALVES, Carlos Roberto. Expression of infection-related genes in parasites and host during murine experimental infection with Leishmania (Leishmania) amazonensis. Microbial Pathogenesis, v.52, n.2, p.101-108, Feb. 2012..
0882-4010
10.1016/j.micpath.2011.11.004
1096-1208
url https://www.arca.fiocruz.br/handle/icict/16221
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/16221/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/16221/2/carlos%20_alves_etal_IOC_2012.pdf
https://www.arca.fiocruz.br/bitstream/icict/16221/3/carlos%20_alves_etal_IOC_2012.pdf.txt
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