Untargeted Metabolomics Insights into Newborns with Congenital Zika Infection

Detalhes bibliográficos
Autor(a) principal: Nunes, Estéfane da C.
Data de Publicação: 2021
Outros Autores: Filippis, Ana M. B. de, Pereira, Taiane do E. S., Faria, Nieli R. da C., Salgado, Álvaro, Santos, Cleiton S., Carvalho, Teresa C. P. X., Calcagno, Juan I., Chalhoub, Flávia L. L., Brown, David, Giovanetti, Marta, Alcantara Junior, Luiz Carlos, Barreto, Fernanda K., Siqueira, Isadora Cristina de, Canuto, Gisele A. B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/50255
Resumo: 1 Departamento de Química Analítica, Instituto de Química, Universidade Federal da Bahia, Rua Barao de Jeremoabo, 147, Salvador, BA 40170-115, Brazil; estefane.cruz@gmail.com (E.d.C.N.); taianepereira94@gmail.com (T.d.E.S.P.) 2 Laboratório de Flavivírus, Instituto Oswaldo Cruz, Fiocruz, Avenida Brasil, 4365, Manguinhos, Rio de Janeiro, RJ 21040-900, Brazil; ana.bispo@ioc.fiocruz.br (A.M.B.d.F.); flaviallevy@yahoo.com.br (F.L.L.C.); David.Brown@phe.gov.uk (D.B.); giovanetti.marta@gmail.com (M.G.); luiz.alcantara@ioc.fiocruz.br (L.C.J.A.) 3 Laboratório de Genética Celular e Molecular, Universidade Federal de Minas Gerais, Avenida Presidente Antônio Carlos, 6627, Belo Horizonte, MG 31270-901, Brazil; alvaro.salgado.81@gmail.com 4 Instituto Gonçalo Moniz, Fiocruz, Rua Waldemar Falcão, 121, Salvador, BA 40295-010, Brazil; Cleitonsantos29@outlook.com 5 Maternidade de Referência Professor José Maria de Magalhães Neto, SESAB, Rua Marquês de Maricá, Salvador, BA 40310-000, Brazil; terezaxpaim@gmail.com (T.C.P.X.C.); calcagnoji@gmail.com (J.I.C.) 6 Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, Rua Hormindo Barros, 58, Vitória da Conquista, BA 45029-094, Brazil
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spelling Nunes, Estéfane da C.Filippis, Ana M. B. dePereira, Taiane do E. S.Faria, Nieli R. da C.Salgado, ÁlvaroSantos, Cleiton S.Carvalho, Teresa C. P. X.Calcagno, Juan I.Chalhoub, Flávia L. L.Brown, DavidGiovanetti, MartaAlcantara Junior, Luiz CarlosBarreto, Fernanda K.Siqueira, Isadora Cristina deCanuto, Gisele A. B.2021-12-09T17:31:49Z2021-12-09T17:31:49Z2021NUNES, Estéfane da C. et al. Untargeted Metabolomics Insights into Newborns with Congenital Zika Infection. Pathogens, 2021.2076-0817https://www.arca.fiocruz.br/handle/icict/5025510.3390/ pathogens100404681 Departamento de Química Analítica, Instituto de Química, Universidade Federal da Bahia, Rua Barao de Jeremoabo, 147, Salvador, BA 40170-115, Brazil; estefane.cruz@gmail.com (E.d.C.N.); taianepereira94@gmail.com (T.d.E.S.P.) 2 Laboratório de Flavivírus, Instituto Oswaldo Cruz, Fiocruz, Avenida Brasil, 4365, Manguinhos, Rio de Janeiro, RJ 21040-900, Brazil; ana.bispo@ioc.fiocruz.br (A.M.B.d.F.); flaviallevy@yahoo.com.br (F.L.L.C.); David.Brown@phe.gov.uk (D.B.); giovanetti.marta@gmail.com (M.G.); luiz.alcantara@ioc.fiocruz.br (L.C.J.A.) 3 Laboratório de Genética Celular e Molecular, Universidade Federal de Minas Gerais, Avenida Presidente Antônio Carlos, 6627, Belo Horizonte, MG 31270-901, Brazil; alvaro.salgado.81@gmail.com 4 Instituto Gonçalo Moniz, Fiocruz, Rua Waldemar Falcão, 121, Salvador, BA 40295-010, Brazil; Cleitonsantos29@outlook.com 5 Maternidade de Referência Professor José Maria de Magalhães Neto, SESAB, Rua Marquês de Maricá, Salvador, BA 40310-000, Brazil; terezaxpaim@gmail.com (T.C.P.X.C.); calcagnoji@gmail.com (J.I.C.) 6 Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, Rua Hormindo Barros, 58, Vitória da Conquista, BA 45029-094, BrazilFundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) under the grant number E-26/2002.930/2016, by the Canadian International Development Research Centre (IDRC), grant number 108411-001. I.C.S was supported by the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) grant number 443875/2018-9 and the Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB) grant number 5125/2017).