The association of exercise test variables with long-term mortality in patients with chronic Chagas disease
| Main Author: | |
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| Publication Date: | 2022 |
| Other Authors: | , , , , , , , , , , , , , , , |
| Format: | Article |
| Language: | eng |
| Source: | Repositório Institucional da FIOCRUZ (ARCA) |
| Download full: | https://www.arca.fiocruz.br/handle/icict/55101 |
Summary: | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. |
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Silva, Rudson SantosMendes, Fernanda de Souza Nogueira SardinhaFleg, Jerome L.Rodrigues Junior, Luiz F.Vieira, Marcelo C.Xavier, Isis G. G.Costa, Henrique S.Reis, Michel S.Mazzoli-Rocha, FlaviaCosta, Andrea RHolanda, Marcelo Teixeira deVeloso, Henrique H.Silva, Gilberto Marcelo Sperandio daSousa, Andrea Silvestre deSaraiva, Roberto MagalhaesHasslocher-Moreno, Alejandro MarcelMediano, Mauro Felippe Felix2022-10-11T12:32:58Z2022-10-11T12:32:58Z2022SILVA, Rudson S. et al. The association of exercise test variables with long-term mortality in patients with chronic Chagas disease. Frontiers in medicine, v. 9, p. 1-11, 2022.2296-858Xhttps://www.arca.fiocruz.br/handle/icict/5510110.3389/fmed.2022.972514engFrontiers MediaThe association of exercise test variables with long-term mortality in patients with chronic Chagas diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.National Institutes of Health. National Heart, Lung, and Blood Institute. Bethesda, MD, United States.National Institute of Cardiology. Department of Research and Education. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Aloysio de Castro State Institute of Cardiology. Center for Cardiology and Exercise. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Federal University of Jequitinhonha and Mucuri Valleys. Physical Therapy Department. Diamantina, MG, Brazil.Federal University of Rio de Janeiro. School of Medicine. Faculty of Physical Therapy. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / National Institute of Cardiology. Department of Research and Education. Rio de Janeiro, RJ, Brazil.Background: The identification of variables obtained in the exercise test (ET) associated with increased risk of death is clinically relevant and would provide additional information for the management of Chagas disease (CD). The objective of the present study was to evaluate the association of ET variables with mortality in patients with chronic CD. Methods: This retrospective longitudinal observational study included 232 patients (median age 46.0 years; 50% women) with CD that were followed at the Evandro Chagas National Institute of Infectious Diseases (Rio de Janeiro, Brazil) and performed an ET between 1989 and 2000. The outcome of interest was all-cause mortality. Results: There were 103 deaths (44.4%) during a median follow-up of 21.5 years (IQR 25-75% 8.0-27.8), resulting in 24.5 per 1,000 patients/year incidence rate. The ET variables associated with mortality after adjustments for potential confounders were increased maximal (HR 1.02; 95% CI 1.00-1.03 per mmHg) and change (HR 1.03; 95% CI 1.01-1.06 per mmHg) of diastolic blood pressure (DBP) during ET, ventricular tachycardia at rest (HR 3.95; 95% CI 1.14-13.74), during exercise (HR 2.73; 95% CI 1.44-5.20), and recovery (HR 2.60; 95% CI 1.14-5.91), and premature ventricular complexes during recovery (HR 2.06; 1.33-3.21). Conclusion: Our findings suggest that ET provides important prognostic value for mortality risk assessment in patients with CD, with hemodynamic (increased DBP during exercise) and electrocardiographic (presence of ventricular arrhythmias) variables independently associated with an increased mortality risk in patients with CD. The identification of individuals at higher mortality risk can facilitate the development of intervention strategies (e.g., close follow-up) that may potentially have an impact on the longevity of patients with CD.Chagas diseaseVO2maxMaximal functional capacityMortalityPrognosisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALThe association of exercise test variables with long-term mortality in patients with chronic Chagas disease.pdfThe association of exercise test variables with long-term mortality in patients with chronic Chagas disease.pdfMain articleapplication/pdf571305https://www.arca.fiocruz.br/bitstream/icict/55101/2/The%20association%20of%20exercise%20test%20variables%20with%20long-term%20mortality%20in%20patients%20with%20chronic%20Chagas%20disease.pdfa677694dc233e9181fd15c5ea8790951MD52LICENSElicense.txtlicense.txttext/plain; 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| dc.title.en_US.fl_str_mv |
