Genome-wide association study of asthma, total IgE, and lung function in a cohort of Peruvian children
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/50155 |
Resumo: | athe Division of Pediatric Allergy and Immunology, cthe Division of Pulmonary and Critical Care Medicine, ethe Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore; bthe Division of Biomedical Informatics and Personalized Medicine, University of Colorado, Denver; dthe A.B. PRISMA, Lima; fthe Department of Internal Medicine, Center for Precision Medicine, Wake Forest School of Medicine, Winston-Salem; gInstituto de Ci^encias da Sa ude, Universidade Federal da Bahia (UFBA), Salvador; hthe Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem; ithe Department of Medicine, University of Arizona, Tucson; jthe Fundaçãao ProAR, Salvador; kthe Centro de Integraçãao de Dados e Conhecimento para Sa ude, Fiocruz, Salvador; and lthe Department of International Health, Program in Global Disease Epidemiology and Control, Johns Hopkins Bloomberg School of Public Health, Baltimore. |
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Akenroye, Ayobami T.Brunetti, TonyaRomero, KarinaDaya, MichelleKanchan, KanikaShankar, GautamChavan, SameerBoorgula, Meher PreethiAmpleford, Elizabeth A.Fonseca, Hellen FreitasHawkins, Gregory A.Teixeira, Helena Mariana PitangueiraCampbell, MonicaRafaels, NicholasWinters, AlexandraBleecker, Eugene R.Cruz, Alvaro A.Barreto, Mauricio LimaMeyers, Deborah A.Ortega, Victor E.Figueiredo, Camila A.Barnes, Kathleen C.Checkley, WilliamHansel, Nadia N.Mathias, Rasika A.2021-12-03T14:33:55Z2021-12-03T14:33:55Z2021AKENROYE, Ayobami T. et al. Genome-wide association study of asthma, total IgE, and lung function in a cohort of Peruvian children. Journal of Allergy and Clinical Immunology., 2021.0091-6749https://www.arca.fiocruz.br/handle/icict/5015510.1016/j.jaci.2021.02.035athe Division of Pediatric Allergy and Immunology, cthe Division of Pulmonary and Critical Care Medicine, ethe Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore; bthe Division of Biomedical Informatics and Personalized Medicine, University of Colorado, Denver; dthe A.B. PRISMA, Lima; fthe Department of Internal Medicine, Center for Precision Medicine, Wake Forest School of Medicine, Winston-Salem; gInstituto de Ci^encias da Sa ude, Universidade Federal da Bahia (UFBA), Salvador; hthe Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem; ithe Department of Medicine, University of Arizona, Tucson; jthe Fundaçãao ProAR, Salvador; kthe Centro de Integraçãao de Dados e Conhecimento para Sa ude, Fiocruz, Salvador; and lthe Department of International Health, Program in Global Disease Epidemiology and Control, Johns Hopkins Bloomberg School of Public Health, Baltimore.National Institute of Environmental Health Sciences, National Institutes of Health (grants R01ES018845 and R01ES018845-S1 and NHLBI R01 HL142992). A.T.A was supported by the National Institute of Allergy and Infectious Diseases T32 Research Training Grant in Pediatric Allergy and Immunology (grant no. 2T32AI007007-41) and the Johns Hopkins University Provost’s Postdoctoral Award. K.R. was a Fogarty Global Health Fellow through the consortium comprising the University of North Carolina, Johns Hopkins University, Morehouse School of Medicine, and Tulane University during the conduct of this work (through grant 5R25TW009340) W.C. was supported by Pathway to Independence Award R00HL096955 from the National Heart, Lung, and Blood Institute, National Institutes of Health."Múltipla ver em Notas"Background: Genetic ancestry plays a role in asthma health disparities. Objective: Our aim was to evaluate the impact of ancestry on and identify genetic variants associated with asthma, total serum IgE level, and lung function. Methods: A total of 436 Peruvian children (aged 9-19 years) with asthma and 291 without asthma were genotyped by using the Illumina Multi-Ethnic Global Array. Genome-wide proportions of indigenous ancestry populations from continental America (NAT) and European ancestry from the Iberian populations in Spain (IBS) were estimated by using ADMIXTURE. We assessed the relationship between ancestry and the phenotypes and performed a genome-wide association study. Results: The mean ancestry proportions were 84.7% NAT (case patients, 84.2%; controls, 85.4%) and 15.3% IBS (15.8%; 14.6%). With adjustment for asthma, NAT was associated with higher total serum IgE levels (P < .001) and IBS was associated with lower total serum IgE levels (P < .001). NAT was associated with higher FEV1 percent predicted values (P < .001), whereas IBS was associated with lower FEV1 values in the controls but not in the case patients. The HLA-DR/DQ region on chromosome 6 (Chr6) was strongly associated with total serum IgE (rs3135348; P 5 3.438 3 10–10) and was independent of an association with the haplotype HLA-DQA1 HLADQB1: 04.01 04.02 (P 5 1.55 3 10–05). For lung function, we identified a locus (rs4410198; P 5 5.536 3 10–11) mapping to Chr19, near a cluster of zinc finger interacting genes that colocalizes to the long noncoding RNA CTD-2537I9.5. This novel locus was replicated in an independent sample of pediatric case patients with asthma with similar admixture from Brazil (P 5 .005). Conclusion: This study confirms the role of HLA in atopy, and identifies a novel locus mapping to a long noncoding RNA for lung function that may be specific to children with NAT.engElsevierAsmaImunoglobulina EFunção RespiratóriaEstudo de Associação Genômica AmplaPeruAncestralidadeAlergiaAsthmaImmunoglobulin ELung functionAdmixtureGenome wide association analysesPeruAncestryAllergyGenome-wide association study of asthma, total IgE, and lung function in a cohort of Peruvian childreninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/50155/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALAkenroye, Ayobami T.pdfAkenroye, Ayobami 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| dc.title.pt_BR.fl_str_mv |
