Diagnostic biomarkers for active tuberculosis: progress and challenges
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/56301 |
Resumo: | National Institute of Health. Programa de Pesquisa Intramural da Fundação Oswaldo Cruz. Conselho Nacional de Desenvolvimento Científico e Tecnológico Desenvolvimento (CNPq). |
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Nogueira, Betânia M. F.Krishnan, SonyaDuarte, Beatriz BarretoPereira, Mariana AraújoQueiroz, Artur T. L .Ellner, Jerrold J.Salgame, PadminiScriba, Thomas J.Sterling, Timothy R.Gupta, AmitaAndrade, Bruno B.2023-01-03T19:02:44Z2023-01-03T19:02:44Z2022NOGUEIRA, Betânia M. F. et al. Diagnostic biomarkers for active tuberculosis: progress and challenges. EMBO Molecular Medicine, v. 14, p. 1-13, 2022.1757-4684https://www.arca.fiocruz.br/handle/icict/5630110.15252/emmm.202114088National Institute of Health. Programa de Pesquisa Intramural da Fundação Oswaldo Cruz. Conselho Nacional de Desenvolvimento Científico e Tecnológico Desenvolvimento (CNPq).Universidade Federal da Bahia. Programa de Pós-graduação em Ciências da Saúde. Salvador, BA, Brasil / Instituto Couto Maia. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil.Division of Infectious Diseases. Department of Medicine. Johns Hopkins University School of Medicine. Baltimore, MD, USA.Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil / Universidade Salvador. Curso de Medicina. Salvador, BA, Brasil / Universidade Federal do Rio de Janeiro. Programa de Pós-graduação em Clínica Médica. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil.Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil /Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Instituto Couto Maia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Center of Data and Knowledge Integration for Health. Salvador, BA, Brasil.Department of Medicine. Centre for Emerging Pathogens. Rutgers-New Jersey Medical School. Newark, NJ, USA.Department of Medicine. Centre for Emerging Pathogens. Rutgers-New Jersey Medical School. Newark, NJ, USA.South African Tuberculosis Vaccine Initiative and Institute of Infectious Disease and Molecular Medicine. Division of Immunology. Department of Pathology. University of Cape Town. Cape Town, South Africa.Division of Infectious Diseases. Department of Medicine. Vanderbilt University Medical Center. Nashville, TN, USA.Division of Infectious Diseases. Department of Medicine. Johns Hopkins University School of Medicine. Baltimore, MD, USA.Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil / Universidade Salvador. Curso de Medicina. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Curso de Medicina. Salvador, Brasil.Tuberculosis (TB) is a leading cause of morbidity and mortality from a single infectious agent, despite being preventable and curable. Early and accurate diagnosis of active TB is critical to both enhance patient care, improve patient outcomes, and break Mycobacterium tuberculosis (Mtb) transmission cycles. In 2020 an estimated 9.9 million people fell ill from Mtb, but only a little over half (5.8 million) received an active TB diagnosis and treatment. The World Health Organization has proposed target product profiles for biomarker- or biosignature-based diagnostics using point-of-care tests from easily accessible specimens such as urine or blood. Here we review and summarize progress made in the development of pathogen- and host-based biomarkers for active TB diagnosis. We describe several unique patient populations that have posed challenges to development of a universal diagnostic TB biomarker, such as people living with HIV, extrapulmonary TB, and children. We also review additional limitations to widespread validation and utilization of published biomarkers. We conclude with proposed solutions to enhance TB diagnostic biomarker validation and uptake.engEMBO PressTuberculose ativaBiomarcadoresBiomarcadores de diagnósticoTuberculoseActive TBBiomarkersDagnostic biomarkersTuberculosisBiomarcadoresTuberculoseDiagnostic biomarkers for active tuberculosis: progress and challengesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/56301/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALNogueira B. Diagnostic biomarkers.pdfNogueira B. Diagnostic biomarkers.pdfapplication/pdf927187https://www.arca.fiocruz.br/bitstream/icict/56301/2/Nogueira%20B.%20Diagnostic%20biomarkers.pdf8d2533ab25f192c91c37b3812839129fMD52icict/563012023-03-15 14:32:49.715oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:49Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.en_US.fl_str_mv |