“Múltipla – ver em notas”Abstract: Zika virus (ZIKV), an emerging virus belonging to the Flaviviridae family, causes severe neurological clinical complications and has been associated with Guillain-Barré syndrome, fetal abnormalities known collectively as congenital Zika syndrome, and microcephaly. Studies have shown that ZIKV infection can alter cellular metabolism, directly affecting neural development. Brain growth requires controlled cellular metabolism, which is essential for cell proliferation and maturation. However, little is known regarding the metabolic profile of ZIKV-infected newborns and possible associations related to microcephaly. Furthering the understanding surrounding underlying mechanisms is essential to developing personalized treatments for affected individuals. Thus, metabolomics, the study of the metabolites produced by or modified in an organism, constitutes a valuable approach in the study of complex diseases. Here, 26 serum samples from ZIKV-positive newborns with or without microcephaly, as well as controls, were analyzed using an untargeted metabolomics approach involving gas chromatography–mass spectrometry (GC-MS). Significant alterations in essential and non-essential amino acids, as well as carbohydrates (including aldohexoses, such as glucose or mannose) and their derivatives (urea and pyruvic acid), were observed in the metabolic profiles analyzed. Our results provide insight into relevant metabolic processes in patients with ZIKV and microcephaly.engMDPIVírus ZikaMicrocefaliaMetabolômicaAprendizado de máquinaZika virusMicrocephalyMetabolomicsMachine learningUntargeted Metabolomics Insights into Newborns with Congenital Zika Infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/50255/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALNunes, Estefane da C. Untargeted....pdfNunes, Estefane da C. 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dc.title.pt_BR.fl_str_mv Untargeted Metabolomics Insights into Newborns with Congenital Zika Infection
title Untargeted Metabolomics Insights into Newborns with Congenital Zika Infection
spellingShingle Untargeted Metabolomics Insights into Newborns with Congenital Zika Infection
Nunes, Estéfane da C.
Vírus Zika
Microcefalia
Metabolômica
Aprendizado de máquina
Zika virus
Microcephaly
Metabolomics
Machine learning
title_short Untargeted Metabolomics Insights into Newborns with Congenital Zika Infection
title_full Untargeted Metabolomics Insights into Newborns with Congenital Zika Infection
title_fullStr Untargeted Metabolomics Insights into Newborns with Congenital Zika Infection
title_full_unstemmed Untargeted Metabolomics Insights into Newborns with Congenital Zika Infection
title_sort Untargeted Metabolomics Insights into Newborns with Congenital Zika Infection
author Nunes, Estéfane da C.
author_facet Nunes, Estéfane da C.
Filippis, Ana M. B. de
Pereira, Taiane do E. S.
Faria, Nieli R. da C.
Salgado, Álvaro
Santos, Cleiton S.
Carvalho, Teresa C. P. X.
Calcagno, Juan I.
Chalhoub, Flávia L. L.
Brown, David
Giovanetti, Marta
Alcantara Junior, Luiz Carlos
Barreto, Fernanda K.
