Immunological Profile of HTLV-1-Infected Patients Associated with Infectious or Autoimmune Dermatological Disorders
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2013 |
| Outros Autores: | , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/30692 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil/Aaron Diamond AIDS Research Center. Rockefeller University. New York, NY, United States of America/HEMOMINAS. Grupo de Pesquisa Interdisciplinar do HTLV – GIPH. Belo Horizonte, MG, Brazil |
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Reis, Jordana Grazziela Alves Coelho dosPassos, LiviaDuarte, Mariana CostaAraújo, Marcelo GrossiAzevedo, Ana Carolina CampiCarvalho, Andréa Teixeira deMagalhães, Vanessa PeruhypeTrindade, Bruno CaetanoDias, Raquel dos SantosMartins, Marina LobatoProietti, Anna Barbara de Freitas CarneiroGuedes, Antônio CarlosGonçalves, Denise UtschMartins Filho, Olindo Assis2018-12-19T12:53:29Z2018-12-19T12:53:29Z2013REIS, Jordana Grazziela Alves Coelho dos et al. Immunological Profile of HTLV-1-Infected Patients Associated with Infectious or Autoimmune Dermatological Disorders. PLoS Negl Trop Dis., v. 7, n. 7, e2328, 2013.1935-2735https://www.arca.fiocruz.br/handle/icict/3069210.1371/journal.pntd.0002328engPublic Library of ScienceHTLV-1HTLV-1Immunological Profile of HTLV-1-Infected Patients Associated with Infectious or Autoimmune Dermatological Disordersinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil/Aaron Diamond AIDS Research Center. Rockefeller University. New York, NY, United States of America/HEMOMINAS. Grupo de Pesquisa Interdisciplinar do HTLV – GIPH. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil/HEMOMINAS. Grupo de Pesquisa Interdisciplinar do HTLV – GIPH. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração.HEMOMINAS. Grupo de Pesquisa Interdisciplinar do HTLV – GIPH. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, BraziFundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração.Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração.Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração.Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração.HEMOMINAS. Grupo de Pesquisa Interdisciplinar do HTLV – GIPH. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, BrazilHEMOMINAS. Grupo de Pesquisa Interdisciplinar do HTLV – GIPH. Belo Horizonte, MG, BrazilHEMOMINAS. Grupo de Pesquisa Interdisciplinar do HTLV – GIPH. Belo Horizonte, MG, BrazilHEMOMINAS. Grupo de Pesquisa Interdisciplinar do HTLV – GIPH. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, BrazilHEMOMINAS. Grupo de Pesquisa Interdisciplinar do HTLV – GIPH. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil/HEMOMINAS. Grupo de Pesquisa Interdisciplinar do HTLV – GIPH. Belo Horizonte, MG, BrazilIn the present study, the frequency, the activation and the cytokine and chemokine profile of HTLV-1 carriers with or without dermatological lesions were thoroughly described and compared. The results indicated that HTLV-1-infected patients with dermatological lesions have distinct frequency and activation status when compared to asymptomatic carriers. Alterations in the CD4+HLA-DR+, CD8+ T cell, macrophage-like and NKT subsets as well as in the serum chemokines CCL5, CXCL8, CXCL9 and CXCL10 were observed in the HTLV-1-infected group with skin lesions. Additionally, HTLV-1 carriers with dermatological skin lesions showed more frequently high proviral load as compared to asymptomatic carriers. The elevated proviral load in HTLV-1 patients with infectious skin lesions correlated significantly with TNF-α/IL-10 ratio, while the same significant correlation was found for the IL-12/IL-10 ratio and the high proviral load in HTLV-1-infected patients with autoimmune skin lesions. All in all, these results suggest a distinct and unique immunological profile in the peripheral blood of HTLV-1-infected patients with skin disorders, and the different nature of skin lesion observed in these patients may be an outcome of a distinct unbalance of the systemic inflammatory response upon HTLV-1 infection.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/30692/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALHTLV-1.pdfHTLV-1.pdfapplication/pdf5155431https://www.arca.fiocruz.br/bitstream/icict/30692/2/HTLV-1.pdf2c62ec6500112fbd49c7fa7daacd3664MD52TEXTHTLV-1.pdf.txtHTLV-1.pdf.txtExtracted texttext/plain93https://www.arca.fiocruz.br/bitstream/icict/30692/3/HTLV-1.pdf.txt4c1384e7ee512e597af430464de6b815MD53icict/306922019-06-19 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| dc.title.pt_BR.fl_str_mv |