The association of exercise test variables with long-term mortality in patients with chronic Chagas disease |
| title |
The association of exercise test variables with long-term mortality in patients with chronic Chagas disease |
| spellingShingle |
The association of exercise test variables with long-term mortality in patients with chronic Chagas disease Silva, Rudson Santos Chagas disease VO2max Maximal functional capacity Mortality Prognosis |
| title_short |
The association of exercise test variables with long-term mortality in patients with chronic Chagas disease |
| title_full |
The association of exercise test variables with long-term mortality in patients with chronic Chagas disease |
| title_fullStr |
The association of exercise test variables with long-term mortality in patients with chronic Chagas disease |
| title_full_unstemmed |
The association of exercise test variables with long-term mortality in patients with chronic Chagas disease |
| title_sort |
The association of exercise test variables with long-term mortality in patients with chronic Chagas disease |
| author |
Silva, Rudson Santos |
| author_facet |
Silva, Rudson Santos Mendes, Fernanda de Souza Nogueira Sardinha Fleg, Jerome L. Rodrigues Junior, Luiz F. Vieira, Marcelo C. Xavier, Isis G. G. Costa, Henrique S. Reis, Michel S. Mazzoli-Rocha, Flavia Costa, Andrea R Holanda, Marcelo Teixeira de Veloso, Henrique H. Silva, Gilberto Marcelo Sperandio da Sousa, Andrea Silvestre de Saraiva, Roberto Magalhaes Hasslocher-Moreno, Alejandro Marcel Mediano, Mauro Felippe Felix |
| author_role |
author |
| author2 |
Mendes, Fernanda de Souza Nogueira Sardinha Fleg, Jerome L. Rodrigues Junior, Luiz F. Vieira, Marcelo C. Xavier, Isis G. G. Costa, Henrique S. Reis, Michel S. Mazzoli-Rocha, Flavia Costa, Andrea R Holanda, Marcelo Teixeira de Veloso, Henrique H. Silva, Gilberto Marcelo Sperandio da Sousa, Andrea Silvestre de Saraiva, Roberto Magalhaes Hasslocher-Moreno, Alejandro Marcel Mediano, Mauro Felippe Felix |
| author2_role |
author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Silva, Rudson Santos Mendes, Fernanda de Souza Nogueira Sardinha Fleg, Jerome L. Rodrigues Junior, Luiz F. Vieira, Marcelo C. Xavier, Isis G. G. Costa, Henrique S. Reis, Michel S. Mazzoli-Rocha, Flavia Costa, Andrea R Holanda, Marcelo Teixeira de Veloso, Henrique H. Silva, Gilberto Marcelo Sperandio da Sousa, Andrea Silvestre de Saraiva, Roberto Magalhaes Hasslocher-Moreno, Alejandro Marcel Mediano, Mauro Felippe Felix |
| dc.subject.en.en_US.fl_str_mv |
Chagas disease VO2max Maximal functional capacity Mortality Prognosis |
| topic |
Chagas disease VO2max Maximal functional capacity Mortality Prognosis |
| description |
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. |
| publishDate |
2022 |
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2022-10-11T12:32:58Z |
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2022-10-11T12:32:58Z |
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2022 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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SILVA, Rudson S. et al. The association of exercise test variables with long-term mortality in patients with chronic Chagas disease. Frontiers in medicine, v. 9, p. 1-11, 2022. |
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https://www.arca.fiocruz.br/handle/icict/55101 |
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2296-858X |
| dc.identifier.doi.none.fl_str_mv |
10.3389/fmed.2022.972514 |
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SILVA, Rudson S. et al. The association of exercise test variables with long-term mortality in patients with chronic Chagas disease. Frontiers in medicine, v. 9, p. 1-11, 2022. 2296-858X 10.3389/fmed.2022.972514 |
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Frontiers Media |
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