Siqueira, Isadora Cristina de
Canuto, Gisele A. B.
author_role author
author2 Filippis, Ana M. B. de
Pereira, Taiane do E. S.
Faria, Nieli R. da C.
Salgado, Álvaro
Santos, Cleiton S.
Carvalho, Teresa C. P. X.
Calcagno, Juan I.
Chalhoub, Flávia L. L.
Brown, David
Giovanetti, Marta
Alcantara Junior, Luiz Carlos
Barreto, Fernanda K.
Siqueira, Isadora Cristina de
Canuto, Gisele A. B.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Nunes, Estéfane da C.
Filippis, Ana M. B. de
Pereira, Taiane do E. S.
Faria, Nieli R. da C.
Salgado, Álvaro
Santos, Cleiton S.
Carvalho, Teresa C. P. X.
Calcagno, Juan I.
Chalhoub, Flávia L. L.
Brown, David
Giovanetti, Marta
Alcantara Junior, Luiz Carlos
Barreto, Fernanda K.
Siqueira, Isadora Cristina de
Canuto, Gisele A. B.
dc.subject.other.pt_BR.fl_str_mv Vírus Zika
Microcefalia
Metabolômica
Aprendizado de máquina
topic Vírus Zika
Microcefalia
Metabolômica
Aprendizado de máquina
Zika virus
Microcephaly
Metabolomics
Machine learning
dc.subject.en.pt_BR.fl_str_mv Zika virus
Microcephaly
Metabolomics
Machine learning
description 1 Departamento de Química Analítica, Instituto de Química, Universidade Federal da Bahia, Rua Barao de Jeremoabo, 147, Salvador, BA 40170-115, Brazil; estefane.cruz@gmail.com (E.d.C.N.); taianepereira94@gmail.com (T.d.E.S.P.) 2 Laboratório de Flavivírus, Instituto Oswaldo Cruz, Fiocruz, Avenida Brasil, 4365, Manguinhos, Rio de Janeiro, RJ 21040-900, Brazil; ana.bispo@ioc.fiocruz.br (A.M.B.d.F.); flaviallevy@yahoo.com.br (F.L.L.C.); David.Brown@phe.gov.uk (D.B.); giovanetti.marta@gmail.com (M.G.); luiz.alcantara@ioc.fiocruz.br (L.C.J.A.) 3 Laboratório de Genética Celular e Molecular, Universidade Federal de Minas Gerais, Avenida Presidente Antônio Carlos, 6627, Belo Horizonte, MG 31270-901, Brazil; alvaro.salgado.81@gmail.com 4 Instituto Gonçalo Moniz, Fiocruz, Rua Waldemar Falcão, 121, Salvador, BA 40295-010, Brazil; Cleitonsantos29@outlook.com 5 Maternidade de Referência Professor José Maria de Magalhães Neto, SESAB, Rua Marquês de Maricá, Salvador, BA 40310-000, Brazil; terezaxpaim@gmail.com (T.C.P.X.C.); calcagnoji@gmail.com (J.I.C.) 6 Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, Rua Hormindo Barros, 58, Vitória da Conquista, BA 45029-094, Brazil
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-12-09T17:31:49Z
dc.date.available.fl_str_mv 2021-12-09T17:31:49Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv NUNES, Estéfane da C. et al. Untargeted Metabolomics Insights into Newborns with Congenital Zika Infection. Pathogens, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/50255
dc.identifier.issn.pt_BR.fl_str_mv 2076-0817
dc.identifier.doi.none.fl_str_mv 10.3390/ pathogens10040468
identifier_str_mv NUNES, Estéfane da C. et al. Untargeted Metabolomics Insights into Newborns with Congenital Zika Infection. Pathogens, 2021.
2076-0817
10.3390/ pathogens10040468
url https://www.arca.fiocruz.br/handle/icict/50255
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/50255/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/50255/2/Nunes%2c%20Estefane%20da%20C.%20Untargeted....pdf
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