Immunological Profile of HTLV-1-Infected Patients Associated with Infectious or Autoimmune Dermatological Disorders |
| title |
Immunological Profile of HTLV-1-Infected Patients Associated with Infectious or Autoimmune Dermatological Disorders |
| spellingShingle |
Immunological Profile of HTLV-1-Infected Patients Associated with Infectious or Autoimmune Dermatological Disorders Reis, Jordana Grazziela Alves Coelho dos HTLV-1 HTLV-1 |
| title_short |
Immunological Profile of HTLV-1-Infected Patients Associated with Infectious or Autoimmune Dermatological Disorders |
| title_full |
Immunological Profile of HTLV-1-Infected Patients Associated with Infectious or Autoimmune Dermatological Disorders |
| title_fullStr |
Immunological Profile of HTLV-1-Infected Patients Associated with Infectious or Autoimmune Dermatological Disorders |
| title_full_unstemmed |
Immunological Profile of HTLV-1-Infected Patients Associated with Infectious or Autoimmune Dermatological Disorders |
| title_sort |
Immunological Profile of HTLV-1-Infected Patients Associated with Infectious or Autoimmune Dermatological Disorders |
| author |
Reis, Jordana Grazziela Alves Coelho dos |
| author_facet |
Reis, Jordana Grazziela Alves Coelho dos Passos, Livia Duarte, Mariana Costa Araújo, Marcelo Grossi Azevedo, Ana Carolina Campi Carvalho, Andréa Teixeira de Magalhães, Vanessa Peruhype Trindade, Bruno Caetano Dias, Raquel dos Santos Martins, Marina Lobato Proietti, Anna Barbara de Freitas Carneiro Guedes, Antônio Carlos Gonçalves, Denise Utsch Martins Filho, Olindo Assis |
| author_role |
author |
| author2 |
Passos, Livia Duarte, Mariana Costa Araújo, Marcelo Grossi Azevedo, Ana Carolina Campi Carvalho, Andréa Teixeira de Magalhães, Vanessa Peruhype Trindade, Bruno Caetano Dias, Raquel dos Santos Martins, Marina Lobato Proietti, Anna Barbara de Freitas Carneiro Guedes, Antônio Carlos Gonçalves, Denise Utsch Martins Filho, Olindo Assis |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Reis, Jordana Grazziela Alves Coelho dos Passos, Livia Duarte, Mariana Costa Araújo, Marcelo Grossi Azevedo, Ana Carolina Campi Carvalho, Andréa Teixeira de Magalhães, Vanessa Peruhype Trindade, Bruno Caetano Dias, Raquel dos Santos Martins, Marina Lobato Proietti, Anna Barbara de Freitas Carneiro Guedes, Antônio Carlos Gonçalves, Denise Utsch Martins Filho, Olindo Assis |
| dc.subject.other.pt_BR.fl_str_mv |
HTLV-1 |
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HTLV-1 HTLV-1 |
| dc.subject.en.pt_BR.fl_str_mv |
HTLV-1 |
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Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil/Aaron Diamond AIDS Research Center. Rockefeller University. New York, NY, United States of America/HEMOMINAS. Grupo de Pesquisa Interdisciplinar do HTLV – GIPH. Belo Horizonte, MG, Brazil |
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2013 |
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2013 |
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2018-12-19T12:53:29Z |
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2018-12-19T12:53:29Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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REIS, Jordana Grazziela Alves Coelho dos et al. Immunological Profile of HTLV-1-Infected Patients Associated with Infectious or Autoimmune Dermatological Disorders. PLoS Negl Trop Dis., v. 7, n. 7, e2328, 2013. |
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https://www.arca.fiocruz.br/handle/icict/30692 |
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1935-2735 |
| dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pntd.0002328 |
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REIS, Jordana Grazziela Alves Coelho dos et al. Immunological Profile of HTLV-1-Infected Patients Associated with Infectious or Autoimmune Dermatological Disorders. PLoS Negl Trop Dis., v. 7, n. 7, e2328, 2013. 1935-2735 10.1371/journal.pntd.0002328 |
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Public Library of Science |
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Public Library of Science |
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