Genome-wide association study of asthma, total IgE, and lung function in a cohort of Peruvian children |
| title |
Genome-wide association study of asthma, total IgE, and lung function in a cohort of Peruvian children |
| spellingShingle |
Genome-wide association study of asthma, total IgE, and lung function in a cohort of Peruvian children Akenroye, Ayobami T. Asma Imunoglobulina E Função Respiratória Estudo de Associação Genômica Ampla Peru Ancestralidade Alergia Asthma Immunoglobulin E Lung function Admixture Genome wide association analyses Peru Ancestry Allergy |
| title_short |
Genome-wide association study of asthma, total IgE, and lung function in a cohort of Peruvian children |
| title_full |
Genome-wide association study of asthma, total IgE, and lung function in a cohort of Peruvian children |
| title_fullStr |
Genome-wide association study of asthma, total IgE, and lung function in a cohort of Peruvian children |
| title_full_unstemmed |
Genome-wide association study of asthma, total IgE, and lung function in a cohort of Peruvian children |
| title_sort |
Genome-wide association study of asthma, total IgE, and lung function in a cohort of Peruvian children |
| author |
Akenroye, Ayobami T. |
| author_facet |
Akenroye, Ayobami T. Brunetti, Tonya Romero, Karina Daya, Michelle Kanchan, Kanika Shankar, Gautam Chavan, Sameer Boorgula, Meher Preethi Ampleford, Elizabeth A. Fonseca, Hellen Freitas Hawkins, Gregory A. Teixeira, Helena Mariana Pitangueira Campbell, Monica Rafaels, Nicholas Winters, Alexandra Bleecker, Eugene R. Cruz, Alvaro A. Barreto, Mauricio Lima Meyers, Deborah A. Ortega, Victor E. Figueiredo, Camila A. Barnes, Kathleen C. Checkley, William Hansel, Nadia N. Mathias, Rasika A. |
| author_role |
author |
| author2 |
Brunetti, Tonya Romero, Karina Daya, Michelle Kanchan, Kanika Shankar, Gautam Chavan, Sameer Boorgula, Meher Preethi Ampleford, Elizabeth A. Fonseca, Hellen Freitas Hawkins, Gregory A. Teixeira, Helena Mariana Pitangueira Campbell, Monica Rafaels, Nicholas Winters, Alexandra Bleecker, Eugene R. Cruz, Alvaro A. Barreto, Mauricio Lima Meyers, Deborah A. Ortega, Victor E. Figueiredo, Camila A. Barnes, Kathleen C. Checkley, William Hansel, Nadia N. Mathias, Rasika A. |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Akenroye, Ayobami T. Brunetti, Tonya Romero, Karina Daya, Michelle Kanchan, Kanika Shankar, Gautam Chavan, Sameer Boorgula, Meher Preethi Ampleford, Elizabeth A. Fonseca, Hellen Freitas Hawkins, Gregory A. Teixeira, Helena Mariana Pitangueira Campbell, Monica Rafaels, Nicholas Winters, Alexandra Bleecker, Eugene R. Cruz, Alvaro A. Barreto, Mauricio Lima Meyers, Deborah A. Ortega, Victor E. Figueiredo, Camila A. Barnes, Kathleen C. Checkley, William Hansel, Nadia N. Mathias, Rasika A. |
| dc.subject.other.pt_BR.fl_str_mv |
Asma Imunoglobulina E Função Respiratória Estudo de Associação Genômica Ampla Peru Ancestralidade Alergia |
| topic |
Asma Imunoglobulina E Função Respiratória Estudo de Associação Genômica Ampla Peru Ancestralidade Alergia Asthma Immunoglobulin E Lung function Admixture Genome wide association analyses Peru Ancestry Allergy |
| dc.subject.en.pt_BR.fl_str_mv |
Asthma Immunoglobulin E Lung function Admixture Genome wide association analyses Peru Ancestry Allergy |
| description |
athe Division of Pediatric Allergy and Immunology, cthe Division of Pulmonary and Critical Care Medicine, ethe Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore; bthe Division of Biomedical Informatics and Personalized Medicine, University of Colorado, Denver; dthe A.B. PRISMA, Lima; fthe Department of Internal Medicine, Center for Precision Medicine, Wake Forest School of Medicine, Winston-Salem; gInstituto de Ci^encias da Sa ude, Universidade Federal da Bahia (UFBA), Salvador; hthe Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem; ithe Department of Medicine, University of Arizona, Tucson; jthe Fundaçãao ProAR, Salvador; kthe Centro de Integraçãao de Dados e Conhecimento para Sa ude, Fiocruz, Salvador; and lthe Department of International Health, Program in Global Disease Epidemiology and Control, Johns Hopkins Bloomberg School of Public Health, Baltimore. |
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2021 |
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2021-12-03T14:33:55Z |
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2021-12-03T14:33:55Z |
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2021 |
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AKENROYE, Ayobami T. et al. Genome-wide association study of asthma, total IgE, and lung function in a cohort of Peruvian children. Journal of Allergy and Clinical Immunology., 2021. |
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https://www.arca.fiocruz.br/handle/icict/50155 |
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0091-6749 |
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10.1016/j.jaci.2021.02.035 |
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AKENROYE, Ayobami T. et al. Genome-wide association study of asthma, total IgE, and lung function in a cohort of Peruvian children. Journal of Allergy and Clinical Immunology., 2021. 0091-6749 10.1016/j.jaci.2021.02.035 |
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