Diagnostic biomarkers for active tuberculosis: progress and challenges |
| title |
Diagnostic biomarkers for active tuberculosis: progress and challenges |
| spellingShingle |
Diagnostic biomarkers for active tuberculosis: progress and challenges Nogueira, Betânia M. F. Tuberculose ativa Biomarcadores Biomarcadores de diagnóstico Tuberculose Active TB Biomarkers Dagnostic biomarkers Tuberculosis Biomarcadores Tuberculose |
| title_short |
Diagnostic biomarkers for active tuberculosis: progress and challenges |
| title_full |
Diagnostic biomarkers for active tuberculosis: progress and challenges |
| title_fullStr |
Diagnostic biomarkers for active tuberculosis: progress and challenges |
| title_full_unstemmed |
Diagnostic biomarkers for active tuberculosis: progress and challenges |
| title_sort |
Diagnostic biomarkers for active tuberculosis: progress and challenges |
| author |
Nogueira, Betânia M. F. |
| author_facet |
Nogueira, Betânia M. F. Krishnan, Sonya Duarte, Beatriz Barreto Pereira, Mariana Araújo Queiroz, Artur T. L . Ellner, Jerrold J. Salgame, Padmini Scriba, Thomas J. Sterling, Timothy R. Gupta, Amita Andrade, Bruno B. |
| author_role |
author |
| author2 |
Krishnan, Sonya Duarte, Beatriz Barreto Pereira, Mariana Araújo Queiroz, Artur T. L . Ellner, Jerrold J. Salgame, Padmini Scriba, Thomas J. Sterling, Timothy R. Gupta, Amita Andrade, Bruno B. |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Nogueira, Betânia M. F. Krishnan, Sonya Duarte, Beatriz Barreto Pereira, Mariana Araújo Queiroz, Artur T. L . Ellner, Jerrold J. Salgame, Padmini Scriba, Thomas J. Sterling, Timothy R. Gupta, Amita Andrade, Bruno B. |
| dc.subject.other.en_US.fl_str_mv |
Tuberculose ativa Biomarcadores Biomarcadores de diagnóstico Tuberculose |
| topic |
Tuberculose ativa Biomarcadores Biomarcadores de diagnóstico Tuberculose Active TB Biomarkers Dagnostic biomarkers Tuberculosis Biomarcadores Tuberculose |
| dc.subject.en.en_US.fl_str_mv |
Active TB Biomarkers Dagnostic biomarkers Tuberculosis |
| dc.subject.decs.en_US.fl_str_mv |
Biomarcadores Tuberculose |
| description |
National Institute of Health. Programa de Pesquisa Intramural da Fundação Oswaldo Cruz. Conselho Nacional de Desenvolvimento Científico e Tecnológico Desenvolvimento (CNPq). |
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2022 |
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2022 |
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2023-01-03T19:02:44Z |
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2023-01-03T19:02:44Z |
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info:eu-repo/semantics/publishedVersion |
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NOGUEIRA, Betânia M. F. et al. Diagnostic biomarkers for active tuberculosis: progress and challenges. EMBO Molecular Medicine, v. 14, p. 1-13, 2022. |
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https://www.arca.fiocruz.br/handle/icict/56301 |
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1757-4684 |
| dc.identifier.doi.none.fl_str_mv |
10.15252/emmm.202114088 |
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NOGUEIRA, Betânia M. F. et al. Diagnostic biomarkers for active tuberculosis: progress and challenges. EMBO Molecular Medicine, v. 14, p. 1-13, 2022. 1757-4684 10.15252/emmm.202114088 |
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eng |
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eng |
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EMBO Press |
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EMBO Press |
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